{"id":"https://openalex.org/W2992904553","doi":"https://doi.org/10.1002/yea.3452","title":"The wide\u2010ranging phenotypes of ergosterol biosynthesis mutants, and implications for microbial cell factories","display_name":"The wide\u2010ranging phenotypes of ergosterol biosynthesis mutants, and implications for microbial cell factories","publication_year":2019,"publication_date":"2019-12-04","ids":{"openalex":"https://openalex.org/W2992904553","doi":"https://doi.org/10.1002/yea.3452","mag":"2992904553","pmid":"https://pubmed.ncbi.nlm.nih.gov/31800968"},"language":"en","primary_location":{"id":"doi:10.1002/yea.3452","doi":"https://doi.org/10.1002/yea.3452","is_oa":true,"landing_page_url":"https://doi.org/10.1002/yea.3452","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/yea.3452","source":{"id":"https://openalex.org/S80252601","display_name":"Yeast","issn_l":"0749-503X","issn":["0749-503X","1097-0061"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yeast","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/yea.3452","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073652995","display_name":"Emily J. Johnston","orcid":"https://orcid.org/0000-0003-0592-0992","observed_orcids":["https://orcid.org/0000-0003-0592-0992"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Emily J. Johnston","raw_affiliation_strings":["School of Biological Sciences, University of Edinburgh, Edinburgh, UK"],"raw_orcid":"https://orcid.org/0000-0003-0592-0992","affiliations":[{"raw_affiliation_string":"School of Biological Sciences, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019660033","display_name":"Tessa Moses","orcid":"https://orcid.org/0000-0001-9366-4727","observed_orcids":["https://orcid.org/0000-0001-9366-4727"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tessa Moses","raw_affiliation_strings":["School of Biological Sciences, University of Edinburgh, Edinburgh, UK"],"raw_orcid":"https://orcid.org/0000-0001-9366-4727","affiliations":[{"raw_affiliation_string":"School of Biological Sciences, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036161341","display_name":"Susan J. Rosser","orcid":"https://orcid.org/0000-0002-2560-6485","observed_orcids":["https://orcid.org/0000-0002-2560-6485"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Susan J. Rosser","raw_affiliation_strings":["School of Biological Sciences, University of Edinburgh, Edinburgh, UK"],"raw_orcid":"https://orcid.org/0000-0002-2560-6485","affiliations":[{"raw_affiliation_string":"School of Biological Sciences, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5073652995"],"corresponding_institution_ids":["https://openalex.org/I98677209"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":{"value":3400,"currency":"USD","value_usd":3400},"fwci":0.514,"has_fulltext":true,"cited_by_count":79,"citation_normalized_percentile":{"value":0.48275862,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"37","issue":"1","first_page":"27","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.823199987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.823199987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.163100004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ergosterol-biosynthesis","display_name":"ergosterol biosynthesis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9940000176429749},{"id":"https://openalex.org/keywords/yeast-phenotypes","display_name":"yeast phenotypes","score":0.746999979019165},{"id":"https://openalex.org/keywords/plasma-membrane-dynamics","display_name":"plasma membrane dynamics","score":0.6700000166893005},{"id":"https://openalex.org/keywords/thermal-tolerance","display_name":"heat tolerance","score":0.8700000047683716},{"id":"https://openalex.org/keywords/stress-tolerance","display_name":"stress tolerance","score":0.7739999890327454},{"id":"https://openalex.org/keywords/ethanol-tolerance","display_name":"ethanol tolerance","score":0.8550000190734863},{"id":"https://openalex.org/keywords/salt-tolerance","display_name":"salt tolerance","score":0.7289999723434448},{"id":"https://openalex.org/keywords/sterol-content","display_name":"sterol content","score":0.5130000114440918},{"id":"https://openalex.org/keywords/microbial-cell-factories","display_name":"microbial cell factories","score":0.8519999980926514},{"id":"https://openalex.org/keywords/strain-engineering","display_name":"strain engineering","score":0.621999979019165},{"id":"https://openalex.org/keywords/artemisinin-production","display_name":"artemisinin production","score":0.5860000252723694},{"id":"https://openalex.org/keywords/bioethanol-production","display_name":"bioethanol