{"id":"https://openalex.org/W2991776232","doi":"https://doi.org/10.3390/cells8121560","title":"Extracellular Vesicles\u2013Encapsulated MicroRNA-125b Produced in Genetically Modified Mesenchymal Stromal Cells Inhibits Hepatocellular Carcinoma Cell Proliferation","display_name":"Extracellular Vesicles\u2013Encapsulated MicroRNA-125b Produced in Genetically Modified Mesenchymal Stromal Cells Inhibits Hepatocellular Carcinoma Cell Proliferation","publication_year":2019,"publication_date":"2019-12-03","ids":{"openalex":"https://openalex.org/W2991776232","doi":"https://doi.org/10.3390/cells8121560","mag":"2991776232","pmid":"https://pubmed.ncbi.nlm.nih.gov/31816923","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6952965"},"language":"en","primary_location":{"id":"doi:10.3390/cells8121560","doi":"https://doi.org/10.3390/cells8121560","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells8121560","pdf_url":"https://www.mdpi.com/2073-4409/8/12/1560/pdf?version=1575372359","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4409/8/12/1560/pdf?version=1575372359","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043662056","display_name":"Silvia Baldari","orcid":"https://orcid.org/0000-0001-7982-9468","observed_orcids":["https://orcid.org/0000-0001-7982-9468"]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Baldari","raw_affiliation_strings":["Department of Medical Surgical Sciences and Biotechnologies, University of Rome \u201cLa Sapienza\u201d, C.so della Repubblica 79, 04100 Latina, Italy","Department of Research, Advanced Diagnostic, and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Via E. Chianesi 53, 00144 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Surgical Sciences and Biotechnologies, University of Rome \u201cLa Sapienza\u201d, C.so della Repubblica 79, 04100 Latina, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Department of Research, Advanced Diagnostic, and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Via E. Chianesi 53, 00144 Rome, Italy","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029693506","display_name":"Giuliana Di Rocco","orcid":"https://orcid.org/0000-0003-1210-6008","observed_orcids":["https://orcid.org/0000-0003-1210-6008"]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuliana Di Rocco","raw_affiliation_strings":["Department of Research, Advanced Diagnostic, and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Via E. Chianesi 53, 00144 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, Advanced Diagnostic, and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Via E. Chianesi 53, 00144 Rome, Italy","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043406398","display_name":"Alessandra Magenta","orcid":"https://orcid.org/0000-0002-9054-337X","observed_orcids":["https://orcid.org/0000-0002-9054-337X"]},"institutions":[{"id":"https://openalex.org/I4210116004","display_name":"Istituto Dermopatico dell'Immacolata","ror":"https://ror.org/02b5mfy68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210116004","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Magenta","raw_affiliation_strings":["Istituto Dermopatico dell\u2019Immacolata, IDI-IRCCS, Via dei Monti di Creta 104, 00167 Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-9054-337X","affiliations":[{"raw_affiliation_string":"Istituto Dermopatico dell\u2019Immacolata, IDI-IRCCS, Via dei Monti di Creta 104, 00167 Rome, Italy","institution_ids":["https://openalex.org/I4210116004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036923356","display_name":"Mario Picozza","orcid":"https://orcid.org/0000-0002-2529-6456","observed_orcids":["https://orcid.org/0000-0002-2529-6456"]},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mario Picozza","raw_affiliation_strings":["Laboratory of Neuroimmunology, IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64, 00143 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroimmunology, IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64, 00143 Rome, Italy","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020273307","display_name":"Gabriele Toietta","orcid":"https://orcid.org/0000-0003-4182-2468","observed_orcids":["https://orcid.org/0000-0003-4182-2468"]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Gabriele Toietta","raw_affiliation_strings":["Department of Research, Advanced Diagnostic, and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Via E. Chianesi 53, 00144 Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0003-4182-2468","affiliations":[{"raw_affiliation_string":"Department of Research, Advanced Diagnostic, and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Via E. Chianesi 53, 00144 