{"id":"https://openalex.org/W2992390877","doi":"https://doi.org/10.1021/acs.biochem.9b00689","title":"Nucleation Inhibition of Huntingtin Protein (htt) by Polyproline PPII Helices: A Potential Interaction with the N-Terminal \u03b1-Helical Region of Htt","display_name":"Nucleation Inhibition of Huntingtin Protein (htt) by Polyproline PPII Helices: A Potential Interaction with the N-Terminal \u03b1-Helical Region of Htt","publication_year":2019,"publication_date":"2019-12-09","ids":{"openalex":"https://openalex.org/W2992390877","doi":"https://doi.org/10.1021/acs.biochem.9b00689","mag":"2992390877","pmid":"https://pubmed.ncbi.nlm.nih.gov/31814404","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7344267"},"language":"en","primary_location":{"id":"doi:10.1021/acs.biochem.9b00689","doi":"https://doi.org/10.1021/acs.biochem.9b00689","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biochem.9b00689","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC7344267","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029517828","display_name":"James R. Arndt","orcid":"https://orcid.org/0000-0001-7628-0422","observed_orcids":["https://orcid.org/0000-0001-7628-0422"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James R. Arndt","raw_affiliation_strings":["C. Eugene Bennett Department of Chemistry, West Virginia University, 100 Prospect Street, Morgantown, West Virginia 26506, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C. Eugene Bennett Department of Chemistry, West Virginia University, 100 Prospect Street, Morgantown, West Virginia 26506, United States","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018325347","display_name":"Maxmore Chaibva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maxmore Chaibva","raw_affiliation_strings":["C. Eugene Bennett Department of Chemistry, West Virginia University, 100 Prospect Street, Morgantown, West Virginia 26506, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C. Eugene Bennett Department of Chemistry, West Virginia University, 100 Prospect Street, Morgantown, West Virginia 26506, United States","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083214496","display_name":"Maryssa A. Beasley","orcid":"https://orcid.org/0000-0002-3481-5596","observed_orcids":["https://orcid.org/0000-0002-3481-5596","https://orcid.org/0009-0005-2324-5849"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maryssa Beasley","raw_affiliation_strings":["C. Eugene Bennett Department of Chemistry, West Virginia University, 100 Prospect Street, Morgantown, West Virginia 26506, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C. Eugene Bennett Department of Chemistry, West Virginia University, 100 Prospect Street, Morgantown, West Virginia 26506, United States","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040115125","display_name":"Ahmad Kiani Karanji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmad Kiani Karanji","raw_affiliation_strings":["C. Eugene Bennett Department of Chemistry, West Virginia University, 100 Prospect Street, Morgantown, West Virginia 26506, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C. Eugene Bennett Department of Chemistry, West Virginia University, 100 Prospect Street, Morgantown, West Virginia 26506, United States","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040006161","display_name":"Samaneh Ghassabi Kondalaji","orcid":"https://orcid.org/0000-0003-0000-6691","observed_orcids":["https://orcid.org/0000-0003-0000-6691"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samaneh Ghassabi Kondalaji","raw_affiliation_strings":["C. Eugene Bennett Department of Chemistry, West Virginia University, 100 Prospect Street, Morgantown, West Virginia 26506, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C. Eugene Bennett Department of Chemistry, West Virginia University, 100 Prospect Street, Morgantown, West Virginia 26506, United States","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068311543","display_name":"Mahdiar Khakinejad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahdiar Khakinejad","raw_affiliation_strings":["C. Eugene Bennett Department of Chemistry, West Virginia University, 100 Prospect Street, Morgantown, West Virginia 26506, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C. Eugene Bennett Department of Chemistry, West Virginia University, 100 Prospect Street, Morgantown, West Virginia 26506, United