{"id":"https://openalex.org/W2992683136","doi":"https://doi.org/10.1182/blood.v106.11.384.384","title":"Activation of Platelet \u03b1 Iib\u03b2 3 by Exogenous Peptides Corresponding to the Transmembrane Domains of \u03b1 Iib and \u03b2 3.","display_name":"Activation of Platelet \u03b1 Iib\u03b2 3 by Exogenous Peptides Corresponding to the Transmembrane Domains of \u03b1 Iib and \u03b2 3.","publication_year":2005,"publication_date":"2005-11-16","ids":{"openalex":"https://openalex.org/W2992683136","doi":"https://doi.org/10.1182/blood.v106.11.384.384","mag":"2992683136"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v106.11.384.384","doi":"https://doi.org/10.1182/blood.v106.11.384.384","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v106.11.384.384","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025581121","display_name":"Hang Hubert Yin","orcid":"https://orcid.org/0000-0002-9762-4818","observed_orcids":["https://orcid.org/0000-0002-9762-4818"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hang Yin","raw_affiliation_strings":["Biochemisry/Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemisry/Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hua Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Zhu","raw_affiliation_strings":["Hematology-Oncology Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology-Oncology Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013580848","display_name":"Gaston Vilaire","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gaston Vilaire","raw_affiliation_strings":["Hematology-Oncology Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology-Oncology Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318444","display_name":"Wei Li","orcid":"https://orcid.org/0000-0003-4143-8597","observed_orcids":["https://orcid.org/0000-0003-4143-8597"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Hematology-Oncology Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology-Oncology Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007009397","display_name":"\u041b\u0438\u0442\u0432\u0438\u043d\u043e\u0432 \u0420\u0443\u0441\u0442\u0435\u043c \u0418\u0433\u043e\u0440\u0435\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0003-0643-1496","observed_orcids":["https://orcid.org/0000-0003-0643-1496"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rustem I. Litvinov","raw_affiliation_strings":["Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021623971","display_name":"William F. DeGrado","orcid":"https://orcid.org/0000-0003-4745-263X","observed_orcids":["https://orcid.org/0000-0003-4745-263X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William F. DeGrado","raw_affiliation_strings":["Biochemisry/Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemisry/Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058801586","display_name":"JOEL S. BENNETT","orcid":"https://orcid.org/0000-0003-4650-221X","observed_orcids":["https://orcid.org/0000-0003-4650-221X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel S. Bennett","raw_affiliation_strings":["Hematology-Oncology Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology-Oncology Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.41327327,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"106","issue":"11","first_page":"384","last_page":"384"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.7768999934196472,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.7768999934196472,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.2011999934911728,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.6660000085830688},{"id":"https://openalex.org/keywords/peptide-agonists","display_name":"peptide agonists","score":0.44999998807907104},{"id":"https://openalex.org/keywords/integrin-activation","display_name":"integrin activation","score":0.5759999752044678},{"id":"https://openalex.org/keywords/homodimerization","display_name":"homodimerization","score":0.6729999780654907},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/fibrinogen-receptor","display_name":"fibrinogen receptor","score":0.7839999794960022},{"id":"https://openalex.org/keywords/gxxxg-motif","display_name":"GxxxG motif","score":0.7699999809265137},{"id":"https://openalex.org/keywords/adp-induced-platelet-aggregation","display_name":"ADP-induced aggregation","score":0.5870000123977661},{"id":"https://openalex.org/keywords/prostaglandin-e1","display_name":"prostaglandin E1","score":0.5989999771118164},{"id":"https://openalex.org/keywords/apyrase","display_name":"apyrase","score":0.8970000147819519},{"id":"https://openalex.org/keywords/integrin-conformation","display_name":"integrin conformation","score":0.3889999985694885}],"concepts":[{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.7536687254905701},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7217698097229004},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5954048037528992},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.5435717701911926},{"id":"https://openalex.org/C2779508331","wikidata":"https://www.wikidata.org/wiki/Q24770179","display_name":"Apyrase","level":3,"score":0.4857816994190216},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4784007966518402},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.4716174900531769},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.4650588631629944},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.405938982963562},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4019094705581665},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3004486560821533},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15201231837272644},