production","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C2777910421","wikidata":"https://www.wikidata.org/wiki/Q143263","display_name":"Ergosterol","level":2,"score":0.8863015174865723},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.7804526090621948},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7184113264083862},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.6777254343032837},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.5324289202690125},{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.5241361260414124},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45904842019081116},{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.43471765518188477},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.18454954028129578},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13271969556808472},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12729549407958984},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.06557992100715637}],"mesh":[{"descriptor_ui":"D004875","descriptor_name":"Ergosterol","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D005285","descriptor_name":"Fermentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013261","descriptor_name":"Sterols","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D056804","descriptor_name":"Biofuels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/yea.3452","doi":"https://doi.org/10.1002/yea.3452","is_oa":true,"landing_page_url":"https://doi.org/10.1002/yea.3452","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/yea.3452","source":{"id":"https://openalex.org/S80252601","display_name":"Yeast","issn_l":"0749-503X","issn":["0749-503X","1097-0061"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yeast","raw_type":"journal-article"},{"id":"pmid:31800968","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31800968","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yeast (Chichester, England)","raw_type":"Journal Article"},{"id":"pmh:oai:pure.ed.ac.uk:openaire/2d801bbb-a027-4377-90f2-955db8e20177","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.11820/2d801bbb-a027-4377-90f2-955db8e20177","pdf_url":null,"source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Johnston, E J, Moses, T & Rosser, S J 2019, 'The wide\u2010ranging phenotypes of ergosterol biosynthesis mutants, and implications for microbial cell factories', Yeast, vol. 37, no. 1, pp. 27-44. https://doi.org/10.1002/yea.3452","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1002/yea.3452","doi":"https://doi.org/10.1002/yea.3452","is_oa":true,"landing_page_url":"https://doi.org/10.1002/yea.3452","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/yea.3452","source":{"id":"https://openalex.org/S80252601","display_name":"Yeast","issn_l":"0749-503X","issn":["0749-503X","1097-0061"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yeast","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1258999831","display_name":"Harnessing enzymes from plants for selective functionalisation of triterpenoid scaffolds","funder_award_id":"BB/S017712/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G2678767778","display_name":null,"funder_award_id":"102297","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6158046631","display_name":null,"funder_award_id":"Project-2016-150","funder_id":"https://openalex.org/F4320331582","funder_display_name":"Industrial Biotechnology Innovation Centre"},{"id":"https://openalex.org/G6825702238","display_name":null,"funder_award_id":"2016-150","funder_id":"https://openalex.org/F4320331582","funder_display_name":"Industrial Biotechnology Innovation Centre"},{"id":"https://openalex.org/G7331214210","display_name":"Industrial Saponins","funder_award_id":"BB/M028860/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8121947308","display_name":"Harnessing enzymes from plants for selective functionalisation of triterpenoid scaffolds","funder_award_id":"BB/S016023/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320331582","display_name":"Industrial Biotechnology Innovation Centre","ror":"https://ror.org/02e250j72"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2992904553.pdf","grobid_xml":"https://content.openalex.org/works/W2992904553.grobid-xml"},"referenced_works_count":139,"referenced_works":["https://openalex.org/W20155414","https://openalex.org/W82875452","https://openalex.org/W1514220190","https://openalex.org/W1548630007","https://openalex.org/W1552198311","https://openalex.org/W1577027659","https://openalex.org/W1861495492","https://openalex.org/W1896630930","https://openalex.org/W1909944883","https://openalex.org/W1927096570","https://openalex.org/W1952627112","https://openalex.org/W1961393177","https://openalex.org/W1964581982","https://openalex.org/W1965367429","https://openalex.org/W1965813899","https://openalex.org/W1965859532","https://openalex.org/W1969365827","https://openalex.org/W1972502085","https://openalex.org/W1973047231","https://openalex.org/W1974019266","https://openalex.org/W1978286648","https://openalex.org/W1978427086","https://openalex.org/W1982758823","https://openalex.org/W1984954439","https://openalex.org/W1987455793","https://openalex.org/W1987640473","https://openalex.org/W1989285948","https://openalex.org/W1990226486","https://openalex.org/W1993718303","https://openalex.org/W1993902553","https://openalex.org/W1995653318","https://openalex.org/W1996228271","https://openalex.org/W2004084851","https://openalex.org/W2004296371","https://openalex.org/W2006266631","https://openalex.org/W2010658450","https://openalex.org/W2011963593","https://openalex.org/W2014176614","https://openalex.org/W2014903703","https://openalex.org/W2015989284","https://openalex.org/W2016738767","https://openalex.org/W2016747889","https://openalex.org/W2016748121","https://openalex.org/W2022014977","https://openalex.org/W2023075963","https://openalex.org/W2026420793","https://openalex.org/W2028414840","https://openalex.org/W2028726487","https://openalex.org/W2029269187","https://openalex.org/W2031271408","https://openalex.org/W2031315147","https://openalex.org/W2037135781","https://openalex.org/W2037735248","https://openalex.org/W2038191669","https://openalex.org/W2047076849","https://openalex.org/W2052