Rome, Italy","institution_ids":["https://openalex.org/I4387152244"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5020273307"],"corresponding_institution_ids":["https://openalex.org/I4387152244"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1824},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1824},"fwci":2.1975,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.89269196,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"8","issue":"12","first_page":"1560","last_page":"1560"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9300000071525574},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.9670000076293945},{"id":"https://openalex.org/keywords/mir-125b","display_name":"miR-125b","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/adipose-tissue-derived-stromal-cells","display_name":"adipose tissue-derived stromal cells","score":0.8640000224113464},{"id":"https://openalex.org/keywords/lentiviral-vectors","display_name":"lentiviral vectors","score":0.8870000243186951},{"id":"https://openalex.org/keywords/microrna-delivery","display_name":"microRNA delivery","score":0.7820000052452087},{"id":"https://openalex.org/keywords/p53-signaling-pathway","display_name":"p53 pathway","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6119999885559082},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7499378323554993},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.684661328792572},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6721786856651306},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5648970007896423},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5269349813461304},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5216708183288574},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.4981424808502197},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.4710794985294342},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4607264995574951},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.45416221022605896},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4245007634162903},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42179998755455017},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.4186869263648987},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40657731890678406},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3606504499912262},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07955354452133179},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.061484724283218384},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3390/cells8121560","doi":"https://doi.org/10.3390/cells8121560","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells8121560","pdf_url":"https://www.mdpi.com/2073-4409/8/12/1560/pdf?version=1575372359","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5922911","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6952965","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31816923","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31816923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6952965","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6952965/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Text"},{"id":"pmh:oai:zenodo.org:3786318","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/3786318","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/cells8121560","doi":"https://doi.org/10.3390/cells8121560","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells8121560","pdf_url":"https://www.mdpi.com/2073-4409/8/12/1560/pdf?version=1575372359","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G387172998","display_name":null,"funder_award_id":"\u201c5\u00d71000\u201d","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"}],"funders":[{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"},{"id":"https://openalex.org/F4320323662","display_name":"ERAB: The European Foundation for Alcohol Research","ror":"https://ror.org/04g6qfd94"},{"id":"https://openalex.org/F4320329188","display_name":"Fondazione Roma","ror":"https://ror.org/00gtjrz72"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2991776232.pdf","grobid_xml":"https://content.openalex.org/works/W2991776232.grobid-xml"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W282221905","https://openalex.org/W1626698443","https://openalex.org/W1830346366","https://openalex.org/W1931006327","https://openalex.org/W1934417607","https://openalex.org/W1964296201","https://openalex.org/W1969699638","https://openalex.org/W1971806005","https://openalex.org/W1972434476","https://openalex.org/W1975167804","https://openalex.org/W1985844219","https://openalex.org/W2004462371","https://openalex.org/W2005154332","https://openalex.org/W2008945738","https://openalex.org/W2020438602","https://openalex.org/W2021720429","https://openalex.org/W2029007648","https://openalex.org/W2033969079","https://openalex.org/W2046855645","https://openalex.org/W2055442199","https://openalex.org/W2064735925","https://openalex.org/W2073341747","https://openalex.org/W2083156208","https://openalex.org/W2083796374