{"id":"https://openalex.org/W2992855815","doi":null,"title":"Intergenerational factors in cardiovascular health : A prospective cohort study","display_name":"Intergenerational factors in cardiovascular health : A prospective cohort study","publication_year":2019,"publication_date":"2019-12-11","ids":{"openalex":"https://openalex.org/W2992855815","mag":"2992855815"},"language":"en","primary_location":{"id":"pmh:oai:helda.helsinki.fi:10138/307133","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/307133","pdf_url":"http://hdl.handle.net/10138/307133","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/307133","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001761087","display_name":"Kaisla Komulainen","orcid":"https://orcid.org/0000-0002-1576-7111","observed_orcids":["https://orcid.org/0000-0002-1576-7111"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kaisla Komulainen","raw_affiliation_strings":["Psykologian ja logopedian osasto"],"raw_orcid":"https://orcid.org/0000-0002-1576-7111","affiliations":[{"raw_affiliation_string":"Psykologian ja logopedian osasto","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5001761087"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13522","display_name":"Cardiovascular Health and Risk Factors","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13522","display_name":"Cardiovascular Health and Risk Factors","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiovascular-health","display_name":"cardiovascular health","score":0.9279999732971191},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.9120000004768372},{"id":"https://openalex.org/keywords/socioeconomic-position","display_name":"socioeconomic position","score":0.7450000047683716},{"id":"https://openalex.org/keywords/parental-health-behavior","display_name":"parental health behavior","score":0.6240000128746033},{"id":"https://openalex.org/keywords/left-ventricular-mass","display_name":"left ventricular mass","score":0.968999981880188},{"id":"https://openalex.org/keywords/diastolic-function","display_name":"diastolic function","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cardiovascular-health-behaviors","display_name":"cardiovascular health behaviors","score":0.6389999985694885},{"id":"https://openalex.org/keywords/mediation","display_name":"mediation","score":0.6880000233650208},{"id":"https://openalex.org/keywords/life-course-exposure","display_name":"life course exposure","score":0.5899999737739563},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.7900000214576721},{"id":"https://openalex.org/keywords/young-adults","display_name":"young adults","score":0.4320000112056732},{"id":"https://openalex.org/keywords/cardiovascular-risk-in-young-finns-study","display_name":"Cardiovascular Risk in Young Finns Study","score":0.7870000004768372},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.4909999966621399},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.9940000176429749},{"id":"https://openalex.org/keywords/diet","display_name":"diet","score":0.9700000286102295}],"concepts":[{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.512722373008728},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5051599144935608},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4425169825553894},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.40235334634780884},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.330513596534729},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14949023723602295}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:helda.helsinki.fi:10138/307133","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/307133","pdf_url":"http://hdl.handle.net/10138/307133","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},{"id":"mag:2992855815","doi":null,"is_oa":false,"landing_page_url":"https://helda.helsinki.fi/handle/10138/307133","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/307133","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/307133","pdf_url":"http://hdl.handle.net/10138/307133","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2992855815.pdf","grobid_xml":"https://content.openalex.org/works/W2992855815.