{"id":"https://openalex.org/W2993660155","doi":null,"title":"Migraine in pregnancy.","display_name":"Migraine in pregnancy.","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2993660155","mag":"2993660155","pmid":"https://pubmed.ncbi.nlm.nih.gov/10487510"},"language":"en","primary_location":{"id":"pmid:10487510","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10487510","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107840645","display_name":"M Aub\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"M Aub\u00e9","raw_affiliation_strings":["McGill University and the Montr\u00e9al Neurological Institute, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGill University and the Montr\u00e9al Neurological Institute, Quebec, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5107840645"],"corresponding_institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"],"apc_list":null,"apc_paid":null,"fwci":0.7149,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.72873734,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"53","issue":"4 Suppl 1","first_page":"S26","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10786","display_name":"Maternal Mental Health During Pregnancy and Postpartum","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/migraine-in-pregnancy","display_name":"migraine in pregnancy","score":0.8740000128746033},{"id":"https://openalex.org/keywords/migraine-remission","display_name":"migraine remission","score":0.6729999780654907},{"id":"https://openalex.org/keywords/migraine-with-aura","display_name":"migraine with aura","score":0.7350000143051147},{"id":"https://openalex.org/keywords/pregnancy-complications","display_name":"pregnancy complications","score":0.6029999852180481},{"id":"https://openalex.org/keywords/paracetamol","display_name":"paracetamol","score":0.6790000200271606},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.824999988079071},{"id":"https://openalex.org/keywords/chlorpromazine","display_name":"chlorpromazine","score":0.6449999809265137},{"id":"https://openalex.org/keywords/metoclopramide","display_name":"metoclopramide","score":0.8560000061988831},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.6919999718666077},{"id":"https://openalex.org/keywords/migraine-prevention","display_name":"migraine prophylaxis","score":0.8820000290870667},{"id":"https://openalex.org/keywords/medication-safety-in-pregnancy","display_name":"drug safety in pregnancy","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.9364198446273804},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8575036525726318},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.786770224571228},{"id":"https://openalex.org/C2777350023","wikidata":"https://www.wikidata.org/wiki/Q1154226","display_name":"Aura","level":3,"score":0.7160392999649048},{"id":"https://openalex.org/C2780966972","wikidata":"https://www.wikidata.org/wiki/Q86","display_name":"Headaches","level":2,"score":0.532042384147644},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5249505043029785},{"id":"https://openalex.org/C2776497919","wikidata":"https://www.wikidata.org/wiki/Q739481","display_name":"Migraine with aura","level":4,"score":0.5216729640960693},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.46871891617774963},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4421394169330597},{"id":"https://openalex.org/C2778479196","wikidata":"https://www.wikidata.org/wiki/Q421095","display_name":"Metoclopramide","level":3,"score":0.4297446310520172},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4162624180316925},{"id":"https://openalex.org/C2781324269","wikidata":"https://www.wikidata.org/wiki/Q2359690","display_name":"Prochlorperazine","level":3,"score":0.4127587676048279},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.19439470767974854},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.18884217739105225},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.09912127256393433},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:10487510","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10487510","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Journal Article"},{"id":"mag:2993660155","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10487510","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2403294230","https://openalex.org/W2078930334","https://openalex.org/W2181217724","https://openalex.org/W7125582216","https://openalex.org/W20838428","https://openalex.org/W4239156051","https://openalex.org/W2070877887","https://openalex.org/W7216911009","https://openalex.org/W4378876935","https://openalex.org/W7117930763"],"abstract_inverted_index":{"Migraine":[0],"does":[1,92],"not":[2,93,199,256],"increase":[3],"the":[4,11,15,17,33,64,105,138,211,233,238,260,263,281],"risk":[5,242,251],"for":[6,10,14,43,101,200],"complications":[7],"of":[8,19,32,53,108,127,147,152,203,216,219,250,262],"pregnancy":[9,155],"mother":[12],"or":[13,59,271],"fetus:":[16],"incidences":[18],"toxemia,":[20],"miscarriages,":[21],"abnormal":[22],"labour,":[23],"congenital":[24],"anomalies,":[25],"and":[26,51,66,75,177,187,205,223,245],"stillbirths":[27],"are":[28,80],"comparable":[29],"to":[30,45,83,95,120,132,168,232,237],"those":[31,76],"general":[34],"population.":[35],"Several":[36],"retrospective":[37],"studies":[38],"have":[39],"shown":[40],"a":[41,97,124,144,195],"tendency":[42],"migraine":[44,71,79,90,116,130,148,153],"improve":[46,60],"with":[47,70,77,114,117,134,149],"pregnancy.":[48,88],"Between":[49],"60":[50],"70%":[52],"women":[54,109],"either":[55],"go":[56,84],"into":[57,85],"remission":[58,86],"significantly,":[61],"mainly":[62],"during":[63,87,154,210],"second":[65,196],"third":[67,234,264],"trimesters.":[68],"Women":[69],"onset":[72],"at":[73,259],"menarche":[74],"perimenstrual":[78],"more":[81],"likely":[82],"The":[89],"type":[91],"seem":[94],"be":[96,121,166,180,192,208,226,230,257,274,288],"significant":[98],"prognostic":[99],"factor":[100],"improvement.":[102],"However,":[103],"in":[104,137,252],"small":[106,125],"number":[107,126],"(4-8%)":[110],"whose":[111],"migraines":[112],"worsen":[113],"pregnancy,":[115,135],"aura":[118],"appears":[119,131],"overrepresented.":[122],"In":[123,266],"cases":[128],"(1.3-16.5%),":[129],"start":[133],"often":[136],"first":[139,157],"trimester;":[140],"these":[141],"headaches":[142],"involve":[143],"higher":[145],"proportion":[146],"aura.":[150],"Management":[151],"should":[156,164,207,229,255],"focus":[158],"on":[159],"avoiding":[160],"potential":[161],"triggers.":[162],"Consideration":[163],"also":[165],"given":[167],"nonpharmacologic":[169],"therapies.":[170],"If":[171],"pharmacologic":[172],"treatment":[173,215,278],"becomes":[174],"necessary,":[175],"acetaminophen":[176],"codeine":[178],"can":[179,191,225,273,287],"used":[181,193,258],"safely":[182],"as":[183,194],"abortive":[184],"agents;":[185],"ASA":[186],"NSAIDs":[188],"(ibuprofen,":[189],"naproxen)":[190],"choice,":[197],"but":[198,254],"long":[201],"periods":[202],"time,":[204],"they":[206],"avoided":[209],"last":[212],"trimester.":[213,235,265],"For":[214],"severe":[217],"attacks":[218],"migraine,":[220],"chlorpromazine,":[221],"dimenhydrinate,":[222],"diphenhydramine":[224],"used;":[227],"metoclopramide":[228],"restricted":[231],"According":[236],"United":[239],"States":[240],"FDA":[241],"categories,":[243],"meperidine":[244],"morphine":[246],"show":[247],"no":[248],"evidence":[249],"humans":[253],"end":[261],"some":[267],"refractory":[268],"cases,":[269],"dexamethasone":[270],"prednisone":[272],"considered.":[275],"Should":[276],"prophylactic":[277],"become":[279],"indicated,":[280],"beta-adrenergic":[282],"receptor":[283],"antagonists":[284],"(e.g.,":[285],"propranolol)":[286],"used.":[289]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-13T00:00:00"}