{"id":"https://openalex.org/W2993079100","doi":"https://doi.org/10.17504/protocols.io.pjwdkpe","title":"3D Nanofibrillar Cellulose hydrogel platform for long-term human islet culture v1","display_name":"3D Nanofibrillar Cellulose hydrogel platform for long-term human islet culture v1","publication_year":2018,"publication_date":"2018-04-18","ids":{"openalex":"https://openalex.org/W2993079100","doi":"https://doi.org/10.17504/protocols.io.pjwdkpe","mag":"2993079100"},"language":"en","primary_location":{"id":"doi:10.17504/protocols.io.pjwdkpe","doi":"https://doi.org/10.17504/protocols.io.pjwdkpe","is_oa":true,"landing_page_url":"https://doi.org/10.17504/protocols.io.pjwdkpe","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.17504/protocols.io.pjwdkpe","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040205600","display_name":"Yi-Ju Chen","orcid":"https://orcid.org/0000-0002-4367-5724","observed_orcids":["https://orcid.org/0000-0002-4367-5724"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi-Ju Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4367-5724","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5057187872","display_name":"Ben Z. Stanger","orcid":"https://orcid.org/0000-0003-0410-4037","observed_orcids":["https://orcid.org/0000-0003-0410-4037"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ben Z. Stanger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10610","display_name":"Advanced Cellulose Research Studies","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-islets","display_name":"human islets","score":0.8289999961853027},{"id":"https://openalex.org/keywords/wood-derived-cellulose","display_name":"wood-derived cellulose","score":0.7979999780654907},{"id":"https://openalex.org/keywords/islet-transplantation","display_name":"islet transplantation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/transwell-culture","display_name":"transwell culture","score":0.656000018119812},{"id":"https://openalex.org/keywords/islet-preservation","display_name":"islet preservation","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.9399385452270508},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.7201789617538452},{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.475433349609375},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4670739471912384},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3820590376853943},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33351725339889526},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27796465158462524},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.251045823097229},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22994819283485413},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.21368515491485596}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.17504/protocols.io.pjwdkpe","doi":"https://doi.org/10.17504/protocols.io.pjwdkpe","is_oa":true,"landing_page_url":"https://doi.org/10.17504/protocols.io.pjwdkpe","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.17504/protocols.io.pjwdkpe","doi":"https://doi.org/10.17504/protocols.io.pjwdkpe","is_oa":true,"landing_page_url":"https://doi.org/10.17504/protocols.io.pjwdkpe","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2988126628","https://openalex.org/W4387424248","https://openalex.org/W4396893541","https://openalex.org/W4387877301","https://openalex.org/W2070603258","https://openalex.org/W2394669064","https://openalex.org/W4309611267","https://openalex.org/W2048911095","https://openalex.org/W2085841600","https://openalex.org/W2890799880"],"abstract_inverted_index":{"It":[0],"remains":[1],"a":[2,10,30,77,142,149],"challenge":[3],"to":[4,87,94,119,124,140],"maintain":[5],"human":[6,84,102,153,159,172],"isletsex":[7],"vivoto":[8],"provide":[9,141],"functional":[11],"and":[12,19,38,53,63,107,155,170],"sufficient":[13,143],"source":[14],"for":[15,22,145,158],"clinical":[16],"islet":[17,131,147,160,166,173],"transplantation":[18],"anin":[20,156],"vitromodel":[21,157],"drug":[23],"screening":[24],"or":[25],"basic":[26,171],"biological":[27,54],"studies.":[28],"With":[29],"conventional":[31],"culture":[32],"method,":[33],"islets":[34,85,103],"lost":[35],"their":[36],"functionality":[37],"mass":[39],"rapidly":[40],"upon":[41],"they":[42],"were":[43],"isolated":[44,96],"from":[45],"the":[46,58,64,69,128,134],"native":[47],"environment,":[48],"which":[49,81],"provides":[50],"both":[51],"mechanical":[52,65],"supports.":[55],"By":[56],"merging":[57],"advantage":[59],"of":[60,136,152],"transwell":[61],"cultures":[62],"properties":[66],"provided":[67],"by":[68],"wood-derived":[70],"nanofibrillar":[71],"cellulose":[72],"(NFC)":[73],"hydrogel,":[74],"we":[75],"developed":[76],"new":[78],"isletex":[79],"vivoplatform,":[80],"can":[82,108],"preserve":[83],"up":[86],"83":[88],"days":[89],"with":[90],"intact":[91],"morphology":[92],"similar":[93],"freshly":[95],"counterparts.":[97],"Importantly,":[98],"these":[99],"long-term":[100],"cultured":[101],"are":[104],"still":[105],"potent":[106],"ameliorate":[109],"hyperglycemia":[110],"in":[111,130,162],"diabetic":[112],"mice":[113],"post-transplantation.":[114],"The":[115],"platform":[116,138],"is":[117],"designed":[118],"beuser":[120],"friendlyand":[121],"easily":[122],"adapted":[123],"help":[125],"scientists":[126],"overcome":[127],"difficulties":[129],"cultures.":[132],"Furthermore,":[133],"application":[135],"this":[137],"aims":[139],"window":[144],"pre-transplantation":[146],"assessment,":[148],"biobanking":[150],"opportunity":[151],"islets,":[154],"studies":[161],"drug-screening,":[163],"stem":[164],"cell-derived":[165],"(beta)-like":[167],"organoids":[168],"maturation,":[169],"biology.":[174]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-12-13T00:00:00"}
