{"id":"https://openalex.org/W2991411084","doi":"https://doi.org/10.1016/j.ophtha.2019.11.010","title":"Anti\u2013Vascular Endothelial Growth Factor Use and Atrophy in Neovascular Age-Related Macular Degeneration","display_name":"Anti\u2013Vascular Endothelial Growth Factor Use and Atrophy in Neovascular Age-Related Macular Degeneration","publication_year":2019,"publication_date":"2019-11-22","ids":{"openalex":"https://openalex.org/W2991411084","doi":"https://doi.org/10.1016/j.ophtha.2019.11.010","mag":"2991411084","pmid":"https://pubmed.ncbi.nlm.nih.gov/32081493"},"language":"en","primary_location":{"id":"doi:10.1016/j.ophtha.2019.11.010","doi":"https://doi.org/10.1016/j.ophtha.2019.11.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ophtha.2019.11.010","pdf_url":"http://www.aaojournal.org/article/S0161642019322821/pdf","source":{"id":"https://openalex.org/S207341048","display_name":"Ophthalmology","issn_l":"0161-6420","issn":["0161-6420","1549-4713"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.aaojournal.org/article/S0161642019322821/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112882370","display_name":"SriniVas R. Sadda","orcid":"https://orcid.org/0000-0002-4939-3306","observed_orcids":["https://orcid.org/0000-0002-4939-3306"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210095445","display_name":"Doheny Eye Institute","ror":"https://ror.org/00qvx5329","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210095445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"SriniVas R. Sadda","raw_affiliation_strings":["Doheny Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California. Electronic address: ssadda@doheny.org","Doheny Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doheny Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California. Electronic address: ssadda@doheny.org","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210095445"]},{"raw_affiliation_string":"Doheny Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210095445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051997081","display_name":"Robyn H. Guymer","orcid":"https://orcid.org/0000-0002-9441-4356","observed_orcids":["https://orcid.org/0000-0002-9441-4356"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105949","display_name":"Centre for Eye Research Australia","ror":"https://ror.org/01sqdef20","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210105949"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Robyn Guymer","raw_affiliation_strings":["Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Department of Surgery (Ophthalmology), Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Department of Surgery (Ophthalmology), Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075601330","display_name":"Jordi Mon\u00e9s","orcid":"https://orcid.org/0000-0003-3685-2160","observed_orcids":["https://orcid.org/0000-0003-3685-2160"]},"institutions":[{"id":"https://openalex.org/I4210166098","display_name":"Barcelona Macula Foundation","ror":"https://ror.org/05s74p982","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210166098"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jordi M. Mon\u00e9s","raw_affiliation_strings":["Institut de la M\u00e0cula and Barcelona Macula Foundation, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de la M\u00e0cula and Barcelona Macula Foundation, Barcelona, Spain","institution_ids":["https://openalex.org/I4210166098"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016588157","display_name":"Adnan Tufail","orcid":"https://orcid.org/0000-0001-6131-7640","observed_orcids":["https://orcid.org/0000-0001-6131-7640","https://orcid.org/0000-0002-0965-4890"]},"institutions":[{"id":"https://openalex.org/I4210150574","display_name":"Moorfields Eye Hospital","ror":"https://ror.org/03tb37539","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325675289","https://openalex.org/I4210150574"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Adnan Tufail","raw_affiliation_strings":["Institute of Ophthalmology, University College London, and Moorfields Eye Hospital, NHS Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ophthalmology, University College London, and Moorfields Eye Hospital, NHS Trust, London, United Kingdom","institution_ids":["https://openalex.org/I4210150574","https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090864408","display_name":"Glenn J. Jaffe","orcid":"https://orcid.org/0000-0003-2568-7892","observed_orcids":["https://orcid.org/0000-0003-2568-7892"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glenn J. Jaffe","raw_affiliation_strings":["Department of Ophthalmology, Duke University, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Duke University, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5112882370"],"corresponding_institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210095445"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":{"value":3300,"currency":"USD","value_usd":3300},"fwci":1.5262,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.80878553,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"127","issue":"5","first_page":"648","last_page":"659"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neovascular-age-related-macular-degeneration","display_name":"neovascular