{"id":"https://openalex.org/W2993593483","doi":"https://doi.org/10.21873/anticanres.13918","title":"Detection and Clinical Implications of a Novel BCR-ABL1 E12A2 Insertion/Deletion in a CML Patient Expressing the E13A2 Isoform","display_name":"Detection and Clinical Implications of a Novel BCR-ABL1 E12A2 Insertion/Deletion in a CML Patient Expressing the E13A2 Isoform","publication_year":2019,"publication_date":"2019-12-01","ids":{"openalex":"https://openalex.org/W2993593483","doi":"https://doi.org/10.21873/anticanres.13918","mag":"2993593483","pmid":"https://pubmed.ncbi.nlm.nih.gov/31810968"},"language":"en","primary_location":{"id":"doi:10.21873/anticanres.13918","doi":"https://doi.org/10.21873/anticanres.13918","is_oa":true,"landing_page_url":"https://doi.org/10.21873/anticanres.13918","pdf_url":"https://ar.iiarjournals.org/content/anticanres/39/12/6965.full.pdf","source":{"id":"https://openalex.org/S157347057","display_name":"Anticancer Research","issn_l":"0250-7005","issn":["0250-7005","1791-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4320800545","host_organization_name":"International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts","host_organization_lineage":["https://openalex.org/P4320800545"],"host_organization_lineage_names":["International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ar.iiarjournals.org/content/anticanres/39/12/6965.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052162438","display_name":"Stefania Stella","orcid":"https://orcid.org/0000-0002-7189-2312","observed_orcids":["https://orcid.org/0000-0002-7189-2312"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]},{"id":"https://openalex.org/I4210160210","display_name":"Azienda Ospedaliero Universitaria Policlinico \"G.Rodolico - San Marco\"","ror":"https://ror.org/051tt6c85","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210160210"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"STEFANIA STELLA","raw_affiliation_strings":["Center of Experimental Oncology and Hematology, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy","Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy stefania.stel@gmail.com","Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Experimental Oncology and Hematology, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy","institution_ids":["https://openalex.org/I4210160210"]},{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy stefania.stel@gmail.com","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053466740","display_name":"Michele Massimino","orcid":"https://orcid.org/0000-0001-5896-8573","observed_orcids":["https://orcid.org/0000-0001-5896-8573"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]},{"id":"https://openalex.org/I4210160210","display_name":"Azienda Ospedaliero Universitaria Policlinico \"G.Rodolico - San Marco\"","ror":"https://ror.org/051tt6c85","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210160210"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"MICHELE MASSIMINO","raw_affiliation_strings":["Center of Experimental Oncology and Hematology, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy","Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Experimental Oncology and Hematology, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy","institution_ids":["https://openalex.org/I4210160210"]},{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030170002","display_name":"Elena Tirr\u00f2","orcid":"https://orcid.org/0000-0001-8012-5134","observed_orcids":["https://orcid.org/0000-0001-8012-5134"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]},{"id":"https://openalex.org/I4210160210","display_name":"Azienda Ospedaliero Universitaria Policlinico \"G.Rodolico - San Marco\"","ror":"https://ror.org/051tt6c85","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210160210"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"ELENA TIRR\u00d2","raw_affiliation_strings":["Center of Experimental Oncology and Hematology, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy","Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Experimental Oncology and Hematology, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy","institution_ids":["https://openalex.org/I4210160210"]},{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068350069","display_name":"Silvia Rita Vitale","orcid":"https://orcid.org/0000-0002-7948-3580","observed_orcids":["https://orcid.org/0000-0002-7948-3580"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]},{"id":"https://openalex.org/I4210160210","display_name":"Azienda Ospedaliero Universitaria Policlinico \"G.Rodolico - San Marco\"","ror":"https://ror.org/051tt6c85","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210160210"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"SILVIA RITA VITALE","raw_affiliation_strings":["Center of Experimental Oncology and Hematology, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy","Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Experimental Oncology and Hematology, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy","institution_ids":["https://openalex.org/I4210160210"]},{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025440569","display_name":"Vincenzo