{"id":"https://openalex.org/W2991543335","doi":"https://doi.org/10.1002/jcp.29403","title":"The role of activation of K\u0410TP channels on hydrogen sulfide induced renoprotective effect on diabetic nephropathy","display_name":"The role of activation of K\u0410TP channels on hydrogen sulfide induced renoprotective effect on diabetic nephropathy","publication_year":2019,"publication_date":"2019-11-27","ids":{"openalex":"https://openalex.org/W2991543335","doi":"https://doi.org/10.1002/jcp.29403","mag":"2991543335","pmid":"https://pubmed.ncbi.nlm.nih.gov/31774182"},"language":"en","primary_location":{"id":"doi:10.1002/jcp.29403","doi":"https://doi.org/10.1002/jcp.29403","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.29403","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084568645","display_name":"Eman Elbassuoni","orcid":"https://orcid.org/0000-0003-1408-1131","observed_orcids":["https://orcid.org/0000-0003-1408-1131"]},"institutions":[{"id":"https://openalex.org/I89466785","display_name":"Minia University","ror":"https://ror.org/02hcv4z63","country_code":"EG","type":"education","lineage":["https://openalex.org/I89466785"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Eman A. Elbassuoni","raw_affiliation_strings":["Department of Physiology, Minia University Faculty of Medicine, Minia, Egypt"],"raw_orcid":"https://orcid.org/0000-0003-1408-1131","affiliations":[{"raw_affiliation_string":"Department of Physiology, Minia University Faculty of Medicine, Minia, Egypt","institution_ids":["https://openalex.org/I89466785"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015536938","display_name":"Neven Makram Aziz","orcid":"https://orcid.org/0000-0001-5178-0084","observed_orcids":["https://orcid.org/0000-0001-5178-0084"]},"institutions":[{"id":"https://openalex.org/I4401727001","display_name":"Deraya University","ror":"https://ror.org/05252fg05","country_code":"EG","type":"education","lineage":["https://openalex.org/I4401727001"]},{"id":"https://openalex.org/I89466785","display_name":"Minia University","ror":"https://ror.org/02hcv4z63","country_code":"EG","type":"education","lineage":["https://openalex.org/I89466785"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Neven M. \u0410ziz","raw_affiliation_strings":["Delegated to Medical Department in Pharmacy and Physiotherapy Faculties, Deraya University, New Minia City, Egypt","Department of Physiology, Minia University Faculty of Medicine, Minia, Egypt"],"raw_orcid":"https://orcid.org/0000-0001-5178-0084","affiliations":[{"raw_affiliation_string":"Delegated to Medical Department in Pharmacy and Physiotherapy Faculties, Deraya University, New Minia City, Egypt","institution_ids":["https://openalex.org/I4401727001"]},{"raw_affiliation_string":"Department of Physiology, Minia University Faculty of Medicine, Minia, Egypt","institution_ids":["https://openalex.org/I89466785"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048636671","display_name":"Wagdy N. Habeeb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89466785","display_name":"Minia University","ror":"https://ror.org/02hcv4z63","country_code":"EG","type":"education","lineage":["https://openalex.org/I89466785"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Wagd\u0443 N. Habeeb","raw_affiliation_strings":["Department of Physiology, Minia University Faculty of Medicine, Minia, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Minia University Faculty of Medicine, Minia, Egypt","institution_ids":["https://openalex.org/I89466785"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5084568645"],"corresponding_institution_ids":["https://openalex.org/I89466785"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.6295,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.55154394,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"235","issue":"6","first_page":"5223","last_page":"5228"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrogen-sulfide","display_name":"hydrogen sulfide","score":0.996999979019165},{"id":"https://openalex.org/keywords/atp-sensitive-potassium-channels","display_name":"ATP-sensitive potassium channels","score":0.8109999895095825},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9639999866485596},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.8939999938011169},{"id":"https://openalex.org/keywords/glibenclamide","display_name":"glibenclamide","score":0.9240000247955322},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9509999752044678},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9330000281333923},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8830000162124634},{"id":"https://openalex.org/keywords/antioxidant-capacity","display_name":"antioxidant capacity","score":0.8299999833106995},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8600000143051147},{"id":"https://openalex.org/keywords/renal-inflammation","display_name":"renal inflammation","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C2780564542","wikidata":"https://www.wikidata.org/wiki/Q170591","display_name":"Hydrogen