{"id":"https://openalex.org/W2993267658","doi":null,"title":"A double-blinded, randomized, controlled trial to quantitate photoprotective effects of an antioxidant combination product.","display_name":"A double-blinded, randomized, controlled trial to quantitate photoprotective effects of an antioxidant combination product.","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W2993267658","mag":"2993267658","pmid":"https://pubmed.ncbi.nlm.nih.gov/22708005","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3366441"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2381620","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3366441","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3366441","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028533771","display_name":"Xinaida Taligare Vasconcelos Lima","orcid":"https://orcid.org/0000-0001-7999-6979","observed_orcids":["https://orcid.org/0000-0001-7999-6979"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinaida Taligare Lima","raw_affiliation_strings":["Clinical Unit for Research Trials and Outcomes in Skin (CURTIS), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Unit for Research Trials and Outcomes in Skin (CURTIS), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044628660","display_name":"Maria B. Alora-Palli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Beatrice Alora-Palli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Susan Beck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan Beck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059337854","display_name":"Alexa B. Kimball","orcid":"https://orcid.org/0000-0001-9405-0479","observed_orcids":["https://orcid.org/0000-0001-9405-0479"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandra Boer Kimball","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7546,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.76404202,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"5","issue":"4","first_page":"29","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.6299999952316284},{"id":"https://openalex.org/keywords/photoprotection","display_name":"photoprotection","score":0.859000027179718},{"id":"https://openalex.org/keywords/photoaging","display_name":"photoaging","score":0.8899999856948853},{"id":"https://openalex.org/keywords/antioxidant-synergism","display_name":"synergistic antioxidant effect","score":0.7480000257492065},{"id":"https://openalex.org/keywords/orac-assay","display_name":"ORAC","score":0.9089999794960022},{"id":"https://openalex.org/keywords/minimal-erythema-dose","display_name":"minimal erythema dose","score":0.9769999980926514},{"id":"https://openalex.org/keywords/skin-aging","display_name":"skin aging","score":0.6430000066757202},{"id":"https://openalex.org/keywords/dietary-supplements","display_name":"dietary supplements","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8752208352088928},{"id":"https://openalex.org/C2776188313","wikidata":"https://www.wikidata.org/wiki/Q902552","display_name":"Oxygen radical absorbance capacity","level":4,"score":0.8673266172409058},{"id":"https://openalex.org/C2779121184","wikidata":"https://www.wikidata.org/wiki/Q1166142","display_name":"Erythema","level":2,"score":0.8426092267036438},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.727082371711731},{"id":"https://openalex.org/C2776960578","wikidata":"https://www.wikidata.org/wiki/Q3705873","display_name":"Photoaging","level":2,"score":0.6570916175842285},{"id":"https://openalex.org/C193230392","wikidata":"https://www.wikidata.org/wiki/Q1663054","display_name":"Ingestion","level":2,"score":0.5823940634727478},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5459226369857788},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.41991251707077026},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.38126590847969055},{"id":"https://openalex.org/C2993539680","wikidata":"https://www.wikidata.org/wiki/Q902552","display_name":"Antioxidant capacity","level":3,"score":0.35523170232772827},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.342602014541626},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.19473111629486084},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19022920727729797},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19021978974342346},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.08605331182479858},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.06855776906013489}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:2381620","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3366441","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3366441","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3366441","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Aesthet Dermatol","raw_type":"Text"},{"id":"pmid:22708005","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22708005","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical and aesthetic dermatology","raw_type":"Journal Article"},{"id":"mag:2993267658","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22708005","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2381620","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3366441","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1500360861","https://openalex.org/W1986299517","https://openalex.org/W2007229145","https://openalex.org/W2037304101","https://openalex.org/W2039364304","https://openalex.org/W2040884797","https://openalex.org/W2046628533","https://openalex.org/W2080053848","https://openalex.org/W2099314511","https://openalex.org/W2117056590","https://openalex.org/W2142441374","https://openalex.org/W2144232924","https://openalex.org/W2169326967"],"related_works":["https://openalex.org/W2956642004","https://openalex.org/W2992445810","https://openalex.org/W2026140133","https://openalex.org/W1986299517","https://openalex.org/W4252006566","https://openalex.org/W124446647","https://openalex.org/W2064909539","https://openalex.org/W1576649181","https://openalex.org/W4237276401","https://openalex.org/W2531946123"],"abstract_inverted_index":{"BACKGROUND:":[0],"Ingestion":[1],"of":[2,25,115,118],"multiple":[3],"antioxidants":[4,119],"may":[5],"result":[6],"in":[7,10,30,66,90],"synergistic":[8],"increases":[9],"skin":[11],"protection.":[12],"METHODS:":[13],"In":[14],"a":[15,116],"double-blind,":[16],"randomized,":[17],"controlled":[18],"study,":[19],"the":[20,23,52,69,74,94,105],"authors":[21],"evaluated":[22],"effect":[24],"an":[26],"antioxidant":[27,70,100],"combination":[28,71,117],"product":[29],"women":[31,67,91],"with":[32,73],"mild-to-moderate":[33],"photoaging":[34],"over":[35],"20":[36],"weeks.":[37],"Changes":[38],"on":[39,124],"Oxygen":[40,60,133],"Radical":[41,61,134],"Absorbance":[42,62,135],"Capacity":[43,63,136],"levels":[44,64],"and":[45,59,132],"Minimal":[46,56,129],"Erythema":[47,57,130],"Dose":[48,58,131],"were":[49,88,108],"measured":[50],"throughout":[51],"study.":[53],"RESULTS:":[54],"Both":[55],"increased":[65],"receiving":[68],"product,":[72,96],"difference":[75],"from":[76],"baseline":[77,141],"being":[78],"statistically":[79,110],"significant":[80],"as":[81,83,128],"early":[82],"Week":[84],"4.":[85],"Similar":[86],"findings":[87],"observed":[89],"who":[92],"received":[93],"control":[95],"which":[97],"had":[98],"modest":[99],"activity.":[101],"The":[102],"comparisons":[103],"between":[104],"two":[106],"groups":[107],"not":[109],"significant.":[111],"CONCLUSION:":[112],"Oral":[113],"ingestion":[114],"can":[120],"lead":[121],"to":[122,140],"improvement":[123],"objective":[125],"measurements,":[126],"such":[127],"levels,":[137],"when":[138],"compared":[139],"values.":[142]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-13T00:00:00"}