Accurso","orcid":"https://orcid.org/0000-0002-0161-0957","observed_orcids":["https://orcid.org/0000-0002-0161-0957"]},"institutions":[{"id":"https://openalex.org/I4210147076","display_name":"Azienda Ospedaliera Universitaria Policlinico \"Paolo Giaccone\" di Palermo","ror":"https://ror.org/05p21z194","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210147076"]},{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"VINCENZO ACCURSO","raw_affiliation_strings":["Division of Hematology, A.O.U. Policlinico \"P. Giaccone\", University of Palermo, Palermo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, A.O.U. Policlinico \"P. Giaccone\", University of Palermo, Palermo, Italy","institution_ids":["https://openalex.org/I4210147076","https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082328751","display_name":"Adriana Puma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]},{"id":"https://openalex.org/I4210160210","display_name":"Azienda Ospedaliero Universitaria Policlinico \"G.Rodolico - San Marco\"","ror":"https://ror.org/051tt6c85","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210160210"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"ADRIANA PUMA","raw_affiliation_strings":["Center of Experimental Oncology and Hematology, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy","Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Experimental Oncology and Hematology, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy","institution_ids":["https://openalex.org/I4210160210"]},{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075118920","display_name":"Maria Stella Pennisi","orcid":"https://orcid.org/0000-0003-4442-4406","observed_orcids":["https://orcid.org/0000-0003-4442-4406"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]},{"id":"https://openalex.org/I4210160210","display_name":"Azienda Ospedaliero Universitaria Policlinico \"G.Rodolico - San Marco\"","ror":"https://ror.org/051tt6c85","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210160210"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"MARIA STELLA PENNISI","raw_affiliation_strings":["Center of Experimental Oncology and Hematology, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy","Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Experimental Oncology and Hematology, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy","institution_ids":["https://openalex.org/I4210160210"]},{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014708779","display_name":"Sandra Di Gregorio","orcid":"https://orcid.org/0000-0002-6015-746X","observed_orcids":["https://orcid.org/0000-0002-6015-746X"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]},{"id":"https://openalex.org/I4210160210","display_name":"Azienda Ospedaliero Universitaria Policlinico \"G.Rodolico - San Marco\"","ror":"https://ror.org/051tt6c85","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210160210"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"SANDRA DI GREGORIO","raw_affiliation_strings":["Center of Experimental Oncology and Hematology, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy","Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Experimental Oncology and Hematology, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy","institution_ids":["https://openalex.org/I4210160210"]},{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045641208","display_name":"Chiara Romano","orcid":"https://orcid.org/0000-0002-2586-8266","observed_orcids":["https://orcid.org/0000-0002-2586-8266"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]},{"id":"https://openalex.org/I4210160210","display_name":"Azienda Ospedaliero Universitaria Policlinico \"G.Rodolico - San Marco\"","ror":"https://ror.org/051tt6c85","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210160210"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"CHIARA ROMANO","raw_affiliation_strings":["Center of Experimental Oncology and Hematology, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy","Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Experimental Oncology and Hematology, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy","institution_ids":["https://openalex.org/I4210160210"]},{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034393745","display_name":"Francesco Di Raimondo","orcid":"https://orcid.org/0000-0002-7749-0293","observed_orcids":["https://orcid.org/0000-0002-7749-0293"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]},{"id":"https://openalex.org/I4210160210","display_name":"Azienda Ospedaliero Universitaria Policlinico \"G.Rodolico - San Marco\"","ror":"https://ror.org/051tt6c85","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210160210"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"FRANCESCO DI RAIMONDO","raw_affiliation_strings":["Department of Surgery, Medical and Surgical Specialities, University of Catania, Catania, Italy","Division of Hematology and Bone Marrow Transplant, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Medical and Surgical Specialities, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"Division of Hematology and Bone Marrow Transplant, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy","institution_ids":["https://openalex.org/I4210160210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085841362","display_name":"Sergio Mario