{"id":"https://openalex.org/W2992851995","doi":"https://doi.org/10.1084/jem.20190580","title":"The human fetal thymus generates invariant effector \u03b3\u03b4 T cells","display_name":"The human fetal thymus generates invariant effector \u03b3\u03b4 T cells","publication_year":2019,"publication_date":"2019-12-05","ids":{"openalex":"https://openalex.org/W2992851995","doi":"https://doi.org/10.1084/jem.20190580","mag":"2992851995","pmid":"https://pubmed.ncbi.nlm.nih.gov/31816633","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7062527"},"language":"en","primary_location":{"id":"doi:10.1084/jem.20190580","doi":"https://doi.org/10.1084/jem.20190580","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20190580","pdf_url":"https://rupress.org/jem/article-pdf/217/3/e20190580/839424/jem_20190580.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Medicine","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2992851995"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://rupress.org/jem/article-pdf/217/3/e20190580/839424/jem_20190580.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001052808","display_name":"Paola Tieppo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Paola Tieppo","raw_affiliation_strings":["Department of Pharmacotherapy and Pharmaceutics, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium 1","Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium 2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacotherapy and Pharmaceutics, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium 1","institution_ids":["https://openalex.org/I132053463"]},{"raw_affiliation_string":"Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium 2","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Maria Papadopoulou","orcid":"https://orcid.org/0000-0002-3006-1993","observed_orcids":["https://orcid.org/0000-0002-3006-1993"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Maria Papadopoulou","raw_affiliation_strings":["Department of Pharmacotherapy and Pharmaceutics, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium 1","Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium 2"],"raw_orcid":"https://orcid.org/0000-0002-3006-1993","affiliations":[{"raw_affiliation_string":"Department of Pharmacotherapy and Pharmaceutics, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium 1","institution_ids":["https://openalex.org/I132053463"]},{"raw_affiliation_string":"Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium 2","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085775267","display_name":"Deborah Gatti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Deborah Gatti","raw_affiliation_strings":["Department of Pharmacotherapy and Pharmaceutics, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium 1","Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium 2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacotherapy and Pharmaceutics, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium 1","institution_ids":["https://openalex.org/I132053463"]},{"raw_affiliation_string":"Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium 2","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028591025","display_name":"Naomi N. McGovern","orcid":"https://orcid.org/0000-0001-5200-2698","observed_orcids":["https://orcid.org/0000-0001-5200-2698"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4405263101","display_name":"The Loke Centre for Trophoblast Research","ror":"https://ror.org/02hmmse52","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749","https://openalex.org/I4405263101"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Naomi McGovern","raw_affiliation_strings":["Department of Pathology and Centre for Trophoblast Research, University of Cambridge, Cambridge, UK 3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Centre for Trophoblast Research, University of Cambridge, Cambridge, UK 3","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4405263101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030659181","display_name":"Jerry Kok Yen Chan","orcid":"https://orcid.org/0000-0002-0246-2159","observed_orcids":["https://orcid.org/0000-0002-0246-2159"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210112252","display_name":"KK Women's and Children's Hospital","ror":"https://ror.org/0228w5t68","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210112252"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jerry K.Y. Chan","raw_affiliation_strings":["Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 5","Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore 4","OBGYN-Academic Clinical Program, Duke-National University of Singapore, Duke-National University of Singapore Medical School, Singapore 6"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 5","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore 4","institution_ids":["https://openalex.org/I4210112252"]},{"raw_affiliation_string":"OBGYN-Academic Clinical Program, Duke-National University of Singapore, Duke-National University of Singapore Medical School, Singapore 6","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084578941","display_name":"Fran\u00e7oise Gosselin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2802054198","display_name":"Erasmus Hospital","ror":"https://ror.org/05j1gs298","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2802054198"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Fran\u00e7oise Gosselin","raw_affiliation_strings":["Department of Obstetrics and Gynecology, H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium 7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium 7","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2802054198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045513197","display_name":"Glenn