{"id":"https://openalex.org/W2991493077","doi":null,"title":"Intestinal preservation for transplantation: translational approaches","display_name":"Intestinal preservation for transplantation: translational approaches","publication_year":2019,"publication_date":"2019-11-13","ids":{"openalex":"https://openalex.org/W2991493077","mag":"2991493077"},"language":"en","primary_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/60814","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2077/60814","pdf_url":null,"source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062784141","display_name":"John Mackay S\u00f8fteland","orcid":"https://orcid.org/0000-0001-7993-5906","observed_orcids":["https://orcid.org/0000-0001-7993-5906"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"John Mackay S\u00f8fteland","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7993-5906","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5062784141"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intestinal-transplantation","display_name":"intestinal transplantation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cold-storage","display_name":"cold storage","score":0.492000013589859},{"id":"https://openalex.org/keywords/polyethylene-glycol","display_name":"polyethylene glycol","score":0.9419999718666077},{"id":"https://openalex.org/keywords/donor-age","display_name":"donor age","score":0.8619999885559082},{"id":"https://openalex.org/keywords/intestinal-mucosal-injury","display_name":"intestinal mucosal injury","score":0.625},{"id":"https://openalex.org/keywords/species-differences","display_name":"species differences","score":0.7059999704360962},{"id":"https://openalex.org/keywords/porcine-intestine","display_name":"porcine intestine","score":0.8209999799728394},{"id":"https://openalex.org/keywords/human-intestine","display_name":"human intestine","score":0.8320000171661377},{"id":"https://openalex.org/keywords/intestinal-ischemia","display_name":"intestinal ischemia","score":0.5289999842643738},{"id":"https://openalex.org/keywords/intestinal-edema","display_name":"intestinal edema","score":0.5350000262260437},{"id":"https://openalex.org/keywords/intestinal-function","display_name":"intestinal function","score":0.39399999380111694},{"id":"https://openalex.org/keywords/bacterial-translocation","display_name":"bacterial translocation","score":0.628000020980835},{"id":"https://openalex.org/keywords/postreperfusion-syndrome","display_name":"postreperfusion syndrome","score":0.8970000147819519},{"id":"https://openalex.org/keywords/alloreactivity","display_name":"alloreactivity","score":0.8349999785423279},{"id":"https://openalex.org/keywords/vascular-perfusion","display_name":"vascular perfusion","score":0.44600000977516174}],"concepts":[{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6698975563049316},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42858463525772095},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3494054675102234},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1389002501964569}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:gupea.ub.gu.se:2077/60814","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2077/60814","pdf_url":null,"source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"mag:2991493077","doi":null,"is_oa":false,"landing_page_url":"https://guoa.ub.gu.se/handle/2077/60814","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.979200005531311,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":102,"referenced_works":["https://openalex.org/W1127532827","https://openalex.org/W1257751653","https://openalex.org/W1503947404","https://openalex.org/W1506333726","https://openalex.org/W1548391840","https://openalex.org/W1593435431","https://openalex.org/W1631658643","https://openalex.org/W1644805691","https://openalex.org/W1645633844","https://openalex.org/W1656145083","