{"id":"https://openalex.org/W2993489639","doi":"https://doi.org/10.1093/neuros/nyz504","title":"In Reply: Retention of ATRX and DAXX Expression in Meningiomas","display_name":"In Reply: Retention of ATRX and DAXX Expression in Meningiomas","publication_year":2019,"publication_date":"2019-10-18","ids":{"openalex":"https://openalex.org/W2993489639","doi":"https://doi.org/10.1093/neuros/nyz504","mag":"2993489639","pmid":"https://pubmed.ncbi.nlm.nih.gov/31803910"},"language":"en","primary_location":{"id":"doi:10.1093/neuros/nyz504","doi":"https://doi.org/10.1093/neuros/nyz504","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuros/nyz504","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"letter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008239489","display_name":"Corey M. Gill","orcid":"https://orcid.org/0000-0003-4494-1948","observed_orcids":["https://orcid.org/0000-0003-4494-1948"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corey M Gill","raw_affiliation_strings":["Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York","Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York, New York","Department of Pathology Icahn School of Medicine at Mount Sinai New York, New York","The Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York, New York"],"raw_orcid":"https://orcid.org/0000-0003-4494-1948","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Pathology Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"The Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056147205","display_name":"Joshua Loewenstern","orcid":"https://orcid.org/0009-0003-1597-2603","observed_orcids":["https://orcid.org/0009-0003-1597-2603"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Loewenstern","raw_affiliation_strings":["Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York","Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York, New York","Department of Pathology Icahn School of Medicine at Mount Sinai New York, New York","The Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Pathology Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"The Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002706376","display_name":"John Watson Rutland","orcid":"https://orcid.org/0000-0002-6412-6708","observed_orcids":["https://orcid.org/0000-0002-6412-6708"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John W Rutland","raw_affiliation_strings":["Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York","Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York, New York","Department of Pathology Icahn School of Medicine at Mount Sinai New York, New York","The Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Pathology Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"The Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035795831","display_name":"Hanane Arib","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanane Arib","raw_affiliation_strings":["Department of Genetics and Genomic Sciences Icahn School of Medicineat Mount Sinai New York, New York","Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York","Department of Pathology Icahn School of Medicine at Mount Sinai New York, New York","The Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Genomic Sciences Icahn School of Medicineat Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Pathology Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"The Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069304601","display_name":"Margaret Pain","orcid":"https://orcid.org/0009-0009-2772-7676","observed_orcids":["https://orcid.org/0009-0009-2772-7676"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret Pain","raw_affiliation_strings":["Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York","Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York, New York","Department of Pathology Icahn School of Medicine at Mount Sinai New York, New York","The Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Pathology Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"The Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068644739","display_name":"Melissa Umphlett","orcid":"https://orcid.org/0000-0001-8150-1779","observed_orcids":["https://orcid.org/0000-0001-8150-1779"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa Umphlett","raw_affiliation_strings":["Department of Pathology Icahn School of Medicine at Mount Sinai New York, New York","Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York, New York","Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York","The Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"The Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112801128","display_name":"Yayoi Kinoshita","orcid":"https://orcid.org/0000-0002-1163-6544","observed_orcids":["https://orcid.org/0000-0002-1163-6544"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yayoi Kinoshita","raw_affiliation_strings":["Department of Pathology