{"id":"https://openalex.org/W2991522372","doi":null,"title":"Molecular mechanisms involved in TGF-\u03b21-induced Muscle-derived stem cells differentiation to smooth muscle cells.","display_name":"Molecular mechanisms involved in TGF-\u03b21-induced Muscle-derived stem cells differentiation to smooth muscle cells.","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2991522372","mag":"2991522372","pmid":"https://pubmed.ncbi.nlm.nih.gov/31497230","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6731421"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:5688758","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6731421","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6731421","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101837153","display_name":"Xiang Tang","orcid":"https://orcid.org/0000-0002-6843-7407","observed_orcids":["https://orcid.org/0000-0002-6843-7407"]},"institutions":[{"id":"https://openalex.org/I4210105982","display_name":"Guangzhou Women and Children Medical Center","ror":"https://ror.org/01g53at17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105982"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang Tang","raw_affiliation_strings":["Department of Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University Guangzhou 510623, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University Guangzhou 510623, China","institution_ids":["https://openalex.org/I4210105982","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076468614","display_name":"Xianghui Su","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105982","display_name":"Guangzhou Women and Children Medical Center","ror":"https://ror.org/01g53at17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105982"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianghui Su","raw_affiliation_strings":["Department of Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University Guangzhou 510623, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University Guangzhou 510623, China","institution_ids":["https://openalex.org/I4210105982","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072951209","display_name":"Zhuohui Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105982","display_name":"Guangzhou Women and Children Medical Center","ror":"https://ror.org/01g53at17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105982"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuohui Zhong","raw_affiliation_strings":["Department of Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University Guangzhou 510623, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University Guangzhou 510623, China","institution_ids":["https://openalex.org/I4210105982","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000049394","display_name":"Canliang Wen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105982","display_name":"Guangzhou Women and Children Medical Center","ror":"https://ror.org/01g53at17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105982"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Canliang Wen","raw_affiliation_strings":["Department of Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University Guangzhou 510623, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University Guangzhou 510623, China","institution_ids":["https://openalex.org/I4210105982","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019534175","display_name":"Tiansong Zhang","orcid":"https://orcid.org/0009-0000-8126-9308","observed_orcids":["https://orcid.org/0009-0000-8126-9308"]},"institutions":[{"id":"https://openalex.org/I4210105982","display_name":"Guangzhou Women and Children Medical Center","ror":"https://ror.org/01g53at17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105982"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tiansong Zhang","raw_affiliation_strings":["Department of Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University Guangzhou 510623, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University Guangzhou 510623, China","institution_ids":["https://openalex.org/I4210105982","https://openalex.org/I92039509"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062291677","display_name":"Yali Zhu","orcid":"https://orcid.org/0000-0003-1375-7750","observed_orcids":["https://orcid.org/0000-0003-1375-7750"]},"institutions":[{"id":"https://openalex.org/I4210105982","display_name":"Guangzhou Women and Children Medical Center","ror":"https://ror.org/01g53at17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105982"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yali Zhu","raw_affiliation_strings":["Department of Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University Guangzhou 510623, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University Guangzhou 510623, China","institution_ids":["https://openalex.org/I4210105982","https://openalex.org/I92039509"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2708,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.43607219,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"11","issue":"8","first_page":"5150","last_page":"5161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.5321999788284302,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.5321999788284302,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.3280999958515167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.09669999778270721,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9259999990463257},{"id":"https://openalex.org/keywords/muscle-derived-stem-cells","display_name":"muscle-derived stem cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/smooth-muscle-cell-differentiation","display_name":"smooth muscle differentiation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/differentially-methylated-sites","display_name":"differentially methylated sites","score":0.996999979019165},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.47600001096725464},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.7850000262260437},{"id":"https://openalex.org/keywords/calponin-1","display_name":"CNN1","score":0.9200000166893005},{"id":"https://openalex.org/keywords/desmin","display_name":"desmin","score":0.6370000243186951},{"id":"https://openalex.org/keywords/sca-1","display_name":"Sca-1","score":0.9150000214576721},{"id":"https://openalex.org/keywords/pelvic-organ-prolapse","display_name":"pelvic