{"id":"https://openalex.org/W2992091908","doi":"https://doi.org/10.21292/2075-1230-2015-0-4-18-23","title":"Heterogeneity of Mycobacterium tuberculosis drug resistance in respect of pharmacokinetics of anti-tuberculosis drugs as a basis for individual treatment regimen","display_name":"Heterogeneity of Mycobacterium tuberculosis drug resistance in respect of pharmacokinetics of anti-tuberculosis drugs as a basis for individual treatment regimen","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W2992091908","doi":"https://doi.org/10.21292/2075-1230-2015-0-4-18-23","mag":"2992091908"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:b85c40754bc0440199978b5bc1c74ebf","doi":"https://doi.org/10.21292/2075-1230-2015-0-4-18-23","is_oa":true,"landing_page_url":"https://doaj.org/article/b85c40754bc0440199978b5bc1c74ebf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0422\u0443\u0431\u0435\u0440\u043a\u0443\u043b\u0435\u0437 \u0438 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u043b\u0451\u0433\u043a\u0438\u0445, Vol 0, Iss 4, Pp 18-23 (2015)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/b85c40754bc0440199978b5bc1c74ebf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049640767","display_name":"S. A. Popov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"S. A. Popov","raw_affiliation_strings":["\u041d\u0418\u0418 \u0444\u0442\u0438\u0437\u0438\u043e\u043f\u0443\u043b\u044c\u043c\u043e\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0413\u0411\u041e\u0423 \u0412\u041f\u041e \u00ab\u041f\u0435\u0440\u0432\u044b\u0439 \u041c\u0413\u041c\u0423 \u0438\u043c. \u0418. \u041c. \u0421\u0435\u0447\u0435\u043d\u043e\u0432\u0430\u00bb \u041c\u0417 \u0420\u0424"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u041d\u0418\u0418 \u0444\u0442\u0438\u0437\u0438\u043e\u043f\u0443\u043b\u044c\u043c\u043e\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0413\u0411\u041e\u0423 \u0412\u041f\u041e \u00ab\u041f\u0435\u0440\u0432\u044b\u0439 \u041c\u0413\u041c\u0423 \u0438\u043c. \u0418. \u041c. \u0421\u0435\u0447\u0435\u043d\u043e\u0432\u0430\u00bb \u041c\u0417 \u0420\u0424","institution_ids":["https://openalex.org/I17877952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112330361","display_name":"\u0422. \u041f. \u0421\u0430\u0431\u0433\u0430\u0439\u0434\u0430","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"T. P. Sabgaida","raw_affiliation_strings":["\u041d\u0418\u0418 \u0444\u0442\u0438\u0437\u0438\u043e\u043f\u0443\u043b\u044c\u043c\u043e\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0413\u0411\u041e\u0423 \u0412\u041f\u041e \u00ab\u041f\u0435\u0440\u0432\u044b\u0439 \u041c\u0413\u041c\u0423 \u0438\u043c. \u0418. \u041c. \u0421\u0435\u0447\u0435\u043d\u043e\u0432\u0430\u00bb \u041c\u0417 \u0420\u0424, \u0433. \u041c\u043e\u0441\u043a\u0432\u0430; \u0424\u0413\u0411\u0423 \u00ab\u0426\u0435\u043d\u0442\u0440\u0430\u043b\u044c\u043d\u044b\u0439 \u041d\u0418\u0418 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u0430\u0446\u0438\u0438 \u0438 \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0442\u0438\u0437\u0430\u0446\u0438\u0438 \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044f\u00bb \u041c\u0417 \u0420\u0424, \u0433. \u041c\u043e\u0441\u043a\u0432\u0430"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u041d\u0418\u0418 \u0444\u0442\u0438\u0437\u0438\u043e\u043f\u0443\u043b\u044c\u043c\u043e\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0413\u0411\u041e\u0423 \u0412\u041f\u041e \u00ab\u041f\u0435\u0440\u0432\u044b\u0439 \u041c\u0413\u041c\u0423 \u0438\u043c. \u0418. \u041c. \u0421\u0435\u0447\u0435\u043d\u043e\u0432\u0430\u00bb \u041c\u0417 \u0420\u0424, \u0433. \u041c\u043e\u0441\u043a\u0432\u0430; \u0424\u0413\u0411\u0423 \u00ab\u0426\u0435\u043d\u0442\u0440\u0430\u043b\u044c\u043d\u044b\u0439 \u041d\u0418\u0418 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u0430\u0446\u0438\u0438 \u0438 \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0442\u0438\u0437\u0430\u0446\u0438\u0438 \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044f\u00bb \u041c\u0417 \u0420\u0424, \u0433. \u041c\u043e\u0441\u043a\u0432\u0430","institution_ids":["https://openalex.org/I17877952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107799354","display_name":"G. N. Mozkokina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"G. N. Mozkokina","raw_affiliation_strings":["\u041d\u0418\u0418 \u0444\u0442\u0438\u0437\u0438\u043e\u043f\u0443\u043b\u044c\u043c\u043e\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0413\u0411\u041e\u0423 \u0412\u041f\u041e \u00ab\u041f\u0435\u0440\u0432\u044b\u0439 \u041c\u0413\u041c\u0423 \u0438\u043c. \u0418. \u041c. \u0421\u0435\u0447\u0435\u043d\u043e\u0432\u0430\u00bb \u041c\u0417 \u0420\u0424, \u0433. \u041c\u043e\u0441\u043a\u0432\u0430"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u041d\u0418\u0418 \u0444\u0442\u0438\u0437\u0438\u043e\u043f\u0443\u043b\u044c\u043c\u043e\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0413\u0411\u041e\u0423 \u0412\u041f\u041e \u00ab\u041f\u0435\u0440\u0432\u044b\u0439 \u041c\u0413\u041c\u0423 \u0438\u043c. \u0418. \u041c. \u0421\u0435\u0447\u0435\u043d\u043e\u0432\u0430\u00bb \u041c\u0417 \u0420\u0424, \u0433. \u041c\u043e\u0441\u043a\u0432\u0430","institution_ids":["https://openalex.org/I17877952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101818083","display_name":"Alexey V. Ku\u017amin","orcid":"https://orcid.org/0000-0001-8218-4058","observed_orcids":["https://orcid.org/0000-0001-8218-4058"]},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. V. Kuzmin","raw_affiliation_strings":["\u041d\u0418\u0418 \u0444\u0442\u0438\u0437\u0438\u043e\u043f\u0443\u043b\u044c\u043c\u043e\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0413\u0411\u041e\u0423 \u0412\u041f\u041e \u00ab\u041f\u0435\u0440\u0432\u044b\u0439 \u041c\u0413\u041c\u0423 \u0438\u043c. \u0418. \u041c. \u0421\u0435\u0447\u0435\u043d\u043e\u0432\u0430\u00bb \u041c\u0417 \u0420\u0424, \u0433. \u041c\u043e\u0441\u043a\u0432\u0430"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u041d\u0418\u0418 \u0444\u0442\u0438\u0437\u0438\u043e\u043f\u0443\u043b\u044c\u043c\u043e\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0413\u0411\u041e\u0423 \u0412\u041f\u041e \u00ab\u041f\u0435\u0440\u0432\u044b\u0439 \u041c\u0413\u041c\u0423 \u0438\u043c. \u0418. \u041c. \u0421\u0435\u0447\u0435\u043d\u043e\u0432\u0430\u00bb \u041c\u0417 \u0420\u0424, \u0433. \u041c\u043e\u0441\u043a\u0432\u0430","institution_ids":["https://openalex.org/I17877952"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040569551","display_name":"N. V. Stavitskaya","orcid":"https://orcid.org/0000-0003-2616-6693","observed_orcids":["https://orcid.org/0000-0003-2616-6693"]},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N. V. Stavitskaya","raw_affiliation_strings":["\u041d\u0418\u0418 \u0444\u0442\u0438\u0437\u0438\u043e\u043f\u0443\u043b\u044c\u043c\u043e\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0413\u0411\u041e\u0423 \u0412\u041f\u041e \u00ab\u041f\u0435\u0440\u0432\u044b\u0439 \u041c\u0413\u041c\u0423 \u0438\u043c. \u0418. \u041c. \u0421\u0435\u0447\u0435\u043d\u043e\u0432\u0430\u00bb \u041c\u0417 \u0420\u0424, \u0433. \u041c\u043e\u0441\u043a\u0432\u0430"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u041d\u0418\u0418 \u0444\u0442\u0438\u0437\u0438\u043e\u043f\u0443\u043b\u044c\u043c\u043e\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0413\u0411\u041e\u0423 \u0412\u041f\u041e \u00ab\u041f\u0435\u0440\u0432\u044b\u0439 \u041c\u0413\u041c\u0423 \u0438\u043c. \u0418. \u041c. \u0421\u0435\u0447\u0435\u043d\u043e\u0432\u0430\u00bb \u041c\u0417 \u0420\u0424, \u0433. \u041c\u043e\u0441\u043a\u0432\u0430","institution_ids":["https://openalex.org/I17877952"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I17877952"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/drug-resistant-tuberculosis","display_name":"drug-resistant