{"id":"https://openalex.org/W2991562362","doi":"https://doi.org/10.1038/s41598-019-53445-2","title":"An exome-wide rare variant analysis of Korean men identifies three novel genes predisposing to prostate cancer","display_name":"An exome-wide rare variant analysis of Korean men identifies three novel genes predisposing to prostate cancer","publication_year":2019,"publication_date":"2019-11-20","ids":{"openalex":"https://openalex.org/W2991562362","doi":"https://doi.org/10.1038/s41598-019-53445-2","mag":"2991562362","pmid":"https://pubmed.ncbi.nlm.nih.gov/31748686","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6868235"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-019-53445-2","doi":"https://doi.org/10.1038/s41598-019-53445-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-53445-2","pdf_url":"https://www.nature.com/articles/s41598-019-53445-2.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-019-53445-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063111787","display_name":"Jong Jin Oh","orcid":"https://orcid.org/0000-0003-0448-5992","observed_orcids":["https://orcid.org/0000-0003-0448-5992"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong Jin Oh","raw_affiliation_strings":["Department of Urology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059958266","display_name":"Manu Shivakumar","orcid":"https://orcid.org/0000-0003-4733-7375","observed_orcids":["https://orcid.org/0000-0003-4733-7375"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manu Shivakumar","raw_affiliation_strings":["Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046872126","display_name":"Jason E. Miller","orcid":"https://orcid.org/0000-0002-1835-3512","observed_orcids":["https://orcid.org/0000-0002-1835-3512"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Miller","raw_affiliation_strings":["Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080251530","display_name":"Shefali S. Verma","orcid":"https://orcid.org/0000-0001-5216-4670","observed_orcids":["https://orcid.org/0000-0001-5216-4670","https://orcid.org/0000-0001-7625-1162"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shefali Verma","raw_affiliation_strings":["Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075338584","display_name":"Hakmin Lee","orcid":"https://orcid.org/0000-0002-1247-9958","observed_orcids":["https://orcid.org/0000-0002-1247-9958"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hakmin Lee","raw_affiliation_strings":["Department of Urology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052439030","display_name":"Sung Kyu Hong","orcid":"https://orcid.org/0000-0002-8344-6774","observed_orcids":["https://orcid.org/0000-0002-8344-6774"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung Kyu Hong","raw_affiliation_strings":["Department of Urology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"],"raw_orcid":"https://orcid.org/0000-0002-8344-6774","affiliations":[{"raw_affiliation_string":"Department of Urology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100671605","display_name":"Sang Eun Lee","orcid":"https://orcid.org/0000-0003-2722-8200","observed_orcids":["https://orcid.org/0000-0003-2722-8200"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang Eun Lee","raw_affiliation_strings":["Complex Diseases and Genome Epidemiology Laboratory, Department of Public Health, Graduate School of Public Health, Seoul National University, Seoul, Korea","Department of Urology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Complex Diseases and Genome Epidemiology Laboratory, Department of Public Health, Graduate School of Public Health, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Urology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100778649","display_name":"Younghee Lee","orcid":"https://orcid.org/0000-0002-6850-0082","observed_orcids":["https://orcid.org/0000-0002-6850-0082"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Younghee Lee","raw_affiliation_strings":["Department of Biomedical Informatics, University of Utah, University of Utah School of Medicine, Salt Lake City, UT, USA"],"raw_orcid":"https://orcid.org/0000-0002-6850-0082","affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, University of Utah, University of Utah School of Medicine, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007919396","display_name":"Soo Ji Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Soo Ji Lee","raw_affiliation_strings":["Complex Diseases and Genome Epidemiology Laboratory, Department of Public Health, Graduate School of Public Health, Seoul National University, Seoul, Korea","Department of Urology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Complex Diseases and Genome Epidemiology Laboratory, Department of Public Health, Graduate School of Public Health, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Urology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045089125","display_name":"Joohon Sung","orcid":"https://orcid.org/0000-0001-9948-0160","observed_orcids":["https://orcid.org/0000-0001-9948-0160"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Joohon Sung","raw_affiliation_strings":["Complex Diseases and Genome Epidemiology Laboratory, Department of Public Health, Graduate School of Public Health, Seoul National University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Complex Diseases and Genome Epidemiology Laboratory, Department of Public Health, Graduate School of Public Health, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078473635","display_name":"Dokyoon