{"id":"https://openalex.org/W2993544933","doi":"https://doi.org/10.1182/hematology.2019000017","title":"Moving immunotherapy into the front line in ALL","display_name":"Moving immunotherapy into the front line in ALL","publication_year":2019,"publication_date":"2019-12-06","ids":{"openalex":"https://openalex.org/W2993544933","doi":"https://doi.org/10.1182/hematology.2019000017","mag":"2993544933","pmid":"https://pubmed.ncbi.nlm.nih.gov/31808875","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6913504"},"language":"en","primary_location":{"id":"doi:10.1182/hematology.2019000017","doi":"https://doi.org/10.1182/hematology.2019000017","is_oa":false,"landing_page_url":"https://doi.org/10.1182/hematology.2019000017","pdf_url":null,"source":{"id":"https://openalex.org/S4210206817","display_name":"Hematology","issn_l":"1520-4383","issn":["1520-4383","1520-4391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320264","host_organization_name":"American Society of Hematology","host_organization_lineage":["https://openalex.org/P4310320264"],"host_organization_lineage_names":["American Society of Hematology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6913504","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015097694","display_name":"Amanda C. Winters","orcid":"https://orcid.org/0000-0001-7916-7505","observed_orcids":["https://orcid.org/0000-0001-7916-7505"]},"institutions":[{"id":"https://openalex.org/I4210096275","display_name":"Children's Hospital Colorado","ror":"https://ror.org/00mj9k629","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096275"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Winters","raw_affiliation_strings":["Center for Cancer and Blood Disorders, Children\u2019s Hospital Colorado, Aurora, CO; and","Department of Medical Oncology,","Department of Pediatrics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer and Blood Disorders, Children\u2019s Hospital Colorado, Aurora, CO; and","institution_ids":["https://openalex.org/I4210096275"]},{"raw_affiliation_string":"Department of Medical Oncology,","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037169725","display_name":"Lia Gore","orcid":"https://orcid.org/0000-0002-2546-4616","observed_orcids":["https://orcid.org/0000-0002-2546-4616"]},"institutions":[{"id":"https://openalex.org/I4210096275","display_name":"Children's Hospital Colorado","ror":"https://ror.org/00mj9k629","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096275"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lia Gore","raw_affiliation_strings":["Center for Cancer and Blood Disorders, Children\u2019s Hospital Colorado, Aurora, CO; and","Department of Hematology, and","Department of Medical Oncology,","Department of Pediatrics,","Section of Pediatric Hematology/Oncology/Bone Marrow Transplant-Cellular Therapeutics, University of Colorado School of Medicine, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer and Blood Disorders, Children\u2019s Hospital Colorado, Aurora, CO; and","institution_ids":["https://openalex.org/I4210096275"]},{"raw_affiliation_string":"Department of Hematology, and","institution_ids":[]},{"raw_affiliation_string":"Department of Medical Oncology,","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics,","institution_ids":[]},{"raw_affiliation_string":"Section of Pediatric Hematology/Oncology/Bone Marrow Transplant-Cellular Therapeutics, University of Colorado School of Medicine, Aurora, CO","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.841,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.84991064,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"2019","issue":"1","first_page":"209","last_page":"217"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.02199999988079071,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.8619999885559082},{"id":"https://openalex.org/keywords/pediatric-leukemia","display_name":"pediatric leukemia","score":0.6740000247955322},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.9539999961853027},{"id":"https://openalex.org/keywords/blinatumomab","display_name":"blinatumomab","score":0.7960000038146973},{"id":"https://openalex.org/keywords/bispecific-t-cell-engagers","display_name":"bispecific T-cell engagers","score":0.9580000042915344},{"id":"https://openalex.org/keywords/inotuzumab-ozogamicin","display_name":"inotuzumab ozogamicin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.9369999766349792},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.875},{"id":"https://openalex.org/keywords/cd19","display_name":"CD19","score":0.9800000190734863},{"id":"https://openalex.org/keywords/newly-diagnosed-leukemia","display_name":"newly diagnosed leukemia","score":0.5649999976158142},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.503000020980835},{"id":"https://openalex.org/keywords/long-term-survivorship","display_name":"long-term