{"id":"https://openalex.org/W2993057445","doi":null,"title":"Gut microbiota and immunity in common variable immunodeficiency: crosstalk with pro-inflammatory cytokines.","display_name":"Gut microbiota and immunity in common variable immunodeficiency: crosstalk with pro-inflammatory cytokines.","publication_year":2019,"publication_date":"2019-03-01","ids":{"openalex":"https://openalex.org/W2993057445","mag":"2993057445","pmid":"https://pubmed.ncbi.nlm.nih.gov/30942065"},"language":"en","primary_location":{"id":"pmid:30942065","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30942065","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological regulators and homeostatic agents","raw_type":"Editorial"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074615917","display_name":"Laura Franza","orcid":"https://orcid.org/0000-0001-8638-7565","observed_orcids":["https://orcid.org/0000-0001-8638-7565"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L Franza","raw_affiliation_strings":["Clinical Immunology Laboratory, Department of Internal Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS - Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy","Department of Infective Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS - Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Immunology Laboratory, Department of Internal Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS - Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943","https://openalex.org/I4210153126"]},{"raw_affiliation_string":"Department of Infective Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS - Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087629543","display_name":"Valentina Carusi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"V Carusi","raw_affiliation_strings":["Clinical Immunology Laboratory, Department of Internal Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS - Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Immunology Laboratory, Department of Internal Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS - Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082847751","display_name":"Simona Altamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S Altamura","raw_affiliation_strings":["Clinical Immunology Laboratory, Department of Internal Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS - Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Immunology Laboratory, Department of Internal Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS - Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031340334","display_name":"Antonio Gasbarrini","orcid":"https://orcid.org/0000-0002-6230-1779","observed_orcids":["https://orcid.org/0000-0002-6230-1779","https://orcid.org/0000-0003-4863-6924"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Gasbarrini","raw_affiliation_strings":["Gastroenterology Deparment, Fondazione Policlinico Universitario A. Gemelli IRCCS - Universit\u00e0 Cattolica del Sacro Cuore, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology Deparment, Fondazione Policlinico Universitario A. Gemelli IRCCS - Universit\u00e0 Cattolica del Sacro Cuore, Roma, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043479380","display_name":"Alessandro Caraffa","orcid":"https://orcid.org/0000-0002-7733-6413","observed_orcids":["https://orcid.org/0000-0002-7733-6413"]},"institutions":[{"id":"https://openalex.org/I112859197","display_name":"Universit\u00e0 di Camerino","ror":"https://ror.org/0005w8d69","country_code":"IT","type":"education","lineage":["https://openalex.org/I112859197"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Al Caraffa","raw_affiliation_strings":["School of Pharmacy, University of Camerino, Camerino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Camerino, Camerino, Italy","institution_ids":["https://openalex.org/I112859197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010719890","display_name":"Spyridon K. Kritas","orcid":"https://orcid.org/0000-0002-3540-9928","observed_orcids":["https://orcid.org/0000-0002-3540-9928"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"S K Kritas","raw_affiliation_strings":["Department of Microbiology and Infectious Diseases, School of Veterinary Medicine, Aristotle University of Thessaloniki, Macedonia, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Infectious Diseases, School of Veterinary Medicine, Aristotle University of Thessaloniki, Macedonia, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071941913","display_name":"Gianpaolo Ronconi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Ronconi","raw_affiliation_strings":["Clinica dei Pazienti del Territorio, Fondazione Policlinico Gemelli, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica dei Pazienti del Territorio, Fondazione Policlinico Gemelli, Rome, Italy","institution_ids":["https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086971584","display_name":"Carla Enrica Gallenga","orcid":"https://orcid.org/0000-0002-7426-8603","observed_orcids":["https://orcid.org/0000-0002-7426-8603"]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C E Gallenga","raw_affiliation_strings":["Department of Biomedical Sciences and Specialist Surgery, Section of Ophthalmology, University of Ferrara, Ferrara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences and Specialist Surgery, Section of Ophthalmology, University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017854085","display_name":"Francesco