{"id":"https://openalex.org/W2992682291","doi":null,"title":"Transcriptional dysregulation of skeletal muscle protein metabolism in streptozotocin-diabetic mice.","display_name":"Transcriptional dysregulation of skeletal muscle protein metabolism in streptozotocin-diabetic mice.","publication_year":2009,"publication_date":"2009-05-01","ids":{"openalex":"https://openalex.org/W2992682291","mag":"2992682291","pmid":"https://pubmed.ncbi.nlm.nih.gov/19609011"},"language":"en","primary_location":{"id":"pmid:19609011","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19609011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084429704","display_name":"W. Wieteska\u2010Skrzeczy\u0144ska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170230895","display_name":"Warsaw University of Life Sciences","ror":"https://ror.org/05srvzs48","country_code":"PL","type":"education","lineage":["https://openalex.org/I170230895"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"W Wieteska-Skrzeczynska","raw_affiliation_strings":["Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159, 02-776 Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159, 02-776 Warsaw, Poland","institution_ids":["https://openalex.org/I170230895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041943960","display_name":"Katarzyna Grzelkowska\u2010Kowalczyk","orcid":"https://orcid.org/0000-0002-3277-6722","observed_orcids":["https://orcid.org/0000-0002-3277-6722"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Grzelkowska-Kowalczyk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032689513","display_name":"M. Jank","orcid":"https://orcid.org/0000-0003-1630-2938","observed_orcids":["https://orcid.org/0000-0003-1630-2938"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Jank","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5047219170","display_name":"Henryk Maciejewski","orcid":"https://orcid.org/0000-0002-8405-9987","observed_orcids":["https://orcid.org/0000-0002-8405-9987"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Maciejewski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5455,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.58998823,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"60 Suppl 1","issue":null,"first_page":"29","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.019600000232458115,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9570000171661377},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.8199999928474426},{"id":"https://openalex.org/keywords/protein-metabolism","display_name":"protein metabolism","score":0.8650000095367432},{"id":"https://openalex.org/keywords/transcriptional-dysregulation","display_name":"transcriptional dysregulation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/gastrocnemius-muscle","display_name":"gastrocnemius","score":0.828000009059906},{"id":"https://openalex.org/keywords/myogenin","display_name":"myogenin","score":0.8429999947547913},{"id":"https://openalex.org/keywords/myostatin","display_name":"myostatin","score":1.0},{"id":"https://openalex.org/keywords/myogenesis","display_name":"myogenesis","score":0.8009999990463257},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.9300000071525574},{"id":"https://openalex.org/keywords/translation-initiation-factors","display_name":"translation initiation factors","score":0.5649999976158142},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.6159999966621399},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.640999972820282},{"id":"https://openalex.org/keywords/muscle-regeneration","display_name":"muscle regeneration","score":0.6240000128746033},{"id":"https://openalex.org/keywords/muscle-growth","display_name":"muscle growth","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.691805899143219},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6285864114761353},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6254637837409973},{"id":"https://openalex.org/C97816823","wikidata":"https://www.wikidata.org/wiki/Q166726","display_name":"Myogenin","level":4,"score":0.6208683252334595},{"id":"https://openalex.org/C2777488582","wikidata":"https://www.wikidata.org/wiki/Q29630","display_name":"Myostatin","level":3,"score":0.5932192802429199},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5716554522514343},{"id":"https://openalex.org/C2776188179","wikidata":"https://www.wikidata.org/wiki/Q24768727","display_name":"GLUT4","level":4,"score":0.5506144165992737},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5315551161766052},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4731634259223938},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.45217469334602356},{"id":"https://openalex.org/C2853687","wikidata":"https://www.wikidata.org/wiki/Q18039976","display_name":"Carbohydrate-responsive element-binding