{"id":"https://openalex.org/W2993263003","doi":"https://doi.org/10.4268/cjcmm20160619","title":"Antagonism mechanism of gingerols against inflammatory effect of toxic raphides from Pinella pedatisecta","display_name":"Antagonism mechanism of gingerols against inflammatory effect of toxic raphides from Pinella pedatisecta","publication_year":2016,"publication_date":"2016-03-15","ids":{"openalex":"https://openalex.org/W2993263003","doi":"https://doi.org/10.4268/cjcmm20160619","mag":"2993263003","pmid":"https://pubmed.ncbi.nlm.nih.gov/28875675"},"language":"zh","primary_location":{"id":"doi:10.4268/cjcmm20160619","doi":"https://doi.org/10.4268/cjcmm20160619","is_oa":false,"landing_page_url":"https://doi.org/10.4268/cjcmm20160619","pdf_url":null,"source":{"id":"https://openalex.org/S2756327665","display_name":"China Journal of Chinese Materia Medica","issn_l":"1001-5302","issn":["1001-5302"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4320800687","host_organization_name":"Chinese Pharmaceutical Association","host_organization_lineage":["https://openalex.org/P4320800687"],"host_organization_lineage_names":["Chinese Pharmaceutical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"China Journal of Chinese Materia Medica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110117057","display_name":"Yangping Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang-Ping Jin","raw_affiliation_strings":["College of Pharmacology, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacology, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034875574","display_name":"Hao Wu","orcid":"https://orcid.org/0000-0002-6713-7752","observed_orcids":["https://orcid.org/0000-0002-6713-7752"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Wu","raw_affiliation_strings":["College of Pharmacology, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China","Jiangsu Key Laboratory of Traditional Chinese Medicine Processing, Nanjing 210046, China","Traditional Chinese Medicine Processing Standardization Engineering Research Center under Ministry of Education, Nanjing 210046, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacology, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"Jiangsu Key Laboratory of Traditional Chinese Medicine Processing, Nanjing 210046, China","institution_ids":[]},{"raw_affiliation_string":"Traditional Chinese Medicine Processing Standardization Engineering Research Center under Ministry of Education, Nanjing 210046, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100610659","display_name":"Hongli Yu","orcid":"https://orcid.org/0000-0003-4375-0496","observed_orcids":["https://orcid.org/0000-0003-4375-0496"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-Li Yu","raw_affiliation_strings":["College of Pharmacology, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China","Jiangsu Key Laboratory of Traditional Chinese Medicine Processing, Nanjing 210046, China","Traditional Chinese Medicine Processing Standardization Engineering Research Center under Ministry of Education, Nanjing 210046, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacology, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"Jiangsu Key Laboratory of Traditional Chinese Medicine Processing, Nanjing 210046, China","institution_ids":[]},{"raw_affiliation_string":"Traditional Chinese Medicine Processing Standardization Engineering Research Center under Ministry of Education, Nanjing 210046, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064026404","display_name":"Yaozong Pan","orcid":"https://orcid.org/0000-0002-4442-6332","observed_orcids":["https://orcid.org/0000-0002-4442-6332"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao-Zong Pan","raw_affiliation_strings":["College of Pharmacology, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacology, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012239004","display_name":"Ye-Qing Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ye-Qing Chen","raw_affiliation_strings":["College of Pharmacology, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacology, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053896524","display_name":"Kui-Long Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kui-Long Wang","raw_affiliation_strings":["College of Pharmacology, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacology, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088482386","display_name":"Cheng-Chao Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng-Chao Zhang","raw_affiliation_strings":["College of Pharmacology, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacology, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100391830","display_name":"Wei Wang","orcid":"https://orcid.org/0000-0001-9963-5062","observed_orcids":["https://orcid.org/0000-0001-9963-5062","https://orcid.org/0000-0002-9861-5577"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Wang","raw_affiliation_strings":["College of Pharmacology, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacology, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China","institution_ids":["https://openalex.org/I131434179"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I131434179"],"apc_list":null,"apc_paid":null,"fwci":0.2434,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.51916239,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"41","issue":"6","first_page":"1087","last_page":"1092"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12347","display_name":"Ginger and Zingiberaceae research","score":0.8330000042915344,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12347","display_name":"Ginger