{"id":"https://openalex.org/W2993591986","doi":null,"title":"Clinical and microbiological effects of probiotics in experimental induced periodontitis","display_name":"Clinical and microbiological effects of probiotics in experimental induced periodontitis","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2993591986","mag":"2993591986"},"language":"en","primary_location":{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/117910","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2440/117910","pdf_url":"https://digital.library.adelaide.edu.au/server/api/core/bitstreams/04262780-29b6-4bbf-a6ec-020d57b05956/content","source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digital.library.adelaide.edu.au/server/api/core/bitstreams/04262780-29b6-4bbf-a6ec-020d57b05956/content","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Simona D\u2019Alessio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Simona D\u2019Alessio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.02850000001490116,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.8709999918937683},{"id":"https://openalex.org/keywords/lactobacillus-rhamnosus-gg","display_name":"Lactobacillus rhamnosus GG","score":0.996999979019165},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/porphyromonas-gingivalis","display_name":"Porphyromonas gingivalis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/fusobacterium-nucleatum","display_name":"Fusobacterium nucleatum","score":1.0},{"id":"https://openalex.org/keywords/alveolar-bone-loss","display_name":"alveolar bone loss","score":0.9620000123977661},{"id":"https://openalex.org/keywords/gingivitis","display_name":"gingivitis","score":0.9309999942779541},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8009999990463257},{"id":"https://openalex.org/keywords/lix","display_name":"LIX","score":0.6759999990463257},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.7609999775886536},{"id":"https://openalex.org/keywords/cecal-microbiota","display_name":"cecal microbiota","score":0.8119999766349792},{"id":"https://openalex.org/keywords/probiotic-administration-route","display_name":"probiotic administration route","score":0.6589999794960022},{"id":"https://openalex.org/keywords/oral-gavage","display_name":"oral gavage","score":0.8059999942779541},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.7860000133514404},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.4749999940395355},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.7184182405471802},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47161322832107544},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.43485361337661743},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.40774258971214294},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4038933217525482},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2655559778213501},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.14221665263175964},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/117910","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2440/117910","pdf_url":"https://digital.library.adelaide.edu.au/server/api/core/bitstreams/04262780-29b6-4bbf-a6ec-020d57b05956/content","source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2993591986","doi":null,"is_oa":false,"landing_page_url":"https://digital.library.adelaide.edu.au/dspace/bitstream/2440/117910/1/Gatej2018_PhD.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/117910","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2440/117910","pdf_url":"https://digital.library.adelaide.edu.au/server/api/core/bitstreams/04262780-29b6-4bbf-a6ec-020d57b05956/content","source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320978","display_name":"University of Adelaide","ror":"https://ror.org/00892tw58"},{"id":"https://openalex.org/F4320322896","display_name":"Australian Dental Research Foundation","ror":"https://ror.org/026h3kw78"},{"id":"https://openalex.org/F4320325697","display_name":"Faculty of Health and Medical Sciences, University of Western Australia","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2993591986.pdf","grobid_xml":"https://content.openalex.org/works/W2993591986.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W985591008","https://openalex.org/W1557339302","https://openalex.org/W1566844255","https://openalex.org/W1599091314","https://openalex.org/W1850804383","https://openalex.org/W1854981564","https://openalex.org/W1878177005","https://openalex.org/W1966764926","https://openalex.org/W1981034583","https://openalex.org/W1988925586","https://openalex.org/W1999146852","https://openalex.org/W2014377276","https://openalex.org/W2033021581","https://openalex.org/W2034223170","https://openalex.org/W2037522393","https://openalex.org/W2042223016","https://openalex.org/W2046932904","https://openalex.org/W2071841602","https://openalex.org/W2072970694","https://openalex.org/W2097177097","https://openalex.org/W2111686162","https://openalex.org/W2128800339","https://openalex.org/W2259258150","https://openalex.org/W2284439892","https://openalex.org/W2296180810","https://openalex.org/W2550762460","https://openalex.org/W2767784598","https://openalex.org/W2980529724"],"related_works":["https://openalex.org/W2767784598","https://openalex.org/W3013518002","https://openalex.org/W7120743918","https://openalex.org/W2926327137","https://openalex.org/W4313429539","https://openalex.org/W4415898396","https://openalex.org/W4376567005","https://openalex.org/W4412513017","https://openalex.org/W7056324720","https://openalex.org/W3159261723"],"abstract_inverted_index":{"Objectives:":[0],"This":[1],"study":[2],"investigated":[3],"the":[4,30,34,64,107,140,143,165,172,177,222,232,247,271,274,295,298,322,331,351,355,359,382,407,431,454,457,464,471,484],"role":[5],"of":[6,25,36,63,78,104,142,164,176,231,273,277,297,328,354,358,381,385,389,430,433,456,466,486],"Lactobacillus":[7],"rhamnosus":[8],"GG":[9],"(LGG)":[10],"on":[11,106,453],"bone":[12,113,202,415],"loss":[13,203,416],"and":[14,16,33,72,92,97,123,133,147,151,157,162,212,262,324,342,377,392,400,403,417,445,448],"local":[15,418],"systemic":[17,244,401,446],"inflammation":[18,135,208,245,319,402,419,447],"in":[19,21,29,61,118,149,237,243,270,294,302,321,330,350,398,406,463,470],"an":[20],"vivo":[22,119],"mouse":[23],"model":[24],"induced":[26,60,373,395],"periodontitis.":[27,487],"Changes":[28],"gastrointestinal":[31,275],"physiology":[32],"influence":[35,452],"different":[37,88],"probiotic":[38,82,223,383,422],"administration":[39],"methods":[40,89],"were":[41,47,115,127,136,168,267],"also":[42],"investigated.":[43],"Methods:":[44],"36":[45],"mice":[46,249,279,289],"allocated":[48],"into":[49],"six":[50],"groups":[51,65,225,424],"(n":[52],"=":[53,217],"6":[54],"per":[55],"group).":[56],"Experimental":[57],"periodontitis":[58],"was":[59,84,110,182],"three":[62],"by":[66,138,170,374],"oral":[67,93,195,198],"inoculation":[68,91,199,338],"with":[69,191,228,252,282,307,311,335,339,411,427,437],"Porphyromonas":[70],"gingivalis":[71,261,341,376,391],"Fusobacterium":[73],"nucleatum":[74,264,344,394],"over":[75],"a":[76,240,291,347,440,450,476],"period":[77],"44":[79],"days.":[80],"The":[81,101,159],"LGG":[83,105,192,254,312,367,412,438,473],"administered":[85],"via":[86,194,313],"two":[87],"(oral":[90],"gavage)":[94],"prior":[95],"to,":[96],"during,":[98],"disease":[99,248,278,288,363,428],"induction.":[100],"antimicrobial":[102,257],"activity":[103,258],"pathogens":[108],"used":[109],"tested.":[111],"Alveolar":[112],"levels":[114,327],"assessed":[116,137],"using":[117,129,154],"micro-computed":[120],"tomography.":[121],"Gingival":[122],"intestinal":[124,134,166,399,408,444],"tissue":[125,150,304,318],"changes":[126,269,372,397,405],"evaluated":[128],"histological":[130],"analysis.":[131],"Systemic":[132],"measuring":[139],"level":[141],"pro-inflammatory":[144,233],"markers":[145],"IL-6":[146,301,329],"LIX":[148,235],"blood":[152],"serum":[153,238],"multiplex":[155],"assays":[156],"immunohistochemistry.":[158],"phylogenetic":[160],"structure":[161],"diversity":[163],"microbiota":[167],"analysed":[169],"sequencing":[171],"16S":[173],"rRNA":[174],"genes":[175],"caecal":[178,356],"content.":[179],"Statistical":[180],"significance":[181],"accepted":[183],"when":[184,226,250,280,305,333,425],"for":[185,221,246,420,483],"p":[186],"<":[187,205,210,285,365],"0.05.":[188],"Results:":[189],"Pre-treatment":[190],"either":[193],"gavage":[196,314],"or":[197],"significantly":[200,316,325],"reduced":[201,317],"(p":[204,209,216,284,364],"0.0001),":[206],"gingival":[207],"0.0001)":[211],"TRAP":[213],"positive":[214],"cells":[215],"0.0020":[218],"\u2013":[219],"0.0176)":[220],"treated":[224,423,467],"compared":[227,251,281,306,334,426],"controls.":[229,253,308],"Analysis":[230],"marker":[234,300],"expression":[236,296],"demonstrated":[239,255],"significant":[241,268,292,348,396,404,451],"increase":[242,293],"no":[256],"against":[259,443],"P.":[260,340,375],"F.":[263,343,378],".":[265],"There":[266],"histology":[272],"tract":[276],"controls":[283],"0.05).":[286,366],"Additionally,":[287,435],"presented":[290],"inflammatory":[299],"gut":[303,370,458],"Mice":[309],"pre-treated":[310],"had":[315,449],"scores":[320],"duodenum":[323],"lower":[326],"ileum":[332],"disease.":[336],"Oral":[337],"led":[345],"to":[346,479],"change":[349],"bacterial":[352],"composition":[353,455],"microbiome":[357,371],"control":[360],"group":[361],"versus":[362],"therapy":[368],"prevented":[369],"nucleatum,":[379],"regardless":[380],"mode":[384,432],"administration.":[386,434],"Conclusions:":[387],"Administration":[388],"P":[390],"F":[393],"microbiome.":[409],"Therapy":[410],"effectively":[413],"supressed":[414],"all":[421],"irrespective":[429],"pre-treatment":[436],"exerted":[439],"protective":[441],"effect":[442],"microbiome,":[459],"promoting":[460],"beneficial":[461],"bacteria":[462],"intestines":[465],"mice.":[468],"Clinically,":[469],"future,":[472],"may":[474],"offer":[475],"low-risk,":[477],"easy":[478],"use":[480],"treatment":[481],"option":[482],"management":[485]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2019-12-13T00:00:00"}