{"id":"https://openalex.org/W2991297076","doi":"https://doi.org/10.1289/isesisee.2018.o02.03.47","title":"Prenatal Exposure to Phthalates and Sex Hormone Levels among Adolescent Boys in the CHAMACOS Birth Cohort Study","display_name":"Prenatal Exposure to Phthalates and Sex Hormone Levels among Adolescent Boys in the CHAMACOS Birth Cohort Study","publication_year":2018,"publication_date":"2018-09-24","ids":{"openalex":"https://openalex.org/W2991297076","doi":"https://doi.org/10.1289/isesisee.2018.o02.03.47","mag":"2991297076"},"language":"en","primary_location":{"id":"doi:10.1289/isesisee.2018.o02.03.47","doi":"https://doi.org/10.1289/isesisee.2018.o02.03.47","is_oa":false,"landing_page_url":"https://doi.org/10.1289/isesisee.2018.o02.03.47","pdf_url":null,"source":{"id":"https://openalex.org/S4210195765","display_name":"ISEE Conference Abstracts","issn_l":"1078-0475","issn":["1078-0475","2169-2181"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISEE Conference Abstracts","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067797858","display_name":"Lesliam Quir\u00f3s-Alcal\u00e1","orcid":"https://orcid.org/0000-0002-6600-7227","observed_orcids":["https://orcid.org/0000-0002-6600-7227"]},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lesliam Quiros-Alcala","raw_affiliation_strings":["Maryland Institute of Applied Environmental Health, University of Maryland, College Park, Maryland, United States,  E-mail Address: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maryland Institute of Applied Environmental Health, University of Maryland, College Park, Maryland, United States,  E-mail Address: [email\u00a0protected]","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016648477","display_name":"Kim G. Harley","orcid":"https://orcid.org/0000-0001-7077-1474","observed_orcids":["https://orcid.org/0000-0001-7077-1474"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kim G. Harley","raw_affiliation_strings":["Center for Environmental Research and Children's Health, University of California, Berkeley, California, United States,  E-mail Address: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Environmental Research and Children's Health, University of California, Berkeley, California, United States,  E-mail Address: [email\u00a0protected]","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071270591","display_name":"Stephen A. Rauch","orcid":"https://orcid.org/0000-0002-6721-4287","observed_orcids":["https://orcid.org/0000-0002-6721-4287"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen A. Rauch","raw_affiliation_strings":["Center for Environmental Research and Children's Health, University of California, Berkeley, California, United States,  E-mail Address: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Environmental Research and Children's Health, University of California, Berkeley, California, United States,  E-mail Address: [email\u00a0protected]","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003686041","display_name":"Robert H. Lustig","orcid":"https://orcid.org/0000-0001-6983-2639","observed_orcids":["https://orcid.org/0000-0001-6983-2639"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert H. Lustig","raw_affiliation_strings":["Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States,  E-mail Address: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States,  E-mail Address: [email\u00a0protected]","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043023935","display_name":"Nina Holland","orcid":"https://orcid.org/0000-0003-3284-8156","observed_orcids":["https://orcid.org/0000-0003-3284-8156"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nina T. Holland","raw_affiliation_strings":["Center for Environmental Research and Children's Health, University of California, Berkeley, California, United States,  E-mail Address: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Environmental Research and Children's Health, University of California, Berkeley, California, United States,  E-mail Address: [email\u00a0protected]","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030022605","display_name":"Brenda Eskenazi","orcid":"https://orcid.org/0000-0001-7609-6852","observed_orcids":["https://orcid.org/0000-0001-7609-6852"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brenda Eskenazi","raw_affiliation_strings":["Center for Environmental Research and Children's Health, University of California, Berkeley, California, United States,  E-mail Address: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Environmental Research and Children's Health, University of California, Berkeley, California, United States,  E-mail Address: [email\u00a0protected]","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2018","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phthalates","display_name":"phthalates","score":0.9760000109672546},{"id":"https://openalex.org/keywords/prenatal-exposure","display_name":"prenatal exposure","score":0.9440000057220459},{"id":"https://openalex.org/keywords/endocrine-disruptors","display_name":"endocrine disruptors","score":0.8019999861717224},{"id":"https://openalex.org/keywords/reproductive-hormones","display_name":"reproductive