{"id":"https://openalex.org/W2992802160","doi":"https://doi.org/10.1182/blood.v112.11.2539.2539","title":"Selective Expression of the Immunoregulatory Lectin, Galectin-1, in Precursor B Cell Acute Lymphoblastic Leukemias (ALLs) with MLL Rearrangements","display_name":"Selective Expression of the Immunoregulatory Lectin, Galectin-1, in Precursor B Cell Acute Lymphoblastic Leukemias (ALLs) with MLL Rearrangements","publication_year":2008,"publication_date":"2008-11-16","ids":{"openalex":"https://openalex.org/W2992802160","doi":"https://doi.org/10.1182/blood.v112.11.2539.2539","mag":"2992802160"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v112.11.2539.2539","doi":"https://doi.org/10.1182/blood.v112.11.2539.2539","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v112.11.2539.2539","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061408064","display_name":"Przemys\u0142aw Juszczy\u0144ski","orcid":"https://orcid.org/0000-0001-7215-0444","observed_orcids":["https://orcid.org/0000-0001-7215-0444"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Przemyslaw Juszczynski","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058975989","display_name":"Scott J. Rodig","orcid":"https://orcid.org/0000-0003-1761-9769","observed_orcids":["https://orcid.org/0000-0003-1761-9769"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott J. Rodig","raw_affiliation_strings":["Brigham & Women\u2019s Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham & Women\u2019s Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110862104","display_name":"Kunihiko Takeyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kunihiko Takeyama","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026857517","display_name":"Jing Ouyang","orcid":"https://orcid.org/0000-0001-5902-7070","observed_orcids":["https://orcid.org/0000-0001-5902-7070"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Ouyang","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112486870","display_name":"J\u00f6rg Faber","orcid":"https://orcid.org/0000-0002-5432-8234","observed_orcids":["https://orcid.org/0000-0002-5432-8234"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorg Faber","raw_affiliation_strings":["Children\u2019s Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012956545","display_name":"Scott A. Armstrong","orcid":"https://orcid.org/0000-0002-9099-4728","observed_orcids":["https://orcid.org/0000-0002-9099-4728"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Armstrong","raw_affiliation_strings":["Children\u2019s Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005876566","display_name":"Jeffery Lorne Kutok","orcid":"https://orcid.org/0009-0009-9931-3106","observed_orcids":["https://orcid.org/0009-0009-9931-3106"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffery L. Kutok","raw_affiliation_strings":["Brigham & Women\u2019s Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham & Women\u2019s Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021363179","display_name":"Margaret Ann Shipp","orcid":"https://orcid.org/0000-0002-3949-6897","observed_orcids":["https://orcid.org/0000-0002-3949-6897"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret A. Shipp","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.43399636,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"112","issue":"11","first_page":"2539","last_page":"2539"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/galectin-1","display_name":"galectin-1","score":0.9679999947547913},{"id":"https://openalex.org/keywords/mll-rearrangement","display_name":"MLL rearrangement","score":0.8939999938011169},{"id":"https://openalex.org/keywords/b-cell-precursor-acute-lymphoblastic-leukemia","display_name":"B-cell precursor acute lymphoblastic leukemia","score":0.9739999771118164},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.6060000061988831},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6480000019073486},{"id":"https://openalex.org/keywords/histone-h3-lysine-79-methylation","display_name":"histone H3 lysine 79 methylation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/h3k79me2","display_name":"H3K79me2","score":0.6179999709129333},{"id":"https://openalex.org/keywords/h3k27me3","display_name":"H3K27me3","score":0.5889999866485596},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.4449999928474426},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.7333546876907349},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6959629654884338},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5022802352905273},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.49270036816596985},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.4495665431022644},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4247337579727173},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4129328429698944},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27922332286834717},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.08474820852279663}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v112.11.2539.2539","doi":"https