{"id":"https://openalex.org/W2992012281","doi":"https://doi.org/10.1038/s41698-019-0105-2","title":"Synchronous inhibition of mTOR and VEGF/NRP1 axis impedes tumor growth and metastasis in renal cancer","display_name":"Synchronous inhibition of mTOR and VEGF/NRP1 axis impedes tumor growth and metastasis in renal cancer","publication_year":2019,"publication_date":"2019-12-05","ids":{"openalex":"https://openalex.org/W2992012281","doi":"https://doi.org/10.1038/s41698-019-0105-2","mag":"2992012281","pmid":"https://pubmed.ncbi.nlm.nih.gov/31840081","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6895165"},"language":"en","primary_location":{"id":"doi:10.1038/s41698-019-0105-2","doi":"https://doi.org/10.1038/s41698-019-0105-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41698-019-0105-2","pdf_url":"https://www.nature.com/articles/s41698-019-0105-2.pdf","source":{"id":"https://openalex.org/S4210211538","display_name":"npj Precision Oncology","issn_l":"2397-768X","issn":["2397-768X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Precision Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41698-019-0105-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076648985","display_name":"Krishnendu Pal","orcid":"https://orcid.org/0000-0002-4006-213X","observed_orcids":["https://orcid.org/0000-0002-4006-213X"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krishnendu Pal","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Mayo Clinic Florida, 4500 San Pablo Road S, Jacksonville, FL, 32224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Mayo Clinic Florida, 4500 San Pablo Road S, Jacksonville, FL, 32224, USA","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008773303","display_name":"Vijay Sagar Madamsetty","orcid":"https://orcid.org/0000-0001-9883-190X","observed_orcids":["https://orcid.org/0000-0001-9883-190X"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vijay Sagar Madamsetty","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Mayo Clinic Florida, 4500 San Pablo Road S, Jacksonville, FL, 32224, USA"],"raw_orcid":"https://orcid.org/0000-0001-9883-190X","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Mayo Clinic Florida, 4500 San Pablo Road S, Jacksonville, FL, 32224, USA","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074232729","display_name":"Shamit Kumar Dutta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shamit Kumar Dutta","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Mayo Clinic Florida, 4500 San Pablo Road S, Jacksonville, FL, 32224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Mayo Clinic Florida, 4500 San Pablo Road S, Jacksonville, FL, 32224, USA","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068240871","display_name":"Enfeng Wang","orcid":"https://orcid.org/0009-0002-8676-3801","observed_orcids":["https://orcid.org/0009-0002-8676-3801"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Enfeng Wang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Mayo Clinic Florida, 4500 San Pablo Road S, Jacksonville, FL, 32224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Mayo Clinic Florida, 4500 San Pablo Road S, Jacksonville, FL, 32224, USA","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012791952","display_name":"Ramcharan Singh Angom","orcid":"https://orcid.org/0000-0002-5894-1108","observed_orcids":["https://orcid.org/0000-0002-5894-1108"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramcharan Singh Angom","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Mayo Clinic Florida, 4500 San Pablo Road S, Jacksonville, FL, 32224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Mayo Clinic Florida, 4500 San Pablo Road S, Jacksonville, FL, 32224, USA","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060391092","display_name":"Debabrata Mukhopadhyay","orcid":"https://orcid.org/0000-0003-1858-5054","observed_orcids":["https://orcid.org/0000-0003-1858-5054"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Debabrata Mukhopadhyay","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Mayo Clinic Florida, 4500 San Pablo Road S, Jacksonville, FL, 32224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Mayo Clinic Florida, 4500 San Pablo Road S, Jacksonville, FL, 32224, USA","institution_ids":["https://openalex.org/I4210146710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5060391092"],"corresponding_institution_ids":["https://openalex.org/I4210146710"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":1.6538,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.84302008,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"3","issue":"1","first_page":"31","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"clear cell renal cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mtor-inhibition","display_name":"mTOR inhibition","score":0.9319999814033508},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.7720000147819519},{"id":"https://openalex.org/keywords/neuropilin-1","display_name":"neuropilin-1","score":0.8130000233650208},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.7720000147819519},{"id":"https://openalex.org/keywords/everolimus","display_name":"everolimus","score":0.972000002861023},{"id":"https://openalex.org/keywords/liposomal-drug-delivery","display_name":"liposomal