and Zingiberaceae research","score":0.8330000042915344,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.0731000006198883,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gingerol","display_name":"gingerol","score":0.9879999756813049},{"id":"https://openalex.org/keywords/anti-inflammatory-mechanism","display_name":"anti-inflammatory mechanism","score":0.8349999785423279},{"id":"https://openalex.org/keywords/peritonitis","display_name":"peritonitis","score":0.890999972820282},{"id":"https://openalex.org/keywords/peritoneal-macrophages","display_name":"peritoneal macrophages","score":0.8759999871253967},{"id":"https://openalex.org/keywords/neutrophil-migration","display_name":"neutrophil migration","score":0.8029999732971191},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.7820000052452087},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.8619999885559082},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.984000027179718},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.4697069823741913},{"id":"https://openalex.org/C2777383412","wikidata":"https://www.wikidata.org/wiki/Q4770891","display_name":"Antagonism","level":3,"score":0.4502444267272949},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43091028928756714},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3934813141822815},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3664712905883789},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25503841042518616},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21639680862426758},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08243349194526672}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002396","descriptor_name":"Catechols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002396","descriptor_name":"Catechols","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004336","descriptor_name":"Drug Antagonism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005233","descriptor_name":"Fatty Alcohols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005233","descriptor_name":"Fatty Alcohols","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030021","descriptor_name":"Pinellia","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D030021","descriptor_name":"Pinellia","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4268/cjcmm20160619","doi":"https://doi.org/10.4268/cjcmm20160619","is_oa":false,"landing_page_url":"https://doi.org/10.4268/cjcmm20160619","pdf_url":null,"source":{"id":"https://openalex.org/S2756327665","display_name":"China Journal of Chinese Materia Medica","issn_l":"1001-5302","issn":["1001-5302"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4320800687","host_organization_name":"Chinese Pharmaceutical Association","host_organization_lineage":["https://openalex.org/P4320800687"],"host_organization_lineage_names":["Chinese Pharmaceutical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"China Journal of Chinese Materia Medica","raw_type":"journal-article"},{"id":"pmid:28875675","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28875675","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2301698595","https://openalex.org/W2028344952","https://openalex.org/W2412291308","https://openalex.org/W2390813077","https://openalex.org/W2724398694","https://openalex.org/W3193730885","https://openalex.org/W2081241211","https://openalex.org/W2791874709","https://openalex.org/W2167243724","https://openalex.org/W2056564326"],"abstract_inverted_index":{"This":[0],"study":[1,59,101],"was":[2,79],"to":[3,31,58,81,100,152],"investigate":[4],"the":[5,10,33,42,60,83,102,107,123,128,146,154,191,197,208],"mechanism":[6,193],"of":[7,13,35,44,63,88,104,109,125,130,156,173,194],"gingerols":[8,36,105,119,168,195],"antagonizing":[9],"inflammatory":[11,38,157,214],"effect":[12,34,108],"toxic":[14,24,66,110,135,147,182,198],"raphides":[15,25,92,136,148,183,199],"from":[16,26,137,149,184,200],"Pinella":[17],"pedatisecta.":[18,186],"Mice":[19],"peritonitis":[20],"models":[21,55,97],"induced":[22,133,180],"by":[23,91,134,181],"P.":[27,138,150,185,201],"pedatisecta":[28,139,151,202],"were":[29,56,98],"applied":[30],"observe":[32,82],"on":[37,113],"mediators":[39],"PGE2":[40,126],"in":[41,47,52,72,85,127,140],"exudates":[43,129],"abdominal":[45,131],"inflammation":[46,132],"mice;":[48],"rats":[49],"peritoneal":[50],"macrophage":[51,212],"vitro":[53],"culture":[54],"adopted":[57],"anti-inflammatory":[61],"effects":[62],"gingerol":[64],"against":[65,106,196],"raphides,":[67],"with":[68,159,206],"TNF-\u03b1":[69],"and":[70,93,177,217],"IL-1\u03b2":[71],"supernatant":[73],"as":[74],"indexes.":[75],"Scanning":[76,163],"electron":[77,164],"microscopy":[78,165],"used":[80,99],"changes":[84],"surface":[86],"morphology":[87],"macrophages":[89],"treated":[90],"gingerols.":[94],"Macrophages-neutrophils":[95],"co-cultured":[96],"antagonism":[103,192],"raphides'":[111],"stimulation":[112],"neutrophils":[114,178,218],"migration.":[115,219],"Results":[116],"showed":[117,166,189],"that":[118,167,190],"could":[120,143,169],"significantly":[121,144,170],"inhibit":[122,145,171],"production":[124],"mice.":[141],"Gingerols":[142],"induce":[153],"release":[155],"factors,":[158],"certain":[160],"dose":[161],"dependence.":[162],"phagocytosis":[172],"macrophages,":[174],"cytomembrane":[175],"injury,":[176],"migration":[179],"The":[187],"results":[188],"may":[203],"be":[204],"associated":[205],"inhibiting":[207],"pro-inflammatory":[209],"toxicity":[210],"including":[211],"activation,":[213],"factors":[215],"release,":[216]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2019-12-13T00:00:00"}