Icahn School of Medicine at Mount Sinai New York, New York","Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York, New York","Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York","The Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"The Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045841123","display_name":"Russell B. McBride","orcid":"https://orcid.org/0000-0002-3890-529X","observed_orcids":["https://orcid.org/0000-0002-3890-529X"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell B McBride","raw_affiliation_strings":["Department of Pathology Icahn School of Medicine at Mount Sinai New York, New York","The Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York, New York","Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York, New York","Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"The Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086410415","display_name":"Joshua B. Bederson","orcid":"https://orcid.org/0000-0002-3676-9175","observed_orcids":["https://orcid.org/0000-0002-3676-9175"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Bederson","raw_affiliation_strings":["Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York","Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York, New York","Department of Pathology Icahn School of Medicine at Mount Sinai New York, New York","The Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Pathology Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"The Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024321239","display_name":"Michael Joseph Donovan","orcid":"https://orcid.org/0000-0003-0772-598X","observed_orcids":["https://orcid.org/0000-0003-0772-598X"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Donovan","raw_affiliation_strings":["Department of Pathology Icahn School of Medicine at Mount Sinai New York, New York","Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York, New York","Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York","The Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"The Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076788078","display_name":"Robert Sebra","orcid":"https://orcid.org/0000-0001-9267-2426","observed_orcids":["https://orcid.org/0000-0001-9267-2426"]},"institutions":[{"id":"https://openalex.org/I4210110193","display_name":"Sema4 (United States)","ror":"https://ror.org/01nprxv78","country_code":"US","type":"company","lineage":["https://openalex.org/I4210110193"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Sebra","raw_affiliation_strings":["Department of Genetics and Genomic Sciences Icahn School of Medicineat Mount Sinai New York, New York","Sema4 A Mount Sinai Venture Stamford, Connecticut","Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York","Department of Pathology Icahn School of Medicine at Mount Sinai New York, New York","The Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Genomic Sciences Icahn School of Medicineat Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Sema4 A Mount Sinai Venture Stamford, Connecticut","institution_ids":["https://openalex.org/I4210110193"]},{"raw_affiliation_string":"Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Pathology Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"The Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063006974","display_name":"Mary Elizabeth Fowkes","orcid":"https://orcid.org/0000-0003-2699-5555","observed_orcids":["https://orcid.org/0000-0003-2699-5555"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Fowkes","raw_affiliation_strings":["Department of Pathology Icahn School of Medicine at Mount Sinai New York, New York","Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York, New York","Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York","The Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"The Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048689357","display_name":"Raj K. Shrivastava","orcid":"https://orcid.org/0000-0002-7454-8525","observed_orcids":["https://orcid.org/0000-0002-7454-8525"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raj K Shrivastava","raw_affiliation_strings":["Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York, New York","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"86","issue":"2","first_page":"E244","last_page":"E246"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11251","display_name":"Meningioma and schwannoma management","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11251","display_name":"Meningioma and schwannoma management","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meningioma","display_name":"meningioma","score":0.8730000257492065},{"id":"https://openalex.org/keywords/atrx","display_name":"ATRX","score":0.7749999761581421},{"id":"https://openalex.org/keywords/daxx","display_name":"DAXX","score":0.9890000224113464},{"id":"https://openalex.org/keywords/meningioma-grading","display_name":"meningioma