{"id":"https://openalex.org/W2992821890","doi":"https://doi.org/10.1161/circ.132.suppl_3.13476","title":"Abstract 13476: Association of HLA-DRB3*01:01 With Heparin-Induced Thrombocytopenia","display_name":"Abstract 13476: Association of HLA-DRB3*01:01 With Heparin-Induced Thrombocytopenia","publication_year":2015,"publication_date":"2015-11-10","ids":{"openalex":"https://openalex.org/W2992821890","doi":"https://doi.org/10.1161/circ.132.suppl_3.13476","mag":"2992821890"},"language":"en","primary_location":{"id":"doi:10.1161/circ.132.suppl_3.13476","doi":"https://doi.org/10.1161/circ.132.suppl_3.13476","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.132.suppl_3.13476","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009496216","display_name":"Jason H. Karnes","orcid":"https://orcid.org/0000-0001-5001-3334","observed_orcids":["https://orcid.org/0000-0001-5001-3334"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason H Karnes","raw_affiliation_strings":["Medicine, Vanderbilt Univ, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Vanderbilt Univ, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070908224","display_name":"Joshua C. Denny","orcid":"https://orcid.org/0000-0002-3049-7332","observed_orcids":["https://orcid.org/0000-0002-3049-7332"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua C Denny","raw_affiliation_strings":["Medicine, Vanderbilt Univ, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Vanderbilt Univ, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069068963","display_name":"Robert Michael Cronin","orcid":"https://orcid.org/0000-0003-1916-6521","observed_orcids":["https://orcid.org/0000-0003-1916-6521"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M Cronin","raw_affiliation_strings":["Medicine, Vanderbilt Univ, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Vanderbilt Univ, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110693535","display_name":"Christian M. Shaffer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian M Shaffer","raw_affiliation_strings":["Medicine, Vanderbilt Univ, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Vanderbilt Univ, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102887489","display_name":"Jonathan D. Mosley","orcid":"https://orcid.org/0000-0001-6421-2887","observed_orcids":["https://orcid.org/0000-0001-6421-2887"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan D Mosley","raw_affiliation_strings":["Medicine, Vanderbilt Univ, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Vanderbilt Univ, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070165631","display_name":"Simon Alexander Mallal","orcid":"https://orcid.org/0000-0002-7036-1309","observed_orcids":["https://orcid.org/0000-0002-7036-1309"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simon A Mallal","raw_affiliation_strings":["Medicine, Vanderbilt Univ, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Vanderbilt Univ, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080985934","display_name":"Elizabeth Jane Phillips","orcid":"https://orcid.org/0000-0002-7623-3383","observed_orcids":["https://orcid.org/0000-0002-7623-3383"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth J Phillips","raw_affiliation_strings":["Medicine, Vanderbilt Univ, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Vanderbilt Univ, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058141203","display_name":"Dan M. Roden","orcid":"https://orcid.org/0000-0002-6302-0389","observed_orcids":["https://orcid.org/0000-0002-6302-0389"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan M Roden","raw_affiliation_strings":["Medicine, Vanderbilt Univ, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Vanderbilt Univ, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"132","issue":"suppl_3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heparin-induced-thrombocytopenia","display_name":"heparin-induced thrombocytopenia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hla-alleles","display_name":"HLA alleles","score":0.8859999775886536},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7590000033378601},{"id":"https://openalex.org/keywords/immune-mediated-adverse-drug-reactions","display_name":"immune-mediated adverse drug reactions","score":0.8939999938011169},{"id":"https://openalex.org/keywords/hla-dr","display_name":"HLA-DR","score":0.6539999842643738},{"id":"https://openalex.org/keywords/t-cell-dependent-antibody-production","display_name":"T cell-dependent antibody production","score":0.6779999732971191},{"id":"https://openalex.org/keywords/low-molecular-weight-heparin","display_name":"low molecular weight heparin","score":0.7990000247955322},{"id":"https://openalex.org/keywords/unfractionated-heparin","display_name":"unfractionated