{"id":"https://openalex.org/W2991668644","doi":null,"title":"Effects of pioglitazone and high-fat diet on ceramide metabolism in rat skeletal muscles.","display_name":"Effects of pioglitazone and high-fat diet on ceramide metabolism in rat skeletal muscles.","publication_year":2006,"publication_date":"2006-11-01","ids":{"openalex":"https://openalex.org/W2991668644","mag":"2991668644","pmid":"https://pubmed.ncbi.nlm.nih.gov/17242494"},"language":"en","primary_location":{"id":"pmid:17242494","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17242494","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M Zendzian-Piotrowska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146122375","display_name":"Medical University of Bia\u0142ystok","ror":"https://ror.org/00y4ya841","country_code":"PL","type":"education","lineage":["https://openalex.org/I146122375"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"M Zendzian-Piotrowska","raw_affiliation_strings":["Department of Physiology, Medical University of Bialystok, Bialystok, Poland. piotrowm@amb.edu.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Medical University of Bialystok, Bialystok, Poland. piotrowm@amb.edu.pl","institution_ids":["https://openalex.org/I146122375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011217044","display_name":"Marcin Baranowski","orcid":"https://orcid.org/0000-0002-3714-5815","observed_orcids":["https://orcid.org/0000-0002-3714-5815"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Baranowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024823786","display_name":"Piotr Zabielski","orcid":"https://orcid.org/0000-0002-4901-5217","observed_orcids":["https://orcid.org/0000-0002-4901-5217"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Zabielski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5075231467","display_name":"J G\u00f3rski","orcid":"https://orcid.org/0000-0001-9886-5069","observed_orcids":["https://orcid.org/0000-0001-9886-5069"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J G\u00f3rski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.898,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.66420798,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"57 Suppl 10","issue":null,"first_page":"101","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pioglitazone","display_name":"pioglitazone","score":1.0},{"id":"https://openalex.org/keywords/ceramide-metabolism","display_name":"ceramide metabolism","score":0.9139999747276306},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.7490000128746033},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8500000238418579},{"id":"https://openalex.org/keywords/thiazolidinediones","display_name":"thiazolidinediones","score":0.9290000200271606},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8759999871253967},{"id":"https://openalex.org/keywords/sphingomyelinase","display_name":"sphingomyelinase","score":0.9330000281333923},{"id":"https://openalex.org/keywords/acid-sphingomyelinase","display_name":"acid sphingomyelinase","score":0.9150000214576721},{"id":"https://openalex.org/keywords/sphingomyelin","display_name":"sphingomyelin","score":0.6050000190734863},{"id":"https://openalex.org/keywords/sphingosine","display_name":"sphingosine","score":0.8220000267028809},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.7590000033378601},{"id":"https://openalex.org/keywords/soleus-muscle","display_name":"soleus muscle","score":0.7070000171661377},{"id":"https://openalex.org/keywords/gastrocnemius-muscle","display_name":"gastrocnemius","score":0.8920000195503235},{"id":"https://openalex.org/keywords/muscle-fiber-type","display_name":"muscle fiber type","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.9414224624633789},{"id":"https://openalex.org/C2778384471","wikidata":"https://www.wikidata.org/wiki/Q417765","display_name":"Pioglitazone","level":4,"score":0.9257717132568359},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7775298953056335},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.7535603046417236},{"id":"https://openalex.org/C61322309","wikidata":"https://www.wikidata.org/wiki/Q423143","display_name":"Sphingomyelin","level":3,"score":0.7471290826797485},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7456594109535217},{"id":"https://openalex.org/C2776104385","wikidata":"https://www.wikidata.org/wiki/Q1954164","display_name":"Soleus muscle","level":3,"score":0.5703579783439636},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5118531584739685},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5016834735870361},{"id":"https://openalex.org/C2778703144","wikidata":"https://www.wikidata.org/wiki/Q46298","display_name":"Sphingosine","level":3,"score":0.42346665263175964},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.41222697496414185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36129236221313477},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26795536279678345},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2544901669025421},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.18804600834846497},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.17344525456428528},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1428219974040985},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12518227100372314},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077205","descriptor_name":"Pioglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004041","descriptor_name":"Dietary