age-related macular degeneration","score":0.9879999756813049},{"id":"https://openalex.org/keywords/foveal-atrophy","display_name":"foveal atrophy","score":0.8619999885559082},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.953000009059906},{"id":"https://openalex.org/keywords/macular-neovascularization","display_name":"macular neovascularization","score":0.9909999966621399},{"id":"https://openalex.org/keywords/reticular-pseudodrusen","display_name":"reticular pseudodrusen","score":0.9539999961853027},{"id":"https://openalex.org/keywords/visual-acuity-loss","display_name":"visual acuity loss","score":0.8790000081062317},{"id":"https://openalex.org/keywords/undertreatment","display_name":"undertreatment","score":0.5680000185966492},{"id":"https://openalex.org/keywords/real-world-outcomes","display_name":"real-world outcomes","score":0.36800000071525574}],"concepts":[{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.9470295906066895},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9383680820465088},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5903652906417847},{"id":"https://openalex.org/C2991880128","wikidata":"https://www.wikidata.org/wiki/Q47200750","display_name":"Geographic atrophy","level":3,"score":0.5585988163948059},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.5376831889152527},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.47144946455955505},{"id":"https://openalex.org/C2781100027","wikidata":"https://www.wikidata.org/wiki/Q414270","display_name":"Ranibizumab","level":4,"score":0.46417662501335144},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.44739001989364624},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.2633647322654724},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.21632131934165955},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.20526617765426636},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17411375045776367},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.05024316906929016}],"mesh":[{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020256","descriptor_name":"Choroidal Neovascularization","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020419","descriptor_name":"Photoreceptor Cells, Vertebrate","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D055213","descriptor_name":"Retinal Pigment Epithelium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D057135","descriptor_name":"Wet Macular Degeneration","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D058449","descriptor_name":"Intravitreal Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ophtha.2019.11.010","doi":"https://doi.org/10.1016/j.ophtha.2019.11.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ophtha.2019.11.010","pdf_url":"http://www.aaojournal.org/article/S0161642019322821/pdf","source":{"id":"https://openalex.org/S207341048","display_name":"Ophthalmology","issn_l":"0161-6420","issn":["0161-6420","1549-4713"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmology","raw_type":"journal-article"},{"id":"pmid:32081493","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32081493","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmology","raw_type":"Journal Article"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/252336","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11343/252336","pdf_url":"http://hdl.handle.net/11343/252336","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.ophtha.2019.11.010","doi":"https://doi.org/10.1016/j.ophtha.2019.11.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ophtha.2019.11.010","pdf_url":"http://www.aaojournal.org/article/S0161642019322821/pdf","source":{"id":"https://openalex.org/S207341048","display_name":"Ophthalmology","issn_l":"0161-6420","issn":["0161-6420","1549-4713"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307778","display_name":"Novartis","ror":"https://ror.org/02f9zrr09"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2991411084.pdf","grobid_xml":"https://content.openalex.org/works/W2991411084.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W633153563","https://openalex.org/W1158091699","https://openalex.org/W1493672163","https://openalex.org/W1658498556","https://openalex.org/W1935342590","https://openalex.org/W1946400411","https://openalex.org/W1981111037","https://openalex.org/W2004117352","https://openalex.org/W2026712831","https://openalex.org/W2037438031","https://openalex.org/W2071110690","https://openalex.org/W2076151830","https://openalex.org/W2084575920","https://openalex.org/W2085712747","https://openalex.org/W2096097549","https://openalex.org/W2107832379","https://openalex.org/W2124415048","https://openalex.org/W2125587232","https://openalex.org/W2128943765","https://openalex.org/W2131192872","https://openalex.org/W2138903426","https://openalex.org/W2150525974","https://openalex.org/W2160226180","https://openalex.org/W2186681554","https://openalex.org/W2195866396","https://openalex.org/W2225799082","https://openalex.org/W2298370529","https://openalex.org/W2302515822","https://openalex.org/W2343042175","https://openalex.org/W2507305505","https://openalex.org/W2523147423","https://openalex.org/W2545082692","https://openalex.org/W2549298049","https://openalex.org/W2556011637","https://openalex.org/W2556922900","https://openalex.org/W2607230919","https://openalex.org/W2761892881","https://openalex.org/W2766820003","https://openalex.org/W2788454982","https://openalex.org/W2800978376","https://openalex.org/W2802822211","https://openalex.org/W2889476633","https://openalex.org/W2891202827","https://openalex.org/W2895700191","https://openalex.org/W2896912918","https://openalex.org/W2901441653","https://openalex.org/W2907240502","https://openalex.org/W2914674044","https://openalex.org/W2918104791","https://openalex.org/W2919004723","https://openalex.org/W2947329651","https://openalex.org/W2965769306","https://openalex.org/W2987790686","https://openalex.org/W4250823169"],"related_works":["https://openalex.org/W2777866155","https://openalex.org/W1987001896","https://openalex.org/W6921776029","https://openalex.org/W6958988221","https://openalex.org/W4406606431","https://openalex.org/W2896912918","https://openalex.org/W4402176137","https://openalex.org/W2805882395","https://openalex.org/W4414351429","https://openalex.org/W2345274487"],"abstract_inverted_index":{"TOPIC:":[0],"To":[1],"summarize":[2],"the":[3,50,86,165,175,224,317,330,339],"rates":[4],"of":[5,42,167,226,242,303,332],"atrophy,":[6,168,197],"risk":[7,187,293,302,331],"factors,":[8],"and":[9,46,126,169,202,292],"atrophy-associated":[10],"visual":[11,208],"outcomes":[12,323],"in":[13,60,75,85,101,181,223,281,324,338],"patients":[14,102,325],"with":[15,63,103,145,192,213,229,247,326,335],"neovascular":[16],"age-related":[17,104],"macular":[18,30,36,105],"degeneration":[19,37,106],"(nAMD)":[20],"who":[21,107],"received":[22,108],"anti-vascular":[23],"endothelial":[24],"growth":[25],"factor":[26],"(VEGF)":[27],"treatment":[28,52,110,239],"for":[29,53,72,82],"neovascularization":[31],"(MNV).":[32],"CLINICAL":[33],"RELEVANCE:":[34],"Age-related":[35],"is":[38,57,234,240,268,307],"a":[39,69,262],"leading":[40],"cause":[41],"vision":[43,322,333],"loss":[44,210,334],"worldwide,":[45],"VEGF":[47],"inhibitors":[48],"are":[49],"primary":[51,263],"nAMD.":[54],"However,":[55],"atrophy":[56,76,99,158,182,193,221,243,248,260,304],"observed":[58,337],"frequently":[59],"eyes":[61],"treated":[62,228],"anti-VEGF":[64,109,230,238],"therapy,":[65],"prompting":[66],"questions":[67],"regarding":[68],"causative":[70,241],"role":[71],"these":[73],"therapies":[74],"development.":[77,249],"METHODS:":[78],"PubMed":[79],"was":[80,132,211],"searched":[81],"articles":[83],"published":[84],"past":[87],"5":[88],"years":[89],"(January":[90],"1,":[91],"2014,":[92],"through":[93],"January":[94],"10,":[95],"2019).":[96],"Studies":[97],"including":[98],"outcome(s)":[100],"were":[111,129,139,143,194,253],"included.":[112],"Review":[113],"articles,":[114],"retrospective":[115],"studies,":[116,120,122],"case":[117],"reports":[118],"or":[119,189,256],"preclinical":[121],"prevalence":[123],"data":[124,173],"reports,":[125],"non-English":[127],"studies":[128,138,163,177,218,252],"excluded.":[130],"Randomization":[131],"not":[133,235,254,285],"required.":[134],"RESULTS:":[135],"Overall,":[136],"145":[137],"identified;":[140],"29":[141],"publications":[142],"included,":[144],"cohorts":[146],"ranging":[147],"from":[148,174],"8":[149],"to":[150,156,258,270,297,309,320],"1185":[151],"eyes.":[152],"Imaging":[153],"methods":[154],"used":[155],"assess":[157,259],"varied":[159],"across":[160],"studies.":[161],"All":[162,217],"confirmed":[164],"occurrence":[166],"when":[170],"available,":[171],"longitudinal":[172],"included":[176,251],"demonstrated":[178,219],"an":[179],"increase":[180],"incidence":[183],"over":[184],"time.":[185],"Key":[186],"factors":[188,274,294],"phenotypes":[190,291],"associated":[191,246],"fellow":[195],"eye":[196],"reticular":[198],"pseudodrusen,":[199],"increased":[200],"injections,":[201],"type":[203],"3":[204],"lesion.":[205],"In":[206,265],"addition,":[207,266],"acuity":[209],"noted":[212],"foveal":[214],"atrophy.":[215,277],"DISCUSSION:":[216],"that":[220,311],"occurs":[222],"context":[225],"MNV":[227,315],"therapy;":[231],"however,":[232],"it":[233,267,306],"clear":[236],"whether":[237,272],"versus":[244],"being":[245],"The":[250],"designed":[255],"powered":[257],"as":[261],"outcome.":[264],"difficult":[269],"determine":[271],"prognostic":[273],"directly":[275],"affect":[276],"Furthermore,":[278],"patient":[279],"populations":[280],"clinical":[282],"trials":[283],"do":[284],"necessarily":[286],"represent":[287],"real-world":[288],"patients.":[289],"Although":[290],"may":[295],"help":[296],"identify":[298],"those":[299],"at":[300],"greater":[301],"developing,":[305],"important":[308],"recognize":[310],"adequately":[312],"treating":[313],"exudative":[314],"remains":[316],"best":[318],"option":[319],"optimize":[321],"nAMD,":[327],"particularly":[328],"given":[329],"undertreatment":[336],"real":[340],"world.":[341]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-05T00:00:00"}