://doi.org/10.1182/blood.v112.11.2539.2539","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v112.11.2539.2539","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2120988920","https://openalex.org/W2042177615","https://openalex.org/W4246697467","https://openalex.org/W7140242861","https://openalex.org/W7095657228","https://openalex.org/W1887579480","https://openalex.org/W7097254143","https://openalex.org/W2041212323","https://openalex.org/W2434740433","https://openalex.org/W2100905170"],"abstract_inverted_index":{"Abstract":[0],"Translocations":[1],"of":[2,17,37,51,91,108,164,178,197,213,236,261,318,405],"the":[3,49,105,176,194,202,258,299,313,332,347,364,400,406],"mixed":[4],"lineage":[5],"leukemia":[6],"(MLL)":[7],"gene":[8,304,356],"on":[9,209],"chromosome":[10],"11q23":[11],"are":[12,63,80],"found":[13],"in":[14,33,98,129,149,154,200,231,257,267,289,295,306,331,346,358,379,388,419],"over":[15],"70%":[16],"infant":[18],"leukemias":[19,115,308],"and":[20,118,136,182,186,277,293,411],"associated":[21],"with":[22,117,140,216,270],"a":[23,29,169,210,241,271,359,374,415],"poor":[24],"prognosis.":[25],"MLL":[26,38,52,92,120,218,244,300,319,365,407],"translocations":[27],"generate":[28],"new":[30],"chimeric":[31],"gene,":[32],"which":[34],"N-terminal":[35],"portion":[36],"is":[39,168,254,385,396,414],"fused":[40],"to":[41,66,312,391],"C-terminal":[42],"sequence":[43],"from":[44,76,133],"multiple":[45],"different":[46],"partners.":[47],"Given":[48],"variety":[50],"fusion":[53,320,353,408],"partners,":[54],"molecular":[55,89],"techniques":[56,79],"such":[57],"as":[58],"FISH":[59],"or":[60],"Southern":[61],"blotting":[62],"not":[64,81],"able":[65],"detect":[67],"all":[68],"genetic":[69],"abnormalities":[70],"involving":[71],"MLL.":[72,380],"In":[73],"addition,":[74],"results":[75],"these":[77,141,420],"time-consuming":[78],"always":[82],"available":[83],"at":[84],"initial":[85],"diagnosis.":[86],"To":[87,192],"identify":[88],"markers":[90],"translocation":[93,245],"that":[94,174,368],"might":[95],"be":[96,310,373],"used":[97,256],"rapid":[99],"diagnostic":[100,195,259,417],"assays,":[101],"we":[102,205,263,323],"first":[103],"compared":[104,390],"transcriptional":[106],"profiles":[107],"primary":[109,214],"precursor":[110],"B":[111],"cell":[112,151,291,349],"acute":[113],"lymphoblastic":[114],"(ALLs)":[116],"without":[119,240,298,363],"translocations.":[121],"Galectin-1":[122],"(Gal1)":[123],"transcripts":[124],"were":[125,163],"significantly":[126,146],"more":[127,147],"abundant":[128,148,226],"MLL-rearranged":[130,222,307],"ALLs":[131,215,224,239],"(MLL-ALL)":[132],"two":[134],"extensive":[135],"independent":[137],"datasets.":[138],"Consistent":[139],"findings,":[142],"Gal1":[143,167,198,207,227,247,265,274,284,333,339,377,384,394,413],"protein":[144,173,285,321,409],"was":[145,287,354],"MLL-ALL":[150,203,290],"lines":[152,157,292,297],"than":[153,357],"non-MLL":[155,392],"ALL":[156,268,296,361],"by":[158,399],"western":[159],"blotting.":[160],"These":[161],"observations":[162],"interest":[165],"because":[166],"secreted":[170],"immunoregulatory":[171],"glycan-binding":[172],"induces":[175],"apoptosis":[177],"cytotoxic":[179],"T":[180,183],"cells":[181,185],"helper1":[184],"fosters":[187],"an":[188],"immunosuppressive":[189],"tumor":[190],"microenvironment.":[191],"assess":[193],"utility":[196],"expression":[199,228,266,286,305],"identifying":[201],"subtype,":[204],"performed":[206],"immunostaining":[208],"large":[211],"series":[212],"known":[217],"status.":[219],"All":[220],"10":[221],"precursor-B":[223],"had":[225],"(10/10,":[229],"100%);":[230],"marked":[232],"contrast,":[233],"only":[234],"1":[235],"38":[237],"pre-B":[238,360],"cytogenetically":[242],"detectable":[243],"expressed":[246],"(3%),":[248],"p<0.001.":[249],"Since":[250,302],"intracellular":[251,278],"flow":[252,279],"cytometry":[253],"routinely":[255],"evaluation":[260],"ALL,":[262],"evaluated":[264],"subtypes":[269],"recently":[272],"developed":[273],"monoclonal":[275],"antibody":[276],"cytometry.":[280],"With":[281],"this":[282,369],"technique,":[283],"high":[288],"low/undetectable":[294],"translocation.":[301],"deregulated":[303],"may":[309,372],"related":[311],"altered":[314,401],"histone":[315,325,402],"methyltransferase":[316,403],"activity":[317,404],"complex,":[322],"analyzed":[324],"H3":[326],"lysine":[327],"79":[328],"(H3K79)":[329],"dimethylation":[330,342],"promoter":[334,340],"region":[335],"using":[336],"chromatin":[337],"immunoprecipitation.":[338],"H3K79":[341],"5":[343],"fold":[344],"higher":[345],"MV-4-11":[348],"line":[350,362],"bearing":[351],"MLL-AF4":[352],"\u2248":[355],"translocation,":[366],"suggesting":[367],"epigenetic":[370],"modification":[371],"mechanism":[375],"for":[376],"overexpression":[378,395],"We":[381],"conclude":[382],"that:":[383],"specifically":[386],"overexpressed":[387],"MLL-ALLs":[389],"ALLs;":[393],"likely":[397],"driven":[398],"complex;":[410],"3)":[412],"promising":[416],"marker":[418],"MLL-ALLs.":[421]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2019-12-13T00:00:00"}
