{"id":"https://openalex.org/W2992616976","doi":null,"title":"From food to nutritional support to specific nutraceuticals: a journey across time in the treatment of disease.","display_name":"From food to nutritional support to specific nutraceuticals: a journey across time in the treatment of disease.","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2992616976","mag":"2992616976","pmid":"https://pubmed.ncbi.nlm.nih.gov/10779206"},"language":"en","primary_location":{"id":"pmid:10779206","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10779206","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastroenterology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"C Klein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Klein","raw_affiliation_strings":["Surgical Metabolism and Nutritional Laboratory, SUNY Health Science Center, University Hospital, Syracuse, NY 13210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Metabolism and Nutritional Laboratory, SUNY Health Science Center, University Hospital, Syracuse, NY 13210, USA","institution_ids":["https://openalex.org/I1327163397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113779170","display_name":"Tomoi Sato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Sato","raw_affiliation_strings":["SUNY Upstate Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SUNY Upstate Medical University","institution_ids":["https://openalex.org/I20388574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111730684","display_name":"Michael M. Meguid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M M Meguid","raw_affiliation_strings":["SUNY Upstate Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SUNY Upstate Medical University","institution_ids":["https://openalex.org/I20388574"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009042310","display_name":"Go Miyata","orcid":"https://orcid.org/0009-0009-3980-2952","observed_orcids":["https://orcid.org/0009-0009-3980-2952"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Miyata","raw_affiliation_strings":["MED - Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MED - Medical Sciences","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9928,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.78738555,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"35 Suppl 12","issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13479","display_name":"Food Science and Nutritional Studies","score":0.4724000096321106,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13479","display_name":"Food Science and Nutritional Studies","score":0.4724000096321106,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10902","display_name":"Complementary and Alternative Medicine Studies","score":0.26510000228881836,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13112","display_name":"Nutrition and Health Studies","score":0.19189999997615814,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nutraceuticals","display_name":"nutraceuticals","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nutritional-support","display_name":"nutritional support","score":0.9340000152587891},{"id":"https://openalex.org/keywords/enteral-nutrition","display_name":"enteral nutrition","score":0.8769999742507935},{"id":"https://openalex.org/keywords/parenteral-nutrition","display_name":"parenteral nutrition","score":0.9990000128746033},{"id":"https://openalex.org/keywords/honey","display_name":"honey","score":0.7590000033378601},{"id":"https://openalex.org/keywords/green-tea","display_name":"green tea","score":0.9829999804496765},{"id":"https://openalex.org/keywords/ginseng","display_name":"ginseng","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vitamin-supplementation","display_name":"vitamin supplementation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/immune-system","display_name":"immune system","score":0.8859999775886536},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.6800000071525574},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.5590000152587891},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.8830000162124634},{"id":"https://openalex.org/keywords/vaccine-antibody-response","display_name":"vaccine antibody response","score":0.8059999942779541},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7440000176429749},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.6990000009536743},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8870000243186951}],"concepts":[{"id":"https://openalex.org/C17857428","wikidata":"https://www.wikidata.org/wiki/Q533025","display_name":"Nutraceutical","level":2,"score":0.7560968399047852},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7363141179084778},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5190559029579163},{"id":"https://openalex.org/C44315111","wikidata":"https://www.wikidata.org/wiki/Q1344580","display_name":"Enteral administration","level":3,"score":0.5092650651931763},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4910855293273926},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40403109788894653},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3548595905303955},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23362386226654053},{"id":"https://openalex.org/C78722104","wikidata":"https://www.wikidata.org/wiki/Q21653202","display_name":"Parenteral nutrition","level":2,"score":0.22242292761802673},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000529","descriptor_name":"Complementary Therapies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007121","descriptor_name":"Immunocompetence","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018529","descriptor_name":"Nutritional Support","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:10779206","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10779206","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastroenterology","raw_type":"Journal Article"},{"id":"mag:2992616976","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10779206","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.5666999816894531,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4382679751","https://openalex.org/W1972980045","https://openalex.org/W3194563148","https://openalex.org/W3193333355","https://openalex.org/W7221055032","https://openalex.org/W1966514917","https://openalex.org/W2412738720","https://openalex.org/W2788973832","https://openalex.org/W7220602370","https://openalex.org/W4226196720"],"abstract_inverted_index":{"Hospitalized":[0],"patients":[1,32,68],"who":[2,69],"are":[3,16,206],"unable":[4],"to":[5,11,31,42,185,214],"eat":[6,9],"or":[7,19],"cannot":[8],"enough":[10],"meet":[12],"their":[13,71],"metabolic":[14],"needs":[15],"given":[17,30],"parenteral":[18],"enteral":[20],"nutritional":[21],"support.":[22],"This":[23],"form":[24],"of":[25,46,58,90,109,121,149,155,161,173,195,202],"therapy":[26,61],"is":[27,37,62,178],"now":[28,63],"also":[29],"at":[33],"home.":[34],"Nutritional":[35],"support":[36],"a":[38,193],"recent":[39],"development,":[40],"prior":[41],"which":[43],"the":[44,88,106,119,130,147,153],"value":[45,57],"food":[47],"was":[48],"recognized":[49],"for":[50,217],"its":[51],"medicinal":[52],"benefits":[53],"as":[54,192,211],"nutraceuticals.":[55,114],"The":[56],"such":[59,91],"\"alternative\"":[60,92],"being":[64],"rediscovered":[65],"by":[66],"many":[67,110],"enhance":[70],"dietary":[72],"intake":[73],"with":[74,180],"these":[75,203],"traditional":[76],"remedies.":[77],"In":[78],"Western":[79],"culture,":[80],"conventional":[81,215],"medicine":[82],"until":[83],"recently":[84],"has":[85,102,134],"largely":[86],"rejected":[87],"use":[89],"therapeutic":[93],"intervention.":[94],"Based":[95],"on":[96,118,129],"an":[97,212],"increasing":[98],"database,":[99],"though,":[100],"insight":[101],"been":[103],"gained":[104],"concerning":[105],"scientific":[107],"validity":[108],"previously":[111],"termed":[112],"established":[113],"We":[115],"focus":[116],"here":[117],"effects":[120],"honey,":[122],"green":[123],"tea,":[124],"ginseng,":[125],"and":[126,142,152,164,170,189,197],"vitamin":[127],"supplementation":[128,177],"immune":[131],"system.":[132],"Honey":[133],"proven":[135],"antimicrobial":[136],"activity.":[137],"Green":[138],"tea":[139],"enhances":[140,159],"humoral":[141],"cell-mediated":[143],"immunity":[144],"while":[145],"decreasing":[146],"risk":[148,154],"certain":[150],"cancers":[151],"cardiovascular":[156],"disease.":[157],"Ginseng":[158],"production":[160],"macrophages,":[162],"B":[163,188],"T":[165,198],"cells,":[166,169],"natural":[167],"killer":[168],"colony-forming":[171],"activity":[172],"bone":[174],"marrow.":[175],"Vitamin":[176],"associated":[179],"increased":[181],"antibody":[182],"titer":[183],"response":[184],"both":[186],"hepatitis":[187],"tetanus":[190],"vaccines":[191],"result":[194],"macrophage":[196],"cell":[199],"stimulation.":[200],"Because":[201],"findings,":[204],"nutraceuticals":[205],"becoming":[207],"more":[208],"widely":[209],"accepted":[210],"adjunct":[213],"therapies":[216],"enhancing":[218],"general":[219],"well-being.":[220]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-13T00:00:00"}