{"id":"https://openalex.org/W2991314286","doi":null,"title":"Biochemical markers in osteoarthritis with lessons learned from osteoporosis.","display_name":"Biochemical markers in osteoarthritis with lessons learned from osteoporosis.","publication_year":2019,"publication_date":"2019-09-01","ids":{"openalex":"https://openalex.org/W2991314286","mag":"2991314286","pmid":"https://pubmed.ncbi.nlm.nih.gov/31621570"},"language":"en","primary_location":{"id":"pmid:31621570","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31621570","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063475809","display_name":"M.A. Karsdal","orcid":"https://orcid.org/0000-0001-5026-8740","observed_orcids":["https://orcid.org/0000-0001-5026-8740"]},"institutions":[{"id":"https://openalex.org/I4210142214","display_name":"Nordic Bioscience (Denmark)","ror":"https://ror.org/03nr54n68","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210142214"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Morten Asser Karsdal","raw_affiliation_strings":["Nordic Bioscience, Herlev, Denmark. mk@nordicbio.com","Nordic Bioscience, Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nordic Bioscience, Herlev, Denmark. mk@nordicbio.com","institution_ids":["https://openalex.org/I4210142214"]},{"raw_affiliation_string":"Nordic Bioscience, Herlev, Denmark","institution_ids":["https://openalex.org/I4210142214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082542112","display_name":"Kim Henriksen","orcid":"https://orcid.org/0000-0003-2770-0093","observed_orcids":["https://orcid.org/0000-0003-2770-0093"]},"institutions":[{"id":"https://openalex.org/I4210142214","display_name":"Nordic Bioscience (Denmark)","ror":"https://ror.org/03nr54n68","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210142214"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kim Henriksen","raw_affiliation_strings":["Nordic Bioscience, Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nordic Bioscience, Herlev, Denmark","institution_ids":["https://openalex.org/I4210142214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006255197","display_name":"Anne\u2010Christine Bay\u2010Jensen","orcid":"https://orcid.org/0000-0001-7952-9297","observed_orcids":["https://orcid.org/0000-0001-7952-9297"]},"institutions":[{"id":"https://openalex.org/I4210142214","display_name":"Nordic Bioscience (Denmark)","ror":"https://ror.org/03nr54n68","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210142214"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anne Christine Bay-Jensen","raw_affiliation_strings":["Nordic Bioscience, Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nordic Bioscience, Herlev, Denmark","institution_ids":["https://openalex.org/I4210142214"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210142214"],"apc_list":null,"apc_paid":null,"fwci":1.0159,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.7651899,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"37 Suppl 120","issue":"5","first_page":"73","last_page":"87"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8190000057220459},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/bone-turnover-markers","display_name":"bone turnover markers","score":0.7480000257492065},{"id":"https://openalex.org/keywords/cartilage-biomarkers","display_name":"cartilage biomarkers","score":0.9959999918937683},{"id":"https://openalex.org/keywords/synovial-biomarkers","display_name":"synovial biomarkers","score":0.9559999704360962},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.777999997138977},{"id":"https://openalex.org/keywords/clinical-trial-enrichment","display_name":"clinical trial enrichment","score":0.5009999871253967},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.4000000059604645},{"id":"https://openalex.org/keywords/joint-degeneration","display_name":"joint degeneration","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9143476486206055},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.8334070444107056},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.6670555472373962},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6650522351264954},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5796815752983093},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.514635443687439},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.45530810952186584},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.45243221521377563},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.40507936477661133},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3840906322002411},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31190213561058044},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27984118461608887},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.2525370717048645},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.13383269309997559},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013583","descriptor_name":"Synovial Membrane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:31621570","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31621570","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},{"id":"mag:2991314286","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31621570","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2059670411","https://openalex.org/W1985973049","https://openalex.org/W7097367479","https://openalex.org/W3199371574","https://openalex.org/W2037928435","https://openalex.org/W2327993259","https://openalex.org/W2098403209","https://openalex.org/W2128468094","https://openalex.org/W1981286109","https://openalex.org/W3135135096"],"abstract_inverted_index":{"Osteoarthritis":[0],"(OA)":[1],"is":[2,15],"a":[3,16,133],"disease":[4,28],"of":[5,27,50,55,78,102,149,166],"the":[6,44,47,96,100,108,120,122,127,141,147,164,175],"whole":[7],"joint,":[8],"including":[9],"synovium,":[10],"bone":[11],"and":[12,19,30,42,69,87,114,156,159,171],"cartilage.":[13],"OA":[14,70,109],"slow":[17],"degenerative":[18],"very":[20],"heterogeneous":[21],"disease,":[22],"with":[23,46,83,151],"both":[24,112],"varying":[25],"levels":[26],"activity":[29],"progression.":[31],"Biomarkers":[32,52],"are":[33,66,80],"urgently":[34],"needed":[35],"to":[36,130,136,163],"assist":[37,137],"drug":[38,169],"developers":[39],"in":[40,99,107,174],"selecting":[41],"developing":[43],"projects":[45],"highest":[48],"chance":[49],"success.":[51],"for":[53,168],"enrichment":[54],"clinical":[56,85,172],"studies,":[57],"early":[58],"efficacy":[59,86],"as":[60,62],"well":[61],"other":[63],"diagnostic":[64],"tools":[65],"needed.":[67],"Osteoporosis":[68],"have":[71],"many":[72],"similarities.":[73],"In":[74,140],"osteoporosis":[75,97,176],"an":[76],"armamentarium":[77],"treatments":[79],"now":[81],"available":[82],"high":[84],"well-described":[88],"effects":[89],"on":[90,153],"biomarkers.":[91],"Possibly,":[92],"lessons":[93],"learned":[94],"from":[95,111],"field":[98],"use":[101,165],"biomarkers":[103,148,167],"may":[104],"be":[105],"applied":[106],"field,":[110],"technical":[113],"scientific":[115],"perspectives.":[116],"To":[117],"help":[118],"guide":[119],"way,":[121],"FDA":[123],"has":[124],"recently":[125],"published":[126],"BEST":[128],"guidelines,":[129],"facilitate":[131],"obtaining":[132],"common":[134],"vocabulary":[135],"biomarker":[138],"researchers.":[139],"current":[142],"review,":[143],"we":[144],"will":[145],"review":[146],"OA,":[150],"emphasis":[152],"bone,":[154],"cartilage":[155],"synovial":[157],"biomarkers,":[158],"draw":[160],"clear":[161],"perspectives":[162],"development":[170],"practice":[173],"field.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-05T00:00:00"}