Kim","orcid":"https://orcid.org/0000-0002-4592-9564","observed_orcids":["https://orcid.org/0000-0002-4592-9564","https://orcid.org/0009-0009-4239-9308"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dokyoon Kim","raw_affiliation_strings":["Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Dokyoon.Kim@pennmedicine.upenn.edu","Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA, USA. Dokyoon.Kim@pennmedicine.upenn.edu","Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Dokyoon.Kim@pennmedicine.upenn.edu","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA, USA. Dokyoon.Kim@pennmedicine.upenn.edu","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019050469","display_name":"Seok\u2010Soo Byun","orcid":"https://orcid.org/0000-0001-9356-9500","observed_orcids":["https://orcid.org/0000-0001-9356-9500","https://orcid.org/0000-0001-7979-9035"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Seok-Soo Byun","raw_affiliation_strings":["Department of Urology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. ssbyun@snubh.org","Department of Urology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. ssbyun@snubh.org","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125"]},{"raw_affiliation_string":"Department of Urology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5019050469","https://openalex.org/A5078473635"],"corresponding_institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2803058125","https://openalex.org/I79576946"],"apc_list":{"value":1790,"currency":"USD","value_usd":1790},"apc_paid":{"value":1790,"currency":"USD","value_usd":1790},"fwci":0.4551,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.52447683,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"1","first_page":"17173","last_page":"17173"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.5234000086784363,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.5234000086784363,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.3571999967098236,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.020999999716877937,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/rare-variants","display_name":"rare variants","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cancer-susceptibility-genes","display_name":"cancer susceptibility genes","score":0.6940000057220459},{"id":"https://openalex.org/keywords/korean-men","display_name":"Korean men","score":0.7390000224113464},{"id":"https://openalex.org/keywords/exome-wide-association","display_name":"exome-wide association","score":0.6890000104904175},{"id":"https://openalex.org/keywords/estrogen-signaling-pathway","display_name":"estrogen signaling pathway","score":0.8569999933242798},{"id":"https://openalex.org/keywords/il-15","display_name":"IL-15","score":0.8769999742507935},{"id":"https://openalex.org/keywords/il-12-signaling","display_name":"IL-12 signaling","score":0.753000020980835},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9210000038146973},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.492000013589859},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8249046802520752},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.7081118226051331},{"id":"https://openalex.org/C10590036","wikidata":"https://www.wikidata.org/wiki/Q417664","display_name":"Exome","level":5,"score":0.6054049730300903},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5711371898651123},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5540472865104675},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5298172235488892},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48328259587287903},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47253870964050293},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.45031288266181946},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37358319759368896},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3021348714828491},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.24624064564704895},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20506495237350464},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-019-53445-2","doi":"https://doi.org/10.1038/s41598-019-53445-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-53445-2","pdf_url":"https://www.nature.com/articles/s41598-019-53445-2.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6868235","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6868235","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:31748686","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31748686","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7e265e93de9c4757bf2c0096c2e6161c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7e265e93de9c4757bf2c0096c2e6161c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-019-53445-2","doi":"https://doi.org/10.1038/s41598-019-53445-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-53445-2","pdf_url":"https://www.nature.com/articles/s41598-019-53445-2.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2738784800","display_name":null,"funder_award_id":"4100070267","funder_id":"https://openalex.org/F4320308109","funder_display_name":"Pennsylvania Department of Health"},{"id":"https://openalex.org/G3728810218","display_name":null,"funder_award_id":"NLM R01 LM012535","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G5771693100","display_name":"Integrating Neuroimaging, Multi-omics, and Clinical Data in Complex Disease","funder_award_id":"R01LM012535","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G9000892397","display_name":"Postdoctoral Training Program in Genomic Medicine","funder_award_id":"T32HG009495","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G927697331","display_name":null,"funder_award_id":"SAP 4100070267","funder_id":"https://openalex.org/F4320308109","funder_display_name":"Pennsylvania Department of Health"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320308109","display_name":"Pennsylvania Department of Health","ror":"https://ror.org/00ra1fg11"},{"id":"https://openalex.org/F4320316485","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2991562362.pdf","grobid_xml":"https://content.openalex.org/works/W2991562362.