drug delivery","score":0.8569999933242798},{"id":"https://openalex.org/keywords/tumor-targeting-peptides","display_name":"tumor-targeting peptides","score":0.9700000286102295},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6729999780654907},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7056424021720886},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6064622402191162},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5728861093521118},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5416032075881958},{"id":"https://openalex.org/C2779699572","wikidata":"https://www.wikidata.org/wiki/Q421052","display_name":"Everolimus","level":2,"score":0.5049307942390442},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.357219934463501},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34686511754989624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.329107403755188},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32270607352256775},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.22653210163116455},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20689669251441956},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18170207738876343},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.12030518054962158}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41698-019-0105-2","doi":"https://doi.org/10.1038/s41698-019-0105-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41698-019-0105-2","pdf_url":"https://www.nature.com/articles/s41698-019-0105-2.pdf","source":{"id":"https://openalex.org/S4210211538","display_name":"npj Precision Oncology","issn_l":"2397-768X","issn":["2397-768X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Precision Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6895165","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6895165","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ Precis Oncol","raw_type":"Text"},{"id":"pmid:31840081","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31840081","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ precision oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:1e9284e8e78446b9bc8d087be5506885","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/1e9284e8e78446b9bc8d087be5506885","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Precision Oncology, Vol 3, Iss 1, Pp 1-11 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41698-019-0105-2","doi":"https://doi.org/10.1038/s41698-019-0105-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41698-019-0105-2","pdf_url":"https://www.nature.com/articles/s41698-019-0105-2.pdf","source":{"id":"https://openalex.org/S4210211538","display_name":"npj Precision Oncology","issn_l":"2397-768X","issn":["2397-768X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Precision Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1727436225","display_name":null,"funder_award_id":"CA78383","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G2706384329","display_name":null,"funder_award_id":"R01-CA150190","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5007289846","display_name":"Targeting Pancreatic Cancer Using Peptide Chemistry: From Bench to Bedside","funder_award_id":"5r01ca150190-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G615882648","display_name":null,"funder_award_id":"CA150190","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G6828637803","display_name":"REGULATORY PATHWAYS AND ROLE OF VPF/VEGF IN RENAL CANCER","funder_award_id":"R29CA078383","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G758939006","display_name":null,"funder_award_id":"Florida #3J","funder_id":"https://openalex.org/F4320309360","funder_display_name":"Florida Department of Health"},{"id":"https://openalex.org/G8955017435","display_name":"Regulatory Pathways and Role of VPF/VEGF in Renal Cancer","funder_award_id":"R01CA078383","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000083088","display_name":null,"funder_award_id":"CA150190","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000095913","display_name":null,"funder_award_id":"CA78383","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320309360","display_name":"Florida Department of Health","ror":"https://ror.org/03e1xkn26"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2992012281.pdf","grobid_xml":"https://content.openalex.org/works/W2992012281.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W32167704","https://openalex.org/W1967114357","https://openalex.org/W1975638707","https://openalex.org/W1978139448","https://openalex.org/W1980969801","https://openalex.org/W1994001783","https://openalex.org/W1998254898","https://openalex.org/W2003240567","https://openalex.org/W2011841073","https://openalex.org/W2017322644","https://openalex.org/W2020102380","https://openalex.org/W2022728604","https://openalex.org/W2024036382","https://openalex.org/W2026144900","https://openalex.org/W2026351725","https://openalex.org/W2029336551","https://openalex.org/W2036237251","https://openalex.org/W2038781838","https://openalex.org/W2040329251","https://openalex.org/W2045384974","https://openalex.org/W2049689068","https://openalex.org/W2050003881","https://openalex.org/W2056347516","https://openalex.org/W2059239871","https://