{"id":"https://openalex.org/W2992227805","doi":"https://doi.org/10.1016/j.bbrc.2019.11.135","title":"Molecular hydrogen suppresses superoxide generation in the mitochondrial complex I and reduced mitochondrial membrane potential","display_name":"Molecular hydrogen suppresses superoxide generation in the mitochondrial complex I and reduced mitochondrial membrane potential","publication_year":2019,"publication_date":"2019-12-03","ids":{"openalex":"https://openalex.org/W2992227805","doi":"https://doi.org/10.1016/j.bbrc.2019.11.135","mag":"2992227805","pmid":"https://pubmed.ncbi.nlm.nih.gov/31810604"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrc.2019.11.135","doi":"https://doi.org/10.1016/j.bbrc.2019.11.135","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2019.11.135","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0006291X19322636/pdf","source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0006291X19322636/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054430339","display_name":"Genki Ishihara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Genki Ishihara","raw_affiliation_strings":["Anicom Specialty Medical Institute, Sumitomofudosan-Nishishinnjuku-Grand-tower-39F, 8-17-1 Nishishinjuku, Shinjuku-ku, Tokyo, 161-0023, Japan. Electronic address: genki.ishihara@ani-com.com","Anicom Specialty Medical Institute, Sumitomofudosan-Nishishinnjuku-Grand-tower-39F, 8-17-1 Nishishinjuku, Shinjuku-ku, Tokyo, 161-0023, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anicom Specialty Medical Institute, Sumitomofudosan-Nishishinnjuku-Grand-tower-39F, 8-17-1 Nishishinjuku, Shinjuku-ku, Tokyo, 161-0023, Japan. Electronic address: genki.ishihara@ani-com.com","institution_ids":[]},{"raw_affiliation_string":"Anicom Specialty Medical Institute, Sumitomofudosan-Nishishinnjuku-Grand-tower-39F, 8-17-1 Nishishinjuku, Shinjuku-ku, Tokyo, 161-0023, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018497409","display_name":"Kosuke Kawamoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kosuke Kawamoto","raw_affiliation_strings":["Anicom Specialty Medical Institute, Sumitomofudosan-Nishishinnjuku-Grand-tower-39F, 8-17-1 Nishishinjuku, Shinjuku-ku, Tokyo, 161-0023, Japan. Electronic address: kosuke.kawamoto@ani-com.com","Anicom Specialty Medical Institute, Sumitomofudosan-Nishishinnjuku-Grand-tower-39F, 8-17-1 Nishishinjuku, Shinjuku-ku, Tokyo, 161-0023, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anicom Specialty Medical Institute, Sumitomofudosan-Nishishinnjuku-Grand-tower-39F, 8-17-1 Nishishinjuku, Shinjuku-ku, Tokyo, 161-0023, Japan. Electronic address: kosuke.kawamoto@ani-com.com","institution_ids":[]},{"raw_affiliation_string":"Anicom Specialty Medical Institute, Sumitomofudosan-Nishishinnjuku-Grand-tower-39F, 8-17-1 Nishishinjuku, Shinjuku-ku, Tokyo, 161-0023, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042085443","display_name":"Nobuaki Komori","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nobuaki Komori","raw_affiliation_strings":["Anicom Specialty Medical Institute, Sumitomofudosan-Nishishinnjuku-Grand-tower-39F, 8-17-1 Nishishinjuku, Shinjuku-ku, Tokyo, 161-0023, Japan. Electronic address: n.komori@ani-com.com","Anicom Specialty Medical Institute, Sumitomofudosan-Nishishinnjuku-Grand-tower-39F, 8-17-1 Nishishinjuku, Shinjuku-ku, Tokyo, 161-0023, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anicom Specialty Medical Institute, Sumitomofudosan-Nishishinnjuku-Grand-tower-39F, 8-17-1 Nishishinjuku, Shinjuku-ku, Tokyo, 161-0023, Japan. Electronic address: n.komori@ani-com.com","institution_ids":[]},{"raw_affiliation_string":"Anicom Specialty Medical Institute, Sumitomofudosan-Nishishinnjuku-Grand-tower-39F, 8-17-1 Nishishinjuku, Shinjuku-ku, Tokyo, 161-0023, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103263754","display_name":"T\u00f4ru Ishibashi","orcid":"https://orcid.org/0000-0002-2473-4012","observed_orcids":["https://orcid.org/0000-0002-2473-4012"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Toru Ishibashi","raw_affiliation_strings":["Anicom Specialty Medical Institute, Sumitomofudosan-Nishishinnjuku-Grand-tower-39F, 8-17-1 Nishishinjuku, Shinjuku-ku, Tokyo, 