{"id":"https://openalex.org/W2993653799","doi":null,"title":"Efficacy of Autologous Platelet-Rich Plasma (PRP) Activated By Thromboplastin-D on the Repair and Regeneration of Wounds in Dogs","display_name":"Efficacy of Autologous Platelet-Rich Plasma (PRP) Activated By Thromboplastin-D on the Repair and Regeneration of Wounds in Dogs","publication_year":2008,"publication_date":"2008-12-01","ids":{"openalex":"https://openalex.org/W2993653799","mag":"2993653799"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:0f89abcd7efa46a0bd706e2b954d5362","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0f89abcd7efa46a0bd706e2b954d5362","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Iranian Journal of Veterinary Surgery, Vol 03, Iss 4, Pp 19-30 (2008)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/0f89abcd7efa46a0bd706e2b954d5362","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026077515","display_name":"Hossein Kazemi Mehrjerdi","orcid":"https://orcid.org/0000-0002-5593-6864","observed_orcids":["https://orcid.org/0000-0002-5593-6864"]},"institutions":[{"id":"https://openalex.org/I86958956","display_name":"Ferdowsi University of Mashhad","ror":"https://ror.org/00g6ka752","country_code":"IR","type":"education","lineage":["https://openalex.org/I86958956"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hossein Kazemi Mehrjerdi","raw_affiliation_strings":["Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran","Dept. of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran","institution_ids":["https://openalex.org/I86958956"]},{"raw_affiliation_string":"Dept. of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran","institution_ids":["https://openalex.org/I86958956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055773308","display_name":"Kamran Sardari","orcid":"https://orcid.org/0000-0002-9121-499X","observed_orcids":["https://orcid.org/0000-0002-9121-499X"]},"institutions":[{"id":"https://openalex.org/I86958956","display_name":"Ferdowsi University of Mashhad","ror":"https://ror.org/00g6ka752","country_code":"IR","type":"education","lineage":["https://openalex.org/I86958956"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Kamran Sardari","raw_affiliation_strings":["Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran","Dept. of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran","institution_ids":["https://openalex.org/I86958956"]},{"raw_affiliation_string":"Dept. of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran","institution_ids":["https://openalex.org/I86958956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027773218","display_name":"Mohammadreza Emami","orcid":"https://orcid.org/0000-0001-9469-3255","observed_orcids":["https://orcid.org/0000-0001-9469-3255"]},"institutions":[{"id":"https://openalex.org/I86958956","display_name":"Ferdowsi University of Mashhad","ror":"https://ror.org/00g6ka752","country_code":"IR","type":"education","lineage":["https://openalex.org/I86958956"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohamad Reza Emami","raw_affiliation_strings":["Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran","Dept. of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran","institution_ids":["https://openalex.org/I86958956"]},{"raw_affiliation_string":"Dept. of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran","institution_ids":["https://openalex.org/I86958956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109045898","display_name":"Ahmad Reza Movassaghi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86958956","display_name":"Ferdowsi University of Mashhad","ror":"https://ror.org/00g6ka752","country_code":"IR","type":"education","lineage":["https://openalex.org/I86958956"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Ahmad Reza Movassaghi","raw_affiliation_strings":["Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran","institution_ids":["https://openalex.org/I86958956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007157169","display_name":"Amir Afkhami Goli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86958956","display_name":"Ferdowsi University of Mashhad","ror":"https://ror.org/00g6ka752","country_code":"IR","type":"education","lineage":["https://openalex.org/I86958956"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Amir Afkhami Goli","raw_affiliation_strings":["Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran","institution_ids":["https://openalex.org/I86958956"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Abbas Lotfi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86958956","display_name":"Ferdowsi University of Mashhad","ror":"https://ror.org/00g6ka752","country_code":"IR","type":"education","lineage":["https://openalex.org/I86958956"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Abbas Lotfi","raw_affiliation_strings":["Graduated Student, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduated Student, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran","institution_ids":["https://openalex.org/I86958956"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007168314","display_name":"Sara Malekzadeh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86958956","display_name":"Ferdowsi University of Mashhad","ror":"https://ror.org/00g6ka752","country_code":"IR","type":"education","lineage":["https://openalex.org/I86958956"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Sara Malekzadeh","raw_affiliation_strings":["Graduated Student, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduated Student, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran","institution_ids":["https://openalex.org/I86958956"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I86958956"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.5102999806404114,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.5102999806404114,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.4749000072479248,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11580","display_name":"Veterinary Medicine and Surgery","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-rich-plasma","display_name":"platelet-rich plasma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.7770000100135803},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.6669999957084656},{"id":"https://openalex.org/keywords/full-thickness-skin-wounds","display_name":"full-thickness skin wounds","score":0.9459999799728394},{"id":"https://openalex.org/keywords/topical-application","display_name":"topical