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v106.11.384.384","doi":"https://doi.org/10.1182/blood.v106.11.384.384","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v106.11.384.384","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2092964767","https://openalex.org/W2566882392","https://openalex.org/W2510913168","https://openalex.org/W2015323951","https://openalex.org/W2044757857","https://openalex.org/W2588411449","https://openalex.org/W1930120034","https://openalex.org/W7097275705","https://openalex.org/W2106428814","https://openalex.org/W6989638337"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"platelet":[2,174,192],"fibrinogen":[3],"receptor":[4],"\u03b1":[5,26,36,47,77,91,104,110,117,124,139,207,246,281,307,313,321,328,344,356,367,404,422,436,454,468,501,515],"IIb\u03b2":[6,37,111,208,247,314,329,502],"3":[7,30,38,112,126,170,254,330,438,472,503,517],"exists":[8],"in":[9,53,56,153,165,228,258,285,382,442,452,460,504],"an":[10,166,259,263,280,435,505],"equilibrium":[11],"between":[12,372],"inactive":[13,19,506],"and":[14,28,55,59,155,205,231,289,293,376,446,470],"active":[15,41],"conformations.":[16],"In":[17,353],"its":[18,40,151,157,419,461],"conformation,":[20],"the":[21,46,60,68,72,76,87,103,116,123,138,206,214,229,238,252,266,291,306,339,343,350,355,366,377,383,390,393,403,409,432,449,453,464,488,491,495,509,514,526],"transmembrane":[22],"(TM)":[23],"domains":[24,474],"of":[25,75,83,90,146,169,233,296,361,386,392,434,467,528],"IIb":[27,48,78,92,105,118,140,282,308,322,345,357,368,405,455,469],"\u03b2":[29,84,253,471],"interact,":[31],"but":[32,180],"they":[33],"separate":[34],"when":[35],"assumes":[39],"conformation.":[42],"Peptides":[43],"corresponding":[44,136,251],"to":[45,115,137,149,159,245,279,302,312,408,499],"TM":[49,79,93,106,119,127,141,255,268,283,309,323,346,358,369,406,439,456,473,492,518],"domain":[50,80,94,107,128,256,269,370,381,440,457],"form":[51],"homodimers":[52],"vitro":[54],"bacterial":[57,410],"membranes":[58],"interface":[61,69],"that":[62,70,82,100,237,305,318,401,418,448,490,512],"mediates":[63,71],"this":[64],"interaction":[65,341,466],"overlaps":[66],"with":[67,81,219,326,487],"heteromeric":[73,480],"association":[74,89],"3.":[85,248],"Because":[86,463],"homomeric":[88,465],"is":[95,458,475],"relatively":[96],"strong,":[97],"we":[98,316,348],"expected":[99],"peptides":[101,493],"spanning":[102],"might":[108],"activate":[109,160],"by":[113,144,184,191,203,242],"binding":[114,243,374],"domain,":[120,142,347],"thereby":[121],"disrupting":[122],"IIb/\u03b2":[125,437,516],"heterodimer.":[129],"We":[130,399],"synthesized":[131],"a":[132,177,225,297,319,362,522],"26":[133],"residue":[134],"peptide":[135,172,239,250,284,310,324,407],"flanked":[143],"pairs":[145],"lysine":[147],"residues":[148,295],"increase":[150],"solubility":[152],"water,":[154],"assessed":[156],"ability":[158],"washed":[161],"or":[162,221],"gel-filtered":[163],"platelets":[164,218,445],"aggregometer.":[167],"Addition":[168],"\u03bcM":[171],"induced":[173,240],"aggregation":[175,182,187,200,241],"after":[176],"short":[178],"lag,":[179],"unlike":[181],"stimulated":[183],"ADP,":[185],"peptide-induced":[186,199,234],"was":[188,201,276],"not":[189],"preceded":[190],"shape":[193],"change.":[194],"Nonetheless,":[195],"like":[196],"ADP-induced":[197],"aggregation,":[198,235],"inhibited":[202],"EDTA":[204],"3-specific":[209],"monoclonal":[210],"antibody":[211],"A2A9.":[212],"On":[213],"other":[215],"hand,":[216],"pre-incubating":[217],"PGE1":[220],"apyrase":[222],"caused":[223],"only":[224],"small":[226],"decrease":[227],"rate":[230],"extent":[232],"suggesting":[236],"directly":[244],"A":[249],"behaved":[257],"identical":[260],"manner,":[261],"whereas":[262],"unrelated":[264],"peptide,":[265],"model":[267],"MS-1,":[270],"had":[271],"no":[272],"effect.":[273],"Similarly,":[274],"there":[275],"little":[277],"response":[278],"which":[286,497],"glycines":[287],"972":[288],"976,":[290],"first":[292],"last":[294],"GxxxG":[298,450],"motif,":[299],"were":[300],"changed":[301],"leucine.":[303],"Confirming":[304],"binds":[311],"3,":[315],"found":[317,400],"FITC-labeled":[320],"co-eluted":[325],"purified":[327],"during":[331],"size":[332],"exclusion":[333],"gel":[334],"filtration.":[335],"To":[336],"determine":[337],"whether":[338],"latter":[340],"involved":[342,459],"used":[349],"TOXCAT":[351],"assay.":[352],"TOXCAT,":[354],"domain-mediated":[359],"dimerization":[360],"fusion":[363,424],"protein":[364,375,425],"containing":[365],"interposed":[371],"maltose":[373],"ToxR\u2019":[378],"transcriptional":[379],"activation":[380,391],"inner":[384],"membrane":[385],"E.":[387],"coli":[388],"drives":[389],"chloramphenicol":[394],"acetyl":[395],"transferase":[396],"(CAT)":[397],"gene.":[398],"adding":[402],"growth":[411],"medium":[412],"consistently":[413],"decreased":[414],"CAT":[415],"synthesis,":[416],"implying":[417],"presence":[420,433],"impaired":[421],"IIb-mediated":[423],"dimerization.":[426],"These":[427],"results":[428],"provide":[429],"evidence":[430],"for":[431,525],"heterodimer":[441,496,519],"unstimulated":[443],"human":[444],"suggest":[447,511],"motif":[451],"formation.":[462],"substantially":[476],"stronger":[477],"than":[478],"their":[479],"interaction,":[481],"our":[482],"data":[483,510],"are":[484],"also":[485],"consistent":[486],"hypothesis":[489],"disrupt":[494],"functions":[498],"maintain":[500],"state.":[507],"Lastly,":[508],"stabilizing":[513],"may":[520],"represent":[521],"new":[523],"approach":[524],"development":[527],"novel":[529],"anti-platelet":[530],"agents.":[531]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2019-12-13T00:00:00"}