161-0023, Japan. Electronic address: tishibashi@h2-lab.jp","Anicom Specialty Medical Institute, Sumitomofudosan-Nishishinnjuku-Grand-tower-39F, 8-17-1 Nishishinjuku, Shinjuku-ku, Tokyo, 161-0023, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anicom Specialty Medical Institute, Sumitomofudosan-Nishishinnjuku-Grand-tower-39F, 8-17-1 Nishishinjuku, Shinjuku-ku, Tokyo, 161-0023, Japan. Electronic address: tishibashi@h2-lab.jp","institution_ids":[]},{"raw_affiliation_string":"Anicom Specialty Medical Institute, Sumitomofudosan-Nishishinnjuku-Grand-tower-39F, 8-17-1 Nishishinjuku, Shinjuku-ku, Tokyo, 161-0023, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103263754"],"corresponding_institution_ids":[],"apc_list":{"value":2450,"currency":"USD","value_usd":2450},"apc_paid":{"value":2450,"currency":"USD","value_usd":2450},"fwci":3.8171,"has_fulltext":true,"cited_by_count":56,"citation_normalized_percentile":{"value":0.94023932,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"522","issue":"4","first_page":"965","last_page":"970"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-hydrogen","display_name":"molecular hydrogen","score":0.9990000128746033},{"id":"https://openalex.org/keywords/superoxide-production","display_name":"superoxide production","score":0.800000011920929},{"id":"https://openalex.org/keywords/mitochondrial-complex-i","display_name":"mitochondrial complex I","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.953000009059906},{"id":"https://openalex.org/keywords/reverse-electron-transport","display_name":"reverse electron transfer","score":0.8140000104904175},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.765999972820282},{"id":"https://openalex.org/keywords/nad-nadh-ratio","display_name":"NAD+/NADH ratio","score":0.8579999804496765},{"id":"https://openalex.org/keywords/semiquinone-radicals","display_name":"semiquinone","score":0.8299999833106995},{"id":"https://openalex.org/keywords/electron-flow","display_name":"electron flow","score":0.32600000500679016},{"id":"https://openalex.org/keywords/hydrogen-therapy","display_name":"hydrogen treatment","score":0.4320000112056732},{"id":"https://openalex.org/keywords/oxidative-damage","display_name":"oxidative damage","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.6530560255050659},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6083359718322754},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.569395124912262},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.49534502625465393},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3979772627353668},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3489427864551544},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3448895812034607},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2557055950164795},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.18501988053321838}],"mesh":[{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004579","descriptor_name":"Electron Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006859","descriptor_name":"Hydrogen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042967","descriptor_name":"Electron Transport Complex I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053078","descriptor_name":"Membrane Potential, Mitochondrial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbrc.2019.11.135","doi":"https://doi.org/10.1016/j.bbrc.2019.11.135","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2019.11.135","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0006291X19322636/pdf","source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:31810604","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31810604","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.bbrc.2019.11.135","doi":"https://doi.org/10.1016/j.bbrc.2019.11.135","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2019.11.135","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0006291X19322636/pdf","source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2992227805.pdf","grobid_xml":"https://content.openalex.org/works/W2992227805.