Goetgeluk","orcid":"https://orcid.org/0000-0002-9123-5707","observed_orcids":["https://orcid.org/0000-0002-9123-5707"]},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Glenn Goetgeluk","raw_affiliation_strings":["Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium 8"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium 8","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090268794","display_name":"Karin Weening","orcid":"https://orcid.org/0000-0002-8874-5300","observed_orcids":["https://orcid.org/0000-0002-8874-5300"]},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Karin Weening","raw_affiliation_strings":["Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium 8"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium 8","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024554623","display_name":"Ling Ma","orcid":"https://orcid.org/0000-0002-1485-8994","observed_orcids":["https://orcid.org/0000-0002-1485-8994"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Ling Ma","raw_affiliation_strings":["Department of Pharmacotherapy and Pharmaceutics, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium 1","Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium 2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacotherapy and Pharmaceutics, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium 1","institution_ids":["https://openalex.org/I132053463"]},{"raw_affiliation_string":"Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium 2","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067019998","display_name":"Nicol\u00e1s Dauby","orcid":"https://orcid.org/0000-0002-7697-6849","observed_orcids":["https://orcid.org/0000-0002-7697-6849"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I4210154425","display_name":"Centre Hospitalier Universitaire de Saint-Pierre","ror":"https://ror.org/05cmp5q80","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210154425"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Nicolas Dauby","raw_affiliation_strings":["Department of Infectious Diseases, Centre Hospitalier Universitaire Saint-Pierre, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium 9","Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium 2"],"raw_orcid":"https://orcid.org/0000-0002-7697-6849","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Centre Hospitalier Universitaire Saint-Pierre, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium 9","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I4210154425"]},{"raw_affiliation_string":"Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium 2","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072067393","display_name":"Alexandra Cogan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I4210154425","display_name":"Centre Hospitalier Universitaire de Saint-Pierre","ror":"https://ror.org/05cmp5q80","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210154425"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Alexandra Cogan","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire Saint-Pierre, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium 10"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire Saint-Pierre, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium 10","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I4210154425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013640135","display_name":"Catherine Donner","orcid":"https://orcid.org/0009-0005-1946-4870","observed_orcids":["https://orcid.org/0009-0005-1946-4870","https://orcid.org/0000-0002-2090-4977"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2802054198","display_name":"Erasmus Hospital","ror":"https://ror.org/05j1gs298","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2802054198"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Catherine Donner","raw_affiliation_strings":["Department of Obstetrics and Gynecology, H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium 7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium 7","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2802054198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045293467","display_name":"Florent Ginhoux","orcid":"https://orcid.org/0000-0002-2857-7755","observed_orcids":["https://orcid.org/0000-0002-2857-7755"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I2800824516","display_name":"Singapore Immunology Network","ror":"https://ror.org/03vmmgg57","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2800824516","https://openalex.org/I2801752549"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Florent Ginhoux","raw_affiliation_strings":["Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 11"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 11","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I2800824516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001976368","display_name":"Bart Vandekerckhove","orcid":"https://orcid.org/0000-0003-3828-4195","observed_orcids":["https://orcid.org/0000-0003-3828-4195"]},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Bart Vandekerckhove","raw_affiliation_strings":["Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium 8"],"raw_orcid":"https://orcid.org/0000-0003-3828-4195","affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium 8","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038764330","display_name":"David Vermijlen","orcid":"https://orcid.org/0000-0002-7605-8845","observed_orcids":["https://orcid.org/0000-0002-7605-8845"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"David Vermijlen","raw_affiliation_strings":["Department of Pharmacotherapy and Pharmaceutics, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium 1","Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium 