{"id":"https://openalex.org/W2992813238","doi":null,"title":"[Intermittent long-term administration of intravenous bisphosphonates for treatment of osteoporosis].","display_name":"[Intermittent long-term administration of intravenous bisphosphonates for treatment of osteoporosis].","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2992813238","mag":"2992813238","pmid":"https://pubmed.ncbi.nlm.nih.gov/24369285"},"language":"ja","primary_location":{"id":"pmid:24369285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24369285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical calcium","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070505728","display_name":"Naohisa Miyakoshi","orcid":"https://orcid.org/0000-0001-5175-3350","observed_orcids":["https://orcid.org/0000-0001-5175-3350"]},"institutions":[{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Naohisa Miyakoshi","raw_affiliation_strings":["Department of Orthopedic Surgery, Akita University Graduate School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Akita University Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I203765153"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070505728"],"corresponding_institution_ids":["https://openalex.org/I203765153"],"apc_list":null,"apc_paid":null,"fwci":1.0416,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.75416173,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"24","issue":"1","first_page":"93","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.04859999939799309,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.9620000123977661},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.8730000257492065},{"id":"https://openalex.org/keywords/osteoporosis-treatment","display_name":"osteoporosis treatment","score":0.824999988079071},{"id":"https://openalex.org/keywords/alendronate","display_name":"alendronate","score":0.8790000081062317},{"id":"https://openalex.org/keywords/ibandronate","display_name":"ibandronate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/zoledronic-acid","display_name":"zoledronic acid","score":0.8889999985694885},{"id":"https://openalex.org/keywords/osteoporotic-fracture-prevention","display_name":"osteoporotic fracture prevention","score":0.8399999737739563},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.8489999771118164},{"id":"https://openalex.org/keywords/long-term-drug-administration","display_name":"long-term drug administration","score":0.3930000066757202}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9096567630767822},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.7596409320831299},{"id":"https://openalex.org/C36434225","wikidata":"https://www.wikidata.org/wiki/Q1895998","display_name":"Polypharmacy","level":2,"score":0.6019486784934998},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.5837721228599548},{"id":"https://openalex.org/C2777251235","wikidata":"https://www.wikidata.org/wiki/Q412205","display_name":"Bisphosphonate","level":3,"score":0.5244027376174927},{"id":"https://openalex.org/C3020175042","wikidata":"https://www.wikidata.org/wiki/Q2145130","display_name":"Fracture reduction","level":3,"score":0.5154086351394653},{"id":"https://openalex.org/C2910138400","wikidata":"https://www.wikidata.org/wiki/Q640448","display_name":"Intravenous route","level":2,"score":0.4962306618690491},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.4958105981349945},{"id":"https://openalex.org/C2780608335","wikidata":"https://www.wikidata.org/wiki/Q640448","display_name":"Intravenous therapy","level":2,"score":0.4301125407218933},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3728974163532257},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.31625089049339294},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30343097448349},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2759241461753845},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.22159865498542786},{"id":"https://openalex.org/C2780660378","wikidata":"https://www.wikidata.org/wiki/Q1667915","display_name":"Internal fixation","level":2,"score":0.10939976572990417}],"mesh":[{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050071","descriptor_name":"Bone Density Conservation Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D050071","descriptor_name":"Bone Density Conservation Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:24369285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24369285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical calcium","raw_type":"English Abstract"},{"id":"mag:2992813238","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24369285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W41516964","https://openalex.org/W58690323","https://openalex.org/W93053989","https://openalex.org/W1501473386","https://openalex.org/W1547733031","https://openalex.org/W1594144334","https://openalex.org/W2008492357","https://openalex.org/W2014707628","https://openalex.org/W2045562495","https://openalex.org/W2066613071","https://openalex.org/W2098511755","https://openalex.org/W2100604852","https://openalex.org/W2101503666","https://openalex.org/W2105894548","https://openalex.org/W2142099365","https://openalex.org/W2144930991","https://openalex.org/W2150891147","https://openalex.org/W2172421250","https://openalex.org/W2337485820","https://openalex.org/W2409360547","https://openalex.org/W2409679560","https://openalex.org/W2414044484","https://openalex.org/W2508997451","https://openalex.org/W2520211681","https://openalex.org/W2542822064","https://openalex.org/W2769671204","https://openalex.org/W2791309620","https://openalex.org/W2895903821","https://openalex.org/W2909894833","https://openalex.org/W2981617674","https://openalex.org/W2990840371","https://openalex.org/W3016852213","https://openalex.org/W3016940380","https://openalex.org/W3025259451","https://openalex.org/W3028330817","https://openalex.org/W3034225365","https://openalex.org/W3035467903","https://openalex.org/W3036451283","https://openalex.org/W3092541624","https://openalex.org/W3147479802","https://openalex.org/W6776928405"],"related_works":["https://openalex.org/W2078590783","https://openalex.org/W2160862323","https://openalex.org/W1975627611","https://openalex.org/W2150489401","https://openalex.org/W2084559399","https://openalex.org/W2415394983","https://openalex.org/W2585730802","https://openalex.org/W2440396940","https://openalex.org/W2135233546","https://openalex.org/W2064580477"],"abstract_inverted_index":{"Bisphosphonates":[0],"(BPs)":[1],"are":[2,24,94],"prescribed":[3],"most":[4],"frequently":[5],"in":[6,84,99,110],"an":[7],"oral":[8,31,97,119],"formulation.":[9],"However,":[10],"they":[11],"have":[12,49,89],"very":[13],"limited":[14],"bioavailability,":[15],"and":[16,43,63,72],"less":[17],"than":[18],"1%":[19],"of":[20,61],"BPs":[21,32,93,98],"administered":[22],"orally":[23],"absorbed.":[25],"In":[26,56],"addition,":[27],"poor":[28],"adherence":[29],"to":[30,36,52,81,96,118,130],"has":[33],"been":[34,50],"shown":[35,90],"be":[37,82],"associated":[38],"with":[39,123],"suboptimal":[40],"fracture":[41],"reduction":[42],"prevention.":[44],"Therefore,":[45],"intravenous":[46,59,73,92,104],"BP":[47,105],"regimens":[48],"developed":[51],"address":[53],"this":[54],"issue.":[55],"Japan,":[57],"intermittent":[58],"administration":[60,106],"alendronate":[62],"ibandronate":[64],"on":[65,75],"a":[66,76],"monthly":[67],"basis":[68,78],"is":[69,79,107],"currently":[70],"available,":[71],"zoledronate":[74],"yearly":[77],"expected":[80],"available":[83],"the":[85,128],"near":[86],"future.":[87],"Data":[88],"that":[91],"noninferior":[95],"preventing":[100],"osteoporotic":[101],"fractures.":[102],"Furthermore,":[103],"particularly":[108],"advantageous":[109],"patients":[111],"who":[112],"do":[113],"not":[114],"tolerate":[115],"or":[116,127],"adhere":[117],"BPs,":[120],"including":[121],"those":[122],"gastrointestinal":[124],"pathology,":[125],"polypharmacy,":[126],"inability":[129],"remain":[131],"upright.":[132]},"counts_by_year":[{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2019-12-13T00:00:00"}