States","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060037909","display_name":"Olivia Sarver","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olivia Sarver","raw_affiliation_strings":["C. Eugene Bennett Department of Chemistry, West Virginia University, 100 Prospect Street, Morgantown, West Virginia 26506, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C. Eugene Bennett Department of Chemistry, West Virginia University, 100 Prospect Street, Morgantown, West Virginia 26506, United States","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006211066","display_name":"Justin A. Legleiter","orcid":"https://orcid.org/0000-0002-5262-1867","observed_orcids":["https://orcid.org/0000-0002-5262-1867"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Justin Legleiter","raw_affiliation_strings":["C. Eugene Bennett Department of Chemistry, West Virginia University, 100 Prospect Street, Morgantown, West Virginia 26506, United States","The Center for Neuroscience, West Virginia University, Morgantown, West Virginia 26506, United States","WV Nano Safe Iniative, West Virginia University, Morgantown, West Virginia 26506, United States"],"raw_orcid":"https://orcid.org/0000-0002-5262-1867","affiliations":[{"raw_affiliation_string":"C. Eugene Bennett Department of Chemistry, West Virginia University, 100 Prospect Street, Morgantown, West Virginia 26506, United States","institution_ids":["https://openalex.org/I12097938"]},{"raw_affiliation_string":"The Center for Neuroscience, West Virginia University, Morgantown, West Virginia 26506, United States","institution_ids":["https://openalex.org/I12097938"]},{"raw_affiliation_string":"WV Nano Safe Iniative, West Virginia University, Morgantown, West Virginia 26506, United States","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037830220","display_name":"Stephen J. Valentine","orcid":"https://orcid.org/0000-0003-4360-2928","observed_orcids":["https://orcid.org/0000-0003-4360-2928"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen J. Valentine","raw_affiliation_strings":["C. Eugene Bennett Department of Chemistry, West Virginia University, 100 Prospect Street, Morgantown, West Virginia 26506, United States"],"raw_orcid":"https://orcid.org/0000-0003-4360-2928","affiliations":[{"raw_affiliation_string":"C. Eugene Bennett Department of Chemistry, West Virginia University, 100 Prospect Street, Morgantown, West Virginia 26506, United States","institution_ids":["https://openalex.org/I12097938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006211066","https://openalex.org/A5037830220"],"corresponding_institution_ids":["https://openalex.org/I12097938"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.0745,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.73215414,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"59","issue":"4","first_page":"436","last_page":"449"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/huntingtin","display_name":"huntingtin","score":0.8550000190734863},{"id":"https://openalex.org/keywords/nucleation-inhibition","display_name":"nucleation inhibition","score":0.7089999914169312},{"id":"https://openalex.org/keywords/amyloid-fibril-formation","display_name":"amyloid fibril formation","score":0.8339999914169312},{"id":"https://openalex.org/keywords/oligomerization","display_name":"oligomerization","score":0.8500000238418579},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.8500000238418579},{"id":"https://openalex.org/keywords/protein-peptide-interactions","display_name":"protein-peptide interactions","score":0.7799999713897705},{"id":"https://openalex.org/keywords/helix-coil-transition","display_name":"helix-coil transition","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C109300003","wikidata":"https://www.wikidata.org/wiki/Q4384651","display_name":"Polyproline helix","level":3,"score":0.9959303736686707},{"id":"https://openalex.org/C2781427258","wikidata":"https://www.wikidata.org/wiki/Q2620886","display_name":"Huntingtin","level":4,"score":0.6796556115150452},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6462640166282654},{"id":"https://openalex.org/C3018824666","wikidata":"https://www.wikidata.org/wiki/Q284398","display_name":"Amino terminal","level":4,"score":0.5290034413337708},{"id":"https://openalex.org/C2779664074","wikidata":"https://www.wikidata.org/wiki/Q3518405","display_name":"Terminal (telecommunication)","level":2,"score":0.5277895331382751},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4983184337615967},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.4832473695278168},{"id":"https://openalex.org/C61048295","wikidata":"https://www.wikidata.org/wiki/Q909022","display_name":"Nucleation","level":2,"score":0.41905486583709717},{"id":"https://openalex.org/C2910011555","wikidata":"https://www.wikidata.org/wiki/Q2620886","display_name":"Huntingtin Protein","level":5,"score":0.4170917868614197},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2793978154659271},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.22690606117248535},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20161941647529602},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.16051620244979858},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.06260877847671509},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071058","descriptor_name":"Huntingtin Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071058","descriptor_name":"Huntingtin Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071058","descriptor_name":"Huntingtin Protein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000072756","descriptor_name":"Protein Conformation, alpha-Helical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018625","descriptor_name":"Microscopy, Atomic Force","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.biochem.9b00689","doi":"https://doi.org/10.1021/acs.biochem.9b00689","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biochem.9b00689","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:31814404","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31814404","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:6762755","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7344267","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7344267","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7344267","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:6762755","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7344267","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4300000071525574,"display_name":"Life on land","id":"https://metadata.un.org/sdg/15"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G110136015","display_name":null,"funder_award_id":"R01-GM114494","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3490134524","display_name":"Developing IMS-SID/MAD-MS Instrumentation for Characterizing Intrinsically Disordered Protein Structure","funder_award_id":"5r01gm114494-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4527799097","display_name":"Factors modulating the interaction of huntingtin with lipid membranes: Implications for Huntington's Disease","funder_award_id":"R15NS090380","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":85,"referenced_works":["https://openalex.org/W757827641","https://openalex.org/W816840468","https://openalex.org/W1962249623","https://openalex.org/W1965124901","https://openalex.org/W1968154905","https://openalex.org/W1968363105","https://openalex.org/W1975117323","https://openalex.org/W1978528584","https://openalex.org/W1982138826","https://openalex.org/W1982786241","https://openalex.org/W1984115976","https://openalex.org/W1984588332","https://openalex.org/W1985421309","https://openalex.org/W1988038897","https://openalex.org/W1989948422","https://openalex.org/W1991302621","https://openalex.org/W1996565611","https://openalex.org/W1996757196","https://openalex.org/W1997830142","https://openalex.org/W2000830335","https://openalex.org/W2001299940","https://openalex.org/W2004593644","https://openalex.org/W2007796463","https://openalex.org/W2009404855","https://openalex.org/W2012850328","https://openalex.org/W2014661246","https://openalex.org/W2016865837","https://openalex.org/W2023338599","https://openalex.org/W2025384086","https://openalex.org/W2036734090","https://openalex.org/W2036989160","https://openalex.org/W2037184977","https://openalex.org/W2037751823","https://openalex.org/W2040184129","https://openalex.org/W2042716629","https://openalex.org/W2043787005","https://openalex.org/W2046132401","https://openalex.org/W2048527293","https://openalex.org/W2050275433","https://openalex.org/W2051577979","https://openalex.org/W2058182560","https://openalex.org/W2059266062","https://openalex.org/W2060032450","https://openalex.org/W2061740577","https://openalex.org/W2063627711","https://openalex.org/W2065380