2"],"raw_orcid":"https://orcid.org/0000-0002-7605-8845","affiliations":[{"raw_affiliation_string":"Department of Pharmacotherapy and Pharmaceutics, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium 1","institution_ids":["https://openalex.org/I132053463"]},{"raw_affiliation_string":"Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium 2","institution_ids":["https://openalex.org/I132053463"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5038764330"],"corresponding_institution_ids":["https://openalex.org/I132053463"],"apc_list":null,"apc_paid":null,"fwci":4.3618,"has_fulltext":true,"cited_by_count":101,"citation_normalized_percentile":{"value":0.95606567,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"217","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fetal-thymus","display_name":"fetal thymus","score":0.9520000219345093},{"id":"https://openalex.org/keywords/tcr-repertoire","display_name":"T cell receptor repertoire","score":0.5120000243186951},{"id":"https://openalex.org/keywords/cdr3","display_name":"CDR3","score":0.7129999995231628},{"id":"https://openalex.org/keywords/terminal-deoxynucleotidyl-transferase","display_name":"terminal deoxynucleotidyl transferase","score":0.8759999871253967},{"id":"https://openalex.org/keywords/lin28b","display_name":"LIN28B","score":0.9980000257492065},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.6370000243186951},{"id":"https://openalex.org/keywords/granzymes","display_name":"granzymes","score":0.8650000095367432},{"id":"https://openalex.org/keywords/human-fetal-development","display_name":"human fetal development","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6940449476242065},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5968221426010132},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.507295548915863},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.374175488948822}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004253","descriptor_name":"DNA Nucleotidylexotransferase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016692","descriptor_name":"Receptors, Antigen, T-Cell, gamma-delta","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D060168","descriptor_name":"Thymocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1084/jem.20190580","doi":"https://doi.org/10.1084/jem.20190580","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20190580","pdf_url":"https://rupress.org/jem/article-pdf/217/3/e20190580/839424/jem_20190580.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmid:31816633","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31816633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:archive.ugent.be:8659034","doi":null,"is_oa":true,"landing_page_url":"https://biblio.ugent.be/publication/8659034","pdf_url":null,"source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7062527","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7062527/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmh:oai:archive.ugent.be:8672188","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1854/LU-8672188","pdf_url":"https://biblio.ugent.be/publication/8672188/file/8672190.pdf","source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1540-9538","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/299097","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/299097","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of experimental medicine, 217 (3","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/378835","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/378835","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1084/jem.20190580","doi":"https://doi.org/10.1084/jem.20190580","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20190580","pdf_url":"https://rupress.org/jem/article-pdf/217/3/e20190580/839424/jem_20190580.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2113538137","display_name":"Identification of the ligand of a human public anti-HCMV/cancer \u03b3\u03b4 T cell receptor","funder_award_id":"751954","funder_id":"https://openalex.org/F4320338337","funder_display_name":"H2020 Marie Sk\u0142odowska-Curie Actions"},{"id":"https://openalex.org/G2990810203","display_name":"Characterization of the human extra-embryonic macrophage population, Hofbauer cells, phenotype and function","funder_award_id":"204464/Z/16/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3628914803","display_name":"Identification of the ligand of a human public anti-HCMV/cancer \u03b3\u03b4 T cell receptor","funder_award_id":"751954","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320312060","display_name":"Francis Crick Institute","ror":"https://ror.org/04tnbqb63"},{"id":"https://openalex.org/F4320314181","display_name":"Universitaire Stichting","ror":"https://ror.org/001t02e86"},{"id":"https://openalex.org/F4320320285","display_name":"King's College London","ror":"https://ror.org/0220mzb33"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320325246","display_name":"Fondation Rose et Jean Hoguet","ror":"https://ror.org/05q8csa40"},{"id":"https://openalex.org/F4320326640","display_name":"Centre hospitalier universitaire Sainte-Justine","ror":"https://ror.org/01gv74p78"},{"id":"https://openalex.org/F4320334840","display_name":"Fonds pour la Formation \u00e0 la Recherche dans l\u2019Industrie et dans l\u2019Agriculture","ror":"https://ror.org/03q83t159"},{"id":"https://openalex.org/F4320338337","display_name":"H2020 Marie Sk\u0142odowska-Curie