Fats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013108","descriptor_name":"Sphingomyelin Phosphodiesterase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013108","descriptor_name":"Sphingomyelin Phosphodiesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055572","descriptor_name":"Ceramidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:17242494","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17242494","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},{"id":"mag:2991668644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17242494","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W92665255","https://openalex.org/W1510570168","https://openalex.org/W1848463016","https://openalex.org/W1987720744","https://openalex.org/W1999143122","https://openalex.org/W2003714484","https://openalex.org/W2013678045","https://openalex.org/W2023384909","https://openalex.org/W2025607561","https://openalex.org/W2046378557","https://openalex.org/W2049265308","https://openalex.org/W2059844165","https://openalex.org/W2060937977","https://openalex.org/W2064009012","https://openalex.org/W2065557156","https://openalex.org/W2070937608","https://openalex.org/W2073807083","https://openalex.org/W2075009616","https://openalex.org/W2079389643","https://openalex.org/W2081703555","https://openalex.org/W2104905878","https://openalex.org/W2108462699","https://openalex.org/W2108546663","https://openalex.org/W2111361753","https://openalex.org/W2114424910","https://openalex.org/W2123169439","https://openalex.org/W2126085844","https://openalex.org/W2127056938","https://openalex.org/W2127908990","https://openalex.org/W2130850001","https://openalex.org/W2133290655","https://openalex.org/W2136238444","https://openalex.org/W2140715341","https://openalex.org/W2148014629","https://openalex.org/W2166788192","https://openalex.org/W2470752100"],"related_works":["https://openalex.org/W1522100973","https://openalex.org/W2049265308","https://openalex.org/W7097870757","https://openalex.org/W2003043041","https://openalex.org/W2119633031","https://openalex.org/W2148397221","https://openalex.org/W2163547766","https://openalex.org/W4220685304","https://openalex.org/W2077079178","https://openalex.org/W7145272172"],"abstract_inverted_index":{"Ceramide":[0],"is":[1],"involved":[2],"in":[3,9,21,73,122,126,135,154,164,168,175,211,243],"the":[4,22,25,42,50,55,64,67,79,118,123,127,131,136,140,165,169,173,204,221,224,250],"pathogenesis":[5],"of":[6,12,27,32,44,52,57,66,70,78,120,130,139,144,159,172,189,206,227,237,249],"insulin":[7,33,258],"resistance":[8],"skeletal":[10,37,75,256],"muscles":[11],"humans":[13],"and":[14,59,62,108,125,148,167],"rodents.":[15],"However,":[16],"there":[17],"are":[18],"conflicting":[19],"reports":[20],"literature":[23],"on":[24,36,54,63,86,214],"effect":[26,51,181],"thiazolidinediones":[28],"(a":[29],"new":[30],"class":[31],"sensitizing":[34],"drugs)":[35],"muscle":[38,76,225,257],"ceramide":[39,58,71,121,162,190,228,244],"content.":[40],"Therefore,":[41,217],"aim":[43],"our":[45,238],"study":[46,239],"was":[47,102,151],"to":[48,186,195,199],"examine":[49],"pioglitazone":[53,111,160,254],"level":[56,163,245],"its":[60,196,231],"metabolites":[61],"activity":[65,143],"key":[68],"enzymes":[69],"metabolism":[72],"different":[74],"types":[77],"rat.":[80],"The":[81,142,235],"experiments":[82],"were":[83],"carried":[84],"out":[85],"rats":[87,176,212],"fed":[88,177,213],"either":[89,178,215],"a":[90,94],"standard":[91],"chow":[92],"or":[93,194],"high-fat":[95],"diet":[96,116],"for":[97,112],"21":[98],"days.":[99,114],"Each":[100],"group":[101],"divided":[103],"into":[104],"two":[105],"subgroups:":[106],"control":[107],"treated":[109],"with":[110],"14":[113],"High-fat":[115],"increased":[117],"content":[119,226],"soleus":[124,166],"red":[128,170],"section":[129,138,171],"gastrocnemius,":[132],"but":[133],"not":[134,183],"white":[137],"latter.":[141],"neutral":[145],"Mg(2+)-dependent":[146],"sphingomyelinase":[147,150],"acid":[149],"simultaneously":[152],"reduced":[153,203],"all":[155],"examined":[156],"muscles.":[157],"Administration":[158],"decreased":[161,187,223],"gastrocnemius":[174],"diet.":[179,216],"This":[180],"could":[182],"be":[184,247],"attributed":[185],"rate":[188],"formation":[191],"from":[192],"sphingomyelin":[193],"augmented":[197],"deacylation":[198],"sphingosine.":[200],"Pioglitazone":[201],"treatment":[202],"concentration":[205],"plasma":[207],"free":[208],"fatty":[209],"acids":[210],"we":[218],"conclude":[219],"that":[220,241],"drug":[222],"by":[229,252],"reducing":[230],"de":[232],"novo":[233],"synthesis.":[234],"results":[236],"indicate":[240],"reduction":[242],"may":[246],"one":[248],"mechanisms":[251],"which":[253],"improves":[255],"sensitivity.":[259]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-13T00:00:00"}
