{"id":"https://openalex.org/W2991986217","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.e20588","title":"The molecular and immune characteristics, antitumor activity of crizotinib in non-small cell lung cancer (NSCLC) patients with MET exon 14 skipping alterations.","display_name":"The molecular and immune characteristics, antitumor activity of crizotinib in non-small cell lung cancer (NSCLC) patients with MET exon 14 skipping alterations.","publication_year":2019,"publication_date":"2019-05-20","ids":{"openalex":"https://openalex.org/W2991986217","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.e20588","mag":"2991986217"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2019.37.15_suppl.e20588","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.e20588","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2019.37.15_suppl.e20588","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109525483","display_name":"Jiadi Gan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiadi Gan","raw_affiliation_strings":["Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China;","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101713307","display_name":"Wenfeng Fang","orcid":"https://orcid.org/0000-0002-6440-8246","observed_orcids":["https://orcid.org/0000-0002-6440-8246"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenfeng Fang","raw_affiliation_strings":["State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China;","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027373861","display_name":"Weineng Feng","orcid":"https://orcid.org/0000-0001-5453-8605","observed_orcids":["https://orcid.org/0000-0001-5453-8605"]},"institutions":[{"id":"https://openalex.org/I4210105740","display_name":"First People's Hospital of Foshan","ror":"https://ror.org/01cqwmh55","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weineng Feng","raw_affiliation_strings":["Department of Head and Neck/Thoracic Oncology, The First People's Hospital of Foshan, Foshan, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head and Neck/Thoracic Oncology, The First People's Hospital of Foshan, Foshan, China;","institution_ids":["https://openalex.org/I4210105740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049965913","display_name":"Jiexia Zhang","orcid":"https://orcid.org/0000-0002-2254-862X","observed_orcids":["https://orcid.org/0000-0002-2254-862X"]},"institutions":[{"id":"https://openalex.org/I4210098361","display_name":"First Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00z0j0d77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098361"]},{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I4405273215","display_name":"Guangzhou Institute of Respiratory Health","ror":"https://ror.org/05fvcq462","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273215"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiexia Zhang","raw_affiliation_strings":["State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;","institution_ids":["https://openalex.org/I4210098361","https://openalex.org/I4210154954","https://openalex.org/I4405273215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039517471","display_name":"Huojin Deng","orcid":"https://orcid.org/0000-0001-7633-964X","observed_orcids":["https://orcid.org/0000-0001-7633-964X"]},"institutions":[{"id":"https://openalex.org/I4210120929","display_name":"Zhujiang Hospital","ror":"https://ror.org/02mhxa927","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120929"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huojin Deng","raw_affiliation_strings":["Department of Respiratory Medicine, Zhujiang Hospital, Southern MedicaI University, Guangzhou, 510280, China, Guangzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Zhujiang Hospital, Southern MedicaI University, Guangzhou, 510280, China, Guangzhou, China;","institution_ids":["https://openalex.org/I4210120929","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042984215","display_name":"Lei Zhang","orcid":"https://orcid.org/0000-0002-0580-0889","observed_orcids":["https://orcid.org/0000-0002-0580-0889"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4210161489","display_name":"Genecast (China)","ror":"https://ror.org/059r2qd49","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210161489"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Zhang","raw_affiliation_strings":["Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China;","Genecast Precision Medicine Technology Institute, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China;","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711","https://openalex.org/I4391768007"]},{"raw_affiliation_string":"Genecast Precision Medicine Technology Institute, Beijing, China;","institution_ids":["https://openalex.org/I4210161489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079202247","display_name":"Yadan Li","orcid":"https://orcid.org/0000-0003-4825-7887","observed_orcids":["https://orcid.org/0000-0003-4825-7887"]},"institutions":[{"id":"https://openalex.org/I4210161489","display_name":"Genecast (China)","ror":"https://ror.org/059r2qd49","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210161489"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yadan Li","raw_affiliation_strings":["Genecast Precision Medicine Technology Institute, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genecast Precision Medicine Technology Institute, Beijing, China;","institution_ids":["https://openalex.org/I4210161489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079826209","display_name":"Juanjuan Qian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161489","display_name":"Genecast (China)","ror":"https://ror.org/059r2qd49","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210161489"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juanjuan Qian","raw_affiliation_strings":["Genecast Precision Medicine Technology Institute, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genecast Precision Medicine Technology Institute, Beijing, China;","institution_ids":["https://openalex.org/I4210161489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080311177","display_name":"Hongli Luo","orcid":"https://orcid.org/0000-0002-9312-2079","observed_orcids":["https://orcid.org/0000-0002-9312-2079"]},"institutions":[{"id":"https://openalex.org/I4210161489","display_name":"Genecast (China)","ror":"https://ror.org/059r2qd49","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210161489"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongli Luo","raw_affiliation_strings":["Genecast Precision Medicine Technology Institute, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genecast Precision Medicine Technology Institute, Beijing, China;","institution_ids":["https://openalex.org/I4210161489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100777643","display_name":"Yanhui Chen","orcid":"https://orcid.org/0000-0001-6511-1738","observed_orcids":["https://orcid.org/0000-0001-6511-1738","https://orcid.org/0000-0003-3556-1476","https://orcid.org/0009-0003-0277-4384"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210150338","display_name":"Beijing Ditan Hospital","ror":"https://ror.org/05kkkes98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210150338"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanhui Chen","raw_affiliation_strings":["Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China;","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210150338"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101717480","display_name":"Ying Yang","orcid":"https://orcid.org/0000-0003-0797-4353","observed_orcids":["https://orcid.org/0000-0003-0797-4353"]},"institutions":[{"id":"https://openalex.org/I4210161489","display_name":"Genecast (China)","ror":"https://ror.org/059r2qd49","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210161489"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Yang","raw_affiliation_strings":["Genecast Precision Medicine Technology Institute, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genecast Precision Medicine Technology Institute, Beijing, China;","institution_ids":["https://openalex.org/I4210161489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015849886","display_name":"Henghui Zhang","orcid":"https://orcid.org/0000-0002-2820-7447","observed_orcids":["https://orcid.org/0000-0002-2820-7447","https://orcid.org/0009-0005-0177-8804"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210150338","display_name":"Beijing Ditan Hospital","ror":"https://ror.org/05kkkes98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210150338"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Henghui Zhang","raw_affiliation_strings":["Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China, Genecast Precision Medicine Technology Institute, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China, Genecast Precision Medicine Technology Institute, Beijing, China;","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210150338"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100425624","display_name":"Li Zhang","orcid":"https://orcid.org/0000-0002-7000-2955","observed_orcids":["https://orcid.org/0000-0002-7000-2955"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4210161489","display_name":"Genecast (China)","ror":"https://ror.org/059r2qd49","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210161489"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Zhang","raw_affiliation_strings":["Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China;","Genecast Precision Medicine Technology Institute, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China;","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711","https://openalex.org/I4391768007"]},{"raw_affiliation_string":"Genecast Precision Medicine Technology Institute, Beijing, China;","institution_ids":["https://openalex.org/I4210161489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"15_suppl","first_page":"e20588","last_page":"e20588"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crizotinib","display_name":"crizotinib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/met-exon-14-skipping","display_name":"MET exon 14 skipping","score":0.8939999938011169},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8930000066757202},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.7929999828338623},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cd8-t-cell-infiltration","display_name":"CD8+ T cell infiltration","score":0.9670000076293945},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8220000267028809},{"id":"https://openalex.org/keywords/chinese-patients","display_name":"Chinese patients","score":0.5960000157356262},{"id":"https://openalex.org/keywords/low-frequency-mutations","display_name":"low-frequency mutations","score":0.4950000047683716},{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/immunotherapy-response","display_name":"immunotherapy response","score":0.47200000286102295},{"id":"https://openalex.org/keywords/tumor-genomic-profiling","display_name":"tumor genomic profiling","score":0.5479999780654907},{"id":"https://openalex.org/keywords/multiplex-immunohistochemistry","display_name":"multiplex