{"id":"https://openalex.org/W2993468685","doi":"https://doi.org/10.1182/blood.v112.11.295.295","title":"BCL6-Mediated Survival Signaling Promotes Drug-Resistance in BCRABL1- Driven Acute Lymphoblastic Leukemia","display_name":"BCL6-Mediated Survival Signaling Promotes Drug-Resistance in BCRABL1- Driven Acute Lymphoblastic Leukemia","publication_year":2008,"publication_date":"2008-11-16","ids":{"openalex":"https://openalex.org/W2993468685","doi":"https://doi.org/10.1182/blood.v112.11.295.295","mag":"2993468685"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v112.11.295.295","doi":"https://doi.org/10.1182/blood.v112.11.295.295","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v112.11.295.295","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059800716","display_name":"Cihangir Duy","orcid":"https://orcid.org/0000-0001-9150-9379","observed_orcids":["https://orcid.org/0000-0001-9150-9379"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cihangir Duy","raw_affiliation_strings":["Childrens Hospital Los Angeles, University of Southern California, Leukemia Research Program, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Childrens Hospital Los Angeles, University of Southern California, Leukemia Research Program, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056366117","display_name":"Jinmei Yu","orcid":"https://orcid.org/0000-0002-3719-5601","observed_orcids":["https://orcid.org/0000-0002-3719-5601"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Jessica Yu","raw_affiliation_strings":["Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059389744","display_name":"Leandro C. A. Cerchietti","orcid":"https://orcid.org/0000-0003-0608-1350","observed_orcids":["https://orcid.org/0000-0003-0608-1350"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leandro Cerchietti","raw_affiliation_strings":["Hematology and Oncology Division, Weill Cornell Medical College, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Oncology Division, Weill Cornell Medical College, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017078665","display_name":"Lars Klemm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lars Klemm","raw_affiliation_strings":["Childrens Hospital Los Angeles, University of Southern California, Leukemia Research Program, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Childrens Hospital Los Angeles, University of Southern California, Leukemia Research Program, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109438691","display_name":"Rahul R. Nahar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rahul Nahar","raw_affiliation_strings":["Childrens Hospital Los Angeles, University of Southern California, Leukemia Research Program, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Childrens Hospital Los Angeles, University of Southern California, Leukemia Research Program, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065325837","display_name":"Yong\u2010Mi Kim","orcid":"https://orcid.org/0000-0003-3793-6438","observed_orcids":["https://orcid.org/0000-0003-3793-6438"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong-mi Kim","raw_affiliation_strings":["Childrens Hospital Los Angeles, University of Southern California, Leukemia Research Program, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Childrens Hospital Los Angeles, University of Southern California, Leukemia Research Program, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077589394","display_name":"Nora Heisterkamp","orcid":"https://orcid.org/0000-0003-2769-2273","observed_orcids":["https://orcid.org/0000-0003-2769-2273"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nora Heisterkamp","raw_affiliation_strings":["Childrens Hospital Los Angeles, University of Southern California, Leukemia Research Program, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Childrens Hospital Los Angeles, University of Southern California, Leukemia Research Program, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073761054","display_name":"Giovanni Martinelli","orcid":"https://orcid.org/0000-0002-1025-4210","observed_orcids":["https://orcid.org/0000-0002-1025-4210"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Martinelli","raw_affiliation_strings":["Department of Hematology/Oncology \u201cL. and A. Sera\u0300gnoli\u201d, University of Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology/Oncology \u201cL. and A. Sera\u0300gnoli\u201d, University of Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110195351","display_name":"Wolf\u2010Karsten Hofmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wolf-Karsten Hofmann","raw_affiliation_strings":["MILE Study Group, on Behalf of European LeukemiaNet (ELN, WP13), Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MILE Study Group, on Behalf of European LeukemiaNet (ELN, WP13), Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078953949","display_name":"Hassan Jumaa","orcid":"https://orcid.org/0000-0003-3383-141X","observed_orcids":["https://orcid.org/0000-0003-3383-141X"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hassan Jumaa","raw_affiliation_strings":["Molecular Immunology, Max-Planck-Institute for Immunology, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Immunology, Max-Planck-Institute for