{"id":"https://openalex.org/W2993083418","doi":null,"title":"Morphology and distribution of plaque and related deposits in the brains of Alzheimer's disease and control cases. An immunohistochemical study using amyloid beta-protein antibody.","display_name":"Morphology and distribution of plaque and related deposits in the brains of Alzheimer's disease and control cases. An immunohistochemical study using amyloid beta-protein antibody.","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2993083418","mag":"2993083418","pmid":"https://pubmed.ncbi.nlm.nih.gov/2642985"},"language":"en","primary_location":{"id":"pmid:2642985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2642985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074998675","display_name":"Shu\u2010ichi Ikeda","orcid":"https://orcid.org/0000-0001-7589-6161","observed_orcids":["https://orcid.org/0000-0001-7589-6161"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Ikeda","raw_affiliation_strings":["University of California, San Diego, School of Medicine, Department of Pathology, La Jolla"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, School of Medicine, Department of Pathology, La Jolla","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020554752","display_name":"David Allsop","orcid":"https://orcid.org/0000-0002-0513-5575","observed_orcids":["https://orcid.org/0000-0002-0513-5575"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Allsop","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072599758","display_name":"George G. Glenner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G G Glenner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.9294,"has_fulltext":false,"cited_by_count":144,"citation_normalized_percentile":{"value":0.98760514,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"60","issue":"1","first_page":"113","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuritic-plaques","display_name":"neuritic plaques","score":0.8820000290870667},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.9950000047683716},{"id":"https://openalex.org/keywords/plaque-morphology","display_name":"plaque morphology","score":0.5400000214576721},{"id":"https://openalex.org/keywords/diffuse-plaques","display_name":"diffuse plaques","score":0.800000011920929},{"id":"https://openalex.org/keywords/formic-acid-pretreatment","display_name":"formic acid pretreatment","score":0.8059999942779541},{"id":"https://openalex.org/keywords/congo-red-staining","display_name":"Congo red staining","score":0.9779999852180481},{"id":"https://openalex.org/keywords/silver-impregnation","display_name":"silver impregnation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/postmortem-diagnosis","display_name":"postmortem diagnosis","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.9046179056167603},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7787253856658936},{"id":"https://openalex.org/C68026918","wikidata":"https://www.wikidata.org/wiki/Q1970256","display_name":"Senile plaques","level":4,"score":0.6549136638641357},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.630321204662323},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5965451598167419},{"id":"https://openalex.org/C2779155187","wikidata":"https://www.wikidata.org/wiki/Q114391","display_name":"Congo red","level":3,"score":0.5848628878593445},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.5438840985298157},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5163044333457947},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4958549439907074},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4602348804473877},{"id":"https://openalex.org/C25330733","wikidata":"https://www.wikidata.org/wiki/Q907841","display_name":"Silver stain","level":2,"score":0.42579782009124756},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3454021215438843},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2987315058708191},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.202769935131073},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11726781725883484},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.05639803409576416},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003224","descriptor_name":"Congo Red","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012834","descriptor_name":"Silver","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:2642985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2642985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Comparative Study"},{"id":"pmh:oai:eprints.lancs.ac.uk:50863","doi":null,"is_oa":false,"landing_page_url":"https://eprints.lancs.ac.uk/id/eprint/50863/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401916","display_name":"Lancaster EPrints (Lancaster University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67415387","host_organization_name":"Lancaster University","host_organization_lineage":["https://openalex.org/I67415387"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"mag:2993083418","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2642985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7039512956","https://openalex.org/W7043718165","https://openalex.org/W2280733710","https://openalex.org/W2046725122","https://openalex.org/W2030100345","https://openalex.org/W1969876437","https://openalex.org/W1995624369","https://openalex.org/W2009459205","https://openalex.org/W2087738171","https://openalex.org/W2569345834"],"abstract_inverted_index":{"A":[0],"monoclonal":[1,238],"antibody":[2,239],"(4D12/2/6)":[3],"to":[4,25,143,173],"a":[5,45,236],"synthetic":[6],"peptide":[7],"consisting":[8],"of":[9,12,16,29,38,48,55,62,73,106,157,164,198,213,221,250],"residues":[10],"8-17":[11],"the":[13,27,36,60,74,103,112,127,146,188,204,247],"amyloid":[14,107,165],"beta-protein":[15,30,241],"Alzheimer's":[17,42,214,251],"disease":[18,43,215],"was":[19,126],"used":[20],"in":[21,32,35,108,178,187],"an":[22,195],"immunohistochemical":[23],"study":[24],"investigate":[26],"localization":[28],"immunoreactivity":[31],"neuritic":[33],"plaques":[34,222],"brains":[37],"20":[39],"cases":[40],"with":[41,67,81,122,145,161,235],"and":[44,53,59,68,76,88,95,131,206],"similar":[46],"number":[47],"nonAlzheimer":[49,189],"controls.":[50,190],"The":[51],"morphology":[52],"distribution":[54],"immunoreactive":[56,136,183,200],"plaque-like":[57],"lesions":[58,137,152,184,202],"sensitivity":[61],"immunostaining":[63,96,233],"were":[64,79,139,185],"assessed":[65],"both":[66],"without":[69,97],"formic":[70,98,123],"acid":[71,99,124],"pretreatment":[72,100,125],"sections,":[75],"these":[77],"results":[78],"compared":[80],"those":[82],"obtained":[83],"using":[84],"conventional":[85],"Congo":[86,93,227],"red":[87,94,228],"silver":[89,113,230],"impregnation":[90],"staining":[91,148,160],"methods.":[92,149],"mainly":[101],"stained":[102],"core":[104],"deposits":[105],"compact":[109],"plaques,":[110],"whereas":[111],"stain":[114],"could":[115],"also":[116],"detect":[117,144],"numerous":[118],"diffuse":[119],"plaques.":[120],"Immunostaining":[121],"most":[128],"sensitive":[129],"technique,":[130],"this":[132],"revealed":[133],"many":[134],"additional":[135,151],"which":[138],"impossible":[140],"or":[141,167,229],"difficult":[142],"other":[147],"These":[150],"included":[153],"variable":[154],"sized":[155],"areas":[156],"faint":[158],"granular":[159],"little":[162],"evidence":[163],"deposition":[166],"degenerating":[168],"neurites":[169],"that":[170,194],"are":[171],"presumed":[172],"be":[174,224,243],"very":[175,244],"early":[176],"stages":[177],"plaque":[179,201],"development.":[180],"Far":[181],"fewer":[182],"observed":[186],"It":[191],"is":[192,211],"concluded":[193],"abundant":[196],"presence":[197],"anti-beta-protein":[199],"throughout":[203],"cortex":[205],"subcortical":[207],"gray":[208],"matter":[209],"structures":[210],"typical":[212],"even":[216],"when":[217],"only":[218],"moderate":[219],"numbers":[220],"can":[223],"detected":[225],"by":[226],"stain.":[231],"This":[232],"procedure":[234],"specific":[237],"for":[240,246],"may":[242],"useful":[245],"postmortem":[248],"diagnosis":[249],"disease.":[252]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-13T00:00:00"}
