{"id":"https://openalex.org/W2991990868","doi":"https://doi.org/10.2217/ijh-2019-0009","title":"Rational Targeted Therapeutics for Double-Hit Lymphoma","display_name":"Rational Targeted Therapeutics for Double-Hit Lymphoma","publication_year":2019,"publication_date":"2019-11-01","ids":{"openalex":"https://openalex.org/W2991990868","doi":"https://doi.org/10.2217/ijh-2019-0009","mag":"2991990868","pmid":"https://pubmed.ncbi.nlm.nih.gov/31850145","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6912852"},"language":"en","primary_location":{"id":"doi:10.2217/ijh-2019-0009","doi":"https://doi.org/10.2217/ijh-2019-0009","is_oa":true,"landing_page_url":"https://doi.org/10.2217/ijh-2019-0009","pdf_url":"https://www.futuremedicine.com/doi/pdf/10.2217/ijh-2019-0009","source":{"id":"https://openalex.org/S2765011716","display_name":"International Journal of Hematologic Oncology","issn_l":"2045-1393","issn":["2045-1393","2045-1407"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Hematologic Oncology","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.futuremedicine.com/doi/pdf/10.2217/ijh-2019-0009","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029181255","display_name":"Nancy G. Azizian","orcid":"https://orcid.org/0000-0002-1158-0608","observed_orcids":["https://orcid.org/0000-0002-1158-0608"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy G Azizian","raw_affiliation_strings":["Center for Immunotherapy Research, Houston Methodist Research Institute, Houston, TX 77030, USA","Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA","Center for Immunotherapy Research, Houston Methodist Research Institute, Houston, TX 77030, USADepartment of Medicine, Weill Cornell Medical College, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunotherapy Research, Houston Methodist Research Institute, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]},{"raw_affiliation_string":"Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Center for Immunotherapy Research, Houston Methodist Research Institute, Houston, TX 77030, USADepartment of Medicine, Weill Cornell Medical College, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466","https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuanhui Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanhui Liu","raw_affiliation_strings":["Center for Immunotherapy Research, Houston Methodist Research Institute, Houston, TX 77030, USA","Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA","Center for Immunotherapy Research, Houston Methodist Research Institute, Houston, TX 77030, USADepartment of Medicine, Weill Cornell Medical College, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunotherapy Research, Houston Methodist Research Institute, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]},{"raw_affiliation_string":"Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Center for Immunotherapy Research, Houston Methodist Research Institute, Houston, TX 77030, USADepartment of Medicine, Weill Cornell Medical College, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466","https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111796881","display_name":"Lan V. Pham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lan V Pham","raw_affiliation_strings":["Department of Hematopathology, Division of Pathology & Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematopathology, Division of Pathology & Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":null,"display_name":"Yulin Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yulin Li","raw_affiliation_strings":["Center for Immunotherapy Research, Houston Methodist Research Institute, Houston, TX 77030, USA","Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunotherapy Research, Houston Methodist Research Institute, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]},{"raw_affiliation_string":"Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4387153466","https://openalex.org/I4405286254"],"apc_list":{"value":1415,"currency":"USD","value_usd":1415},"apc_paid":{"value":1415,"currency":"USD","value_usd":1415},"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"3","first_page":"IJH19","last_page":"IJH19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/double-hit-lymphoma","display_name":"double-hit lymphoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/myc-translocation","display_name":"MYC translocation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/bcl2-translocation","display_name":"BCL2 translocation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cancer-driver-genes","display_name":"cancer driver genes","score":0.8040000200271606},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.906000018119812},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8487598896026611},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.531897783279419},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5262907147407532},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.5135853290557861},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.4342384934425354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22607386112213135},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.16119590401649475},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13738352060317993},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11900368332862854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07347995042800903}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.2217/ijh-2019-0009","doi":"https://doi.org/10.2217/ijh-2019-0009","is_oa":true,"landing_page_url":"https://doi.org/10.2217/ijh-2019-0009","pdf_url":"https://www.futuremedicine.com/doi/pdf/10.2217/ijh-2019-0009","source":{"id":"https://openalex.org/S2765011716","display_name":"International Journal of Hematologic Oncology","issn_l":"2045-1393","issn":["2045-1393","2045-1407"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Hematologic Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6912852","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6912852","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Hematol Oncol","raw_type":"Text"},{"id":"pmid:31850145","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31850145","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of hematologic oncology","raw_type":"Editorial"},{"id":"pmh:oai:doaj.org/article:d06cf3d574484d32928d3391a1dc040c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d06cf3d574484d32928d3391a1dc040c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Hematologic Oncology, Vol 8, Iss 3 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.2217/ijh-2019-0009","doi":"https://doi.org/10.2217/ijh-2019-0009","is_oa":true,"landing_page_url":"https://doi.org/10.2217/ijh-2019-0009","pdf_url":"https://www.futuremedicine.com/doi/pdf/10.2217/ijh-2019-0009","source":{"id":"https://openalex.org/S2765011716","display_name":"International Journal of Hematologic Oncology","issn_l":"2045-1393","issn":["2045-1393","2045-1407"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Hematologic Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5383650987","display_name":"The Role of Suv420h1 Histone Methyltransferase in MYC-Driven Tumorigenesis","funder_award_id":"K22CA207598","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2991990868.pdf","grobid_xml":"https://content.openalex.org/works/W2991990868.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1712566393","https://openalex.org/W1929028280","https://openalex.org/W1979840572","https://openalex.org/W1999025078","https://openalex.org/W2018571395","https://openalex.org/W2028850684","https://openalex.org/W2048679391","https://openalex.org/W2054149360","https://openalex.org/W2056755041","https://openalex.org/W2058743530","https://openalex.org/W2125833389","https://openalex.org/W2130649080","https://openalex.org/W2310716991","https://openalex.org/W2602169105","https://openalex.org/W2771344728","https://openalex.org/W2794340145","https://openalex.org/W2801331982","https://openalex.org/W2902608107","https://openalex.org/W2905980862","https://openalex.org/W2991331711"],"related_works":["https://openalex.org/W2994108273","https://openalex.org/W4220865566","https://openalex.org/W2991331711","https://openalex.org/W2960184952","https://openalex.org/W1996326223","https://openalex.org/W2097561270","https://openalex.org/W7097293768","https://openalex.org/W2235200284","https://openalex.org/W2666179132","https://openalex.org/W2348786255"],"abstract_inverted_index":{"Due":[0],"to":[1],"simultaneous":[2],"activation":[3],"of":[4,36],"these":[5],"driver":[6,38],"oncogenes,":[7],"DHLs":[8],"are":[9],"among":[10],"the":[11,37],"most":[12],"aggressive":[13],"and":[14,26],"chemoresistant":[15],"lymphoma":[16],"subtypes":[17],"with":[18,24],"minimal":[19],"treatment":[20],"options":[21],"\"\"Double-hit":[22],"lymphomas":[23],"MYC":[25],"BCL2":[27],"translocations":[28],"can":[29],"be":[30],"effectively":[31],"treated":[32],"by":[33],"combined":[34],"targeting":[35],"oncogenes\".":[39]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-12-13T00:00:00"}