{"id":"https://openalex.org/W2991799377","doi":null,"title":"Preclinical evaluation of 89Zr-DBN based virus labeling method for PET imaging of virus trafficking","display_name":"Preclinical evaluation of 89Zr-DBN based virus labeling method for PET imaging of virus trafficking","publication_year":2016,"publication_date":"2016-05-01","ids":{"openalex":"https://openalex.org/W2991799377","mag":"2991799377"},"language":"en","primary_location":{"id":"mag:2991799377","doi":null,"is_oa":false,"landing_page_url":"http://jnm.snmjournals.org/content/57/supplement_2/1139","pdf_url":null,"source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013482505","display_name":"Aditya Bansal","orcid":"https://orcid.org/0000-0001-7657-4981","observed_orcids":["https://orcid.org/0000-0001-7657-4981"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aditya Bansal","raw_affiliation_strings":["2Radiology Mayo Clinic Rochester MN United States"],"raw_orcid":"https://orcid.org/0000-0001-7657-4981","affiliations":[{"raw_affiliation_string":"2Radiology Mayo Clinic Rochester MN United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044553363","display_name":"Matthew L. Hillestad","orcid":"https://orcid.org/0009-0000-7115-7513","observed_orcids":["https://orcid.org/0009-0000-7115-7513"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew L. Hillestad","raw_affiliation_strings":["1Division of Cardiovascular Diseases Mayo Clinic Rochester MN United States"],"raw_orcid":"https://orcid.org/0009-0000-7115-7513","affiliations":[{"raw_affiliation_string":"1Division of Cardiovascular Diseases Mayo Clinic Rochester MN United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081493510","display_name":"Mukesh K. Pandey","orcid":"https://orcid.org/0000-0002-2332-5305","observed_orcids":["https://orcid.org/0000-0002-2332-5305"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mukesh K. Pandey","raw_affiliation_strings":["2Radiology Mayo Clinic Rochester MN United States"],"raw_orcid":"https://orcid.org/0000-0002-2332-5305","affiliations":[{"raw_affiliation_string":"2Radiology Mayo Clinic Rochester MN United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047902810","display_name":"Andr\u00e9 Terzic","orcid":"https://orcid.org/0000-0001-9210-009X","observed_orcids":["https://orcid.org/0000-0001-9210-009X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Terzic","raw_affiliation_strings":["1Division of Cardiovascular Diseases Mayo Clinic Rochester MN United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Cardiovascular Diseases Mayo Clinic Rochester MN United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021057573","display_name":"Atta Behfar","orcid":"https://orcid.org/0000-0003-3775-5784","observed_orcids":["https://orcid.org/0000-0003-3775-5784"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Atta Behfar","raw_affiliation_strings":["1Division of Cardiovascular Diseases Mayo Clinic Rochester MN United States"],"raw_orcid":"https://orcid.org/0000-0003-3775-5784","affiliations":[{"raw_affiliation_string":"1Division of Cardiovascular Diseases Mayo Clinic Rochester MN United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040861278","display_name":"Timothy R. DeGrado","orcid":"https://orcid.org/0000-0002-0511-5398","observed_orcids":["https://orcid.org/0000-0002-0511-5398"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy R. DeGrado","raw_affiliation_strings":["2Radiology Mayo Clinic Rochester MN United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Radiology Mayo Clinic Rochester MN United States","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34837101,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"57","issue":null,"first_page":"1139","last_page":"1139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adeno-associated-virus","display_name":"adeno-associated virus","score":0.6639999747276306},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.82856285572052},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6598671674728394},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.6086249351501465},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5684136748313904},{"id":"https://openalex.org/C161997846","wikidata":"https://www.wikidata.org/wiki/Q4915066","display_name":"Bioluminescence imaging","level":5,"score":0.4940774738788605},{"id":"https://openalex.org/C2778107364","wikidata":"https://www.wikidata.org/wiki/Q355989","display_name":"Adeno-associated virus","level":5,"score":0.4872850179672241},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4024987816810608},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3900126814842224},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3404783606529236},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33405739068984985},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.29027053713798523},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.23615601658821106},{"id":"https://openalex.org/C111335760","wikidata":"https://www.wikidata.org/wiki/Q95385166","display_name":"Luciferase","level":4,"score":0.21546047925949097},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.20672869682312012},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.1972447633743286},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11175277829170227},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2991799377","doi":null,"is_oa":false,"landing_page_url":"http://jnm.snmjournals.org/content/57/supplement_2/1139","pdf_url":null,"source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4407135641","https://openalex.org/W4376605130","https://openalex.org/W2144126123","https://openalex.org/W4250791648","https://openalex.org/W4388421496","https://openalex.org/W4401689054","https://openalex.org/W4387968312","https://openalex.org/W2170297339","https://openalex.org/W2108733009","https://openalex.org/W4389400442"],"abstract_inverted_index":{"1139":[0],"Objectives":[2],"There":[5],"is":[6,23,193,203],"a":[7,17,31,70,111,194],"growing":[8],"interest":[9],"in":[10,44,144,157,175],"virus-based":[11],"gene":[12,72,100],"therapies,":[13],"but":[14],"like":[15],"drugs,":[16],"better":[18],"understanding":[19],"of":[20,43,65,82,92,132,147,154,186,208],"their":[21,26],"pharmacokinetics":[22],"critical":[24],"to":[25,84,139],"advancement.":[27],"This":[28],"study":[29],"evaluates":[30],"novel":[32,53],"virus":[33,46,58,198,210],"labeling":[34,59,130,188,199],"approach":[35,60,200],"with":[36,76,126,128,150],"89Zr":[37,127],"(T1/2":[38],"=78.4h)":[39],"for":[40,206,211],"PET":[41,96,181],"imaging":[42,107],"vivo":[45,145,176],"trafficking.":[47],"Methods":[49],"A":[52],"89Zr-DBN":[54],"based":[55,101],"\u201cone":[56,195],"pot\u201d":[57,196],"was":[61,87],"developed.":[62],"Various":[63],"serotypes":[64],"adeno-associated":[66],"viruses":[67],"(AAVs)":[68],"encoding":[69,114],"Cre":[71],"were":[73,108,124,137],"covalently":[74],"labeled":[75,125],"89Zr-DBN.":[77],"The":[78,89,122,135,143,169,183],"cell":[79],"binding":[80],"potential":[81],"89Zr-DBN-AAV8/9":[83,93],"liver":[85,141],"hepatocytes":[86],"assessed.":[88],"physical":[90],"biodistribution":[91,146],"assessed":[94,104],"by":[95,105,163,177],"and":[97,201],"the":[98,151,155,158,209],"reporter":[99,116],"infection":[102,152],"profile":[103,153],"luminescence":[106],"compared":[109],"using":[110],"mouse":[112,159],"model":[113,160],"Cre-inducible":[115],"genes.":[117],"Results":[119],"AAVs":[123,156],"viral":[129],"yield":[131],"~20mCi/1014":[133],"AAVs.":[134],"89Zr-AAVs":[136,148,170],"able":[138],"bind":[140],"hepatocytes.":[142],"correlated":[149],"as":[161],"monitored":[162],"bioluminescence.":[164],"Conclusions":[166],"can":[171],"be":[172],"reliably":[173],"tracked":[174],"high":[178],"resolution":[179],"non-invasive":[180],"imaging.":[182],"major":[184],"advantages":[185],"this":[187],"method":[189],"are":[190],"that":[191],"it":[192],"mild":[197],"there":[202],"no":[204],"need":[205],"pre-modification":[207],"labeling.":[212]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2019-12-13T00:00:00"}