Actions","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2992851995.pdf","grobid_xml":"https://content.openalex.org/works/W2992851995.grobid-xml"},"referenced_works_count":91,"referenced_works":["https://openalex.org/W146865214","https://openalex.org/W202718674","https://openalex.org/W1479992619","https://openalex.org/W1511233348","https://openalex.org/W1534145247","https://openalex.org/W1574496133","https://openalex.org/W1899931331","https://openalex.org/W1963717607","https://openalex.org/W1965163675","https://openalex.org/W1970579419","https://openalex.org/W1982393172","https://openalex.org/W1982780950","https://openalex.org/W1983598990","https://openalex.org/W1984922621","https://openalex.org/W1996253034","https://openalex.org/W1996893147","https://openalex.org/W2000230310","https://openalex.org/W2008661167","https://openalex.org/W2014422435","https://openalex.org/W2029393400","https://openalex.org/W2032760411","https://openalex.org/W2033799236","https://openalex.org/W2034607893","https://openalex.org/W2036843903","https://openalex.org/W2046746241","https://openalex.org/W2054195270","https://openalex.org/W2055620105","https://openalex.org/W2062152693","https://openalex.org/W2072066004","https://openalex.org/W2079254194","https://openalex.org/W2085266588","https://openalex.org/W2088624964","https://openalex.org/W2088907802","https://openalex.org/W2089041106","https://openalex.org/W2097815590","https://openalex.org/W2100035392","https://openalex.org/W2109606712","https://openalex.org/W2109963121","https://openalex.org/W2111675378","https://openalex.org/W2114104545","https://openalex.org/W2114951959","https://openalex.org/W2115566055","https://openalex.org/W2116362436","https://openalex.org/W2116818706","https://openalex.org/W2124871845","https://openalex.org/W2126043518","https://openalex.org/W2130410032","https://openalex.org/W2139128291","https://openalex.org/W2142565339","https://openalex.org/W2155255799","https://openalex.org/W2158217645","https://openalex.org/W2160540170","https://openalex.org/W2171432910","https://openalex.org/W2183777144","https://openalex.org/W2185265351","https://openalex.org/W2232693424","https://openalex.org/W2291461209","https://openalex.org/W2299138507","https://openalex.org/W2299671353","https://openalex.org/W2338753015","https://openalex.org/W2409661324","https://openalex.org/W2474323862","https://openalex.org/W2520176593","https://openalex.org/W2521223951","https://openalex.org/W2543937724","https://openalex.org/W2577046495","https://openalex.org/W2590092547","https://openalex.org/W2593493913","https://openalex.org/W2598736658","https://openalex.org/W2599501186","https://openalex.org/W2625822122","https://openalex.org/W2632422275","https://openalex.org/W2738012346","https://openalex.org/W2744416534","https://openalex.org/W2747585701","https://openalex.org/W2786804236","https://openalex.org/W2787039411","https://openalex.org/W2792867842","https://openalex.org/W2794202817","https://openalex.org/W2799881184","https://openalex.org/W2802819733","https://openalex.org/W2808096245","https://openalex.org/W2889115052","https://openalex.org/W2889882116","https://openalex.org/W2900285642","https://openalex.org/W2902011675","https://openalex.org/W2955032078","https://openalex.org/W2960044378","https://openalex.org/W2967943639","https://openalex.org/W2979366073","https://openalex.org/W3048952568"],"related_works":["https://openalex.org/W7046280174","https://openalex.org/W4301398506","https://openalex.org/W7128845346","https://openalex.org/W3154371246","https://openalex.org/W1557090560","https://openalex.org/W2016026615","https://openalex.org/W6990383558","https://openalex.org/W2967943639","https://openalex.org/W4313342461","https://openalex.org/W2082226019"],"abstract_inverted_index":{"In":[0,151],"the":[1,21,84,93,100,116,122,147,157],"mouse":[2],"thymus,":[3],"invariant":[4,32,119,166],"\u03b3\u03b4":[5,33,48,52,167],"T":[6,34,168],"cells":[7,35,140,169],"are":[8],"generated":[9],"at":[10],"well-defined":[11],"times":[12],"during":[13],"development":[14],"and":[15,28,60,112,121,138],"acquire":[16],"effector":[17,126,172],"functions":[18,127],"before":[19],"exiting":[20],"thymus.":[22],"However,":[23],"whether":[24],"such":[25],"thymic":[26],"programming":[27],"age-dependent":[29],"generation":[30,117],"of":[31,64,72,79,88,95,118,125,134,146],"occur":[36],"in":[37,75,83,162],"humans":[38],"is":[39],"not":[40],"known.":[41],"Here":[42],"we":[43],"found":[44],"that,":[45],"unlike":[46],"postnatal":[47],"thymocytes,":[49],"human":[50,158],"fetal":[51,135,159],"thymocytes":[53],"were":[54,128],"functionally":[55],"programmed":[56,171],"(e.g.,":[57],"IFN\u03b3,":[58],"granzymes)":[59],"expressed":[61],"low":[62,70,77],"levels":[63],"terminal":[65],"deoxynucleotidyl":[66],"transferase":[67],"(TdT).":[68],"This":[69],"level":[71],"TdT":[73],"resulted":[74],"a":[76],"number":[78],"N":[80],"nucleotide":[81],"insertions":[82],"complementarity-determining":[85],"region-3":[86],"(CDR3)":[87],"their":[89],"TCR":[90],"repertoire,":[91],"allowing":[92],"usage":[94],"short":[96],"homology":[97],"repeats":[98],"within":[99],"germline-encoded":[101],"VDJ":[102],"segments":[103],"to":[104,130],"generate":[105],"invariant/public":[106],"cytomegalovirus-reactive":[107],"CDR3":[108],"sequences":[109],"(TRGV8-TRJP1-CATWDTTGWFKIF,":[110],"TRDV2-TRDD3-CACDTGGY,":[111],"TRDV1-TRDD3-CALGELGD).":[113],"Furthermore,":[114],"both":[115],"TCRs":[120],"intrathymic":[123],"acquisition":[124],"due":[129],"an":[131,163],"intrinsic":[132],"property":[133],"hematopoietic":[136],"stem":[137],"precursor":[139],"(HSPCs)":[141],"caused":[142],"by":[143],"high":[144],"expression":[145],"RNA-binding":[148],"protein":[149],"Lin28b.":[150],"conclusion,":[152],"our":[153],"data":[154],"indicate":[155],"that":[156],"thymus":[160],"generates,":[161],"HSPC/Lin28b-dependent":[164],"manner,":[165],"with":[170],"functions.":[173]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":18}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2019-12-13T00:00:00"}