","https://openalex.org/W2097352128","https://openalex.org/W2104961360","https://openalex.org/W2109377963","https://openalex.org/W2143377286","https://openalex.org/W2159401023","https://openalex.org/W2207291742","https://openalex.org/W2273372601","https://openalex.org/W2321597802","https://openalex.org/W2414250949","https://openalex.org/W2472885775","https://openalex.org/W2520827869","https://openalex.org/W2528206229","https://openalex.org/W2554641030","https://openalex.org/W2558389982","https://openalex.org/W2570212616","https://openalex.org/W2582141810","https://openalex.org/W2584102880","https://openalex.org/W2586294088","https://openalex.org/W2586972991","https://openalex.org/W2588025094","https://openalex.org/W2593629244","https://openalex.org/W2594614289","https://openalex.org/W2604116492","https://openalex.org/W2608209876","https://openalex.org/W2619411792","https://openalex.org/W2625053775","https://openalex.org/W2728114048","https://openalex.org/W2740751697","https://openalex.org/W2762505064","https://openalex.org/W2774967673","https://openalex.org/W2782619056","https://openalex.org/W2783658058","https://openalex.org/W2786202610","https://openalex.org/W2792995236","https://openalex.org/W2803304758","https://openalex.org/W2884359622","https://openalex.org/W2887887037","https://openalex.org/W2898568606","https://openalex.org/W2900713991","https://openalex.org/W2900756811","https://openalex.org/W2910555711","https://openalex.org/W2922209521","https://openalex.org/W2925372744","https://openalex.org/W2929213012","https://openalex.org/W2939918997","https://openalex.org/W2945162057","https://openalex.org/W2948443239","https://openalex.org/W2962176767","https://openalex.org/W2965740555","https://openalex.org/W2968489197","https://openalex.org/W2970839635","https://openalex.org/W2971671150","https://openalex.org/W2976429808","https://openalex.org/W2980870177","https://openalex.org/W2981718346","https://openalex.org/W4210955410","https://openalex.org/W6715745969","https://openalex.org/W6752977271"],"related_works":["https://openalex.org/W2790679336","https://openalex.org/W7147894778","https://openalex.org/W4210582967","https://openalex.org/W2528206229","https://openalex.org/W4384825228","https://openalex.org/W3128936798","https://openalex.org/W7163896117","https://openalex.org/W4226542106","https://openalex.org/W4318591704","https://openalex.org/W4210990260"],"abstract_inverted_index":{"Hepatocellular":[0],"carcinoma":[1],"(HCC)":[2],"is":[3,33],"the":[4,15,103,137,147,172,180],"most":[5],"frequent":[6],"type":[7],"of":[8,14,18,30,42,78,105,109,149,166,182],"primary":[9],"liver":[10],"cancer":[11,19,92],"and":[12,54,68],"one":[13],"prominent":[16],"causes":[17],"mortality,":[20],"leading":[21],"to":[22,135,171],"approximately":[23],"780,000":[24],"deaths":[25],"per":[26],"year":[27],"worldwide.":[28],"Down-regulation":[29],"microRNA-125b":[31],"(miR-125b)":[32],"a":[34,99,124,130,164],"prognostic":[35],"indicator":[36],"in":[37,44,82,153,161],"HCC":[38,45,106,158,187],"patients.":[39],"Conversely,":[40],"over-expression":[41],"miR-125b":[43,128,167],"cells":[46,119],"induces":[47],"cell":[48,159],"cycle":[49],"arrest,":[50],"inhibits":[51],"proliferation,":[52],"migration":[53],"invasion.":[55],"Extracellular":[56],"vesicles":[57],"(EVs)":[58],"function":[59],"as":[60],"intercellular":[61],"messengers":[62],"transferring":[63],"proteins,":[64],"RNAs,":[65],"DNAs,":[66],"carbohydrates,":[67],"lipids.":[69],"Since":[70],"EVs":[71,86,110,151],"protect":[72],"their":[73],"cargo":[74],"from":[75,112],"degradation,":[76],"delivery":[77,108,148],"therapeutic":[79,184],"bioactive":[80],"molecules,":[81],"particular":[83],"miRNAs,":[84],"through":[85],"represents":[87],"an":[88],"innovative":[89,183],"avenue":[90],"for":[91,102,186],"therapy.":[93],"In":[94,142],"this":[95],"study,":[96],"we":[97,144],"evaluated":[98],"replacement":[100],"strategy":[101],"treatment":[104],"via":[107,188],"secreted":[111],"human":[113],"adipose":[114],"tissue-derived":[115],"mesenchymal":[116],"stromal/medicinal":[117],"signaling":[118,174],"(ASCs)":[120],"genetically":[121],"modified":[122],"with":[123,129],"lentiviral":[125],"vector":[126],"expressing":[127],"specific":[131],"ExoMotif":[132],"sequence":[133],"tag":[134],"enhance":[136],"loading":[138],"into":[139],"extracellular":[140],"vesicles.":[141],"particular,":[143],"determined":[145],"that":[146],"miR-125b-loaded":[150],"produced":[152],"engineered":[154],"ASCs":[155],"specifically":[156],"reduces":[157],"proliferation":[160],"vitro":[162],"modulating":[163],"series":[165],"targets,":[168],"which":[169],"belong":[170],"p53":[173],"pathway.":[175],"This":[176],"proof-of-concept":[177],"study":[178],"supports":[179],"development":[181],"strategies":[185],"EV-mediated":[189],"miRNA":[190],"delivery.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-12-13T00:00:00"}