application","score":0.6349999904632568},{"id":"https://openalex.org/keywords/hydroxyproline","display_name":"hydroxyproline","score":0.8109999895095825},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.9440000057220459},{"id":"https://openalex.org/keywords/granulation-tissue","display_name":"granulation tissue","score":0.7900000214576721},{"id":"https://openalex.org/keywords/re-epithelialization","display_name":"re-epithelialization","score":0.8629999756813049},{"id":"https://openalex.org/keywords/fibroblast-proliferation","display_name":"fibroblast proliferation","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9511469602584839},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.6883450746536255},{"id":"https://openalex.org/C2778261982","wikidata":"https://www.wikidata.org/wiki/Q1755136","display_name":"Partial thromboplastin time","level":3,"score":0.6309374570846558},{"id":"https://openalex.org/C2780076745","wikidata":"https://www.wikidata.org/wiki/Q613879","display_name":"Platelet-rich plasma","level":3,"score":0.6213870048522949},{"id":"https://openalex.org/C144594695","wikidata":"https://www.wikidata.org/wiki/Q6153218","display_name":"Thromboplastin","level":3,"score":0.5609334111213684},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.5197479724884033},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.40343672037124634},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.23214861750602722},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21047377586364746},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18127000331878662},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.07483622431755066},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:doaj.org/article:0f89abcd7efa46a0bd706e2b954d5362","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0f89abcd7efa46a0bd706e2b954d5362","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Iranian Journal of Veterinary Surgery, Vol 03, Iss 4, Pp 19-30 (2008)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:0f89abcd7efa46a0bd706e2b954d5362","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0f89abcd7efa46a0bd706e2b954d5362","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Iranian Journal of Veterinary Surgery, Vol 03, Iss 4, Pp 19-30 (2008)","raw_type":"article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W28424370","https://openalex.org/W305391746","https://openalex.org/W1547475680","https://openalex.org/W1966509471","https://openalex.org/W1966999008","https://openalex.org/W1977562999","https://openalex.org/W1984830708","https://openalex.org/W1988794582","https://openalex.org/W1989483643","https://openalex.org/W2001725691","https://openalex.org/W2013798124","https://openalex.org/W2017862021","https://openalex.org/W2032589933","https://openalex.org/W2032666845","https://openalex.org/W2034462747","https://openalex.org/W2040987751","https://openalex.org/W2049572985","https://openalex.org/W2052444060","https://openalex.org/W2057243415","https://openalex.org/W2062307013","https://openalex.org/W2064563396","https://openalex.org/W2066337189","https://openalex.org/W2066659963","https://openalex.org/W2070348874","https://openalex.org/W2071237033","https://openalex.org/W2074519869","https://openalex.org/W2075366187","https://openalex.org/W2084121599","https://openalex.org/W2096005542","https://openalex.org/W2103707611","https://openalex.org/W2104015009","https://openalex.org/W2109124138","https://openalex.org/W2120014063","https://openalex.org/W2123569166","https://openalex.org/W2132938887","https://openalex.org/W2134238204","https://openalex.org/W2142605112","https://openalex.org/W2145639361","https://openalex.org/W2149837482","https://openalex.org/W2165791013","https://openalex.org/W2339677954","https://openalex.org/W2413253782"],"related_works":["https://openalex.org/W7097625067","https://openalex.org/W2912721893","https://openalex.org/W2317472811","https://openalex.org/W3096763305","https://openalex.org/W4366580959","https://openalex.org/W2373954885","https://openalex.org/W2361744115","https://openalex.org/W2086318638","https://openalex.org/W7088138185","https://openalex.org/W2031196864"],"abstract_inverted_index":{"Objective-":[0],"To":[1],"evaluate":[2],"the":[3,39,100,170,192],"effects":[4],"of":[5,41,104,123,144,148,153,160,184,191,196],"autologous":[6],"platelet-rich":[7,185],"plasma":[8,186],"(PRP)":[9],"on":[10,38],"wound":[11,106,124],"healing":[12,128],"in":[13,121,169],"dogs.":[14,24,197],"Design-":[15],"Experimental":[16],"in-vivo":[17],"study.":[18],"Animals-":[19],"5":[20],"mix-breed":[21],"male":[22],"adult":[23],"Procedures-":[25],"Under":[26],"general":[27],"anesthesia,":[28],"six":[29],"2":[30],"\u00d7":[31],"2-cm,":[32],"full-thickness":[33],"skin":[34,95],"wounds":[35,50,62,176,195],"were":[36,51,83,97,119,138],"created":[37],"back":[40],"dogs":[42],"symmetrically.":[43],"In":[44],"each":[45,105],"dog,":[46],"three":[47],"right":[48,175],"side":[49,61],"treated":[52],"topically":[53],"with":[54],"1.5":[55],"ml":[56],"PRP":[57],"jelly,":[58],"whereas":[59],"left":[60,173],"received":[63],"no":[64,139],"treatment.":[65],"For":[66],"macroscopic":[67],"evaluation,":[68],"at":[69],"days":[70,88],"0,":[71],"3,":[72],"5,":[73],"7,":[74],"10,":[75,89],"13,":[76],"17,":[77],"20,":[78],"and":[79,91,102,110,127,131,164,174,179],"24,":[80],"digital":[81],"photographs":[82],"taken":[84,98],"from":[85,99,172],"wounds.":[86],"At":[87],"17":[90],"24":[92],"after":[93],"wounding,":[94],"biopsies":[96],"center":[101],"corner":[103],"for":[107],"hydroxyprolin":[108,145],"measurement":[109],"histopathologic":[111],"evaluation":[112],"respectively.":[113],"Results-":[114],"No":[115],"statistically":[116],"significant":[117,140],"differences":[118,141],"found":[120],"percentage":[122],"contraction,":[125],"epithelialization":[126],"between":[129,142],"test":[130],"control":[132],"group":[133],"during":[134],"study":[135],"(P>0.05).":[136,177],"There":[137],"median":[143,147],"levels,":[146],"inflammatory":[149],"cells":[150],"infiltration,":[151],"presence":[152],"dermal":[154],"granulation":[155],"tissue,":[156],"fibroblast":[157],"proliferation,":[158],"arrangement":[159],"fibroblasts,":[161],"collagen":[162,165],"deposition":[163],"bundle":[166],"formation":[167],"scores,":[168],"specimens":[171],"Conclusion":[178],"Clinical":[180],"Relevance-":[181],"Topical":[182],"application":[183],"can":[187],"not":[188],"accelerate":[189],"repair":[190],"small":[193],"granulating":[194]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-12-13T00:00:00"}