grading","score":0.5640000104904175},{"id":"https://openalex.org/keywords/who-grade-i-meningioma","display_name":"WHO grade I meningioma","score":0.6669999957084656},{"id":"https://openalex.org/keywords/recurrent-meningioma","display_name":"recurrent meningioma","score":0.7390000224113464},{"id":"https://openalex.org/keywords/nonsense-mutation","display_name":"nonsense mutation","score":0.5139999985694885},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8957003355026245},{"id":"https://openalex.org/C89380225","wikidata":"https://www.wikidata.org/wiki/Q14908178","display_name":"Death-associated protein 6","level":5,"score":0.8262003660202026},{"id":"https://openalex.org/C2776689207","wikidata":"https://www.wikidata.org/wiki/Q17835753","display_name":"ATRX","level":4,"score":0.7209656834602356},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.5118545889854431},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13213708996772766},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.06112205982208252},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.053739070892333984},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuros/nyz504","doi":"https://doi.org/10.1093/neuros/nyz504","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuros/nyz504","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},{"id":"pmid:31803910","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31803910","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1851839265","https://openalex.org/W1986009297","https://openalex.org/W1999626396","https://openalex.org/W2110419228","https://openalex.org/W2114843025","https://openalex.org/W2149441684","https://openalex.org/W2210813576","https://openalex.org/W2615837473","https://openalex.org/W2768507008","https://openalex.org/W2777126971","https://openalex.org/W2806673781","https://openalex.org/W2836380576","https://openalex.org/W2970657071"],"related_works":["https://openalex.org/W2615837473","https://openalex.org/W2272319161","https://openalex.org/W4416085291","https://openalex.org/W2587908960","https://openalex.org/W2999543386","https://openalex.org/W4415902182","https://openalex.org/W2795660162","https://openalex.org/W7098682347","https://openalex.org/W2440637196","https://openalex.org/W2734869387"],"abstract_inverted_index":{"To":[0],"the":[1,8,154,241,505,666,670,691],"Editor:":[2],"We":[3,100,225],"read":[4],"with":[5,31,390,442,457,599],"great":[6],"interest":[7,687],"article":[9],"\u201cLetter:":[10],"Retention":[11],"of":[12,64,70,105,111,124,232,274,463,493,503,546,631,655,659,669,690],"ATRX":[13,29,40,65,74,94,106,227,278,288,350,374,419,532,555,566,594,616,632,651],"and":[14,56,73,122,162,181,185,191,209,212,221,238,258,277,359,364,447,453,533],"DAXX":[15,534],"Expression":[16],"In":[17,435,460,647],"Meningioma\u201d":[18],"by":[19,418,637],"F\u00fcrtjes":[20,609],"et":[21,610,639],"al1":[22,611],"published":[23],"in":[24,34,44,66,76,83,98,107,230,248,268,341,345,354,429,450,471,476,480,501,519,531,575,585,597,606,633,653,688,697],"Neurosurgery.":[25],"The":[26,679],"authors":[27,506,680],"evaluated":[28],"expression":[30,41],"immunohistochemistry":[32],"(IHC)":[33],"101":[35,46],"meningiomas.":[36,99,113,576,607,661],"They":[37],"report":[38,508],"that":[39,521,554,565,674],"was":[42,130,174,393,641],"maintained":[43],"all":[45],"samples,":[47,243,587],"including":[48],"World":[49],"Health":[50],"Organization":[51],"(WHO)":[52],"Grade":[53],"I,":[54],"II,":[55],"III":[57,324],"samples.":[58],"Others":[59],"recently":[60],"performed":[61,101,175],"targeted":[62,103,627],"sequencing":[63,104,630],"a":[67,108,477,540,656],"small":[68],"series":[69,110],"18":[71,634],"meningiomas":[72,208,392,520],"IHC":[75,613],"42":[77],"meningiomas,":[78,366,436,465],"finding":[79],"no":[80,682],"confirmed":[81],"alterations":[82,95,247,267,530],"ATRX.2":[84],"Given":[85],"these":[86,623],"findings,":[87],"we":[88,578,649],"sought":[89],"to":[90,401,487,516,536,591,614,665],"definitively":[91],"characterize":[92],"whether":[93,593],"are":[96,440],"present":[97],"next-generation":[102],"large":[109,657],"188":[112,207,660],"A":[114,490],"board-certified":[115],"neuropathologist":[116],"(M.F.)":[117],"reviewed":[118],"histopathological":[119],"diagnosis,":[120],"grade,":[121],"purity":[123],"each":[125],"case.":[126],"Deoxyribonucleic":[127],"acid":[128],"(DNA)":[129],"extracted":[131],"from":[132,219,371,602],"representative":[133],"formalin-fixed":[134],"paraffin-embedded":[135],"(FFPE)":[136],"tissue":[137,149],"using":[138,153,176,201],"Maxwell":[139],"FFPE":[140],"Plus":[141],"DNA":[142,148,559],"Purification":[143],"Kit":[144],"(Promega,":[145],"Madison,":[146],"Wisconsin).":[147],"libraries":[150],"were":[151,199,245,352,469],"generated":[152],"AmpliSeq":[155],"Oncomine":[156],"Comprehensive":[157],"research":[158],"panel":[159],"versions":[160],"2.0":[161],"3.0":[163],"(ThermoFisher