{"id":"https://openalex.org/W29921653","doi":null,"title":"The use of recombinant human bone morphogenetic protein-2 for the repair of extraction socket defects: a technical modification and case series report.","display_name":"The use of recombinant human bone morphogenetic protein-2 for the repair of extraction socket defects: a technical modification and case series report.","publication_year":2010,"publication_date":"2010-11-01","ids":{"openalex":"https://openalex.org/W29921653","mag":"29921653","pmid":"https://pubmed.ncbi.nlm.nih.gov/21197504"},"language":"en","primary_location":{"id":"pmid:21197504","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21197504","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International journal of oral & maxillofacial implants","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080131774","display_name":"Craig M. Misch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Craig M Misch","raw_affiliation_strings":["New York University College of Dentistry, New York, New York, USA. misch@bonegraft.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University College of Dentistry, New York, New York, USA. misch@bonegraft.com","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5080131774"],"corresponding_institution_ids":["https://openalex.org/I57206974"],"apc_list":null,"apc_paid":null,"fwci":1.8647,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.81454346,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"25","issue":"6","first_page":"1246","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10359","display_name":"Dental Implant Techniques and Outcomes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10359","display_name":"Dental Implant Techniques and Outcomes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhbmp-2","display_name":"rhBMP-2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/bone-defects","display_name":"bone defects","score":0.382999986410141},{"id":"https://openalex.org/keywords/absorbable-collagen-sponge","display_name":"absorbable collagen sponge","score":0.8240000009536743},{"id":"https://openalex.org/keywords/bone-grafting","display_name":"bone grafting","score":0.6320000290870667},{"id":"https://openalex.org/keywords/dental-implants","display_name":"dental implants","score":0.6520000100135803},{"id":"https://openalex.org/keywords/maxillary-central-incisor","display_name":"maxillary central incisor","score":0.8479999899864197},{"id":"https://openalex.org/keywords/connective-tissue-graft","display_name":"connective tissue graft","score":0.8539999723434448},{"id":"https://openalex.org/keywords/primary-wound-closure","display_name":"primary closure","score":0.5130000114440918},{"id":"https://openalex.org/keywords/alveolar-bone-loss","display_name":"alveolar bone loss","score":0.621999979019165},{"id":"https://openalex.org/keywords/bone-augmentation","display_name":"bone augmentation","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7187763452529907},{"id":"https://openalex.org/C2992988709","wikidata":"https://www.wikidata.org/wiki/Q448692","display_name":"Alveolar crest","level":3,"score":0.6361058950424194},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.6203952431678772},{"id":"https://openalex.org/C30352789","wikidata":"https://www.wikidata.org/wiki/Q14903153","display_name":"Bone morphogenetic protein 2","level":3,"score":0.5479313731193542},{"id":"https://openalex.org/C151279780","wikidata":"https://www.wikidata.org/wiki/Q143588","display_name":"Dental alveolus","level":2,"score":0.543999969959259},{"id":"https://openalex.org/C518705261","wikidata":"https://www.wikidata.org/wiki/Q25615","display_name":"Connective tissue","level":2,"score":0.5209106802940369},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.4836246073246002},{"id":"https://openalex.org/C2985771010","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomographic","level":3,"score":0.4810678958892822},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.4780757427215576},{"id":"https://openalex.org/C195735259","wikidata":"https://www.wikidata.org/wiki/Q16963239","display_name":"Buccal administration","level":2,"score":0.4452035129070282},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.37444883584976196},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.16326478123664856},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.06294435262680054},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05942979454994202},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000540","descriptor_name":"Alveolar Ridge Augmentation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D001861","descriptor_name":"Bone Regeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003758","descriptor_name":"Dental Implantation, Endosseous","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013516","descriptor_name":"Oral Surgical Procedures, Preprosthetic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014081","descriptor_name":"Tooth Extraction","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016025","descriptor_name":"Bone Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016301","descriptor_name":"Alveolar Bone Loss","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016301","descriptor_name":"Alveolar Bone Loss","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D016301","descriptor_name":"Alveolar Bone Loss","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D020341","descriptor_name":"Absorbable Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020390","descriptor_name":"Tooth Socket","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D055396","descriptor_name":"Bone Morphogenetic Protein 2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055396","descriptor_name":"Bone Morphogenetic Protein 2","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:21197504","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21197504","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International journal of oral & maxillofacial implants","raw_type":"Journal Article"},{"id":"mag:29921653","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21197504","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.979200005531311,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1607870174","https://openalex.org/W1965945782","https://openalex.org/W1966575505","https://openalex.org/W1978922142","https://openalex.org/W1984348567","https://openalex.org/W1990675764","https://openalex.org/W2002775833","https://openalex.org/W2006725253","https://openalex.org/W2036779551","https://openalex.org/W2050973834","https://openalex.org/W2053383131","https://openalex.org/W2058922921","https://openalex.org/W2060277219","https://openalex.org/W2065994042","https://openalex.org/W2068876730","https://openalex.org/W2089965621","https://openalex.org/W2090910412","https://openalex.org/W2103864755","https://openalex.org/W2110252178","https://openalex.org/W2114437230","https://openalex.org/W2119002351","https://openalex.org/W2124338734","https://openalex.org/W2127396033","https://openalex.org/W2130125333","https://openalex.org/W2137740914","https://openalex.org/W2145173778","https://openalex.org/W2146170053","https://openalex.org/W2149216059","https://openalex.org/W2156059840","https://openalex.org/W2159172669","https://openalex.org/W2163551971","https://openalex.org/W2290788342","https://openalex.org/W2316319365","https://openalex.org/W2336176659","https://openalex.org/W2337071383","https://openalex.org/W2338740682","https://openalex.org/W2342528407","https://openalex.org/W2344547018","https://openalex.org/W2411540490","https://openalex.org/W2484479140","https://openalex.org/W2504568748","https://openalex.org/W2549879827","https://openalex.org/W2581615043","https://openalex.org/W2582629044","https://openalex.org/W2584273077","https://openalex.org/W2605937982","https://openalex.org/W2621555648","https://openalex.org/W2657509782","https://openalex.org/W2755293342","https://openalex.org/W2762929145","https://openalex.org/W2766312069","https://openalex.org/W2778077278","https://openalex.org/W2787871118","https://openalex.org/W3107962477","https://openalex.org/W4211260924","https://openalex.org/W4242426744"],"related_works":["https://openalex.org/W3133403562","https://openalex.org/W2032772487","https://openalex.org/W2753022706","https://openalex.org/W2018624742","https://openalex.org/W4405473102","https://openalex.org/W4410495070","https://openalex.org/W2332930973","https://openalex.org/W2975351189","https://openalex.org/W2094239268","https://openalex.org/W1998450715"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,36,54,75,85,174,188],"purpose":[2],"of":[3,12,29,95,107,111,134,151,176,190],"this":[4],"case":[5],"series":[6,56],"was":[7,39,44,115,178],"to":[8,104,185,199],"evaluate":[9],"the":[10,27,48,112,126,149,194,209],"use":[11,175],"recombinant":[13],"human":[14],"bone":[15,31,83,96,130,204],"morphogenetic":[16],"protein-2":[17],"(rhBMP-2)":[18],"in":[19,121,145,159,180],"an":[20],"absorbable":[21],"collagen":[22],"sponge":[23],"(ACS)":[24],"carrier":[25],"for":[26,128],"repair":[28],"significant":[30],"defects":[32,183],"following":[33],"tooth":[34],"removal.":[35],"surgical":[37],"technique":[38,210],"modified":[40],"because":[41],"primary":[42,191],"closure":[43,192],"not":[45,197],"obtained":[46,73],"over":[47,193],"grafted":[49,88,113,123],"sockets.":[50],"MATERIALS":[51],"AND":[52],"METHODS:":[53],"present":[55],"included":[57],"10":[58,163],"consecutively":[59],"treated":[60,65],"patients":[61],"with":[62,89,170],"failed":[63],"endodontically":[64],"maxillary":[66],"central":[67],"incisors.":[68],"Computed":[69],"tomographic":[70,139],"scans":[71,140],"were":[72,87,100,119,157,168],"preoperatively.":[74],"extraction":[76],"sockets":[77,86,114],"all":[78,122],"had":[79],">":[80],"50%":[81],"buccal":[82],"loss.":[84],"rhBMP-2/ACS":[90,177],"and":[91,136,167,211],"a":[92,142],"small":[93],"amount":[94],"substitute.":[97],"Dental":[98,117],"implants":[99,118,164],"inserted":[101],"after":[102],"4":[103],"6":[105],"months":[106],"healing.":[108],"RESULTS:":[109],"Healing":[110],"uneventful.":[116],"placed":[120,158],"sites":[124],"without":[125],"need":[127],"further":[129],"augmentation.":[131],"A":[132],"comparison":[133],"preoperative":[135],"postgrafting":[137],"computed":[138],"found":[141],"slight":[143],"loss":[144],"alveolar":[146],"width":[147],"at":[148],"crest":[150],"1.07":[152],"mm.":[153],"Connective":[154],"tissue":[155],"grafts":[156],"five":[160],"patients.":[161],"All":[162],"integrated":[165],"well":[166],"restored":[169],"single":[171],"crowns.":[172],"CONCLUSIONS:":[173],"effective":[179],"repairing":[181],"osseous":[182],"prior":[184],"implant":[186],"placement.":[187],"lack":[189],"graft":[195],"did":[196],"appear":[198],"complicate":[200],"healing":[201],"or":[202],"compromise":[203],"growth.":[205],"This":[206],"modification":[207],"simplifies":[208],"may":[212],"reduce":[213],"postoperative":[214],"morbidity":[215],"caused":[216],"by":[217],"flap":[218],"manipulation.":[219]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}