organ prolapse","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6561753749847412},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5428133606910706},{"id":"https://openalex.org/C2779072444","wikidata":"https://www.wikidata.org/wiki/Q425146","display_name":"Desmin","level":4,"score":0.5389851331710815},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5095115303993225},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.48918893933296204},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.4643939137458801},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.4291803240776062},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4154418706893921},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.4132236838340759},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37290745973587036},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36163902282714844},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.32783135771751404},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3180506229400635},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.27242550253868103},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1604350209236145},{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.14182040095329285}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:5688758","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6731421","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31497230","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31497230","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6731421","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6731421/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"mag:2991522372","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31497230","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5688758","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6731421","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W307884343","https://openalex.org/W1507388704","https://openalex.org/W1967188390","https://openalex.org/W1967619562","https://openalex.org/W1975792001","https://openalex.org/W1977264473","https://openalex.org/W1983659356","https://openalex.org/W1985709969","https://openalex.org/W1993329293","https://openalex.org/W2009950682","https://openalex.org/W2010422325","https://openalex.org/W2011465123","https://openalex.org/W2014629853","https://openalex.org/W2036537461","https://openalex.org/W2053439866","https://openalex.org/W2058214637","https://openalex.org/W2060570186","https://openalex.org/W2060907896","https://openalex.org/W2062573580","https://openalex.org/W2072350563","https://openalex.org/W2077351516","https://openalex.org/W2097341408","https://openalex.org/W2098887593","https://openalex.org/W2101486850","https://openalex.org/W2105534128","https://openalex.org/W2111661564","https://openalex.org/W2112129023","https://openalex.org/W2115252759","https://openalex.org/W2121348589","https://openalex.org/W2137499573","https://openalex.org/W2140223314","https://openalex.org/W2146516445","https://openalex.org/W2152656267","https://openalex.org/W2154431984","https://openalex.org/W2158272906","https://openalex.org/W2203234485","https://openalex.org/W2266492038","https://openalex.org/W2296240596","https://openalex.org/W2333778778","https://openalex.org/W2535847218","https://openalex.org/W2701956219","https://openalex.org/W2725804636","https://openalex.org/W7096449427"],"related_works":["https://openalex.org/W3004490112","https://openalex.org/W2132731853","https://openalex.org/W3028960503","https://openalex.org/W2892305017","https://openalex.org/W2769475439","https://openalex.org/W2039397696","https://openalex.org/W1972157351","https://openalex.org/W3030095304","https://openalex.org/W2045010252","https://openalex.org/W2799333636"],"abstract_inverted_index":{"to":[0,15,32,52,71],"examine":[1],"the":[2,36,41,115,120,143,149,153,172],"effects":[3],"of":[4,44,75,84,104,136,146,174],"MDSC":[5],"induction.":[6],"Gene":[7],"ontology":[8],"and":[9,29,39,58,66,68,78,86,158,177],"KEGG":[10],"pathway":[11],"analyses":[12,80],"were":[13,54,62,69,110,125],"performed":[14,26],"analyze":[16,40],"these":[17],"differentially":[18,45,99],"expressed":[19,100],"genes.":[20],"Reduced":[21],"representation":[22],"bisulfite":[23],"sequencing":[24],"was":[25,131],"in":[27,35,114,119,165],"TGF-\u03b21-treated":[28,121],"untreated":[30,116],"cells":[31,53,61],"evaluate":[33],"differences":[34],"methylation":[37],"status":[38],"chromosomal":[42,134],"distribution":[43,135],"methylated":[46],"sites":[47,113],"(DMSs).":[48],"Significant":[49],"morphological":[50],"changes":[51],"observed":[55],"at":[56],"PP3,":[57],"most":[59],"PP3":[60],"positive":[63],"for":[64],"desmin":[65],"SCA-1,":[67],"confirmed":[70],"be":[72],"MDSCs.":[73],"Results":[74,103],"western":[76],"blot":[77],"immunohistochemistry":[79],"suggested":[81],"that":[82,108,139],"expressions":[83],"a-SMA":[85],"CNN1":[87],"significantly":[88],"increased":[89],"after":[90],"treatment":[91],"with":[92],"TGF-\u03b21.":[93],"Global":[94],"transcriptome":[95],"analysis":[96,106],"identified":[97],"1996":[98],"genes":[101,163],"(MSC_TGF\u03b21/MSC_NC).":[102],"methylome":[105],"indicated":[107,138],"there":[109],"more":[111],"hypermethylation":[112],"group":[117],"than":[118],"group.":[122],"Most":[123],"DMSs":[124,137],"hypermethylated,":[126],"whereas":[127,148],"a":[128],"small":[129],"portion":[130],"hypomethylated.":[132],"The":[133],"chromosome":[140,151],"1":[141],"had":[142,152],"highest":[144],"proportion":[145],"DMSs,":[147],"Y":[150],"fewest":[154],"DMSs.":[155],"Sud2,":[156],"Pcdh19,":[157],"Nat14":[159],"are":[160],"potential":[161],"core":[162],"involved":[164],"cell":[166,175],"differentiation.":[167],"These":[168],"results":[169],"may":[170],"explain":[171],"mechanisms":[173],"differentiation":[176],"provide":[178],"useful":[179],"information":[180],"regarding":[181],"diseases":[182],"such":[183],"as":[184],"pelvic":[185],"organ":[186],"prolapse.":[187]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-12-05T00:00:00"}