":[164,183,193],"Scientific,":[165],"Waltham,":[166],"Massachusetts)":[167],"as":[168,215,217,367,369,543,569,571],"described":[169,696],"previously.3":[170],"Sequencing":[171],"data":[172,563,663],"analysis":[173],"Torrent":[177],"Suite":[178],"(versions":[179,188],"5.6.0.":[180],"5.8.0.)":[182],"Scientific)":[184],"Ion":[186],"Reporter":[187],"5.2,":[189],"5.6,":[190],"5.8)":[192],"Scientific).":[194],"Lollipop":[195,263],"plots":[196],"(Figure":[197,236,383],"1)":[198],"created":[200],"cBioPortal":[202],"MutationMapper.4,5":[203],"Our":[204,562],"cohort":[205,234,284,462,492,658],"included":[206,210,251],"low":[211],"high-grade":[213,361,451],"lesions,":[214],"well":[216,368],"samples":[218,473,496,624,636],"primary":[220],"recurrent":[222,372],"surgeries":[223],"(Table).":[224],"identified":[226,470,497,650],"loss-of-function":[228],"mutations":[229,351,439,468,500,567,574,605,652],"6.9%":[231,654],"our":[233,586],"(13/188)":[235],"1":[237,255,259,327],"9).":[239],"From":[240],"13":[242],"there":[244],"17":[246],"ATRX,":[249],"which":[250,431,548],"15":[252],"nonsense":[253],"mutations,":[254,529],"missense":[256],"mutation,":[257],"frame-shift":[260],"insertion.FIGURE":[261],"1.:":[262],"plot":[264],"visualizing":[265],"protein":[266],"ATRX.":[269],"TABLE.":[270],"-":[271],"Clinical":[272,281],"Characteristics":[273],"Whole":[275,283],"Cohort":[276],"Mutated":[279],"Meningiomas":[280],"characteristic":[282],"(n":[285,290],"=":[286,291,409],"188)":[287],"mutated":[289],"13)":[292],"Age":[293],"Median":[294,385],"(interquartile":[295],"range)":[296],"60.9":[297],"(49.1,":[298],"69.9)":[299],"67.6":[300],"(47.1,":[301],"84.9)":[302],"Range":[303],"20.3\u201395.7":[304],"20.3\u201389.9":[305],"Sex":[306],"(Female)":[307],"114":[308],"(60.6)":[309],"7":[310,333],"(53.8)":[311,334],"WHO":[312],"grade":[313],"I":[314],"54":[315],"(28.7)":[316],"3":[317,355],"(23.1)":[318],"II":[319,363],"118":[320],"(62.8)":[321],"9":[322],"(69.2)":[323],"16":[325,472],"(8.5)":[326],"(7.7)":[328],"Occurrence":[329],"Primary":[330],"100":[331],"(53.2)":[332],"Recurrent":[335],"88":[336],"(46.8)":[337],"6":[338,370],"(46.2)":[339],"Data":[340],"parenthesis":[342],"represent":[343],"percentage":[344],"column,":[346],"unless":[347],"otherwise":[348],"indicated.":[349],"seen":[353],"low-grade":[356],"(Grade":[357,362],"I)":[358],"10":[360],"III)":[365],"disease.":[373],"mutation":[375,420],"status":[376,584],"did":[377,579],"not":[378,580],"significantly":[379,509],"affect":[380],"overall":[381,386,416,448,511],"survival":[382,387,417,446,449,483,512],"2).":[384],"for":[388,415,644],"patients":[389],"ATRX-mutated":[391],"10.9":[394],"yr":[395,403],"(95%":[396,404],"CI:":[397,405],"2.2,":[398],"NR)":[399],"compared":[400,486,515],"16.8":[402],"9.9,":[406],"16.8)":[407],"(P":[408],".7,":[410],"log-rank).FIGURE":[411],"2.:":[412],"Kaplan\u2013Meier":[413],"curve":[414],"status.Human":[421],"Telomerase":[422],"Reserve":[423],"Transcriptase":[424],"(TERT)":[425],"is":[426,549],"commonly":[427],"upregulated":[428],"cancer,":[430],"supports":[432,675],"telomere":[433,537,558],"lengthening.6":[434],"TERT":[437,466,498,523,527,572,582,603],"promoter":[438,467,499,524,528,573,583,604],"associated":[441,456],"shorter":[443,510],"progression":[444,481],"free":[445,482],"meningiomas,7":[452],"may":[454],"be":[455,620],"malignant":[458],"progression.8":[459],"one":[461],"252":[464],"(6.4%),":[474],"resulting":[475],"significant":[478],"reduction":[479],"(10.1":[484],"mo":[485,514],"179.0":[488],"mo).9":[489],"second":[491],"128":[494],"meningioma":[495,635,676],"5.5%":[502],"samples;":[504],"similarly":[507],"(53.8":[513],"115.6":[517],"mo)":[518],"harbored":[522],"mutations.10":[525],"Beyond":[526],"lead":[535],"lengthening":[538,545],"through":[539],"mechanism":[541],"known":[542],"alternative":[544],"telomeres,":[547],"telomerase-independent.11,12":[550],"Recent":[551],"evidence":[552],"confirms":[553],"loss":[556,595],"induces":[557],"replication":[560],"dysfunction.13":[561],"support":[564],"occur":[568],"frequently":[570],"While":[577],"assess":[581],"future":[588],"work":[589],"ought":[590],"identify":[592],"occurs":[596],"combination":[598],"or":[600,685,694],"exclusive":[601],"Since":[608],"utilized":[612],"evaluate":[615],"status,":[617],"it":[618],"would":[619],"interesting":[621],"if":[622],"could":[625],"undergo":[626],"sequencing.":[628],"Targeted":[629],"Juratli":[638],"al2":[640],"likely":[642],"underpowered":[643],"such":[645],"analysis.":[646],"summary,":[648],"These":[662],"contribute":[664],"emerging":[667],"understanding":[668],"underlying":[671],"tumor":[672],"biology":[673],"oncogenesis.":[677],"Disclosures":[678],"have":[681],"personal,":[683],"financial,":[684],"institutional":[686],"any":[689],"drugs,":[692],"materials,":[693],"devices":[695],"this":[698],"article.":[699]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-12-13T00:00:00"}