survivorship","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C2778020697","wikidata":"https://www.wikidata.org/wiki/Q410189","display_name":"Blinatumomab","level":4,"score":0.8128862977027893},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7905153036117554},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.7568038702011108},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.604915976524353},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5928735733032227},{"id":"https://openalex.org/C2777198975","wikidata":"https://www.wikidata.org/wiki/Q5134875","display_name":"Clofarabine","level":4,"score":0.4592130184173584},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45859140157699585},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.45216429233551025},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4136936664581299},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38268786668777466},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3521787226200104},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.34989407658576965},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.2523622512817383},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.16264963150024414}],"mesh":[{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018941","descriptor_name":"Antigens, CD19","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1182/hematology.2019000017","doi":"https://doi.org/10.1182/hematology.2019000017","is_oa":false,"landing_page_url":"https://doi.org/10.1182/hematology.2019000017","pdf_url":null,"source":{"id":"https://openalex.org/S4210206817","display_name":"Hematology","issn_l":"1520-4383","issn":["1520-4383","1520-4391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320264","host_organization_name":"American Society of Hematology","host_organization_lineage":["https://openalex.org/P4310320264"],"host_organization_lineage_names":["American Society of Hematology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6913504","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6913504","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology Am Soc Hematol Educ Program","raw_type":"Text"},{"id":"pmid:31808875","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31808875","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology. American Society of Hematology. Education Program","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6913504","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6913504","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology Am Soc Hematol Educ Program","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8600000143051147,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1488000644","https://openalex.org/W1801876107","https://openalex.org/W1967512987","https://openalex.org/W2066064966","https://openalex.org/W2107925822","https://openalex.org/W2118241155","https://openalex.org/W2118796952","https://openalex.org/W2120853229","https://openalex.org/W2127742735","https://openalex.org/W2129702476","https://openalex.org/W2130011407","https://openalex.org/W2159877301","https://openalex.org/W2220679566","https://openalex.org/W2419639370","https://openalex.org/W2521076777","https://openalex.org/W2529226476","https://openalex.org/W2591709377","https://openalex.org/W2606654718","https://openalex.org/W2742474398","https://openalex.org/W2783032930","https://openalex.org/W2787145330","https://openalex.org/W2787301955","https://openalex.org/W2888107969","https://openalex.org/W2892984448","https://openalex.org/W2893765519"],"related_works":["https://openalex.org/W3082654025","https://openalex.org/W4282823177","https://openalex.org/W4405624388","https://openalex.org/W2991695207","https://openalex.org/W4383104021","https://openalex.org/W3019605854","https://openalex.org/W4399263011","https://openalex.org/W3040540467","https://openalex.org/W2892546385","https://openalex.org/W4399263032"],"abstract_inverted_index":{"Although":[0],"almost":[1],"90%":[2],"of":[3,12,45,74,83,121,175],"children":[4,13,159],"with":[5,14,20,37,160],"acute":[6,15,41],"lymphoblastic":[7],"leukemia":[8,17],"(ALL)":[9],"and":[10,24,34,42,52,63,66,123,151,164],"\u223c60%":[11],"myeloid":[16],"are":[18,27,47],"cured":[19],"frontline":[21],"therapy,":[22],"relapse":[23,76],"chemotherapy":[25],"resistance":[26],"significant":[28],"challenges":[29],"that":[30],"contribute":[31],"to":[32,88,126],"morbidity":[33],"mortality.":[35],"Even":[36],"long-term":[38],"survival,":[39],"the":[40,89,140,145,166,173],"chronic":[43],"burdens":[44],"therapy":[46],"major":[48,99],"issues":[49],"for":[50,128,168],"patients":[51],"families.":[53],"Long-term":[54],"side":[55],"effects":[56],"occur,":[57],"including":[58],"cardiac,":[59],"endocrinologic,":[60],"neurcognitive,":[61],"orthopedic,":[62],"psychosocial":[64],"problems,":[65],"healthy":[67],"survivorship":[68],"is":[69],"frequently":[70],"compromised.":[71],"With":[72],"goals":[73],"minimizing":[75],"and/or":[77],"decreasing":[78],"traditional":[79],"chemotherapy-associated":[80],"toxicities,":[81],"exploration":[82],"immunotherapeutic":[84],"strategies":[85],"has":[86],"moved":[87],"forefront":[90],"in":[91,102,158,172],"pediatric":[92],"cancer.":[93],"New":[94],"immunotherapy":[95],"approaches":[96,138],"provide":[97],"a":[98,119],"paradigm":[100],"shift":[101],"oncology":[103],"overall,":[104],"often":[105],"curing":[106],"previously":[107],"incurable":[108],"patients.":[109],"The":[110],"past":[111],"several":[112],"years":[113],"have":[114],"yielded":[115],"successful":[116],"uses":[117],"across":[118],"variety":[120],"malignancies,":[122],"enthusiasm":[124],"continues":[125],"rise":[127],"applying":[129],"these":[130,170],"therapies":[131],"more":[132],"broadly.":[133],"Herein":[134],"we":[135],"discuss":[136,165],"current":[137],"incorporating":[139],"bispecific":[141],"T-cell":[142],"engager":[143],"blinatumomab,":[144],"antibody-drug":[146],"conjugate":[147],"inotuzumab":[148],"ozogamicin":[149],"(InO),":[150],"CD19-directed":[152],"chimeric":[153],"antigen":[154],"receptor":[155],"T":[156],"cells":[157],"relapsed/refractory":[161],"B-cell":[162],"ALL":[163],"potential":[167],"using":[169],"immunotherapies":[171],"treatment":[174],"newly":[176],"diagnosed":[177],"children.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-13T00:00:00"}