https://openalex.org/W1713120398","https://openalex.org/W1735764346","https://openalex.org/W1778785291","https://openalex.org/W1821971731","https://openalex.org/W1855608622","https://openalex.org/W1896582778","https://openalex.org/W1963953337","https://openalex.org/W1966651494","https://openalex.org/W1983143582","https://openalex.org/W1990327099","https://openalex.org/W1992730456","https://openalex.org/W1996805844","https://openalex.org/W1997472755","https://openalex.org/W2002533643","https://openalex.org/W2005417237","https://openalex.org/W2006008435","https://openalex.org/W2006183803","https://openalex.org/W2007196951","https://openalex.org/W2008757142","https://openalex.org/W2014277764","https://openalex.org/W2015404562","https://openalex.org/W2020853440","https://openalex.org/W2020922864","https://openalex.org/W2027073025","https://openalex.org/W2029126990","https://openalex.org/W2030489979","https://openalex.org/W2033985537","https://openalex.org/W2034861956","https://openalex.org/W2038643144","https://openalex.org/W2041394758","https://openalex.org/W2054959660","https://openalex.org/W2055542082","https://openalex.org/W2055548116","https://openalex.org/W2059699981","https://openalex.org/W2062906915","https://openalex.org/W2064517350","https://openalex.org/W2064923543","https://openalex.org/W2065800760","https://openalex.org/W2066906245","https://openalex.org/W2067645747","https://openalex.org/W2074911776","https://openalex.org/W2076460789","https://openalex.org/W2077706067","https://openalex.org/W2078984848","https://openalex.org/W2083686498","https://openalex.org/W2087061882","https://openalex.org/W2095336107","https://openalex.org/W2098003938","https://openalex.org/W2102507957","https://openalex.org/W2106203516","https://openalex.org/W2112357770","https://openalex.org/W2116459891","https://openalex.org/W2122292170","https://openalex.org/W2123471272","https://openalex.org/W2124246410","https://openalex.org/W2126057926","https://openalex.org/W2129276762","https://openalex.org/W2132785650","https://openalex.org/W2142578843","https://openalex.org/W2145189896","https://openalex.org/W2152380059","https://openalex.org/W2153567217","https://openalex.org/W2154626149","https://openalex.org/W2154986481","https://openalex.org/W2155124532","https://openalex.org/W2156951651","https://openalex.org/W2160091933","https://openalex.org/W2162861612","https://openalex.org/W2163190373","https://openalex.org/W2164162206","https://openalex.org/W2165981892","https://openalex.org/W2166203425","https://openalex.org/W2194928240","https://openalex.org/W2217024838","https://openalex.org/W2254140844","https://openalex.org/W2280262045","https://openalex.org/W2371948111","https://openalex.org/W2462023038","https://openalex.org/W2514741985","https://openalex.org/W2556056809","https://openalex.org/W2580944979","https://openalex.org/W2584854590","https://openalex.org/W2791170020","https://openalex.org/W2793463418","https://openalex.org/W2803201468","https://openalex.org/W2895307797","https://openalex.org/W2907483664","https://openalex.org/W2939731554","https://openalex.org/W2964546132","https://openalex.org/W2968645588","https://openalex.org/W2969727796","https://openalex.org/W2974086585"],"related_works":["https://openalex.org/W2981792332","https://openalex.org/W4382055131","https://openalex.org/W2799920521","https://openalex.org/W7217823895","https://openalex.org/W3082209343","https://openalex.org/W3176366623","https://openalex.org/W3109956404","https://openalex.org/W2955055351","https://openalex.org/W3175427641","https://openalex.org/W2416544780"],"abstract_inverted_index":{"Background:":[0],"Intestinal":[1],"preservation":[2,85,152],"injury":[3,86,237,323],"(IPI)":[4],"may":[5,40],"result":[6],"in":[7,160,165,196,212,253,294,299,320,324,353,375,384],"various":[8,92],"degrees":[9],"of":[10,22,72,81,91,121,134,140,163,182,194,207,221,259,272,291,335,358,361,373],"mucosal":[11,43],"damage,":[12],"which\\nmay":[13],"later":[14],"favor":[15],"bacterial":[16],"translocation,":[17],"post-reperfusion":[18],"syndrome,":[19],"and":[20,30,45,63,110,136,158,199,240,269,310,327],"upregulation":[21],"alloreactivity.