Immunology, Freiburg, Germany","institution_ids":["https://openalex.org/I149899117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019770989","display_name":"Ari M. Melnick","orcid":"https://orcid.org/0000-0002-8074-2287","observed_orcids":["https://orcid.org/0000-0002-8074-2287"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ari Melnick","raw_affiliation_strings":["Hematology and Oncology Division, Weill Cornell Medical College, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Oncology Division, Weill Cornell Medical College, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081180470","display_name":"B. Hilda Ye","orcid":"https://orcid.org/0000-0002-2281-422X","observed_orcids":["https://orcid.org/0000-0002-2281-422X"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Hilda Ye","raw_affiliation_strings":["Dept. of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050087793","display_name":"Markus M\u00fcschen","orcid":"https://orcid.org/0000-0002-6064-8613","observed_orcids":["https://orcid.org/0000-0002-6064-8613"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Markus Muschen","raw_affiliation_strings":["Leukemia Research Program, Childrens Hospital Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leukemia Research Program, Childrens Hospital Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1336910626"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.2132,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.65083576,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"112","issue":"11","first_page":"295","last_page":"295"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.6845999956130981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.6845999956130981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.2759000062942505,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.014600000344216824,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bcl6","display_name":"BCL6","score":0.9959999918937683},{"id":"https://openalex.org/keywords/bcr-abl1","display_name":"BCR-ABL1","score":0.9580000042915344},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9879999756813049},{"id":"https://openalex.org/keywords/imatinib-resistance","display_name":"imatinib resistance","score":0.9010000228881836},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8579999804496765},{"id":"https://openalex.org/keywords/pre-b-cells","display_name":"pre-B cells","score":0.7120000123977661},{"id":"https://openalex.org/keywords/leukemia-cell-survival","display_name":"leukemia cell survival","score":0.6309999823570251},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8679999709129333},{"id":"https://openalex.org/keywords/leukemia-engraftment","display_name":"leukemia engraftment","score":0.7710000276565552},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.4650000035762787},{"id":"https://openalex.org/keywords/arf","display_name":"ARF","score":0.8019999861717224},{"id":"https://openalex.org/keywords/transcriptional-repressor","display_name":"transcriptional repressor","score":0.6819999814033508},{"id":"https://openalex.org/keywords/b-cell-development","display_name":"B cell development","score":0.5799999833106995},{"id":"https://openalex.org/keywords/leukemia-stem-cells","display_name":"leukemia stem cells","score":0.42100000381469727}],"concepts":[{"id":"https://openalex.org/C2777537477","wikidata":"https://www.wikidata.org/wiki/Q17847411","display_name":"BCL6","level":5,"score":0.7056297063827515},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.6338802576065063},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6046622395515442},{"id":"https://openalex.org/C3019892230","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib mesylate","level":4,"score":0.569180428981781},{"id":"https://openalex.org/C96926380","wikidata":"https://www.wikidata.org/wiki/Q1737968","display_name":"Germinal center","level":4,"score":0.5098587870597839},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4777316749095917},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.45905908942222595},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4543518126010895},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34193092584609985},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34188610315322876},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.32056868076324463},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.10619792342185974},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v112.11.295.295","doi":"https://doi.org/10.1182/blood.v112.11.295.295","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v112.11.295.295","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2588702032","https://openalex.org/W2596195194","https://openalex.org/W7095646889","https://openalex.org/W2551002076","https://openalex.org/W3110856341","https://openalex.org/W2536496625","https://openalex.org/W894544733","https://openalex.org/W3086660411","https://openalex.org/W2129216024","https://openalex.org/W2554745488"],"abstract_inverted_index":{"Abstract":[0],"During":[1],"B":[2,16,22,36,470],"cell":[3,23,235],"development,":[4],"the":[5,68,90,371,433,445,449],"transcriptional":[6],"repressor":[7],"BCL6":[8,38,61,80,101,165,321,348,436,460,571,586],"is":[9,39,63],"almost":[10],"exclusively":[11],"expressed":[12,40],"in":[13,45,51,102,167,203,210,237,257,335,338,375,389,437,467,547,