711","https://openalex.org/W2071327389","https://openalex.org/W2071648839","https://openalex.org/W2073687064","https://openalex.org/W2077450456","https://openalex.org/W2078472182","https://openalex.org/W2079002615","https://openalex.org/W2079089817","https://openalex.org/W2090786642","https://openalex.org/W2091089938","https://openalex.org/W2091633981","https://openalex.org/W2109410754","https://openalex.org/W2110130604","https://openalex.org/W2121612064","https://openalex.org/W2121642311","https://openalex.org/W2131741443","https://openalex.org/W2134335872","https://openalex.org/W2136634229","https://openalex.org/W2160659542","https://openalex.org/W2161588820","https://openalex.org/W2310133706","https://openalex.org/W2313780865","https://openalex.org/W2318414036","https://openalex.org/W2334805276","https://openalex.org/W2335361727","https://openalex.org/W2410137933","https://openalex.org/W2485366889","https://openalex.org/W2586220680","https://openalex.org/W2597179976","https://openalex.org/W2606208218","https://openalex.org/W2771581693","https://openalex.org/W2783982456","https://openalex.org/W2795307962","https://openalex.org/W2800788078","https://openalex.org/W2810318887","https://openalex.org/W2890108523","https://openalex.org/W2896398063","https://openalex.org/W2913970828","https://openalex.org/W2916640091","https://openalex.org/W2981182757"],"related_works":["https://openalex.org/W2071327389","https://openalex.org/W3201521086","https://openalex.org/W2021379498","https://openalex.org/W2023338599","https://openalex.org/W2090786642","https://openalex.org/W4407435837","https://openalex.org/W3169292759","https://openalex.org/W4211089496","https://openalex.org/W4387541799","https://openalex.org/W2012363008"],"abstract_inverted_index":{"Huntington\u2019s":[0],"disease":[1],"is":[2,120,188,222],"a":[3,47,72,77,178,198],"genetic":[4],"neurodegenerative":[5],"disorder":[6],"characterized":[7],"by":[8,88,149,196,232],"the":[9,15,32,57,67,104,110,123,133,170,186,203,211,215,224],"formation":[10,33,58,119],"of":[11,14,23,34,53,59,69,71,74,130,173,181,185,206],"amyloid":[12],"fibrils":[13],"huntingtin":[16],"protein":[17,111],"(htt).":[18],"The":[19],"17-residue":[20],"N-terminal":[21],"region":[22,52,73,136,172,201],"htt":[24,54,75],"(Nt":[25],"17":[26,135,142,175,195],")":[27],"has":[28,85],"been":[29,86,147],"implicated":[30],"in":[31,98,117,202],"early":[35],"phase":[36],"oligomeric":[37,99],"species,":[38,66],"which":[39,61],"may":[40,55,176,191],"be":[41,177],"neurotoxic.":[42],"Because":[43],"tertiary":[44],"interactions":[45,229],"with":[46,76,109,158,164],"downstream":[48],"(C-terminal)":[49],"polyproline":[50],"(polyP)":[51],"disrupt":[56],"oligomers,":[60],"are":[62,101,230],"precursors":[63],"to":[64,213],"fibrillar":[65],"effect":[68],"co-incubation":[70],"10-residue":[78],"polyP":[79,144,190,233],"peptide":[80],"on":[81],"oligomerization":[82],"and":[83,107,137,143,153],"fibrillization":[84],"examined":[87,148],"atomic":[89],"force":[90],"microscopy.":[91],"From":[92],"multiple,":[93],"time-course":[94],"experiments,":[95],"morphological":[96],"changes":[97],"species":[100],"observed":[102,121],"for":[103,122,227],"protein/peptide":[105],"mixture":[106],"compared":[108],"alone.":[112],"Additionally,":[113],"an":[114],"overall":[115],"decrease":[116],"fibril":[118],"heterogeneous":[124],"mixture.":[125],"To":[126],"consider":[127],"potential":[128],"sites":[129],"interaction":[131],"between":[132],"Nt":[134,141,174,194,207],"polyP,":[138],"mixtures":[139],"containing":[140],"peptides":[145],"have":[146],"ion":[150],"mobility":[151],"spectrometry":[152],"gas-phase":[154],"hydrogen\u2013deuterium":[155],"exchange":[156],"coupled":[157],"mass":[159],"spectrometry.":[160],"These":[161],"data":[162],"combined":[163],"molecular":[165],"dynamics":[166],"simulations":[167],"suggest":[168],"that":[169,189,223],"C-terminal":[171,204],"primary":[179],"point":[180],"contact.":[182],"One":[183],"interpretation":[184,221],"results":[187],"possibly":[192],"regulate":[193],"inducing":[197],"random":[199],"coil":[200],"portion":[205],"17,":[208],"thus":[209],"decreasing":[210],"propensity":[212],"form":[214],"reactive":[216],"amphipathic":[217],"\u03b1-helix.":[218],"A":[219],"separate":[220],"residues":[225],"important":[226],"helix\u2013helix":[228],"blocked":[231],"association.":[234]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-13T00:00:00"}