heparin","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7077344059944153},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.7014015913009644},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6701646447181702},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5950911641120911},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4743541479110718},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45701295137405396},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4314529299736023},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28787925839424133},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1993340253829956},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.18194130063056946},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08289235830307007}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.132.suppl_3.13476","doi":"https://doi.org/10.1161/circ.132.suppl_3.13476","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.132.suppl_3.13476","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2733927229","https://openalex.org/W2916610470","https://openalex.org/W2809103729","https://openalex.org/W3095982047","https://openalex.org/W2012181697","https://openalex.org/W2040610002","https://openalex.org/W2900167130","https://openalex.org/W2885919818","https://openalex.org/W1992582226","https://openalex.org/W2043953289"],"abstract_inverted_index":{"Introduction:":[0],"Variation":[1],"in":[2,37,71,151,262,269,280],"the":[3,237,256,264,275,299],"human":[4],"leukocyte":[5],"antigen":[6],"(HLA)":[7],"region":[8],"is":[9,22,54],"now":[10],"used":[11],"clinically":[12],"to":[13,28,45,77,102,158,294,297],"prevent":[14],"immune-mediated":[15,26],"adverse":[16],"drug":[17],"reactions.":[18],"Heparin-induced":[19],"thrombocytopenia":[20],"(HIT)":[21],"an":[23,72],"unpredictable,":[24],"life-threatening,":[25],"reaction":[27],"heparin":[29,111],"treatment.":[30],"Previous":[31],"studies":[32],"have":[33,47],"implicated":[34],"HLA-DR":[35,260,268],"variants":[36],"HIT,":[38,254,263],"but":[39],"HLA":[40,57,124,144,164,184],"alleles":[41,58,145,165,185,227],"which":[42],"predispose":[43],"patients":[44],"HIT":[46,66,86,89,193,218,281,290],"not":[48],"been":[49],"identified.":[50],"Hypothesis:":[51],"Our":[52],"hypothesis":[53],"that":[55],"sequenced":[56,143,183],"are":[59],"associated":[60,216],"with":[61,160,166,217,232],"HIT.":[62,233,245,302],"Methods:":[63],"We":[64,119,139,190,235],"identified":[65,191],"cases":[67,103,194,205],"and":[68,94,108,132,163,195,206,274],"heparin-exposed":[69],"controls":[70,207],"electronic":[73],"medical":[74],"record":[75],"coupled":[76],"a":[78,152,167,178,229,241,249,287],"DNA":[79],"biobank.":[80],"Cases":[81],"were":[82,100,175,202],"defined":[83],"based":[84,104],"on":[85,105],"antibody":[87,272],"results,":[88],"risk":[90,242,300],"scoring":[91],"(4Ts":[92],"score),":[93],"serotonin":[95],"release":[96],"assay":[97],"results.":[98],"Controls":[99],"matched":[101,197],"age,":[106],"gender,":[107],"type":[109],"of":[110,142,267,277,284,289,301],"exposure":[112],"(unfractionated":[113],"versus":[114],"low":[115],"molecular":[116],"weight":[117],"heparin).":[118],"performed":[120],"high":[121],"resolution,":[122],"four-digit":[123],"sequencing":[125],"for":[126,181,208,244,253],"HLA-A,":[127],"HLA-B,":[128],"HLA-C,":[129],"HLA-DR,":[130],"HLA-DP,":[131],"HLA-DQ":[133],"using":[134,146,177],"long-read":[135],"454":[136],"FLX":[137],"sequencing.":[138],"tested":[140],"association":[141,231],"conditional":[147],"univariate":[148],"logistic":[149],"regression":[150],"dominant":[153],"model.":[154],"Analysis":[155],"was":[156,214],"restricted":[157],"individuals":[159],"European":[161],"ancestry":[162],"frequency":[168],"greater":[169],"than":[170],"0.01":[171],"(n=101).":[172],"P":[173],"values":[174],"corrected":[176],"Bonferroni":[179],"correction":[180],"101":[182],"(alpha=4.95x10":[186],"-4":[187,223],").":[188,224],"Results:":[189],"77":[192],"345":[196],"controls.":[198],"No":[199,225],"statistical":[200],"differences":[201],"observed":[203],"between":[204],"baseline":[209],"characteristics.":[210],"The":[211],"HLA-DRB3*01:01":[212,238,285],"allele":[213,239,247],"significantly":[215],"(odds":[219],"ratio":[220],"3.55,":[221],"p=1.09x10":[222],"other":[226],"showed":[228],"significant":[230],"Conclusions:":[234],"implicate":[236],"as":[240,286],"factor":[243],"This":[246],"represents":[248],"biologically":[250],"plausible":[251],"candidate":[252],"considering":[255],"previous":[257],"literature":[258],"implicating":[259],"variation":[261],"central":[265],"role":[266],"T":[270,278],"cell-dependent":[271],"production,":[273],"importance":[276],"cells":[279],"pathogenesis.":[282],"Validation":[283],"predictor":[288],"pathogenesis":[291],"would":[292],"lead":[293],"preventive":[295],"genotyping":[296],"reduce":[298]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2019-12-13T00:00:00"}