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1996582696","https://openalex.org/W2074862395","https://openalex.org/W2077404125","https://openalex.org/W2088125309","https://openalex.org/W2122091775","https://openalex.org/W2122341467","https://openalex.org/W2135082935","https://openalex.org/W2221239255","https://openalex.org/W2304223963","https://openalex.org/W2548637055","https://openalex.org/W2753044726","https://openalex.org/W2757416034","https://openalex.org/W2777957598","https://openalex.org/W2888909823","https://openalex.org/W2900171631","https://openalex.org/W2944790436","https://openalex.org/W3029421782"],"related_works":["https://openalex.org/W2944790436","https://openalex.org/W4391892095","https://openalex.org/W7133332953","https://openalex.org/W4391892134","https://openalex.org/W4414700278","https://openalex.org/W2973733841","https://openalex.org/W3009227836","https://openalex.org/W1985259535","https://openalex.org/W1851540829","https://openalex.org/W2611466812"],"abstract_inverted_index":{"Molecular":[0],"hydrogen":[1],"(H2)":[2],"is":[3,26],"recognized":[4],"as":[5,242,298],"a":[6,174,219,299],"medical":[7],"gas":[8],"applicable":[9],"to":[10,29,141,184,205,212,288,310],"numerous":[11],"diseases":[12],"including":[13],"neurodegenerative":[14],"diseases,":[15],"metabolic":[16],"disorders,":[17],"and":[18,83,276],"rheumatoid":[19],"arthritis.":[20],"Although":[21],"the":[22,34,37,50,55,60,62,70,102,118,128,146,162,170,195,237,257,302,306],"efficacy":[23,42],"of":[24,52,59,64,72,78,106,120,150,172,197,221,236,248,263,301],"H2":[25,53,73,151,230,254,266,282,295],"reportedly":[27],"attributed":[28],"its":[30,40],"scavenging":[31],"capability":[32],"against":[33],"hydroxyl":[35],"radical,":[36],"mechanisms":[38],"underlying":[39],"therapeutic":[41],"are":[43],"not":[44],"fully":[45],"understood.":[46],"Herein,":[47],"we":[48],"estimated":[49],"role":[51],"in":[54,117,127,145,271,274,280,292,314],"energy":[56],"converting":[57],"system":[58],"mitochondria,":[61],"source":[63],"reactive":[65],"oxygen":[66],"species.":[67],"To":[68],"investigate":[69],"effects":[71,149],"on":[74,152,256],"mitochondrial":[75,84,153,233,307],"function,":[76],"direction":[77,247],"electron":[79,90,95,143,249,303],"flow,":[80],"superoxide":[81,134,136,222,264,269,290],"generation,":[82],"membrane":[85,154,234,278,308],"potential":[86,155,235,279,309],"were":[87,156],"investigated.":[88],"Forward":[89],"transport":[91,96],"(FET)":[92],"or":[93,104,113],"reverse":[94],"(RET)":[97],"was":[98,139,177,251],"assessed":[99,243],"by":[100,135,158,189,202,218,228,240,244,253,261],"monitoring":[101],"decrease":[103],"increase":[105],"\u03b2-nicotinamide":[107,121],"adenine":[108,122],"dinucleotide":[109,123],"hydrate":[110],"(NADH,":[111],"-":[112],"+,":[114],"\u03bcM,":[115,216],"respectively)":[116],"presence":[119,196],"(NAD+)":[124],"and/or":[125],"succinate":[126,203],"isolated":[129],"mitochondria.":[130,147,315],"H2O2":[131],"converted":[132],"from":[133,207,225],"dismutase":[137],"(SOD)":[138],"measured":[140],"estimate":[142],"leakage":[144],"The":[148,246],"observed":[157,178],"staining":[159],"cells":[160,239],"with":[161],"fluorescence":[163],"probe,":[164],"teramethylrhodamine":[165],"ethyl":[166],"ester":[167],"(TMRE).":[168],"Despite":[169],"absence":[171],"succinate,":[173],"distinct":[175],"RET":[176,201],"(from":[179],"+0.0313":[180],"\u00b1":[181,186,209,214],"0.0106":[182],"\u03bcM":[183,192,199,211],"+1.20":[185],"0.302":[187],"\u03bcM)":[188],"adding":[190],"25":[191],"H2.":[193],"In":[194],"5":[198],"NADH,":[200],"inverted":[204],"FET":[206],"+1.62":[208],"0.358":[210],"\u22121.83":[213],"0.191":[215],"accompanied":[217,260],"suppression":[220,262],"generated":[223],"predominantly":[224],"complex":[226,272,293],"I":[227,273],"51.1%.":[229],"solely":[231],"reduced":[232],"cultured":[238],"11.3%":[241],"TMRE.":[245],"flow":[250,304],"altered":[252],"depending":[255],"NAD+/NADH":[258],"ratio,":[259],"generation":[265,270],"could":[267],"suppress":[268,311],"vitro":[275],"reduce":[277,289],"vivo.":[281],"may":[283,296],"also":[284],"neutralize":[285],"semiquinone":[286],"radicals":[287],"produced":[291],"III.":[294],"function":[297],"rectifier":[300],"affecting":[305],"oxidative":[312],"damage":[313]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-13T00:00:00"}
