{"id":"https://openalex.org/W2993538656","doi":"https://doi.org/10.1099/acmi.byg2019.po0011","title":"Fungal Transformers: Tracking a Moving Target","display_name":"Fungal Transformers: Tracking a Moving Target","publication_year":2019,"publication_date":"2019-11-01","ids":{"openalex":"https://openalex.org/W2993538656","doi":"https://doi.org/10.1099/acmi.byg2019.po0011","mag":"2993538656"},"language":"en","primary_location":{"id":"doi:10.1099/acmi.byg2019.po0011","doi":"https://doi.org/10.1099/acmi.byg2019.po0011","is_oa":true,"landing_page_url":"https://doi.org/10.1099/acmi.byg2019.po0011","pdf_url":null,"source":{"id":"https://openalex.org/S4210207429","display_name":"Access Microbiology","issn_l":"2516-8290","issn":["2516-8290"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Access Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1099/acmi.byg2019.po0011","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029739406","display_name":"Delma S. Childers","orcid":"https://orcid.org/0000-0003-2869-7332","observed_orcids":["https://orcid.org/0000-0003-2869-7332"]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]},{"id":"https://openalex.org/I4387153154","display_name":"MRC Centre for Medical Mycology","ror":"https://ror.org/00vbzva31","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803","https://openalex.org/I4210087105","https://openalex.org/I4387153154","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Delma Childers","raw_affiliation_strings":["MRC Centre for Medical Mycology at University of Aberdeen, Aberdeen, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Medical Mycology at University of Aberdeen, Aberdeen, United Kingdom","institution_ids":["https://openalex.org/I195460627","https://openalex.org/I4387153154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078285551","display_name":"Gabriela M. Avelar","orcid":"https://orcid.org/0009-0008-5680-9163","observed_orcids":["https://orcid.org/0009-0008-5680-9163"]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]},{"id":"https://openalex.org/I4387153154","display_name":"MRC Centre for Medical Mycology","ror":"https://ror.org/00vbzva31","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803","https://openalex.org/I4210087105","https://openalex.org/I4387153154","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gabriela Mol Avelar","raw_affiliation_strings":["MRC Centre for Medical Mycology at University of Aberdeen, Aberdeen, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Medical Mycology at University of Aberdeen, Aberdeen, United Kingdom","institution_ids":["https://openalex.org/I195460627","https://openalex.org/I4387153154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016608193","display_name":"Judith M. Bain","orcid":"https://orcid.org/0000-0002-1060-0419","observed_orcids":["https://orcid.org/0000-0002-1060-0419"]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]},{"id":"https://openalex.org/I4387153154","display_name":"MRC Centre for Medical Mycology","ror":"https://ror.org/00vbzva31","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803","https://openalex.org/I4210087105","https://openalex.org/I4387153154","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Judith Bain","raw_affiliation_strings":["MRC Centre for Medical Mycology at University of Aberdeen, Aberdeen, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Medical Mycology at University of Aberdeen, Aberdeen, United Kingdom","institution_ids":["https://openalex.org/I195460627","https://openalex.org/I4387153154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050264919","display_name":"Arnab Pradhan","orcid":"https://orcid.org/0000-0003-4328-3912","observed_orcids":["https://orcid.org/0000-0003-4328-3912"]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]},{"id":"https://openalex.org/I4387153154","display_name":"MRC Centre for Medical Mycology","ror":"https://ror.org/00vbzva31","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803","https://openalex.org/I4210087105","https://openalex.org/I4387153154","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Arnab Pradhan","raw_affiliation_strings":["MRC Centre for Medical Mycology at University of Aberdeen, Aberdeen, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Medical Mycology at University of Aberdeen, Aberdeen, United Kingdom","institution_ids":["https://openalex.org/I195460627","https://openalex.org/I4387153154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041493589","display_name":"Daniel E. Larcombe","orcid":"https://orcid.org/0000-0001-5286-1978","observed_orcids":["https://orcid.org/0000-0001-5286-1978"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Larcombe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005394094","display_name":"Lars P. Erwig","orcid":"https://orcid.org/0000-0003-3259-6980","observed_orcids":["https://orcid.org/0000-0003-3259-6980"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lars Erwig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008227126","display_name":"Neil A. R. Gow","orcid":"https://orcid.org/0000-0002-2776-5850","observed_orcids":["https://orcid.org/0000-0002-2776-5850"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neil Gow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Alistair Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]},{"id":"https://openalex.org/I4387153154","display_name":"MRC Centre for Medical Mycology","ror":"https://ror.org/00vbzva31","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803","https://openalex.org/I4210087105","https://openalex.org/I4387153154","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alistair Brown","raw_affiliation_strings":["MRC Centre for Medical Mycology at University of Aberdeen, Aberdeen, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Medical Mycology at University of Aberdeen, Aberdeen, United Kingdom","institution_ids":["https://openalex.org/I195460627","https://openalex.org/I4387153154"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":700,"currency":"GBP","value_usd":858},"apc_paid":{"value":700,"currency":"GBP","value_usd":858},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20347453,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"9","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.5741999745368958,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.5741999745368958,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.40230000019073486,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":1.0},{"id":"https://openalex.org/keywords/beta-glucan","display_name":"\u03b2-glucan","score":0.8180000185966492},{"id":"https://openalex.org/keywords/pathogen-associated-molecular-patterns","display_name":"pathogen-associated