Siragusa","orcid":"https://orcid.org/0000-0002-1641-6508","observed_orcids":["https://orcid.org/0000-0002-1641-6508"]},"institutions":[{"id":"https://openalex.org/I4210147076","display_name":"Azienda Ospedaliera Universitaria Policlinico \"Paolo Giaccone\" di Palermo","ror":"https://ror.org/05p21z194","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210147076"]},{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"SERGIO SIRAGUSA","raw_affiliation_strings":["Division of Hematology, A.O.U. Policlinico \"P. Giaccone\", University of Palermo, Palermo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, A.O.U. Policlinico \"P. Giaccone\", University of Palermo, Palermo, Italy","institution_ids":["https://openalex.org/I4210147076","https://openalex.org/I900890020"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003798152","display_name":"Livia Manzella","orcid":"https://orcid.org/0000-0002-9908-6443","observed_orcids":["https://orcid.org/0000-0002-9908-6443"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]},{"id":"https://openalex.org/I4210160210","display_name":"Azienda Ospedaliero Universitaria Policlinico \"G.Rodolico - San Marco\"","ror":"https://ror.org/051tt6c85","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210160210"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"LIVIA MANZELLA","raw_affiliation_strings":["Center of Experimental Oncology and Hematology, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy","Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Experimental Oncology and Hematology, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy","institution_ids":["https://openalex.org/I4210160210"]},{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0581,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.78631682,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"39","issue":"12","first_page":"6965","last_page":"6971"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9089999794960022},{"id":"https://openalex.org/keywords/bcr-abl-fusion","display_name":"BCR-ABL fusion gene","score":0.828000009059906},{"id":"https://openalex.org/keywords/philadelphia-chromosome","display_name":"Philadelphia chromosome","score":0.7770000100135803},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.824999988079071},{"id":"https://openalex.org/keywords/nilotinib","display_name":"nilotinib","score":0.9639999866485596},{"id":"https://openalex.org/keywords/ponatinib","display_name":"ponatinib","score":0.9980000257492065},{"id":"https://openalex.org/keywords/molecular-monitoring","display_name":"molecular monitoring","score":0.4090000092983246},{"id":"https://openalex.org/keywords/prognostic-implications","display_name":"prognostic implications","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C2780381907","wikidata":"https://www.wikidata.org/wiki/Q198728","display_name":"Ponatinib","level":5,"score":0.6780049800872803},{"id":"https://openalex.org/C2777413986","wikidata":"https://www.wikidata.org/wiki/Q412327","display_name":"Nilotinib","level":4,"score":0.6633206009864807},{"id":"https://openalex.org/C2778904597","wikidata":"https://www.wikidata.org/wiki/Q1129111","display_name":"Philadelphia chromosome","level":4,"score":0.6237728595733643},{"id":"https://openalex.org/C206936463","wikidata":"https://www.wikidata.org/wiki/Q634179","display_name":"Breakpoint","level":4,"score":0.607307493686676},{"id":"https://openalex.org/C43907098","wikidata":"https://www.wikidata.org/wiki/Q903924","display_name":"breakpoint cluster region","level":3,"score":0.5715424418449402},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5120039582252502},{"id":"https://openalex.org/C125418893","wikidata":"https://www.wikidata.org/wiki/Q587961","display_name":"ABL","level":4,"score":0.5046166181564331},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49860191345214844},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.4533296823501587},{"id":"https://openalex.org/C2778274637","wikidata":"https://www.wikidata.org/wiki/Q5510282","display_name":"Fusion transcript","level":4,"score":0.4305080771446228},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4273010492324829},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.4091373383998871},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33066725730895996},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.30164647102355957},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.2669505178928375},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23865050077438354},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.2306009829044342},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22924509644508362},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0795670747756958},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06273514032363892}],"mesh":[{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016044","descriptor_name":"Fusion Proteins, bcr-abl","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054643","descriptor_name":"INDEL Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.21873/anticanres.13918","doi":"https://doi.org/10.21873/anticanres.13918","is_oa":true,"landing_page_url":"https://doi.org/10.21873/anticanres.13918","pdf_url":"https://ar.iiarjournals.org/content/anticanres/39/12/6965.full.pdf","source":{"id":"https://openalex.org/S157347057","display_name":"Anticancer