557,561,575,599],"germinal":[14,20,34,468],"center":[15,21,35,469],"cells":[17,114,150,170,183,196,213,220,256,268,280,295,313,327,361,400,415,494,513],"and":[18,29,47,70,92,118,131,179,217,337,453,464,482,499,509,529,563],"promotes":[19],"survival":[24,573],"by":[25,77,84,271,281,332,579],"suppression":[26,580],"of":[27,100,164,192,208,227,245,265,324,347,396,411,435,448,489,518,527,542,581,585],"Arf":[28,452,463],"p53":[30],"signaling.":[31,583],"Compared":[32,140],"to":[33,86,104,137,141,277,328,356,362,384,418,520,596],"cells,":[37,60,380,441,540],"at":[41,66,89,152,504,531,551],"extremely":[42],"low":[43,162,185],"levels":[44,82,163],"pro-":[46],"pre-B":[48,59,113],"cells.":[49,471,567],"Also":[50],"acute":[52],"lymphoblastic":[53],"leukemia":[54,169,234,493],"(ALL)":[55],"derived":[56],"from":[57,115,144,479],"BCR-ABL1-transformed":[58],"expression":[62,81,166],"hardly":[64],"detectable":[65],"both":[67,129,334],"mRNA":[69,91],"protein":[71,93],"levels.":[72],"Upon":[73,241],"BCR-ABL1":[74,181,194,254,293,325,329,359,378,398,413,439,511,538,565,577],"kinase":[75,330],"inhibition":[76,331],"Imatinib-treatment,":[78],"however,":[79],"increased":[83],"30":[85],"70-":[87],"fold":[88],"levels,":[94],"respectively.":[95],"To":[96,430,472],"test":[97],"whether":[98,343,444],"upregulation":[99],"response":[103],"Imatinib-treatment":[105],"has":[106,171],"a":[107,122,153,238,344,515,588,592],"function":[108,434],"we":[109,382,442,475],"transformed":[110],"bone":[111,133,146,477],"marrow":[112,134,478],"Bcl6\u2212/\u2212":[116,130,148,178,251],"mice":[117,287,308,484],"wildtype":[119,132,145,168,180,193,253,278,292,483,510,558],"littermates":[120],"with":[121,184,291,302,310,391,403,426,485,497,500,522,549],"retrovirus":[123],"encoding":[124],"BCR-ABL1.":[125,486],"After":[126,487],"two":[127],"weeks,":[128],"gave":[135],"rise":[136],"BCR-ABL1-driven":[138,600],"ALL.":[139,601],"BCR-ABL1-induced":[142],"ALL":[143,149,182,195,212,255,267,279,294,312,326,360,379,399,414,440,512,539,566,578],"marrow,":[147],"grow":[151],"significantly":[154,232],"lower":[155],"proliferation":[156],"rate,":[157],"which":[158],"suggests":[159],"that":[160,288,320,459,570],"even":[161],"some":[172],"biological":[173],"significance.":[174],"We":[175,318,340,568],"next":[176,341],"treated":[177,496],"dose":[186],"(1":[187],"\u03bcmol/l)":[188],"Imatinib.":[189],"About":[190],"50%":[191],"were":[197,289,495],"still":[198,316],"viable":[199,219],"after":[200,224],"four":[201,225,408],"days":[202,226],"culture.":[204],"In":[205,229,544],"contrast,":[206,545],"induction":[207],"apoptosis":[209,374,466,555],"Bcl6\u2212/\u2212BCR-ABL1":[211,266,311],"was":[214,269,354,416,424,534],"greatly":[215],"accelerated":[216],"no":[218],"could":[221],"be":[222],"detected":[223],"Imatinib-treatment.":[228,363],"addition,":[230],"Bcl6-deficiency":[231],"delayed":[233,270],"engraftment":[236,264],"transplantation":[239],"experiment:":[240],"tail":[242],"vein":[243],"injection":[244],"3":[246],"\u00d7":[247],"106":[248],"firefly":[249],"luciferase-labeled":[250],"or":[252,501],"each":[258],"ten":[259],"sublethally":[260],"irradiated":[261],"NOD/SCID":[262],"mice,":[263],"approximately":[272],"one":[273],"week":[274],"as":[275],"compared":[276],"luciferase":[282],"bioimaging.":[283],"Whereas":[284,393],"most":[285],"recipient":[286],"injected":[290,309],"died":[296],"within":[297],"three":[298],"weeks":[299],"despite":[300],"treatment":[301,402,521,594],"100":[303],"mg/kg/day":[304],"Imatinib":[305,333,406,423,498,523,528,546],"i.p.,":[306],"all":[307,537],"are":[314],"currently":[315],"alive.":[317],"conclude":[319,569],"decreases":[322],"sensitivity":[323,519],"vitro":[336],"vivo.":[339],"investigated":[342,443],"peptidomimetic":[345,589],"inhibitor":[346,590],"(RI-BPI,":[349],"Cerchietti":[350],"et":[351],"al.,":[352],"2008)":[353],"active":[355],"sensitize":[357],"human":[358,377,397,412],"At":[364],"20":[365,532],"\u03bcmol/l":[366,387,405,428,533,553],"but":[367,559],"not":[368,560],"5":[369,386,427,552],"\u03bcmol/l,":[370],"RI-BPI":[372,388,450,503,550],"induced":[373,554],"untreated":[376],"so":[381],"decided":[383],"study":[385],"combination":[390,526,548],"Imatinib:":[392],"about":[394],"30%":[395],"survived":[401],"10":[404],"for":[407,536],"days,":[409],"viability":[410],"decreased":[417],"less":[419],"than":[420],"5%":[421],"if":[422],"combined":[425],"RI-BPI.":[429],"mechanistically":[431],"address":[432],"Imatinib-treated":[438,576],"cytotoxic":[446],"effect":[447],"requires":[451],"p53.":[454],"Previous":[455],"work":[456],"had":[457],"shown":[458],"negatively":[461],"regulates":[462],"p53-dependent":[465],"this":[473],"end,":[474],"transduced":[476],"Arf\u2212/\u2212,":[480,507],"Tp53\u2212/\u2212":[481,508,564],"establishment":[488],"growth":[490],"factor-independent":[491],"ALL,":[492],"without":[502],"various":[505],"concentrations.":[506],"showed":[514],"similar":[516],"degree":[517],"alone.":[524],"A":[525],"R-BPI":[530],"toxic":[535],"regardless":[541],"genotype.":[543],"selectively":[556],"Arf\u2212/\u2212":[562],"mediates":[572],"signaling":[574],"Arf/p53":[582],"Inhibition":[584],"using":[587],"represents":[591],"novel":[593],"concept":[595],"prevent":[597],"drug-resistance":[598]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2019-12-13T00:00:00"}