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W1193057051","https://openalex.org/W1200752817","https://openalex.org/W1481632969","https://openalex.org/W1544515333","https://openalex.org/W1587682423","https://openalex.org/W1619226291","https://openalex.org/W1622630381","https://openalex.org/W1686749590","https://openalex.org/W1693625871","https://openalex.org/W1745396860","https://openalex.org/W1971420153","https://openalex.org/W1972640642","https://openalex.org/W1973928117","https://openalex.org/W1992124339","https://openalex.org/W1992141724","https://openalex.org/W1995984331","https://openalex.org/W1997338841","https://openalex.org/W1998977949","https://openalex.org/W1999603962","https://openalex.org/W2000745019","https://openalex.org/W2005554640","https://openalex.org/W2009605408","https://openalex.org/W2010636112","https://openalex.org/W2017610921","https://openalex.org/W2018751384","https://openalex.org/W2035285042","https://openalex.org/W2036298368","https://openalex.org/W2037923061","https://openalex.org/W2039153962","https://openalex.org/W2043489981","https://openalex.org/W2046433134","https://openalex.org/W2050761447","https://openalex.org/W2059842747","https://openalex.org/W2077615475","https://openalex.org/W2079838937","https://openalex.org/W2084701241","https://openalex.org/W2089341710","https://openalex.org/W2096203953","https://openalex.org/W2097420581","https://openalex.org/W2097733917","https://openalex.org/W2099614776","https://openalex.org/W2100030703","https://openalex.org/W2102177764","https://openalex.org/W2104251459","https://openalex.org/W2106242560","https://openalex.org/W2111689717","https://openalex.org/W2111778050","https://openalex.org/W2117828851","https://openalex.org/W2119308836","https://openalex.org/W2123921851","https://openalex.org/W2126348824","https://openalex.org/W2130483595","https://openalex.org/W2132329434","https://openalex.org/W2134843796","https://openalex.org/W2137463623","https://openalex.org/W2140011022","https://openalex.org/W2142435658","https://openalex.org/W2142659997","https://openalex.org/W2145925744","https://openalex.org/W2147499654","https://openalex.org/W2150332822","https://openalex.org/W2155593381","https://openalex.org/W2156848121","https://openalex.org/W2161414087","https://openalex.org/W2162896556","https://openalex.org/W2165030669","https://openalex.org/W2172168133","https://openalex.org/W2294670790","https://openalex.org/W2332987513","https://openalex.org/W2337019381","https://openalex.org/W2343273748","https://openalex.org/W2460767514","https://openalex.org/W2472769694","https://openalex.org/W2505428220","https://openalex.org/W2544594608","https://openalex.org/W2547227216","https://openalex.org/W2556052478","https://openalex.org/W2563844704","https://openalex.org/W2570774207","https://openalex.org/W2594811275","https://openalex.org/W2604021708","https://openalex.org/W2605840015","https://openalex.org/W2638099954","https://openalex.org/W2725988230","https://openalex.org/W2736642710","https://openalex.org/W2740726397","https://openalex.org/W2753303450","https://openalex.org/W2769120902","https://openalex.org/W2780541235","https://openalex.org/W2794819865","https://openalex.org/W2801098573","https://openalex.org/W2811108479","https://openalex.org/W2895625430","https://openalex.org/W2954212835"],"related_works":["https://openalex.org/W2944910650","https://openalex.org/W2559786195","https://openalex.org/W1622630381","https://openalex.org/W3029882849","https://openalex.org/W7100112537","https://openalex.org/W329157601","https://openalex.org/W2135207987","https://openalex.org/W4252930253","https://openalex.org/W3160437374","https://openalex.org/W4416551419"],"abstract_inverted_index":{"Background.":[0],"Cardiovascular":[1,141],"etiologies":[2],"are":[3],"complex":[4],"and":[5,46,74,78,105,112,118,170,208,226,231,246,250,307,319,335,337,462,483,584,609,634,698,708],"influenced":[6],"by":[7,52,83,255,278,665,715],"several":[8],"exposures":[9,700],"acting":[10],"together":[11],"across":[12,178],"the":[13,18,48,94,138,194,214,351,369,375,436,440,446,456,468,479,615,618,623,694],"life-course.":[14],"This":[15],"dissertation":[16],"examined":[17,32],"life-course":[19],"pathways":[20,339,703,711],"of":[21,34,37,67,96,182,257,280,312,327,439,459,516,617,646,696,704],"cardiovascular":[22,69,123,200,341,505,657,706],"health":[23,70,124,201,232,251,313,342,506,658,707],"in":[24,143,148,152,156,164,175,186,193,242,260,283,289,350,414,600,611,701],"relation":[25],"to":[26,119,365,652],"three":[27,135],"intergenerational":[28,65,140,533,697],"factors.":[29],"First,":[30],"we":[31,63,92],"associations":[33,50,66,81,128,294,311,401,534],"genetic":[35,49,376,393,400,422,441,480,492],"risk":[36,181,377,394,423,442,481,493],"higher":[38,409,452,465,514,541,550],"body":[39],"mass":[40,110,630],"index":[41],"(BMI)":[42],"with":[43,101,188,266,295,300,304,323,331,346,381,402,408,433,512,581,604],"BMI":[44,172,183,296,361,383,403,454,466],"development,":[45],"whether":[47,79],"differ":[51,82],"socioeconomic":[53,716],"position":[54],"(SEP)":[55],"at":[56,85,435,445,455,467,718],"different":[57,86,719],"life":[58,87,720],"stages":[59,88],"(Study":[60,89,129],"I).":[61],"Second,":[62],"assessed":[64,185,265,316,345],"ideal":[68,122,504,519],"behaviors":[71,125,202,233,252,314,343,659],"between":[72,478],"parents":[73,256,279,509,548],"their":[75],"adult":[76,102,332,426,543,656,666],"offspring,":[77],"these":[80,127,532,710],"SEP":[84,219,230,249,667],"II).":[90],"Third,":[91],"evaluated":[93],"association":[95],"favorable":[97,597],"childhood":[98,328,601,619,650],"psychosocial":[99,275,329,598],"environment":[100,263,330,599,651],"cardiac":[103,333,607],"structure":[104,334,608],"function":[106,115,336,610],"(left":[107],"ventricular":[108],"(LV)":[109],"(g/m2.7)":[111],"LV":[113,629,653,675],"diastolic":[114],"(E/e\u2019":[116],"ratio)":[117],"which":[120],"extent":[121],"mediate":[126],"III).":[130,158],"Methods.":[131],"Study":[132,146,149,153,157,358,500,595],"participants":[133,259,282],"were":[134,211,234,253,298,315,344,404,535,579,592,688],"subsamples":[136],"from":[137,162,272,363,588,649],"prospective":[139],"Risk":[142],"Young":[144],"Finns":[145],"(n=2441":[147],"I,":[150,359],"n=1856":[151],"II,":[154,501],"n=880":[155],"We":[159],"used":[160],"data":[161,271],"follow-ups":[163,177],"1980,":[165],"1983,":[166],"1986,":[167,243],"2001,":[168,244],"2007":[169,245],"2011.":[171,247,290],"was":[173,184,220,264,287,379,476,510,602,643],"recorded":[174,212],"all":[176],"1980-2011.":[179],"Genetic":[180,293],"2001":[187],"97":[189],"single-nucleotide":[190],"polymorphisms":[191],"identified":[192],"most":[195],"recent":[196],"GWAS":[197],"meta-analysis.":[198],"Four":[199],"\u2013":[203,210],"smoking,":[204],"BMI,":[205],"physical":[206],"activity":[207],"diet":[209],"following":[213],"American":[215],"Heart":[216],"Association":[217],"definitions.":[218],"measured":[221,237],"as":[222],"educational":[223,412,460,471,544,551],"attainment,":[224],"income":[225,583],"occupational":[227],"status.":[228],"Adult":[229],"self-reported":[235,254],"or":[236,546],"during":[238,368],"a":[239,267],"study":[240,258,281],"visit":[241],"Parental":[248],"1980.":[261,284],"Childhood":[262],"cumulative":[268],"score":[269,378,395,424,482,494,620],"comprising":[270],"six":[273],"relevant":[274],"domains":[276],"reported":[277],"Echocardiographic":[285],"examination":[286],"conducted":[288],"Statistical":[291],"analysis.":[292],"development":[297],"analyzed":[299],"multilevel":[301,321],"linear":[302,320,589],"regression":[303,590],"random":[305,308,324],"intercepts":[306],"slopes.":[309],"Intergenerational":[310],"using":[317],"ordinal":[318],"models":[322,349],"intercepts.":[325],"Associations":[326],"mediation":[338,353],"through":[340,655],"marginal":[347],"structural":[348],"causal":[352],"analysis":[354],"framework.":[355],"Results.":[356],"In":[357,371,499,594],"mean":[360],"increased":[362],"22.6":[364],"26.6":[366],"kg/m2":[367],"follow-up.":[370],"growth":[372],"curve":[373],"analyses,":[374],"associated":[380,511,603],"faster":[382],"increase":[384],"over":[385],"time":[386],"(b=0.02,":[387],"95%":[388,417,487,526,671,678],"CI,":[389,418,488,527],"0.01,":[390],"0.02":[391],"for":[392,421,491,531,554,558,563,566,570,575,662,674,681],"x":[396,425,495],"age":[397,430],"interaction).":[398,428,498,576],"The":[399],"weaker":[405],"among":[406,508,521,537],"those":[407,434,444],"(vs":[410],"lower)":[411],"attainment":[413,461,545,552],"adulthood":[415],"(b=-0.12,":[416],"-0.23,":[419],"0.01":[420],"education":[427,485,497],"At":[429],"49,":[431],"compared":[432],"10th":[437],"percentile":[438,448],"score,":[443],"90th":[447],"had":[449,540,549,625],"3.3":[450],"units":[451,464],"predicted":[453],"lowest":[457],"level":[458,470],"2.4":[463],"highest":[469],"attainment.":[472],"No":[473],"interaction":[474],"effect":[475,669],"observed":[477],"parental":[484,496,572,582],"(b=0.05,":[486],"-0.09,":[489],"0.18":[490,635],"one":[502,517],"additional":[503,518],"behavior":[507,520],"28%":[513],"odds":[515],"offspring":[522,538,560,585],"(odds":[523],"ratio":[524,638],"(OR)=1.28,":[525],"1.17,1.39).":[528],"Furthermore,":[529],"ORs":[530],"greater":[536],"who":[539],"own":[542],"whose":[547],"(OR=1.32":[553],"high":[555,567],"vs":[556,568],"OR=1.04":[557],"low":[559,571],"education;":[561,573],"p=0.02":[562],"interaction,":[564],"OR=1.56":[565],"OR=1.19":[569],"p=0.01":[574],"Similar":[577],"trends":[578],"seen":[580],"occupation.":[586],"Results":[587,684],"analyses":[591],"similar.":[593,689],"III,":[596],"more":[605],"optimal":[606],"adulthood.":[612],"Those":[613],"above":[614],"median":[616,624],"versus":[621],"below":[622],"1.28":[626],"g/m2.7":[627],"lower":[628,636],"(95%":[631,639],"CI=-2.63,":[632],"0.07)":[633],"E/e\u2019":[637,682],"CI=-0.39,":[640],"0.03).":[641],"There":[642],"no":[644],"evidence":[645],"indirect":[647],"effects":[648],"outcomes":[654],"after":[660,685],"controlling":[661],"time-dependent":[663],"confounding":[664],"(indirect":[668],"b=-0.30,":[670],"CI=-1.22,":[672],"0.63":[673],"mass,":[676],"b=-0.04,":[677],"CI=-0.18,":[679],"0.11":[680],"ratio).":[683],"multiple":[686],"imputation":[687],"Conclusions.":[690],"These":[691],"findings":[692],"highlight":[693],"importance":[695],"early-life":[699],"initiating":[702],"long-term":[705],"suggest":[709],"may":[712],"be":[713],"shaped":[714],"circumstances":[717],"stages.":[721]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-12-13T00:00:00"}