Research","issn_l":"0250-7005","issn":["0250-7005","1791-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4320800545","host_organization_name":"International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts","host_organization_lineage":["https://openalex.org/P4320800545"],"host_organization_lineage_names":["International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer Research","raw_type":"journal-article"},{"id":"pmid:31810968","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31810968","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Case Reports"},{"id":"pmh:oai:iris.unipa.it:10447/403001","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10447/403001","pdf_url":null,"source":{"id":"https://openalex.org/S4306401065","display_name":"Nova Science Publishers (Nova Science Publishers, Inc.)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.21873/anticanres.13918","doi":"https://doi.org/10.21873/anticanres.13918","is_oa":true,"landing_page_url":"https://doi.org/10.21873/anticanres.13918","pdf_url":"https://ar.iiarjournals.org/content/anticanres/39/12/6965.full.pdf","source":{"id":"https://openalex.org/S157347057","display_name":"Anticancer Research","issn_l":"0250-7005","issn":["0250-7005","1791-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4320800545","host_organization_name":"International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts","host_organization_lineage":["https://openalex.org/P4320800545"],"host_organization_lineage_names":["International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2993593483.pdf","grobid_xml":"https://content.openalex.org/works/W2993593483.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W29431178","https://openalex.org/W1799579309","https://openalex.org/W1968747503","https://openalex.org/W1997790249","https://openalex.org/W1999545926","https://openalex.org/W2008717037","https://openalex.org/W2023779399","https://openalex.org/W2024158513","https://openalex.org/W2066850558","https://openalex.org/W2074198797","https://openalex.org/W2099747692","https://openalex.org/W2108689358","https://openalex.org/W2117806883","https://openalex.org/W2137511040","https://openalex.org/W2165900457","https://openalex.org/W2171410472","https://openalex.org/W2253078625","https://openalex.org/W2264725068","https://openalex.org/W2273178174","https://openalex.org/W2532456746","https://openalex.org/W2592060299","https://openalex.org/W2754863652","https://openalex.org/W2770562004","https://openalex.org/W2791220784","https://openalex.org/W2796433444","https://openalex.org/W2848111060","https://openalex.org/W2899226338","https://openalex.org/W2908166135","https://openalex.org/W2943298525","https://openalex.org/W2954585674","https://openalex.org/W2954898009","https://openalex.org/W2955871202","https://openalex.org/W2970033483","https://openalex.org/W3021885440","https://openalex.org/W3120106258"],"related_works":["https://openalex.org/W3021450623","https://openalex.org/W4414481881","https://openalex.org/W4293421070","https://openalex.org/W7123892355","https://openalex.org/W2560599324","https://openalex.org/W2230045810","https://openalex.org/W2097972538","https://openalex.org/W7202276842","https://openalex.org/W2975998911","https://openalex.org/W2563951023"],"abstract_inverted_index":{"BACKGROUND/AIM:":[0],"The":[1,114],"Philadelphia":[2],"chromosome":[3],"is":[4,67],"the":[5,23,37,40,71,123,134,156],"most":[6],"frequent":[7],"cytogenetic":[8],"abnormality":[9],"in":[10,31,102,132,151],"chronic":[11],"myelogenous":[12],"(CML).":[13],"More":[14],"than":[15],"95%":[16],"of":[17,34,46,76,116],"CML":[18,47,82,104],"patients":[19,48,83],"are":[20,49],"diagnosed":[21,50,107],"with":[22,51,108,142],"e13a2":[24,111],"or":[25],"e14a2":[26],"BCR-ABL1":[27,53,99,112,125,138],"fusion":[28,54,100],"transcripts":[29],"while,":[30],"about":[32,44],"1%":[33],"these":[35,77],"individuals,":[36],"break":[38],"generates":[39],"e1a2":[41],"rearrangement.":[42],"Furthermore,":[43],"5%":[45],"rare":[52],"transcripts,":[55],"such":[56],"as":[57],"e19a2,":[58],"e8a2,":[59],"e13a3,":[60],"e14a3,":[61],"e1a3":[62],"and":[63,73,130,145],"e6a2.":[64],"However,":[65],"there":[66],"limited":[68],"evidence":[69],"concerning":[70],"clinical":[72],"prognostic":[74],"implications":[75],"infrequent":[78],"oncogenic":[79],"variants":[80],"for":[81],"receiving":[84],"tyrosine":[85],"kinase":[86],"inhibitors":[87],"(TKIs).":[88],"CASE":[89],"REPORT:":[90],"We":[91],"describe":[92],"a":[93,103,109],"novel":[94],"atypical":[95,135,157],"e12a2":[96,136,158],"insertion/deletion":[97],"(Ins/Del)":[98],"identified":[101,129],"59-year-old":[105],"man":[106],"common":[110,124],"isoform.":[113],"use":[115],"primers":[117],"recognizing":[118],"more":[119],"distant":[120],"exons":[121],"from":[122],"breakpoint":[126],"region":[127],"correctly":[128],"monitored":[131],"time":[133],"Ins/Del":[137,159],"fusion.":[139],"CONCLUSION:":[140],"Treatment":[141],"second-":[143],"(nilotinib)":[144],"third-generation":[146],"(ponatinib)":[147],"TKIs":[148],"was":[149],"effective":[150],"suppressing":[152],"leukemic":[153],"clones":[154],"exhibiting":[155],"BCR-ABL1.":[160]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-13T00:00:00"}
