{"id":"https://openalex.org/W2991633596","doi":null,"title":"Implications of Observer Variation in Gleason Scoring of Prostate Cancer on Clinical Management: A Collaborative Audit.","display_name":"Implications of Observer Variation in Gleason Scoring of Prostate Cancer on Clinical Management: A Collaborative Audit.","publication_year":2017,"publication_date":"2017-09-01","ids":{"openalex":"https://openalex.org/W2991633596","mag":"2991633596","pmid":"https://pubmed.ncbi.nlm.nih.gov/29019329"},"language":"en","primary_location":{"id":"pmid:29019329","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29019329","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Gulf journal of oncology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012329593","display_name":"Aman Harbias","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Harbias","raw_affiliation_strings":["Department of Urology, University Hospital South Manchester, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University Hospital South Manchester, U.K","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111547913","display_name":"Emil Salmo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802144681","display_name":"Bolton NHS Foundation Trust","ror":"https://ror.org/03y9bvk93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802144681"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E Salmo","raw_affiliation_strings":["Department of Histopathology, Bolton NHS Foundation Trust, Bolton, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histopathology, Bolton NHS Foundation Trust, Bolton, U.K","institution_ids":["https://openalex.org/I2802144681"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024074669","display_name":"Ann A. Crump","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801926401","display_name":"Manchester Royal Infirmary","ror":"https://ror.org/03kr30n36","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801926401","https://openalex.org/I4210092852"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A Crump","raw_affiliation_strings":["Department of Urology, Manchester Royal Infirmary, Oxford Road, Manchester, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Manchester Royal Infirmary, Oxford Road, Manchester, U.K","institution_ids":["https://openalex.org/I2801926401"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9631,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.77855652,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"1","issue":"25","first_page":"41","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13309","display_name":"Reliability and Agreement in Measurement","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/gleason-score","display_name":"Gleason score","score":0.9300000071525574},{"id":"https://openalex.org/keywords/interobserver-variability","display_name":"interobserver variability","score":0.847000002861023},{"id":"https://openalex.org/keywords/histological-grading","display_name":"histological grading","score":0.6639999747276306},{"id":"https://openalex.org/keywords/central-review","display_name":"central review","score":0.7490000128746033},{"id":"https://openalex.org/keywords/uropathology","display_name":"uropathology","score":0.7609999775886536},{"id":"https://openalex.org/keywords/treatment-planning","display_name":"treatment planning","score":0.4740000069141388},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.6959999799728394},{"id":"https://openalex.org/keywords/prostate-biopsy","display_name":"prostate biopsy","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.946393609046936},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8109709024429321},{"id":"https://openalex.org/C2777286243","wikidata":"https://www.wikidata.org/wiki/Q5591926","display_name":"Grading (engineering)","level":2,"score":0.6838332414627075},{"id":"https://openalex.org/C2776135927","wikidata":"https://www.wikidata.org/wiki/Q5242559","display_name":"Referral","level":2,"score":0.6038067936897278},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5205370187759399},{"id":"https://openalex.org/C199521495","wikidata":"https://www.wikidata.org/wiki/Q181487","display_name":"Audit","level":2,"score":0.519770085811615},{"id":"https://openalex.org/C2781114028","wikidata":"https://www.wikidata.org/wiki/Q6746708","display_name":"Management of prostate cancer","level":4,"score":0.5079699158668518},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44132617115974426},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3315144181251526},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2669105529785156},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.22389861941337585},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C147176958","wikidata":"https://www.wikidata.org/wiki/Q77590","display_name":"Civil engineering","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008485","descriptor_name":"Medical Audit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D015588","descriptor_name":"Observer Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:29019329","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29019329","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Gulf journal of oncology","raw_type":"Journal Article"},{"id":"mag:2991633596","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29019329","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W2887494772","https://openalex.org/W2906774465"],"related_works":["https://openalex.org/W2185729574","https://openalex.org/W2098367729","https://openalex.org/W180512626","https://openalex.org/W2565428305","https://openalex.org/W2475054117","https://openalex.org/W2030770106","https://openalex.org/W2009107949","https://openalex.org/W3008381464","https://openalex.org/W2241115763","https://openalex.org/W1981331011"],"abstract_inverted_index":{"BACKGROUND:":[0],"Prostate":[1],"cancer":[2,8,37,71],"is":[3,14,207,210],"the":[4,123,129,146,176,211,225,233,243],"most":[5],"frequently":[6],"diagnosed":[7],"in":[9,84,135,163,170,242],"men.":[10,61],"Histological":[11],"tumour":[12],"grade":[13,165],"a":[15,74,81,102,109,161,167,239],"strong":[16],"predictor":[17],"of":[18,245],"outcome":[19],"and":[20,138,166,188,235],"helps":[21],"determine":[22],"what":[23],"treatment":[24,57,91,139,189],"options":[25,58,190],"are":[26,29],"offered.":[27],"There":[28],"numerous":[30],"studies":[31],"on":[32,35,232],"Inter-observer":[33],"agreement/variability":[34],"prostate":[36,53,70,96,246],"grading.":[38],"In":[39,63],"this":[40],"study,":[41],"we":[42],"were":[43,106,141],"looking":[44],"to":[45,60,88,213,223],"establish":[46],"if":[47],"disconcordance":[48,204],"between":[49,205],"pathologists":[50,79,206],"when":[51],"grading":[52],"cancer,":[54],"could":[55,181,191],"affect":[56,214],"offered":[59],"METHODS:":[62],"Greater":[64],"Manchester":[65],"West":[66],"Cancer":[67],"Sector,":[68],"all":[69],"biopsies":[72,97,148,156],"undergo":[73],"central":[75,130,151,218],"review":[76,131,152,219],"by":[77],"three":[78],"with":[80,122],"special":[82],"interest":[83],"urological":[85],"pathology":[86],"prior":[87],"referral":[89],"for":[90,172,184,195],"at":[92,128,150],"specialist":[93],"centres.":[94],"96":[95,147],"(from":[98],"48":[99],"patients)":[100],"from":[101,157],"District":[103],"General":[104],"Hospital":[105],"reviewed":[107],"during":[108],"6-month":[110],"period":[111],"(March":[112],"2014-September":[113],"2014).":[114],"The":[115],"original":[116],"Gleason":[117,164],"Score":[118],"assigned":[119],"was":[120],"compared":[121],"uropathologists":[124],"consensus":[125],"diagnosis":[126],"established":[127],"meeting.":[132],"Any":[133],"changes":[134],"patient":[136,215,234],"risk":[137,171],"plans":[140,180],"subsequently":[142],"reviewed.":[143],"RESULTS:":[144],"Of":[145,175],"discussed":[149],"meeting,":[153],"24":[154],"(25%)":[155],"19":[158,177],"patients":[159,186],"underwent":[160],"change":[162,169],"subsequent":[168],"13":[173],"(68%).":[174],"patients,":[178],"management":[179,244],"be":[182,193,237],"affected":[183,194],"9":[185],"(47%)":[187],"potentially":[192],"5":[196],"(26%).":[197],"CONCLUSION:":[198],"This":[199],"study":[200],"shows":[201],"that":[202],"where":[203],"present,":[208],"there":[209],"potential":[212],"management.":[216],"A":[217],"process":[220],"can":[221,230],"help":[222],"minimize":[224],"effect":[226],"over":[227],"or":[228],"undergrading":[229],"have":[231],"should":[236],"considered":[238],"necessary":[240],"step":[241],"cancer.":[247]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-05T00:00:00"}