molecular patterns","score":0.9169999957084656},{"id":"https://openalex.org/keywords/dectin-1","display_name":"Dectin-1","score":0.9049999713897705},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.6970000267028809},{"id":"https://openalex.org/keywords/cell-wall-stress","display_name":"cell wall stress","score":0.5789999961853027},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.656000018119812},{"id":"https://openalex.org/keywords/fungal-virulence","display_name":"fungal virulence","score":0.6859999895095825},{"id":"https://openalex.org/keywords/opportunistic-fungal-infection","display_name":"opportunistic fungal infection","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7039554715156555},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.6443109512329102},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6076692938804626},{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.5911978483200073},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5358738899230957},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5353432297706604},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.4780172109603882},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4650871157646179},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.43814346194267273},{"id":"https://openalex.org/C145081991","wikidata":"https://www.wikidata.org/wiki/Q2576388","display_name":"Corpus albicans","level":3,"score":0.43654370307922363},{"id":"https://openalex.org/C188899842","wikidata":"https://www.wikidata.org/wiki/Q1483180","display_name":"Pathogen-associated molecular pattern","level":5,"score":0.4243994355201721},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3728238344192505},{"id":"https://openalex.org/C111289621","wikidata":"https://www.wikidata.org/wiki/Q418772","display_name":"Pattern recognition receptor","level":4,"score":0.32205814123153687},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26554739475250244},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23589906096458435},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1791873276233673}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1099/acmi.byg2019.po0011","doi":"https://doi.org/10.1099/acmi.byg2019.po0011","is_oa":true,"landing_page_url":"https://doi.org/10.1099/acmi.byg2019.po0011","pdf_url":null,"source":{"id":"https://openalex.org/S4210207429","display_name":"Access Microbiology","issn_l":"2516-8290","issn":["2516-8290"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Access Microbiology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1099/acmi.byg2019.po0011","doi":"https://doi.org/10.1099/acmi.byg2019.po0011","is_oa":true,"landing_page_url":"https://doi.org/10.1099/acmi.byg2019.po0011","pdf_url":null,"source":{"id":"https://openalex.org/S4210207429","display_name":"Access Microbiology","issn_l":"2516-8290","issn":["2516-8290"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Access Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2563797091","https://openalex.org/W4296516542","https://openalex.org/W4391133188","https://openalex.org/W4200164988","https://openalex.org/W2981959167","https://openalex.org/W4304191933","https://openalex.org/W3003375151","https://openalex.org/W4210681681","https://openalex.org/W4221076649","https://openalex.org/W2981083332"],"abstract_inverted_index":{"In":[0,34],"human":[1],"hosts,":[2],"the":[3,45,77,118,124,144,178,187,200,207,220,231],"opportunistic":[4],"fungal":[5,20],"pathogen":[6],"Candida":[7],"albicans":[8,161],"primarily":[9],"proliferates":[10],"in":[11,68,71,94,120,150,182,210],"nutrient":[12],"diverse":[13],"niches.":[14,167],"Environmental":[15],"condition":[16],"sensing":[17],"regulates":[18],"several":[19],"cellular":[21],"features":[22],"including,":[23],"but":[24],"not":[25],"limited":[26],"to,":[27],"metabolism,":[28],"cell":[29,37,46,62,131,208],"wall":[30,63,132],"elasticity,":[31],"and":[32,61,97,156,173,236],"virulence.":[33],"addition,":[35],"yeast":[36],"division":[38],"exposes":[39],"pathogen-associated":[40],"molecular":[41,78],"patterns":[42],"(PAMPs)":[43],"at":[44],"surface":[47,209],"that":[48,80,87,159],"are":[49,229],"known":[50,75],"to":[51,109,152,199,212,219],"be":[52],"immune-stimulatory":[53],"(e.g.":[54],"\u03b2-glucan).":[55],"While":[56],"various":[57],"host":[58,166,188],"environmental":[59,157],"signals":[60],"stressors":[64],"have":[65,85],"been":[66],"implicated":[67],"PAMP":[69,82,127,134,148,234],"exposure":[70,122,149],"vitro,":[72],"little":[73],"is":[74,115,123],"about":[76],"mechanisms":[79],"modulate":[81],"exposure.":[83,112],"We":[84,142,193],"shown":[86],"lactate,":[88],"an":[89],"alternative":[90],"carbon":[91,154],"source":[92],"present":[93],"mucosal":[95],"niches":[96],"produced":[98],"by":[99,129,186],"activated":[100],"innate":[101],"immune":[102],"cells,":[103],"acts":[104],"as":[105,215,217],"a":[106,137],"signalling":[107],"molecule":[108],"reduce":[110],"\u03b2-glucan":[111,121,184,205],"However,":[113],"it":[114],"unknown":[116],"whether":[117],"reduction":[119],"result":[125],"of":[126,139,203,222,233],"camouflaging":[128],"other":[130],"components,":[133],"modification,":[135],"or":[136],"combination":[138],"both":[140],"processes.":[141],"characterized":[143],"downstream":[145,179],"effectors":[146,180],"affecting":[147],"response":[151,211],"different":[153],"sources":[155],"conditions":[158,214],"C.":[160],"encounters":[162],"during":[163],"transit":[164],"through":[165],"Using":[168],"proteomics,":[169],"gene":[170],"deletion":[171],"analysis,":[172],"pharmacological":[174],"assays,":[175],"we":[176,228],"identified":[177],"involved":[181],"evading":[183],"recognition":[185,190],"pattern":[189],"receptor,":[191],"Dectin-1.":[192],"can":[194],"also":[195],"show":[196],"microscopic":[197],"changes":[198],"overall":[201],"distribution":[202],"Dectin-1-recognised":[204],"on":[206,239],"masking":[213],"well":[216],"alterations":[218],"interactions":[221],"masked":[223],"cells":[224],"with":[225],"phagocytes.":[226],"Finally,":[227],"examining":[230],"impact":[232],"modulation":[235],"its":[237],"inhibition":[238],"disease":[240],"outcomes.":[241]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2019-12-13T00:00:00"}