{"id":"https://openalex.org/W2993343319","doi":"https://doi.org/10.1182/blood.v110.11.3817.3817","title":"Differential Iron Loading of R2* Pancreas in Children with Thalassemia Major and Sickle Cell Disease.","display_name":"Differential Iron Loading of R2* Pancreas in Children with Thalassemia Major and Sickle Cell Disease.","publication_year":2007,"publication_date":"2007-11-16","ids":{"openalex":"https://openalex.org/W2993343319","doi":"https://doi.org/10.1182/blood.v110.11.3817.3817","mag":"2993343319"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v110.11.3817.3817","doi":"https://doi.org/10.1182/blood.v110.11.3817.3817","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v110.11.3817.3817","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085050791","display_name":"Jhansi L. Papudesi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jhansi L. Papudesi","raw_affiliation_strings":["Pediatrics, Children\u2019s Hospital Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, Children\u2019s Hospital Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005965825","display_name":"Shahriar Mokrian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shahriar Mokrian","raw_affiliation_strings":["Pediatrics, Children\u2019s Hospital Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, Children\u2019s Hospital Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077729374","display_name":"Thomas D. Coates","orcid":"https://orcid.org/0000-0001-9878-6029","observed_orcids":["https://orcid.org/0000-0001-9878-6029"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas D. Coates","raw_affiliation_strings":["Pediatrics, Children\u2019s Hospital Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, Children\u2019s Hospital Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034495408","display_name":"John C. Wood","orcid":"https://orcid.org/0000-0003-0996-3439","observed_orcids":["https://orcid.org/0000-0003-0996-3439"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. Wood","raw_affiliation_strings":["Pediatrics, Children\u2019s Hospital Los Angeles, Los Angeles, CA, USA","Radiology, Children\u2019s Hospital Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, Children\u2019s Hospital Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Radiology, Children\u2019s Hospital Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1336910626"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1336910626"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.41886792,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"110","issue":"11","first_page":"3817","last_page":"3817"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thalassemia-major","display_name":"thalassemia major","score":0.8550000190734863},{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":1.0},{"id":"https://openalex.org/keywords/pancreatic-iron-overload","display_name":"pancreatic iron overload","score":0.7590000033378601},{"id":"https://openalex.org/keywords/r2-relaxation-rate","display_name":"R2* relaxation rate","score":0.8119999766349792},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"magnetic resonance imaging","score":0.40400001406669617},{"id":"https://openalex.org/keywords/chronic-transfusion-therapy","display_name":"chronic transfusion","score":0.6480000019073486},{"id":"https://openalex.org/keywords/endocrine-disorders","display_name":"endocrine disorders","score":0.6439999938011169},{"id":"https://openalex.org/keywords/transferrin-saturation","display_name":"transferrin saturation","score":0.7239999771118164},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8130000233650208},{"id":"https://openalex.org/keywords/cardiac-siderosis","display_name":"cardiac