{"id":"https://openalex.org/W2992587933","doi":null,"title":"Next Generation Sequencing Analysis of Gene and Pathway Regulation in the Rat Model of Retinopathy of Prematurity","display_name":"Next Generation Sequencing Analysis of Gene and Pathway Regulation in the Rat Model of Retinopathy of Prematurity","publication_year":2013,"publication_date":"2013-06-16","ids":{"openalex":"https://openalex.org/W2992587933","mag":"2992587933"},"language":"en","primary_location":{"id":"mag:2992587933","doi":null,"is_oa":false,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2151403","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015797026","display_name":"Tara L. Favazza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tara L. Favazza","raw_affiliation_strings":["Ophthalmology, Boston Children's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Boston Children's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006464725","display_name":"Rachel M. Griffith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel M. Griffith","raw_affiliation_strings":["Ophthalmology, Boston Children's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Boston Children's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007837865","display_name":"Li Hu","orcid":"https://orcid.org/0000-0002-8112-734X","observed_orcids":["https://orcid.org/0000-0002-8112-734X"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Hu","raw_affiliation_strings":["Biomedical Engineering, Boston University, Boston, MA","Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, Boston University, Boston, MA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100331321","display_name":"Nan Zhang","orcid":"https://orcid.org/0000-0003-0679-6188","observed_orcids":["https://orcid.org/0000-0003-0679-6188"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nan Zhang","raw_affiliation_strings":["Ophthalmology, Harvard Medical School, Boston, MA","Ophthalmology, Boston Children's Hospital, Boston, MA"],"raw_orcid":"https://orcid.org/0000-0003-0679-6188","affiliations":[{"raw_affiliation_string":"Ophthalmology, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Ophthalmology, Boston Children's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051881574","display_name":"Ronald M. Hansen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald M. Hansen","raw_affiliation_strings":["Ophthalmology, Boston Children's Hospital, Boston, MA","Ophthalmology, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Boston Children's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Ophthalmology, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008165270","display_name":"Anne B. Fulton","orcid":"https://orcid.org/0000-0002-5752-2614","observed_orcids":["https://orcid.org/0000-0002-5752-2614"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne B. Fulton","raw_affiliation_strings":["Ophthalmology, Boston Children's Hospital, Boston, MA","Ophthalmology, Harvard Medical School, Boston, MA"],"raw_orcid":"https://orcid.org/0000-0002-5752-2614","affiliations":[{"raw_affiliation_string":"Ophthalmology, Boston Children's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Ophthalmology, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027457879","display_name":"James D. Akula","orcid":"https://orcid.org/0000-0001-8049-1812","observed_orcids":["https://orcid.org/0000-0001-8049-1812"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James D. Akula","raw_affiliation_strings":["Ophthalmology, Boston Children's Hospital, Boston, MA","Ophthalmology, Harvard Medical School, Boston, MA"],"raw_orcid":"https://orcid.org/0000-0001-8049-1812","affiliations":[{"raw_affiliation_string":"Ophthalmology, Boston Children's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Ophthalmology, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.37963133,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"54","issue":"15","first_page":"636","last_page":"636"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12484","display_name":"Retinopathy of Prematurity Studies","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12484","display_name":"Retinopathy of Prematurity Studies","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinopathy-of-prematurity","display_name":"retinopathy of prematurity","score":1.0},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/pathway-regulation","display_name":"pathway regulation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.8309999704360962},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.6340000033378601},{"id":"https://openalex.org/keywords/preterm-infants","display_name":"preterm infants","score":0.5669999718666077},{"id":"https://openalex.org/keywords/retinal-disease","display_name":"retinal disease","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C2779918416","wikidata":"https://www.wikidata.org/wiki/Q1423087","display_name":"Retinopathy of prematurity","level":4,"score":0.9199346303939819},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47487136721611023},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4708283245563507},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4530602693557739},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4499722719192505},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3374791741371155},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3337441086769104},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.08089646697044373},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.039542973041534424}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2992587933","doi":null,"is_oa":false,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2151403","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","score":0.550000011920929,"display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W988890581","https://openalex.org/W1192900237","https://openalex.org/W951070882","https://openalex.org/W907815034","https://openalex.org/W2162014959","https://openalex.org/W2991955324","https://openalex.org/W1145428207","https://openalex.org/W2441859269","https://openalex.org/W2738452637","https://openalex.org/W752326405"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2019-12-13T00:00:00"}