\\nExperimental":[23],"evidence":[24],"suggests":[25],"that":[26],"combining":[27],"vascular":[28],"perfusion":[29],"cold":[31,280],"storage":[32,48],"with":[33,154,223,276,314,341],"luminal\\ninterventions":[34],"using":[35,61],"polyethylene":[36],"glycol":[37],"(PEG)":[38],"solutions":[39],"mitigate":[41],"the":[42,51,70,84,119,122,126,132,138,166,180,186,192,205,219,289,292,342,359,362,371],"damage":[44],"extend":[46],"the\\nsafe":[47],"time.":[49],"During":[50],"last":[52],"years,":[53],"there":[54],"has":[55,128],"been":[56],"an":[57,129],"increasing":[58],"trend":[59],"towards":[60],"livers":[62],"kidneys\\nfrom":[64],"older":[65],"donors":[66],"for":[67,250],"transplantation,":[68],"yet":[69],"field":[71],"intestinal":[73,201,230],"transplantation":[74],"is":[75,87,101,156,297,351],"far":[76],"more":[77,305],"conservative":[78],"as\\nthe":[79],"impact":[80,130],"age":[82,209,301],"on":[83,131,185,210,227],"unknown.":[88],"Clinical":[89],"translation":[90],"experimental":[93],"models\\nis":[94],"hampered":[95],"by":[96],"interspecies":[97],"differences,":[98],"as":[99],"little":[100],"known":[102],"about":[103],"how":[104],"IPI":[105,135,141,164,195,211,273,293,336,356,374],"development":[106,133,139,193,238,290,334,372],"differs":[107,142,337],"between\\nrodents,":[108],"pigs,":[109],"humans.":[111,146],"The":[112,256,333],"current":[113],"thesis":[114],"aimed":[115],"to":[116,178,267,287,369],"explore":[117],"if":[118,150],"size":[120,184,265,360],"PEG":[123,155,183,260,317,363],"molecule":[124],"or":[125],"donor\\nage":[127,283],"whether":[137],"between":[143,339],"rats,":[144],"pigs,\\nand":[145],"It":[147],"also":[148,245],"examines":[149],"luminal":[151,257],"(LP)":[153],"safe":[157],"efficient":[159],"delaying":[161,321],"the\\ndevelopment":[162,271],"human":[167,200,228,309,325],"intestine.\\nMethods:":[168],"In":[169,232],"Paper":[170,189,203,216,254],"I,":[171],"we":[172,235],"used":[173,246],"small":[174,229],"intestines":[175],"from":[176],"rats":[177],"study":[179],"effect":[181,206,220],"development\\nof":[187],"IPI.":[188,349],"II":[190],"compared":[191,275],"rat,":[197],"porcine,":[198],"specimens.":[202,231],"III\\nassessed":[204],"donor":[208,365],"a":[213,224,315,345],"rat":[214,311,343],"model.":[215],"IV":[217],"studied":[218],"LP":[222,296,313,350,367],"low-sodium\\nPEG":[225],"solution":[226,318],"all":[233,300],"studies,":[234],"analyzed":[236],"using\\nhistological":[239],"molecular":[241,264],"biological":[242],"approaches.":[243],"We":[244],"Ussing":[247],"chamber":[248],"experiments":[249],"intestinal\\nfunctional":[251],"assessment":[252],"I.\\nResults:":[255],"presence":[258],"rather":[261],"than":[262,308],"its":[263],"appears":[266,368],"reduce":[268],"delay":[270,370],"when":[274,347],"controls":[277],"undergoing":[278],"standard":[279],"preservation.":[281],"Increasing":[282],"does":[284,328],"not":[285,329],"appear":[286],"accelerate":[288],"rats.":[295],"effective":[298,352],"groups.":[302],"Pig\\nintestines":[303],"are":[304],"ischemia":[306],"resistant":[307],"intestines.":[312],"low-sodium":[316],"is\\neffective":[319],"tissue":[322,379],"specimens":[326],"cause":[330],"excess":[331],"edema.\\nConclusions:":[332],"significantly":[338],"species,":[340],"being":[344],"sensitive\\nmodel":[346],"studying":[348],"protecting":[354],"against":[355],"regardless":[357],"molecule\\nor":[364],"age.":[366],"humans":[376],"without":[377],"causing":[378],"edema":[380],"and\\ncould":[381],"be":[382],"introduced":[383],"clinical":[385],"practice.":[386]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-05T00:00:00"}