Di Virgilio","orcid":"https://orcid.org/0000-0003-3566-1362","observed_orcids":["https://orcid.org/0000-0003-3566-1362"]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F Di Virgilio","raw_affiliation_strings":["Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5106571602","display_name":"Franco Pandolfi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F Pandolfi","raw_affiliation_strings":["Clinical Immunology Laboratory, Department of Internal Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS - Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Immunology Laboratory, Department of Internal Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS - Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943","https://openalex.org/I4210153126"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"2","first_page":"315","last_page":"319"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9959999918937683},{"id":"https://openalex.org/keywords/common-variable-immunodeficiency","display_name":"common variable immunodeficiency","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mucosal-immunity","display_name":"mucosal immunity","score":0.9100000262260437},{"id":"https://openalex.org/keywords/immunodeficiency","display_name":"immunodeficiency","score":0.7070000171661377},{"id":"https://openalex.org/keywords/prebiotics","display_name":"prebiotics","score":0.9660000205039978},{"id":"https://openalex.org/keywords/antibiotics","display_name":"antibiotics","score":0.9229999780654907},{"id":"https://openalex.org/keywords/microbiota-homeostasis","display_name":"microbiota homeostasis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/immune-mediated-diseases","display_name":"immune-mediated diseases","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.8555783629417419},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7319016456604004},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.7303685545921326},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.5541813969612122},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.48775798082351685},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47112178802490234},{"id":"https://openalex.org/C2777607303","wikidata":"https://www.wikidata.org/wiki/Q641307","display_name":"Immunodeficiency","level":3,"score":0.4447741210460663},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.44047796726226807},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.42159369587898254},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3203948438167572},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017074","descriptor_name":"Common Variable Immunodeficiency","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017074","descriptor_name":"Common Variable Immunodeficiency","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D018928","descriptor_name":"Immunity, Mucosal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:30942065","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30942065","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological regulators and homeostatic agents","raw_type":"Editorial"},{"id":"pmh:oai:sfera.unife.it:11392/2592954","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11392/2592954","pdf_url":null,"source":{"id":"https://openalex.org/S4306400369","display_name":"Institutional Research Information System University of Ferrara (University of Ferrara)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201324441","host_organization_name":"University of Ferrara","host_organization_lineage":["https://openalex.org/I201324441"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2993057445","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30942065","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2564714625","https://openalex.org/W2153546254","https://openalex.org/W2890837460","https://openalex.org/W2584373125","https://openalex.org/W3127285656","https://openalex.org/W3188048417","https://openalex.org/W4221035744","https://openalex.org/W4319072802","https://openalex.org/W3165801417","https://openalex.org/W3095433840"],"abstract_inverted_index":{"In":[0,42],"recent":[1],"years,":[2],"gut":[3],"microbiota":[4],"(GM)":[5],"has":[6,45,80],"emerged":[7],"as":[8,23,25,33],"a":[9,17,46,81,102],"key":[10],"factor":[11],"in":[12,26,49,57,70,89,105],"shaping":[13],"the":[14,27,50,71,85,118],"pathogenesis":[15],"of":[16,20,74,116],"vast":[18],"array":[19],"immune-mediated":[21],"diseases,":[22],"well":[24],"response":[28],"to":[29,96],"immune-based":[30],"treatments":[31],"such":[32],"anti":[34],"PD-1":[35],"and":[36,54,88,109],"anti-CTLA4":[37],"therapy":[38],"or":[39],"influenza":[40],"vaccination.":[41],"addition,":[43],"GM":[44,65,78,107],"significant":[47],"role":[48,69],"immune":[51,72,75,86,90],"system":[52,73,87],"development":[53],"is":[55],"fundamental":[56],"developing":[58],"mucosal":[59],"immunity.":[60,111],"Recent":[61],"data":[62],"suggest":[63],"that":[64],"plays":[66],"an":[67],"important":[68,97],"deficient":[76,91],"patients.":[77],"status":[79],"remarkable":[82],"impact":[83],"on":[84],"patients;":[92],"this":[93],"can":[94],"lead":[95],"consequences.":[98],"Prebiotics":[99],"are":[100,113],"indeed":[101],"promising":[103],"candidate":[104],"restoring":[106],"homeostasis":[108],"improving":[110],"Antibiotics":[112],"also":[114],"capable":[115],"altering":[117],"microbial":[119],"equilibrium.":[120]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-13T00:00:00"}