{"id":"https://openalex.org/W2992350436","doi":null,"title":"Melatonin and serotonin effects on gastrointestinal motility.","display_name":"Melatonin and serotonin effects on gastrointestinal motility.","publication_year":2007,"publication_date":"2007-12-01","ids":{"openalex":"https://openalex.org/W2992350436","mag":"2992350436","pmid":"https://pubmed.ncbi.nlm.nih.gov/18212403"},"language":"en","primary_location":{"id":"pmid:18212403","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18212403","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112142441","display_name":"Thor Pj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"P J Thor","raw_affiliation_strings":["Department of Pathophysiology, Medical College, Jagiellonian University, Czysta 18 str., Cracow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology, Medical College, Jagiellonian University, Czysta 18 str., Cracow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080935527","display_name":"Grzegorz Kr\u00f3lczyk","orcid":"https://orcid.org/0000-0001-8037-6830","observed_orcids":["https://orcid.org/0000-0001-8037-6830"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Krolczyk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105926040","display_name":"Krzysztof Gil","orcid":"https://orcid.org/0000-0002-4732-7698","observed_orcids":["https://orcid.org/0000-0002-4732-7698"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Gil","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086538738","display_name":"Daniel Zurowski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Zurowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068300809","display_name":"\u0141ukasz Nowak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Nowak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.2181,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.94073638,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"58 Suppl 6","issue":null,"first_page":"97","last_page":"103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":1.0},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":1.0},{"id":"https://openalex.org/keywords/gastrointestinal-motility","display_name":"gastrointestinal motility","score":0.9919999837875366},{"id":"https://openalex.org/keywords/enterochromaffin-cells","display_name":"enterochromaffin cells","score":0.968999981880188},{"id":"https://openalex.org/keywords/migrating-motor-complex","display_name":"migrating motor complex","score":0.7799999713897705},{"id":"https://openalex.org/keywords/gastric-emptying","display_name":"gastric emptying","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cholecystokinin-2-receptor","display_name":"cholecystokinin-2 receptor","score":0.765999972820282},{"id":"https://openalex.org/keywords/5-ht3-receptor","display_name":"5-HT3 receptor","score":0.8949999809265137},{"id":"https://openalex.org/keywords/ileal-brake","display_name":"ileal brake","score":0.8939999938011169},{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":0.9290000200271606},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8610000014305115},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/gastric-ulcer","display_name":"gastric ulcer","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.8058890104293823},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7241922616958618},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.688088059425354},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6576077938079834},{"id":"https://openalex.org/C90423213","wikidata":"https://www.wikidata.org/wiki/Q568290","display_name":"Enterochromaffin cell","level":4,"score":0.6113182902336121},{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.5997560024261475},{"id":"https://openalex.org/C3020479747","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Gastric emptying","level":3,"score":0.555200457572937},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4730336368083954},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.44860249757766724},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.3092840313911438},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3092009127140045}],"mesh":[{"descriptor_ui":"D005746","descriptor_name":"Gastric Emptying","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005769","descriptor_name":"Gastrointestinal Motility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005772","descriptor_name":"Gastrointestinal Transit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016065","descriptor_name":"Myoelectric Complex, Migrating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043887","descriptor_name":"Receptor, Cholecystokinin B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D043887","descriptor_name":"Receptor, Cholecystokinin B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D044406","descriptor_name":"Receptors, Serotonin, 5-HT3","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D058831","descriptor_name":"Serotonin 5-HT3 Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:18212403","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18212403","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},{"id":"mag:2992350436","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18212403","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W1938523556","https://openalex.org/W2048142140"],"related_works":["https://openalex.org/W2409832850","https://openalex.org/W4237658639","https://openalex.org/W2085332079","https://openalex.org/W1034616912","https://openalex.org/W105688798","https://openalex.org/W2071691512","https://openalex.org/W2082698581","https://openalex.org/W2143724710","https://openalex.org/W4391843515","https://openalex.org/W2078071268"],"abstract_inverted_index":{"The":[0],"gastrointestinal":[1,97],"tract":[2],"represents":[3],"the":[4,36,90,140,144,173],"most":[5],"important":[6],"extra":[7],"pineal":[8],"source":[9],"of":[10,13,27,35,53,62,67,89,114,143,164,180,193,202,214],"melatonin.":[11],"Presence":[12],"melatonin":[14,29],"(M)":[15],"suggests":[16],"that":[17,121,138],"this":[18],"hormone":[19,77],"is":[20,167,183],"somehow":[21],"involved":[22],"in":[23,59,129,158,162],"digestive":[24,91],"pathophysiology.":[25],"Release":[26],"GI":[28,37],"from":[30],"serotonin-rich":[31],"enterochromaffin":[32],"EC":[33],"cells":[34],"mucosa":[38],"suggest":[39],"close":[40],"antagonistic":[41],"relationship":[42],"with":[43,190],"serotonin":[44],"(S)":[45],"and":[46,64,75,82,99,124,160,221],"seem":[47],"to":[48,51,131],"be":[49,208],"related":[50],"periodicity":[52],"food":[54],"intake.":[55],"Food":[56],"deprivation":[57],"resulted":[58],"an":[60,73],"increase":[61,157],"tissue":[63],"plasma":[65],"concentrations":[66],"M.":[68,170],"Its":[69],"also":[70,86],"act":[71],"as":[72],"autocrine":[74],"paracrine":[76],"affecting":[78],"not":[79,176],"only":[80],"epithelium":[81],"immune":[83],"system":[84],"but":[85,107,175],"smooth":[87],"muscle":[88],"tract.":[92],"Low":[93],"doses":[94,113],"M":[95,102,115,127,171,182,206],"improve":[96],"transit":[98],"affect":[100],"MMC.":[101],"reinforce":[103],"MMCs":[104],"cyclic":[105],"pattern":[106],"inhibits":[108],"spiking":[109],"bowel":[110,152,223],"activity.":[111],"Pharmacological":[112],"delay":[116],"gastric":[117,148,219],"emptying":[118],"via":[119],"mechanisms":[120],"involve":[122],"CCK2":[123],"5HT3":[125],"receptors.":[126],"released":[128],"response":[130],"lipid":[132],"infusion":[133],"exerts":[134],"a":[135,184],"modulatory":[136],"influence":[137],"decreases":[139],"inhibitory":[141],"effects":[142,195],"ileal":[145],"brake":[146],"on":[147,196],"emptying.":[149],"On":[150],"isolated":[151],"S":[153],"induces":[154],"dose":[155],"dependent":[156],"tone":[159,174],"reduction":[161],"amplitude":[163,177],"contraction":[165],"which":[166],"affected":[168],"by":[169],"reduced":[172],"or":[178,199,212],"frequency":[179],"contraction.":[181],"promising":[185],"therapeutic":[186],"agent":[187],"for":[188,210],"IBS":[189],"activities":[191],"independent":[192],"its":[194,203],"sleep,":[197],"anxiety":[198],"depression.":[200],"Since":[201],"unique":[204],"properties":[205],"could":[207],"considered":[209],"prevention":[211],"treatment":[213],"colorectal":[215],"cancer,":[216],"ulcerative":[217],"colitis,":[218],"ulcers":[220],"irritable":[222],"syndrome.":[224]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-13T00:00:00"}