tuberculosis","score":0.8489999771118164},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7360000014305115},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.8360000252723694},{"id":"https://openalex.org/keywords/individualized-treatment-regimens","display_name":"individualized treatment regimens","score":0.8220000267028809},{"id":"https://openalex.org/keywords/population-heterogeneity","display_name":"population heterogeneity","score":0.8040000200271606},{"id":"https://openalex.org/keywords/antituberculosis-drugs","display_name":"antitubercular agents","score":0.890999972820282},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.6121715307235718},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5641240477561951},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5167083740234375},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.5060784220695496},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.43138957023620605},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.35170674324035645},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34739720821380615},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.15565377473831177},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13553839921951294},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09604457020759583},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.070749431848526},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.059158653020858765},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:doaj.org/article:b85c40754bc0440199978b5bc1c74ebf","doi":"https://doi.org/10.21292/2075-1230-2015-0-4-18-23","is_oa":true,"landing_page_url":"https://doaj.org/article/b85c40754bc0440199978b5bc1c74ebf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0422\u0443\u0431\u0435\u0440\u043a\u0443\u043b\u0435\u0437 \u0438 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u043b\u0451\u0433\u043a\u0438\u0445, Vol 0, Iss 4, Pp 18-23 (2015)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:b85c40754bc0440199978b5bc1c74ebf","doi":"https://doi.org/10.21292/2075-1230-2015-0-4-18-23","is_oa":true,"landing_page_url":"https://doaj.org/article/b85c40754bc0440199978b5bc1c74ebf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0422\u0443\u0431\u0435\u0440\u043a\u0443\u043b\u0435\u0437 \u0438 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u043b\u0451\u0433\u043a\u0438\u0445, Vol 0, Iss 4, Pp 18-23 (2015)","raw_type":"article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3025172526","https://openalex.org/W3094525616","https://openalex.org/W4416823721","https://openalex.org/W2509765170","https://openalex.org/W2552450186","https://openalex.org/W2037340930","https://openalex.org/W173845416","https://openalex.org/W2774397080","https://openalex.org/W4214618564","https://openalex.org/W2806252171"],"abstract_inverted_index":{"This":[0],"article":[1,54],"analyzes":[2],"the":[3,17,23,39,51,61,66,72],"ways":[4],"of":[5,29,41,50,57,63,71,77,80],"treatment":[6,19],"efficacy":[7],"enhancement":[8],"in":[9],"drug":[10],"resistant":[11],"tuberculosis":[12,31],"patients":[13],"through":[14],"transfer":[15],"to":[16,43,84],"individual":[18,47],"regimens":[20],"basing":[21],"on":[22],"objective":[24],"laboratory":[25],"data.":[26],"The":[27,53],"presence":[28],"M.":[30],"population":[32],"heterogeneity":[33],"has":[34],"been":[35],"demonstrated":[36],"as":[37],"per":[38],"degree":[40],"resistance":[42,74],"different":[44],"drugs":[45,82],"relating":[46],"pharmacokinetic":[48],"features":[49],"patients.":[52],"includes":[55],"discussion":[56],"technical":[58],"opportunities":[59],"for":[60,68],"implementation":[62],"such":[64],"approach,":[65],"need":[67],"detail":[69],"evaluation":[70],"germ":[73],"and":[75,87],"limits":[76],"effective":[78],"action":[79],"anti-tuberculosis":[81],"related":[83],"their":[85],"pharmacokinetics":[86],"pharmacogenetics.":[88]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2019-12-13T00:00:00"}