openalex.org/W2061181552","https://openalex.org/W2064072638","https://openalex.org/W2067755505","https://openalex.org/W2067955850","https://openalex.org/W2073045469","https://openalex.org/W2083670478","https://openalex.org/W2086347143","https://openalex.org/W2087137617","https://openalex.org/W2091939762","https://openalex.org/W2092440654","https://openalex.org/W2095445076","https://openalex.org/W2102624911","https://openalex.org/W2111378135","https://openalex.org/W2119690971","https://openalex.org/W2125505202","https://openalex.org/W2127931911","https://openalex.org/W2131473365","https://openalex.org/W2134131507","https://openalex.org/W2139178962","https://openalex.org/W2143463421","https://openalex.org/W2150173979","https://openalex.org/W2150594590","https://openalex.org/W2155142470","https://openalex.org/W2168069492","https://openalex.org/W2222086386","https://openalex.org/W2265610272","https://openalex.org/W2269017219","https://openalex.org/W2288326375","https://openalex.org/W2289446148","https://openalex.org/W2323986471","https://openalex.org/W2326645579","https://openalex.org/W2345614766","https://openalex.org/W2397615757","https://openalex.org/W2486397717","https://openalex.org/W2492058432","https://openalex.org/W2516305484","https://openalex.org/W2568364351","https://openalex.org/W2570909166","https://openalex.org/W2593056343","https://openalex.org/W2593816418","https://openalex.org/W2623822591","https://openalex.org/W2626666302","https://openalex.org/W2761867567","https://openalex.org/W2763712070","https://openalex.org/W2765989466","https://openalex.org/W2770247709","https://openalex.org/W2770458596","https://openalex.org/W2792937256","https://openalex.org/W2797992261","https://openalex.org/W2887790253","https://openalex.org/W2911188335","https://openalex.org/W2911812451","https://openalex.org/W2913745075","https://openalex.org/W2961407677"],"related_works":["https://openalex.org/W7100513985","https://openalex.org/W2057068676","https://openalex.org/W2083513799","https://openalex.org/W2121754497","https://openalex.org/W2003470917","https://openalex.org/W3162381294","https://openalex.org/W1519191891","https://openalex.org/W2063526820","https://openalex.org/W2071263415","https://openalex.org/W2594797044"],"abstract_inverted_index":{"Clear":[0],"cell":[1,3],"renal":[2],"carcinoma":[4],"(ccRCC)":[5],"is":[6,14,95,110],"known":[7,27,96,111],"for":[8,40,52,134],"its":[9],"highly":[10,220],"vascular":[11,20,29],"phenotype":[12],"which":[13],"associated":[15],"with":[16,153],"elevated":[17],"expression":[18],"of":[19,90,105,137,142,215,226],"endothelial":[21,119],"growth":[22,183,217],"factor":[23,31],"A":[24],"(VEGF),":[25],"also":[26,147],"as":[28],"permeability":[30],"(VPF).":[32],"Accordingly,":[33],"VEGF":[34,57,67,101],"has":[35],"been":[36,50],"an":[37,237],"attractive":[38],"target":[39,89],"antiangiogenic":[41,54],"therapies":[42],"in":[43,100,118,164,178,181,193,204,207,218,229,245],"ccRCC.":[44,246],"Two":[45],"major":[46],"strategies":[47],"have":[48],"hitherto":[49],"utilized":[51,82],"VEGF-targeted":[53],"therapies:":[55],"targeting":[56,65,87],"by":[58],"antibodies,":[59],"ligand":[60],"traps":[61],"or":[62,72],"aptamers,":[63],"and":[64,103,115,120,126,139,173,180,191,198],"the":[66,78,135,140,186],"receptor":[68],"signaling":[69,117],"via":[70],"antibodies":[71],"small-molecule":[73,128],"tyrosine-kinase":[74],"inhibitors":[75],"(TKIs).":[76],"In":[77,209],"present":[79],"article":[80],"we":[81],"two":[83,162,194],"entirely":[84],"different":[85,195],"approaches:":[86],"mammalian":[88],"rapamycin":[91],"(mTOR)":[92],"pathway":[93],"that":[94,109],"to":[97,112,158,200,240],"be":[98],"involved":[99],"synthesis,":[102],"disruption":[104,141],"VEGF/Neuroplin-1":[106],"(NRP1)":[107],"axis":[108],"activate":[113],"proangiogenic":[114],"pro-tumorigenic":[116],"tumor":[121,216],"cells,":[122],"respectively.":[123,145],"Everolimus":[124,172],"(E)":[125],"a":[127,149,154,165,201,219],"inhibitor":[129],"EG00229":[130,174],"(G)":[131],"were":[132],"used":[133],"inhibition":[136,214],"mTOR":[138],"VEGF/NRP1":[143],"axis,":[144],"We":[146],"exploited":[148],"liposomal":[150],"formulation":[151],"decorated":[152],"proprietary":[155],"tumor-targeting-peptide":[156],"(TTP)":[157],"simultaneously":[159],"deliver":[160],"these":[161],"agents":[163],"tumor-targeted":[166],"manner.":[167],"The":[168],"TTP-liposomes":[169],"encapsulating":[170],"both":[171],"(EG-L)":[175],"demonstrated":[176],"higher":[177],"vitro":[179],"vivo":[182],"retardation":[184],"than":[185],"single":[187],"drug-loaded":[188],"liposomes":[189],"(E-L":[190],"G-L)":[192],"ccRCC":[196,227],"models":[197],"led":[199],"noticeable":[202],"reduction":[203],"lung":[205],"metastasis":[206],"vivo.":[208],"addition,":[210],"EG-L":[211],"displayed":[212],"remarkable":[213],"aggressive":[221],"syngeneic":[222],"immune-competent":[223],"mouse":[224],"model":[225],"developed":[228],"Balb/c":[230],"mice.":[231],"Taken":[232],"together,":[233],"this":[234],"study":[235],"demonstrates":[236],"effective":[238],"approach":[239],"achieve":[241],"improved":[242],"therapeutic":[243],"outcome":[244]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":7}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-12-13T00:00:00"}
