{"id":"https://openalex.org/W2991346568","doi":"https://doi.org/10.1073/pnas.1902909116","title":"Mechanisms of noncanonical binding dynamics in multivalent protein\u2013protein interactions","display_name":"Mechanisms of noncanonical binding dynamics in multivalent protein\u2013protein interactions","publication_year":2019,"publication_date":"2019-11-27","ids":{"openalex":"https://openalex.org/W2991346568","doi":"https://doi.org/10.1073/pnas.1902909116","mag":"2991346568","pmid":"https://pubmed.ncbi.nlm.nih.gov/31776263","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6926015"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1902909116","doi":"https://doi.org/10.1073/pnas.1902909116","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1902909116","pdf_url":"https://www.pnas.org/content/pnas/116/51/25659.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.pnas.org/content/pnas/116/51/25659.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089872726","display_name":"Wesley J. Errington","orcid":"https://orcid.org/0000-0003-4246-7402","observed_orcids":["https://orcid.org/0000-0003-4246-7402"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wesley J. Errington","raw_affiliation_strings":["Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455-0215;","Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455-0215; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455-0215;","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455-0215; and","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081147594","display_name":"Bence Bruncsics","orcid":"https://orcid.org/0000-0003-0032-6935","observed_orcids":["https://orcid.org/0000-0003-0032-6935"]},"institutions":[{"id":"https://openalex.org/I29770179","display_name":"Budapest University of Technology and Economics","ror":"https://ror.org/02w42ss30","country_code":"HU","type":"education","lineage":["https://openalex.org/I29770179"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Bence Bruncsics","raw_affiliation_strings":["Department of Measurement and Information Systems, Budapest University of Technology and Economics, H-1111 Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Measurement and Information Systems, Budapest University of Technology and Economics, H-1111 Budapest, Hungary","institution_ids":["https://openalex.org/I29770179"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033706843","display_name":"Casim A. Sarkar","orcid":"https://orcid.org/0000-0002-0276-8203","observed_orcids":["https://orcid.org/0000-0002-0276-8203"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Casim A. Sarkar","raw_affiliation_strings":["Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455-0215;","Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455-0215; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455-0215;","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455-0215; and","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5033706843"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":null,"apc_paid":null,"fwci":1.9673,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.87300968,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"116","issue":"51","first_page":"25659","last_page":"25667"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.3082999885082245,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.3082999885082245,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13187","display_name":"Diffusion and Search Dynamics","score":0.15880000591278076,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.09099999815225601,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/binding-kinetics","display_name":"binding kinetics","score":0.8820000290870667},{"id":"https://openalex.org/keywords/worm-like-chain-model","display_name":"worm-like chain model","score":0.8659999966621399},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.7939387559890747},{"id":"https://openalex.org/C152900378","wikidata":"https://www.wikidata.org/wiki/Q7302366","display_name":"Receptor\u2013ligand kinetics","level":3,"score":0.6518913507461548},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.5803327560424805},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5421714186668396},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.5214549899101257},{"id":"https://openalex.org/C45424060","wikidata":"https://www.wikidata.org/wiki/Q244381","display_name":"Ministate","level":3,"score":0.5171948671340942},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.515712559223175},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.4740566909313202},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4269671142101288},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.42014622688293457},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.24173176288604736},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.23598983883857727},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18429261445999146},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.15405908226966858},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.15008404850959778},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14717158675193787},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.07956165075302124},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.07096779346466064},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020349","descriptor_name":"Surface Plasmon Resonance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.1902909116","doi":"https://doi.org/10.1073/pnas.1902909116","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1902909116","pdf_url":"https://www.pnas.org/content/pnas/116/51/25659.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6926015","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6926015","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:31776263","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31776263","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:20.500.12942/773632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31776263","pdf_url":null,"source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings Of The National Academy Of Sciences Of The United States Of America, vol. 116 (51), (25659-25667)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1073/pnas.1902909116","doi":"https://doi.org/10.1073/pnas.1902909116","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1902909116","pdf_url":"https://www.pnas.org/content/pnas/116/51/25659.