844055","https://openalex.org/W2057967928","https://openalex.org/W2058779664","https://openalex.org/W2059514697","https://openalex.org/W2060282531","https://openalex.org/W2062815225","https://openalex.org/W2066458127","https://openalex.org/W2066696420","https://openalex.org/W2067883946","https://openalex.org/W2068058585","https://openalex.org/W2069405322","https://openalex.org/W2073700640","https://openalex.org/W2085132198","https://openalex.org/W2085388924","https://openalex.org/W2085519610","https://openalex.org/W2087576311","https://openalex.org/W2088908073","https://openalex.org/W2090491594","https://openalex.org/W2091602891","https://openalex.org/W2094606844","https://openalex.org/W2095926990","https://openalex.org/W2097032828","https://openalex.org/W2099583363","https://openalex.org/W2100929292","https://openalex.org/W2100983555","https://openalex.org/W2103244155","https://openalex.org/W2109056652","https://openalex.org/W2110428217","https://openalex.org/W2112866008","https://openalex.org/W2117199571","https://openalex.org/W2119411909","https://openalex.org/W2122139514","https://openalex.org/W2122250742","https://openalex.org/W2124967803","https://openalex.org/W2129828626","https://openalex.org/W2130745984","https://openalex.org/W2131339809","https://openalex.org/W2131863968","https://openalex.org/W2133576858","https://openalex.org/W2134392026","https://openalex.org/W2134671651","https://openalex.org/W2136219663","https://openalex.org/W2138879042","https://openalex.org/W2139472183","https://openalex.org/W2143109888","https://openalex.org/W2144811436","https://openalex.org/W2146560076","https://openalex.org/W2148959688","https://openalex.org/W2150761911","https://openalex.org/W2155134693","https://openalex.org/W2156681354","https://openalex.org/W2157978054","https://openalex.org/W2159100436","https://openalex.org/W2161302855","https://openalex.org/W2161923371","https://openalex.org/W2163989602","https://openalex.org/W2171996735","https://openalex.org/W2172251739","https://openalex.org/W2180639117","https://openalex.org/W2316754462","https://openalex.org/W2337317157","https://openalex.org/W2337893060","https://openalex.org/W2345462336","https://openalex.org/W2367381994","https://openalex.org/W2403354497","https://openalex.org/W2568801975","https://openalex.org/W2586637063","https://openalex.org/W2617188986","https://openalex.org/W2620930341","https://openalex.org/W2724339814","https://openalex.org/W2733705455","https://openalex.org/W2738479860","https://openalex.org/W2749395116","https://openalex.org/W2782272062","https://openalex.org/W2883719988","https://openalex.org/W2886020648","https://openalex.org/W2890590096","https://openalex.org/W2941961624","https://openalex.org/W2949204090","https://openalex.org/W4235129366","https://openalex.org/W4253661031","https://openalex.org/W6705085006","https://openalex.org/W7073728213","https://openalex.org/W7074089386"],"related_works":["https://openalex.org/W2749395116","https://openalex.org/W2080906705","https://openalex.org/W2948626949","https://openalex.org/W4416421512","https://openalex.org/W3177497168","https://openalex.org/W4401841147","https://openalex.org/W1969583685","https://openalex.org/W2143109888","https://openalex.org/W7148227452","https://openalex.org/W2155229002"],"abstract_inverted_index":{"Yeast":[0],"strains":[1,77,157],"have":[2],"been":[3,87],"used":[4],"extensively":[5],"as":[6,140,170],"robust":[7],"microbial":[8,171],"cell":[9,172],"factories":[10],"for":[11,54,168],"the":[12,69,90,96,150,164],"production":[13],"of":[14,43,71,92,101,113,120,153,166],"bulk":[15],"and":[16,27,32,36,83,99,118,133,144,162],"fine":[17],"chemicals,":[18],"including":[19,115],"biofuels":[20],"(bioethanol),":[21],"complex":[22],"pharmaceuticals":[23],"(antimalarial":[24],"drug":[25],"artemisinin":[26],"opioid":[28],"pain":[29],"killers),":[30],"flavours,":[31],"fragrances":[33],"(vanillin,":[34],"nootkatone,":[35],"resveratrol).":[37],"In":[38],"many":[39],"cases,":[40],"it":[41],"is":[42,78],"benefit":[44],"to":[45,56,60,89,125,130,136],"suppress":[46],"or":[47,59],"modify":[48],"ergosterol":[49,73],"biosynthesis":[50,74],"during":[51],"strain":[52],"engineering,":[53],"example,":[55],"increase":[57,61],"thermotolerance":[58],"metabolic":[62],"flux":[63],"through":[64],"an":[65],"alternate":[66],"pathway.":[67],"However,":[68],"impact":[70],"modifying":[72],"on":[75,95],"engineered":[76],"discussed":[79],"sparsely":[80],"in":[81],"literature,":[82],"little":[84],"attention":[85],"has":[86],"paid":[88],"implications":[91,165],"these":[93,167],"modifications":[94],"general":[97],"health":[98],"well-being":[100],"yeast.":[102],"Importantly,":[103],"yeast":[104,169],"with":[105,158],"modified":[106],"sterol":[107,160],"content":[108,161],"exhibit":[109],"a":[110],"wide":[111],"range":[112],"phenotypes,":[114],"altered":[116,123,159],"organization":[117],"dynamics":[119],"plasma":[121],"membrane,":[122],"susceptibility":[124],"chemical":[126],"treatment,":[127],"increased":[128],"tolerance":[129,135],"high":[131,141],"temperatures,":[132],"reduced":[134],"other":[137],"stresses":[138],"such":[139],"ethanol,":[142],"salt,":[143],"solute":[145],"concentrations.":[146],"Here,":[147],"we":[148],"review":[149],"wide-ranging":[151],"phenotypes":[152],"viable":[154],"Saccharomyces":[155],"cerevisiae":[156],"discuss":[163],"factories.":[173]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-12-13T00:00:00"}