protein","level":4,"score":0.4440910220146179},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.41716018319129944},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.2986369729042053},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2749958634376526},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2625051438808441},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.25535470247268677},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.17631149291992188},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15953034162521362},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09723198413848877}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000943","descriptor_name":"Antigens, Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000943","descriptor_name":"Antigens, Differentiation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:19609011","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19609011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},{"id":"mag:2992682291","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19609011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W18187709","https://openalex.org/W154426487","https://openalex.org/W276267582","https://openalex.org/W1135849107","https://openalex.org/W1804745580","https://openalex.org/W1971857747","https://openalex.org/W1980213297","https://openalex.org/W1997040781","https://openalex.org/W2010307621","https://openalex.org/W2010637767","https://openalex.org/W2013322247","https://openalex.org/W2013515507","https://openalex.org/W2014887370","https://openalex.org/W2017789182","https://openalex.org/W2033937708","https://openalex.org/W2034510788","https://openalex.org/W2035726606","https://openalex.org/W2038863796","https://openalex.org/W2051471929","https://openalex.org/W2054834672","https://openalex.org/W2064895186","https://openalex.org/W2066272256","https://openalex.org/W2070973528","https://openalex.org/W2087266832","https://openalex.org/W2094801904","https://openalex.org/W2111763524","https://openalex.org/W2123384926","https://openalex.org/W2134573448","https://openalex.org/W2141725752","https://openalex.org/W2142716752","https://openalex.org/W2151519672","https://openalex.org/W2152929799","https://openalex.org/W2153030555","https://openalex.org/W2155902778","https://openalex.org/W2167033587","https://openalex.org/W2167636834","https://openalex.org/W2169448756","https://openalex.org/W2171071516","https://openalex.org/W2993065123","https://openalex.org/W7100923047"],"related_works":["https://openalex.org/W2155902778","https://openalex.org/W2148179350","https://openalex.org/W1501851749","https://openalex.org/W2065555206","https://openalex.org/W6964362295","https://openalex.org/W2156988103","https://openalex.org/W2972765830","https://openalex.org/W2112711019","https://openalex.org/W2065806200","https://openalex.org/W2000847929"],"abstract_inverted_index":{"The":[0],"purpose":[1],"of":[2,12,25,35,42,108,122,129,148,157,165,177,190,196],"the":[3,33,106,127,153,158,175,197],"study":[4],"was":[5,99,113],"to":[6,142,163],"evaluate":[7],"potential":[8],"changes":[9,173],"in":[10,15,22,32,39,51,105,126,152,170,174,185],"expression":[11,34,107,121,147,176,192],"genes":[13],"involved":[14,125,151],"protein":[16,46,64,95,138],"metabolism":[17,47],"and":[18,89,131,140,155,188,203],"myogenic":[19,179],"differentiation":[20],"markers":[21],"skeletal":[23,136,200],"muscle":[24,41,137,201],"streptozotocin-diabetic":[26],"mice.":[27,44],"Microarray":[28],"analysis":[29],"revealed":[30],"alterations":[31],"84":[36],"gene":[37,52,123,149],"transcripts":[38,53,124,150],"gastrocnemius":[40],"diabetic":[43],"Regarding":[45],"a":[48,103,183],"marked":[49],"downregulation":[50],"for:":[54],"general":[55],"transcription":[56,130],"factor":[57,70,74,81],"IIA1":[58],"(-1.88,":[59],"P=0.016309),":[60],"TATA":[61],"box":[62],"binding":[63],"(-2.17,":[65],"P=0.037373),":[66,77],"eukaryotic":[67,78],"translation":[68,79],"initiation":[69],"4E":[71],"nuclear":[72],"import":[73],"1":[75,96],"(-1.61,":[76],"elongation":[80],"Ibeta2":[82],"(-1.95,":[83],"P=0.010406),":[84],"ubiquitin-like":[85],"5":[86],"(-1.67,":[87],"P=0.024975)":[88],"ubiquitin":[90],"conjugating":[91],"enzyme":[92],"7":[93],"interacting":[94],"(-1.68,":[97],"P=0.016309)":[98],"observed.":[100],"STZ-diabetes":[101,119],"caused":[102],"drop":[104],"myogenin,":[109],"whereas":[110],"myostatin":[111,191],"level":[112,187],"significantly":[114],"elevated.":[115],"In":[116],"conclusion,":[117],"1)":[118],"attenuates":[120],"process":[128],"translation,":[132],"which":[133],"may":[134,161,193],"affect":[135],"synthesis":[139],"lead":[141],"nitrogen":[143],"imbalance,":[144],"2)":[145],"impaired":[146],"regulation":[154],"activity":[156],"ubiquitin-proteasome":[159],"pathway":[160],"contribute":[162],"attenuation":[164],"mechanisms":[166,198],"eliminating":[167],"damaged":[168],"proteins":[169],"STZ-diabetes,":[171],"3)":[172],"key":[178],"factors,":[180],"manifested":[181],"by":[182],"decrease":[184],"myogenin":[186],"enhancement":[189],"be":[194],"one":[195],"limiting":[199],"growth":[202],"regeneration":[204],"associated":[205],"with":[206],"diabetes.":[207]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-13T00:00:00"}