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1228091187","display_name":"Biacore T200 surface plasmon resonance instrument","funder_award_id":"1s10od021539-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G446161629","display_name":"Interplay between signaling and noise in cellular decision making","funder_award_id":"R01GM113985","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6764796791","display_name":"Rapid discovery of new biologics and cell-surface targets to direct cell behavior","funder_award_id":"R21EB022258","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320311358","display_name":"Budapesti M\u0171szaki \u00e9s Gazdas\u00e1gtudom\u00e1nyi Egyetem","ror":"https://ror.org/02w42ss30"},{"id":"https://openalex.org/F4320323476","display_name":"Emberi Eroforr\u00e1sok Miniszt\u00e9riuma","ror":"https://ror.org/00rb16m44"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337901","display_name":"Office of Research Infrastructure Programs, National Institutes of Health","ror":"https://ror.org/01jdyfj45"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2991346568.pdf","grobid_xml":"https://content.openalex.org/works/W2991346568.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W209496352","https://openalex.org/W581902269","https://openalex.org/W1501203786","https://openalex.org/W1510881494","https://openalex.org/W1563071114","https://openalex.org/W1837454973","https://openalex.org/W1976066719","https://openalex.org/W1979249349","https://openalex.org/W1981433518","https://openalex.org/W1982186905","https://openalex.org/W1984048831","https://openalex.org/W1990686613","https://openalex.org/W1996697191","https://openalex.org/W1996820981","https://openalex.org/W2001018320","https://openalex.org/W2010026263","https://openalex.org/W2016172184","https://openalex.org/W2021755139","https://openalex.org/W2026042310","https://openalex.org/W2029266484","https://openalex.org/W2034699659","https://openalex.org/W2036362341","https://openalex.org/W2057485245","https://openalex.org/W2071139123","https://openalex.org/W2071201507","https://openalex.org/W2074286260","https://openalex.org/W2074639565","https://openalex.org/W2078189636","https://openalex.org/W2082175813","https://openalex.org/W2085978470","https://openalex.org/W2088729407","https://openalex.org/W2092463802","https://openalex.org/W2098182642","https://openalex.org/W2102424174","https://openalex.org/W2107252117","https://openalex.org/W2107894007","https://openalex.org/W2126818937","https://openalex.org/W2142937972","https://openalex.org/W2144494426","https://openalex.org/W2159956236","https://openalex.org/W2164633799","https://openalex.org/W2165718684","https://openalex.org/W2232079326","https://openalex.org/W2252604109","https://openalex.org/W2333591613","https://openalex.org/W2462747123","https://openalex.org/W2485151984","https://openalex.org/W2525772967","https://openalex.org/W2528219264","https://openalex.org/W2564930808","https://openalex.org/W2717925384","https://openalex.org/W2750839950","https://openalex.org/W2756821926","https://openalex.org/W2769061177","https://openalex.org/W2885686631","https://openalex.org/W2887994055","https://openalex.org/W2897623376","https://openalex.org/W2937836868","https://openalex.org/W4243860306","https://openalex.org/W4249422304"],"related_works":["https://openalex.org/W4389491174","https://openalex.org/W1965354743","https://openalex.org/W2752209443","https://openalex.org/W7133515747","https://openalex.org/W4294739952","https://openalex.org/W2897623376","https://openalex.org/W2058253150","https://openalex.org/W7130543299","https://openalex.org/W1896676686","https://openalex.org/W7100989688"],"abstract_inverted_index":{"Protein":[0],"multivalency":[1],"can":[2,160],"provide":[3],"increased":[4],"affinity":[5],"and":[6,17,48,65,72,122,137,151,185,215,235,242],"specificity":[7],"relative":[8],"to":[9,23,97,206,210,219],"monovalent":[10],"counterparts,":[11],"but":[12],"these":[13],"emergent":[14],"biochemical":[15],"properties":[16,31,79,139],"their":[18],"mechanistic":[19],"underpinnings":[20],"are":[21,80],"difficult":[22],"predict":[24],"as":[25,54,116],"a":[26,40,55,86,92,98,117,168,237],"function":[27,56],"of":[28,32,50,57,60,67,75,100,128,143,171,192,232,244],"the":[29,33,58,63,68,73,106,126,132,141,149,211],"biophysical":[30],"multivalent":[34,51,114,158,233],"binding":[35,46,115,165,234],"partners.":[36],"Here,":[37],"we":[38,216],"present":[39],"mathematical":[41],"model":[42,95,107,150],"that":[43],"accurately":[44],"simulates":[45],"kinetics":[47,59,136],"equilibria":[49,177],"protein-protein":[52,118],"interactions":[53,159,208],"monomer-monomer":[61],"binding,":[62],"structure":[64],"topology":[66,90],"multidomain":[69],"interacting":[70,129],"partners,":[71],"valency":[74],"each":[76,144],"partner.":[77],"These":[78],"all":[81],"experimentally":[82],"or":[83],"computationally":[84],"estimated":[85],"priori,":[87],"including":[88,167],"approximating":[89],"with":[91,134],"worm-like":[93],"chain":[94],"applicable":[96],"variety":[99],"structurally":[101],"disparate":[102],"systems,":[103],"thus":[104],"making":[105],"predictive":[108],"without":[109],"parameter":[110],"fitting.":[111],"We":[112],"conceptualize":[113],"interaction":[119],"network:":[120],"ligand":[121],"receptor":[123],"valencies":[124],"determine":[125],"number":[127],"species":[130],"in":[131],"network,":[133,214],"monomer":[135],"structural":[138],"dictating":[140],"dynamics":[142],"species.":[145,195],"As":[146],"predicted":[147],"by":[148,153,224],"validated":[152],"surface":[154],"plasmon":[155],"resonance":[156],"experiments,":[157],"generate":[161],"several":[162],"noncanonical":[163],"macroscopic":[164],"dynamics,":[166],"transient":[169,197],"burst":[170,198,222],"high-energy":[172],"configurations":[173],"during":[174],"association,":[175],"biphasic":[176],"resulting":[178],"from":[179,189],"interligand":[180],"competition":[181],"at":[182],"high":[183],"concentrations,":[184],"multiexponential":[186],"dissociation":[187],"arising":[188],"differential":[190],"lifetimes":[191],"distinct":[193],"network":[194],"The":[196],"was":[199],"only":[200],"uncovered":[201],"when":[202],"extending":[203],"our":[204],"analysis":[205,241],"trivalent":[207],"due":[209],"significantly":[212],"larger":[213],"were":[217],"able":[218],"predictably":[220],"tune":[221],"magnitude":[223],"altering":[225],"linker":[226],"rigidity.":[227],"This":[228],"study":[229],"elucidates":[230],"mechanisms":[231],"establishes":[236],"framework":[238],"for":[239],"model-guided":[240],"engineering":[243],"such":[245],"interactions.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":15}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-05T00:00:00"}