immunohistochemistry","score":0.7360000014305115},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.5370000004768372},{"id":"https://openalex.org/keywords/overall-response-rate","display_name":"overall response rate","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C2779422266","wikidata":"https://www.wikidata.org/wiki/Q5186964","display_name":"Crizotinib","level":4,"score":0.9383622407913208},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7159109115600586},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6965702176094055},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.6022500395774841},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5737278461456299},{"id":"https://openalex.org/C2775999482","wikidata":"https://www.wikidata.org/wiki/Q18031208","display_name":"ROS1","level":4,"score":0.4542056918144226},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.41123926639556885},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3743617534637451},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36853355169296265},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.36261889338493347},{"id":"https://openalex.org/C2776232967","wikidata":"https://www.wikidata.org/wiki/Q6743514","display_name":"Malignant pleural effusion","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2019.37.15_suppl.e20588","doi":"https://doi.org/10.1200/jco.2019.37.15_suppl.e20588","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2019.37.15_suppl.e20588","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3000668520","https://openalex.org/W2606519964","https://openalex.org/W2939792987","https://openalex.org/W2918150347","https://openalex.org/W7162539152","https://openalex.org/W2904499345","https://openalex.org/W3108813953","https://openalex.org/W2544057093","https://openalex.org/W2898260831","https://openalex.org/W3089110999"],"abstract_inverted_index":{"e20588":[0],"Background:":[1],"MET":[2],"exon":[3],"14":[4],"(":[5,236,286],"METex14)":[6],"skipping":[7,62,134,252,276,325,344],"caused":[8],"by":[9,74,100],"certain":[10],"mutations":[11,145,186,204,211,277,290,296,301],"in":[12,129,147,225,233,278,311,338],"splice":[13,149],"sites":[14,150],"of":[15,54,115,126,139,157,243,274,307,320,336],"METex14":[16,61,133,148,185,251,275,289,300,324,343],"has":[17],"been":[18],"regarded":[19],"as":[20,213],"a":[21],"promising":[22,333],"target":[23],"for":[24,56],"non-small":[25],"cell":[26],"lung":[27],"cancer":[28],"(NSCLC)":[29],"treatment":[30],"with":[31,36,143,207,250,260,293,317],"crizotinib,":[32],"and":[33,49,163,175,228],"was":[34,72,98,108,120,254],"observed":[35,224],"lower":[37],"responsiveness":[38,319],"to":[39,65,110,122,190,267,327],"immunotherapy":[40],"(Joshua":[41],"K.":[42],"et":[43],"al":[44],"ASCO":[45],"2017).":[46],"The":[47,239,271],"molecular":[48],"immune":[50,113],"characteristics,":[51],"antitumor":[52,124,334],"activity":[53,125,335],"crizotinib":[55,127,244,337],"Chinese":[57,93,279,339],"NSCLC":[58,94,280,321,340],"patients":[59,131,142,159,165,181,200,249,281,322,341],"harboring":[60,132,342],"alterations":[63,253,326],"remain":[64],"be":[66,315],"elucidated.":[67],"Methods:":[68],"Tumor":[69],"genomic":[70],"profiling":[71],"performed":[73,121],"next-generation":[75],"sequencing":[76],"(NGS)":[77],"assay":[78],"(GeneCast":[79],"Biotechnology":[80],"Co.,":[81],"Beijing)":[82],"on":[83,246],"9722":[84],"samples":[85],"(FFPE":[86],"and/or":[87],"peripheral":[88],"blood":[89],"derived":[90],"from":[91,188,265],"9289":[92],"patients).":[95],"PD-L1":[96],"expression":[97],"determined":[99],"qualitative":[101],"immunohistochemical":[102],"assay.":[103],"Multiplex":[104],"immunohistochemistry":[105],"(mIHC)":[106],"analysis":[107,119],"adopted":[109],"evaluate":[111],"the":[112,247],"microenvironment":[114],"selected":[116],"samples.":[117],"Retrospective":[118],"explore":[123],"monotherapy":[128,245],"10":[130],"alterations.":[135,345],"Results:":[136],"A":[137],"total":[138],"62":[140],"(0.67%)":[141],"somatic":[144],"occurred":[146],"(\u00b1":[151],"3bp)":[152],"were":[153,223],"identified.":[154],"Median":[155],"age":[156],"these":[158],"is":[160,282],"64.5":[161],"years":[162],"39%":[164],"are":[166,171],"female.":[167],"Main":[168],"histologic":[169],"types":[170],"adenocarcinoma":[172],"(81%,":[173],"50/62)":[174],"squamous":[176],"carcinoma":[177],"(13%,":[178],"8/62).":[179],"30":[180],"harbored":[182],"high":[183,298],"frequency":[184,203,285,299],"ranged":[187],"1.34%":[189],"79.49%":[191],"nearly":[192],"without":[193],"co-existed":[194],"known":[195],"driver":[196,295],"variants.":[197],"Other":[198],"32":[199],"had":[201],"low":[202],"(below":[205],"1%)":[206,288],"some":[208],"crucial":[209],"oncogenic":[210],"such":[212],"EGFR":[214],"19del/L858R.":[215],"In":[216],"addition,":[217],"very":[218],"few":[219],"CD8+":[220,308],"T":[221,309],"cells":[222,310],"tumor":[226,312],"region":[227,235,313],"significantly":[229],"less":[230],"infiltrated":[231],"than":[232],"stroma":[234],"P<":[237],"0.01).":[238],"overall":[240],"response":[241],"rate":[242,273],"ten":[248],"70%":[255],"(7/10":[256],"achieved":[257],"partial":[258],"response),":[259],"progression":[261],"free":[262],"survival":[263],"range":[264],"3":[266],"20":[268],"months.":[269],"Conclusions:":[270],"occurrence":[272],"low.":[283],"Low":[284],"<":[287],"usually":[291],"co-exist":[292],"other":[294],"while":[297],"do":[302],"not.":[303],"That":[304],"little":[305],"infiltration":[306],"might":[314],"associated":[316],"poor":[318],"carrying":[323],"immunotherapy.":[328],"Our":[329],"clinical":[330],"cases":[331],"exhibited":[332]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2019-12-13T00:00:00"}