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W67494939","https://openalex.org/W1505805985","https://openalex.org/W1580873320","https://openalex.org/W1856929799","https://openalex.org/W1878939331","https://openalex.org/W1966522008","https://openalex.org/W1966888972","https://openalex.org/W1967438457","https://openalex.org/W1980748988","https://openalex.org/W1992891812","https://openalex.org/W1997696802","https://openalex.org/W2005903270","https://openalex.org/W2009144436","https://openalex.org/W2011364588","https://openalex.org/W2020427316","https://openalex.org/W2029387902","https://openalex.org/W2033288453","https://openalex.org/W2035227451","https://openalex.org/W2042308712","https://openalex.org/W2056516604","https://openalex.org/W2059145105","https://openalex.org/W2070050178","https://openalex.org/W2072881647","https://openalex.org/W2075358173","https://openalex.org/W2080896009","https://openalex.org/W2082554712","https://openalex.org/W2089121621","https://openalex.org/W2089415609","https://openalex.org/W2098613135","https://openalex.org/W2103017472","https://openalex.org/W2108169091","https://openalex.org/W2109372707","https://openalex.org/W2112702439","https://openalex.org/W2113087175","https://openalex.org/W2117692326","https://openalex.org/W2123529223","https://openalex.org/W2135665336","https://openalex.org/W2141829621","https://openalex.org/W2142763130","https://openalex.org/W2143793496","https://openalex.org/W2148864810","https://openalex.org/W2154139219","https://openalex.org/W2154866190","https://openalex.org/W2156428955","https://openalex.org/W2162923066","https://openalex.org/W2205846833","https://openalex.org/W2229599978","https://openalex.org/W2261132199","https://openalex.org/W2311831505","https://openalex.org/W2341084900","https://openalex.org/W2345356016","https://openalex.org/W2416855278","https://openalex.org/W2559028280","https://openalex.org/W2599095921","https://openalex.org/W2605215901","https://openalex.org/W2609771818","https://openalex.org/W2618990461","https://openalex.org/W2753774840","https://openalex.org/W2765777509","https://openalex.org/W2804456101","https://openalex.org/W2982152435","https://openalex.org/W3029661147","https://openalex.org/W4210702584"],"related_works":["https://openalex.org/W3113298620","https://openalex.org/W4396830124","https://openalex.org/W4407725278","https://openalex.org/W2738432387","https://openalex.org/W7154712589","https://openalex.org/W4249740879","https://openalex.org/W4295880250","https://openalex.org/W2258353569","https://openalex.org/W4280534822","https://openalex.org/W2143793496"],"abstract_inverted_index":{"Since":[0],"prostate":[1,10,43,73,92,165,182],"cancer":[2,11,44,74,93,183],"is":[3,204],"highly":[4],"heritable,":[5],"common":[6],"variants":[7,26,41,136,175],"associated":[8,163],"with":[9,72,91,164,214],"have":[12,27,46],"been":[13,49],"studied":[14],"in":[15,20,52,156,181,185],"various":[16],"populations,":[17],"including":[18,118,139],"those":[19],"Korea.":[21],"However,":[22],"rare":[23,40,64,81,174],"and":[24,75,107,124,137,151,154,173],"low-frequency":[25],"a":[28,53,61,179,192,209,215],"significant":[29],"influence":[30],"on":[31,134],"the":[32,35,119,186,197,212],"heritability":[33],"of":[34,39,67,196,200,211,218],"disease.":[36],"The":[37],"contributions":[38],"to":[42,88,97,161,205],"susceptibility":[45,101,184],"not":[47],"yet":[48],"systematically":[50],"evaluated":[51],"Korean":[54,187],"population.":[55,188],"In":[56,78,95,167],"this":[57],"work,":[58],"we":[59,169],"present":[60],"large-scale":[62],"exome-wide":[63],"variant":[65,82],"analysis":[66],"7,258":[68],"individuals":[69],"(985":[70],"cases":[71],"6,273":[76],"controls).":[77],"total,":[79],"19":[80],"loci":[83],"spanning":[84],"7":[85],"genes":[86,102,111,172],"contributed":[87],"an":[89],"association":[90],"susceptibility.":[94],"addition":[96],"replicating":[98],"previously":[99],"known":[100,160],"(e.g.,":[103],"CDYL2,":[104],"MST1R,":[105],"GPER1,":[106],"PARD3B),":[108],"3":[109],"novel":[110,171],"were":[112,131],"identified":[113,132,135],"(FDR":[114],"q":[115],"<":[116],"0.05),":[117],"non-coding":[120],"RNAs":[121],"ENTPD3-AS1,":[122],"LOC102724438,":[123],"protein-coding":[125],"gene":[126],"SPATA3.":[127],"Additionally,":[128],"6":[129],"pathways":[130],"based":[133],"genes,":[138],"estrogen":[140],"signaling":[141,143,149,153],"pathway,":[142,150],"by":[144],"MST1,":[145],"IL-15":[146],"production,":[147],"MSP-RON":[148],"IL-12":[152],"production":[155],"macrophages,":[157],"which":[158,203],"are":[159],"be":[162],"cancer.":[166],"summary,":[168],"report":[170],"that":[176],"potentially":[177],"play":[178],"role":[180],"These":[189],"observations":[190],"demonstrated":[191],"path":[193],"towards":[194],"one":[195],"fundamental":[198],"goals":[199],"precision":[201],"medicine,":[202],"identify":[206],"biomarkers":[207],"for":[208],"subset":[210],"population":[213],"greater":[216],"risk":[217],"disease":[219],"than":[220],"others.":[221]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2019-12-05T00:00:00"}