{"id":"https://openalex.org/W2992793580","doi":null,"title":"Corneal Epithelial Cell Fate Is Maintained During Repair by Notch1 Signaling via Regulation of the Vitamin A Metabolism","display_name":"Corneal Epithelial Cell Fate Is Maintained During Repair by Notch1 Signaling via Regulation of the Vitamin A Metabolism","publication_year":2007,"publication_date":"2007-05-10","ids":{"openalex":"https://openalex.org/W2992793580","mag":"2992793580"},"language":"en","primary_location":{"id":"mag:2992793580","doi":null,"is_oa":false,"landing_page_url":"https://www.cell.com/developmental-cell/pdf/S1534-5807(07)00261-4.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074916755","display_name":"F. Majo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089389","display_name":"H\u00f4pital Ophtalmique Jules-Gonin","ror":"https://ror.org/008dmmd16","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210089389","https://openalex.org/I4210124413"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"F. Majo","raw_affiliation_strings":["Ophthalmology, Jules Gonin Eye Hospital, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Jules Gonin Eye Hospital, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210089389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037880685","display_name":"Sophie Vauclair","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sophie Vauclair","raw_affiliation_strings":["Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066435032","display_name":"Yann Barrandon","orcid":"https://orcid.org/0000-0001-6892-9463","observed_orcids":["https://orcid.org/0000-0001-6892-9463"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Yann Barrandon","raw_affiliation_strings":["Laboratoire de Dynamique des Cellules Souches / Centre de Chirurgie Exp\u00e9rimentale, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne / Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-6892-9463","affiliations":[{"raw_affiliation_string":"Laboratoire de Dynamique des Cellules Souches / Centre de Chirurgie Exp\u00e9rimentale, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne / Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I5124864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061774460","display_name":"Freddy Radtke","orcid":"https://orcid.org/0000-0003-4315-4045","observed_orcids":["https://orcid.org/0000-0003-4315-4045"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Freddy Radtke","raw_affiliation_strings":["Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-4315-4045","affiliations":[{"raw_affiliation_string":"Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":"13","first_page":"4930","last_page":"4930"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12989","display_name":"Ocular Disorders and Treatments","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/notch1-signaling","display_name":"Notch1 signaling","score":0.9589999914169312},{"id":"https://openalex.org/keywords/corneal-epithelium","display_name":"corneal epithelium","score":0.9980000257492065},{"id":"https://openalex.org/keywords/corneal-wound-healing","display_name":"corneal wound healing","score":0.7580000162124634},{"id":"https://openalex.org/keywords/corneal-stem-cells","display_name":"corneal stem cells","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cell-fate-maintenance","display_name":"cell fate maintenance","score":0.6439999938011169},{"id":"https://openalex.org/keywords/keratinization","display_name":"keratinization","score":0.8550000190734863},{"id":"https://openalex.org/keywords/vitamin-a-metabolism","display_name":"vitamin A metabolism","score":0.6859999895095825},{"id":"https://openalex.org/keywords/fgf2","display_name":"FGF2","score":0.8700000047683716},{"id":"https://openalex.org/keywords/corneal-blindness","display_name":"corneal blindness","score":0.8109999895095825},{"id":"https://openalex.org/keywords/non-cell-autonomous-signaling","display_name":"non-cell-autonomous signaling","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.8468782305717468},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.6500488519668579},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6144979000091553},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5547919869422913},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.5396196842193604},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.530677855014801},{"id":"https://openalex.org/C2779257441","wikidata":"https://www.wikidata.org/wiki/Q2040445","display_name":"Corneal epithelium","level":3,"score":0.4801156520843506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4356471002101898},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.42251256108283997},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.35045766830444336},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.17640557885169983},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.17105108499526978},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09635651111602783},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0835205614566803},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.050366729497909546},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0469801127910614}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2992793580","doi":null,"is_oa":false,"landing_page_url":"https://www.cell.com/developmental-cell/pdf/S1534-5807(07)00261-4.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.766700029373169,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W113450198","https://openalex.org/W1768274470","https://openalex.org/W1957742134","https://openalex.org/W1970137796","https://openalex.org/W1970291858","https://openalex.org/W1971989159","https://openalex.org/W1982793777","https://openalex.org/W1984206717","https://openalex.org/W1990906839","https://openalex.org/W1995004385","https://openalex.org/W1997428070","https://openalex.org/W1999876770","https://openalex.org/W2001405592","https://openalex.org/W2020443656","https://openalex.org/W2028505974","https://openalex.org/W2029088626","https://openalex.org/W2031499346","https://openalex.org/W2036795046","https://openalex.org/W2044484847","https://openalex.org/W2056729455","https://openalex.org/W2067131315","https://openalex.org/W2067435927","https://openalex.org/W2072869294","https://openalex.org/W2073890475","https://openalex.org/W2077640765","https://openalex.org/W2079487417","https://openalex.org/W2084954022","https://openalex.org/W2099059205","https://openalex.org/W2100100832","https://openalex.org/W2103440968","https://openalex.org/W2104030002","https://openalex.org/W2109380828","https://openalex.org/W2119226652","https://openalex.org/W2122104511","https://openalex.org/W2128078747","https://openalex.org/W2144579631","https://openalex.org/W2149557024","https://openalex.org/W2154861644","https://openalex.org/W2155449591","https://openalex.org/W2163674890","https://openalex.org/W2254919660","https://openalex.org/W2409936999","https://openalex.org/W4240835837"],"related_works":["https://openalex.org/W1969383593","https://openalex.org/W2077434614","https://openalex.org/W2110163443","https://openalex.org/W1740257755","https://openalex.org/W2564397708","https://openalex.org/W1550641130","https://openalex.org/W7098043003","https://openalex.org/W1769973740","https://openalex.org/W4281550780","https://openalex.org/W862092112"],"abstract_inverted_index":{"Integrity":[0],"and":[1,16,20],"preservation":[2],"of":[3,43,72],"a":[4],"transparent":[5],"cor-nea":[6],"are":[7],"essential":[8,32],"for":[9,33],"good":[10],"vision.":[11],"The":[12],"cornealepithelium":[13],"is":[14,31],"strati\ufb01ed":[15],"nonkeratinized":[17],"andis":[18],"maintained":[19],"repaired":[21],"by":[22,70],"corneal":[23,54,64],"stemcells.":[24],"Here":[25],"we":[26],"demonstrate":[27],"that":[28,52],"Notch1":[29,44,77],"sig-naling":[30],"cell":[34,59,67],"fate":[35,60],"maintenance":[36],"ofcorneal":[37],"epithelium":[38],"during":[39],"repair.":[40],"Inducible":[41],"abla-tion":[42],"in":[45],"the":[46],"cornea":[47],"combined":[48],"withmechanical":[49],"wounding":[50],"show":[51],"Notch1-de\ufb01-cient":[53],"progenitor":[55],"cells":[56],"differentiate":[57],"intoahyperplastic,keratinized,skin-likeepithelium.This":[58],"switch":[61],"leads":[62],"to":[63],"blindnessand":[65],"involves":[66],"nonautonomous":[68],"processes,characterized":[69],"secretion":[71],"\ufb01broblast":[73],"growthfactor-2":[74],"(FGF-2)":[75],"through":[76]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2019-12-13T00:00:00"}