sulfide","level":3,"score":0.7405701279640198},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.6315037608146667},{"id":"https://openalex.org/C2780596425","wikidata":"https://www.wikidata.org/wiki/Q221205","display_name":"Sulfide","level":2,"score":0.5406901240348816},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.510047972202301},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5018260478973389},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.4928469657897949},{"id":"https://openalex.org/C518881349","wikidata":"https://www.wikidata.org/wiki/Q682","display_name":"Sulfur","level":2,"score":0.39591947197914124},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33935752511024475},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2581647038459778},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2330886721611023},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005905","descriptor_name":"Glyburide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006862","descriptor_name":"Hydrogen Sulfide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013440","descriptor_name":"Sulfides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D026902","descriptor_name":"Potassium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcp.29403","doi":"https://doi.org/10.1002/jcp.29403","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.29403","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmid:31774182","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31774182","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1979710206","https://openalex.org/W1994655109","https://openalex.org/W2000314390","https://openalex.org/W2033753222","https://openalex.org/W2055008347","https://openalex.org/W2072733365","https://openalex.org/W2073607082","https://openalex.org/W2119304571","https://openalex.org/W2127803154","https://openalex.org/W2135017906","https://openalex.org/W2142400919","https://openalex.org/W2156615759","https://openalex.org/W2197387265","https://openalex.org/W2225716131","https://openalex.org/W2234786443","https://openalex.org/W2293565428","https://openalex.org/W2337126204","https://openalex.org/W2408777897","https://openalex.org/W2481995427","https://openalex.org/W2547047079","https://openalex.org/W2553261268","https://openalex.org/W2569947792","https://openalex.org/W2617008493","https://openalex.org/W2619559855","https://openalex.org/W2755284451","https://openalex.org/W2802698552","https://openalex.org/W2806024709"],"related_works":["https://openalex.org/W1980773214","https://openalex.org/W2806167094","https://openalex.org/W2916588528","https://openalex.org/W3134300636","https://openalex.org/W108144406","https://openalex.org/W2054860716","https://openalex.org/W2902375533","https://openalex.org/W3025637374","https://openalex.org/W2966417136","https://openalex.org/W3175773440"],"abstract_inverted_index":{"\u0410bstr\u0430ct":[0],"This":[1],"work":[2,145],"aims":[3],"to":[4,117,128],"investigate":[5],"the":[6,14,20,66,74,78,86,99,109,140,143,148,154],"renal":[7,80,122,133,162,180],"effect":[8,178],"of":[9,22,24,93,151,156,173,186],"hydrogen":[10],"sulfide":[11],"(H2S),":[12],"in":[13,29,65,77,121,126,132,153],"experimentally":[15],"induced":[16],"diabetic":[17,44,67,87],"nephropathy,":[18],"besides":[19],"role":[21,92],"activation":[23,172],"\u0410\u0422P\u2010sensitive":[25],"potassium":[26],"(K\u0410TP)":[27],"channel":[28,57],"that":[30,62,147],"effect.":[31],"Thirty\u2010two":[32],"adult":[33],"male":[34],"albino":[35],"rats":[36],"randomly":[37],"divided":[38],"into":[39],"four":[40],"groups:":[41],"Control,":[42],"streptozotocin\u2010induced":[43],"(diabetic":[45],"nephropathy":[46],"[DN]),":[47],"DN+NaHS":[48],"(the":[49],"H2S":[50,152],"inducer),":[51],"and":[52,95,165],"DN+NaHS+Glibenclamide":[53],"(a":[54],"selective":[55],"K\u0410TP":[56,174],"blocker)":[58],"groups.":[59],"Results":[60],"showed":[61],"kidney":[63,101],"functions":[64,102],"group":[68,88],"improved":[69,100],"by":[70,73,104,108],"NaHS":[71,105],"proved":[72],"significant":[75,119,130],"decrease":[76,131],"measured":[79],"injury":[81],"markers":[82],"when":[83],"compared":[84],"with":[85,89,111],"an":[90],"obvious":[91],"inflammation":[94],"oxidative":[96],"stress.":[97],"However,":[98],"produced":[103],"was":[106],"reduced":[107],"combination":[110,114],"Glibenclamide.":[112],"Glibenclamide":[113],"led":[115],"also":[116],"a":[118,129],"increase":[120],"total":[123,134],"antioxidant":[124],"capacity,":[125],"addition":[127],"nitric":[135],"oxide":[136],"(NO)":[137],"level.":[138],"\u0410ccordingly,":[139],"results":[141],"from":[142],"present":[144],"revealed":[146],"renoprotective":[149],"effects":[150,160],"case":[155],"DN":[157],"through":[158],"its":[159,177],"on":[161,171,179],"tissue":[163,181],"antioxidants":[164],"NO":[166],"can":[167],"be":[168],"partially":[169],"dependent":[170],"channels,":[175],"while":[176],"proinflammatory":[182],"cytokines":[183],"is":[184],"independent":[185],"it.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-05T00:00:00"}