siderosis","score":0.5350000262260437},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.609000027179718},{"id":"https://openalex.org/keywords/pancreas","display_name":"pancreas","score":0.3190000057220459},{"id":"https://openalex.org/keywords/ferritin","display_name":"ferritin","score":0.6129999756813049},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.6240000128746033},{"id":"https://openalex.org/keywords/white-blood-cell-count","display_name":"white blood cell count","score":0.8679999709129333}],"concepts":[{"id":"https://openalex.org/C2780883591","wikidata":"https://www.wikidata.org/wiki/Q1413860","display_name":"Siderosis","level":2,"score":0.8432489037513733},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7557604312896729},{"id":"https://openalex.org/C2777799968","wikidata":"https://www.wikidata.org/wiki/Q185137","display_name":"Thalassemia","level":2,"score":0.6988800764083862},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6346594095230103},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5252335071563721},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.49881720542907715},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.4917605221271515},{"id":"https://openalex.org/C2778620579","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Sickle cell anemia","level":3,"score":0.47367292642593384},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4552522897720337},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3931417763233185},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.341059148311615},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.19296687841415405}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v110.11.3817.3817","doi":"https://doi.org/10.1182/blood.v110.11.3817.3817","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v110.11.3817.3817","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1501925511","https://openalex.org/W4294670057","https://openalex.org/W3169145866","https://openalex.org/W2588816571","https://openalex.org/W3083833997","https://openalex.org/W4392043192","https://openalex.org/W2980599738","https://openalex.org/W2018733366","https://openalex.org/W7095888166","https://openalex.org/W2167390893"],"abstract_inverted_index":{"Abstract":[0],"MRI":[1,62],"is":[2,294],"a":[3,67,112,142],"noninvasive":[4],"method":[5],"for":[6,69,158,249],"detection":[7],"of":[8,16,57,144,153,182,259,268,317,346],"transfusional":[9],"siderosis":[10,35],"in":[11,42,106,174,207,236,257,300,350],"the":[12,61,74,149,154,208,245,250,260,269,276,318,340],"liver":[13,89,289],"and":[14,22,36,97,151,196,221,239,297,321,343],"heart":[15],"children":[17],"with":[18,118,134,227,266,306],"thalassemia":[19],"major":[20],"(TM)":[21],"sickle":[23],"cell":[24,224],"disease":[25],"(SCD).":[26],"Previous":[27],"studies":[28],"from":[29,123,141,163],"our":[30],"laboratory":[31],"demonstrated":[32],"that":[33,76],"cardiac":[34,37,284],"failure":[38],"are":[39,172,336],"relatively":[40],"uncommon":[41],"chronically":[43],"transfused":[44],"SCD,":[45,238,304],"despite":[46],"heavy":[47],"somatic":[48],"iron":[49,71,82,90,189,192],"burdens.":[50,91],"Others":[51],"have":[52],"reported":[53,308],"correspondingly":[54],"low":[55],"rates":[56],"endocrinopathies.":[58],"We":[59,93],"used":[60],"relaxation":[63],"rate":[64],"R2*":[65,103,130,138,160,234,254,280,293,348],"as":[66],"surrogate":[68],"pancreatic":[70,81,109,159,233,279,347],"to":[72,125,283,288,303,327,331,338],"test":[73],"hypothesis":[75],"TM":[77,96,177,209,261,277,301],"patients":[78,86,178,210,215,262,271,320],"develop":[79],"greater":[80,228],"load":[83],"than":[84],"SCD":[85,100,214,270,319],"having":[87],"comparable":[88],"Methods":[92],"studied":[94],"70":[95],"31":[98],"chronically-transfused":[99],"patients.":[101],"Pancreatic":[102,253,292],"was":[104,132,139,255,281],"assessed":[105],"several":[107],"mid":[108],"slices":[110],"using":[111],"multi-echo,":[113],"gradient":[114],"echo":[115,120],"pulse":[116],"sequence":[117],"8":[119],"times":[121],"spaced":[122],"2":[124],"16":[126],"ms.":[127],"Pixelwise,":[128],"monoexponential":[129],"reconstruction":[131],"performed":[133],"offset":[135],"correction.":[136],"Mean":[137],"calculated":[140],"region":[143],"interest":[145],"(ROI)":[146],"drawn":[147],"around":[148],"body":[150],"tail":[152],"pancreas.":[155],"Control":[156],"values":[157],"were":[161,179],"derived":[162],"14":[164],"normal":[165],"volunteers,":[166],"ages":[167],"19\u201331.":[168],"Results":[169],"Patient":[170,353],"demographics":[171],"summarized":[173],"Table":[175],"1.":[176],"an":[180],"average":[181],"5":[183,193],"years":[184],"older":[185],"but":[186,286],"less":[187],"heavily":[188],"loaded":[190],"(liver":[191],"mg/g":[194],"lower":[195,323],"ferritin":[197],"1800":[198],"ng/mL":[199],"lower).":[200],"Despite":[201],"this,":[202],"transferrin":[203,324],"saturations":[204,325],"trended":[205],"higher":[206,217],"(76%":[211],"versus":[212],"58%).":[213],"had":[216],"high":[218],"sensitivity":[219],"CRP":[220],"white":[222],"blood":[223],"count,":[225],"consistent":[226,305],"inflammation.":[229],"Figure":[230,485,486],"1":[231],"demonstrates":[232],"distribution":[235],"TM,":[237],"control":[240,251],"subjects;":[241],"dotted":[242],"line":[243],"indicates":[244],"95th":[246],"confidence":[247],"interval":[248],"subjects.":[252],"elevated":[256],"74%":[258],"(R2*":[263,272],"148.9\u00b1200.9),":[264],"compared":[265,302],"48%":[267],"39.6\u00b137,":[273],"p<0.021).":[274],"In":[275],"patients,":[278],"correlated":[282],"R2*,":[285],"not":[287],"R2*.":[290],"Discussion":[291],"more":[295,298],"common":[296],"severe":[299],"previously":[307],"endocrinopathy":[309],"rates.":[310],"The":[311],"younger":[312],"age":[313],"(decreased":[314],"transfusion":[315],"exposure)":[316],"their":[322],"(secondary":[326],"inflammation)":[328],"probably":[329],"contribute":[330],"this":[332],"observation.":[333],"Prospective":[334],"trials":[335],"necessary":[337],"determine":[339],"functional":[341],"correlations":[342],"predictive":[344],"value":[345],"measurements":[349],"these":[351],"populations.":[352],"Demographics":[354],"Parameter":[355],"Thalassemia":[356],"(n=70)":[357],"Sickle":[358],"Cell":[359],"Disease":[360],"(n=31)":[361],"P":[362],"Value":[363],"Age":[364],"19.4":[365],"\u00b1":[366,369,380,383,389,396,403,409,416,421,425,433,437,443,446,452,456,461,465,470,474,479,482],"10":[367,478],"14.5":[368],"5.6":[370],"0.013":[371],"Gender":[372],"40M,":[373],"30F":[374],"17M,":[375],"14F":[376],"NS":[377,385,391,418,458,467],"Height(cm)":[378],"145":[379],"29":[381,438],"147":[382],"20":[384],"Weight(kg)":[386],"45.4\u00b117":[387],"43.8":[388],"19":[390],"Reticulocyte":[392],"2.0\u00b11.9":[393],"(n=34)":[394,454,463],"9.6":[395],"7.8":[397],"<0.001":[398,476],"Iron(mcg/dL)":[399],"193\u00b199":[400],"(n=64)":[401],"146":[402],"89":[404],"0.003":[405],"Ferritin(ng/mL)":[406],"4064\u00b15661":[407],"5905":[408],"6320":[410],"0.15":[411],"Transferrin":[412],"(mg/dL)":[413],"174\u00b170":[414],"169":[415],"87":[417],"HIC(mg/g)":[419],"10.9":[420],"12.2":[422],"(n=68)":[423],"16.1":[424],"11.9":[426],"(n=30)":[427],"0.06":[428,449],"Iron":[429],"%":[430],"Sat(%)":[431],"76":[432],"39":[434],"(n=38)":[435],"58":[436],"(n=14)":[439],"0.11":[440],"TIBC(mcg/dL)":[441],"255":[442],"119":[444],"219":[445],"104":[447],"(n=13)":[448],"AST(U/L)":[450],"62.7":[451],"63":[453],"72":[455,464],"71":[457],"ALT(U/L)":[459],"77.6":[460],"94.4":[462],"99":[466],"hs-CRP(mg/L)":[468],"1.6":[469],"1.9":[471],"(n=46)":[472],"6.2":[473],"7":[475,480,483],"WBC":[477],"12.5":[481],"0.04":[484]},"counts_by_year":[],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2019-12-13T00:00:00"}