hormones","score":0.8220000267028809},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.9309999942779541},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.9900000095367432},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.996999979019165},{"id":"https://openalex.org/keywords/adolescent-boys","display_name":"adolescent boys","score":0.8180000185966492},{"id":"https://openalex.org/keywords/phthalate-metabolites","display_name":"phthalate metabolites","score":0.906000018119812},{"id":"https://openalex.org/keywords/high-molecular-weight-phthalates","display_name":"high molecular weight phthalates","score":0.8899999856948853},{"id":"https://openalex.org/keywords/latino-adolescents","display_name":"Latino adolescents","score":0.6460000276565552},{"id":"https://openalex.org/keywords/maternal-urinary-biomarkers","display_name":"maternal urinary biomarkers","score":0.5460000038146973},{"id":"https://openalex.org/keywords/reproductive-development","display_name":"reproductive development","score":0.47999998927116394},{"id":"https://openalex.org/keywords/puberty-timing","display_name":"puberty timing","score":0.4699999988079071},{"id":"https://openalex.org/keywords/delayed-puberty","display_name":"delayed puberty","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C2781005124","wikidata":"https://www.wikidata.org/wiki/Q84483575","display_name":"Phthalate","level":2,"score":0.7778120040893555},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.6750445365905762},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.6055951714515686},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5902419090270996},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.585961639881134},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5536797046661377},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.549789547920227},{"id":"https://openalex.org/C2777668474","wikidata":"https://www.wikidata.org/wiki/Q17146642","display_name":"Anogenital distance","level":5,"score":0.5162951350212097},{"id":"https://openalex.org/C2779279165","wikidata":"https://www.wikidata.org/wiki/Q200774","display_name":"Follicle-stimulating hormone","level":4,"score":0.49330630898475647},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.46594393253326416},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4466811418533325},{"id":"https://openalex.org/C201614185","wikidata":"https://www.wikidata.org/wiki/Q396833","display_name":"In utero","level":4,"score":0.39778831601142883},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.3700755536556244},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2440737783908844},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2080891728401184},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.13210779428482056},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1289/isesisee.2018.o02.03.47","doi":"https://doi.org/10.1289/isesisee.2018.o02.03.47","is_oa":false,"landing_page_url":"https://doi.org/10.1289/isesisee.2018.o02.03.47","pdf_url":null,"source":{"id":"https://openalex.org/S4210195765","display_name":"ISEE Conference Abstracts","issn_l":"1078-0475","issn":["1078-0475","2169-2181"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISEE Conference Abstracts","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3141681202","https://openalex.org/W2036058164","https://openalex.org/W2990236517","https://openalex.org/W2649120279","https://openalex.org/W3179144759","https://openalex.org/W3049346032","https://openalex.org/W2941494082","https://openalex.org/W4409191768","https://openalex.org/W2901562707","https://openalex.org/W4403284137"],"abstract_inverted_index":{"Background:":[0],"Phthalates":[1],"are":[2,39],"synthetic":[3],"compounds":[4,27],"widely":[5],"used":[6],"in":[7,36,57,70,87,152,171,185,190,217,236],"consumer":[8],"products,":[9],"including":[10],"plastics,":[11],"building":[12],"materials,":[13],"and":[14,49,83,106,116,143,154,166,173,179,195,212],"personal":[15],"care":[16],"products.":[17],"Emerging":[18],"evidence":[19],"indicates":[20],"that":[21],"exposure":[22,48,220],"to":[23,221,230],"these":[24],"endocrine":[25],"disrupting":[26],"could":[28],"alter":[29],"reproductive":[30,50,107,234],"hormones;":[31],"however,":[32],"human":[33],"studies":[34],"examining":[35],"utero":[37],"exposures":[38],"sparse.":[40],"We":[41,63],"examined":[42,101],"the":[43,58,120,128],"associations":[44,102],"of":[45,66,75,127,233,241,244],"prenatal":[46,72,114],"phthalate":[47,68,104],"hormones":[51,235],"among":[52],"Latino":[53],"adolescent":[54],"boys":[55,94],"participating":[56],"longitudinal":[59],"CHAMACOS":[60],"birth":[61],"cohort.Methods:":[62],"measured":[64,86],"concentrations":[65,156],"11":[67],"metabolites":[69,105],"maternal":[71,112],"urine.":[73],"Concentrations":[74],"luteinizing":[76],"hormone":[77,81,130],"(LH),":[78],"follicle":[79],"stimulating":[80],"(FSH),":[82],"testosterone":[84],"were":[85],"fasting":[88],"blood":[89],"samples":[90],"collected":[91],"from":[92],"110":[93],"at":[95,119],"age":[96,118],"12.":[97],"Linear":[98],"regression":[99],"models":[100],"between":[103],"hormones,":[108],"adjusting":[109],"for":[110,136,141,147],"income,":[111],"education,":[113],"BMI,":[115],"child\u2019s":[117],"12-year":[121,237],"visit.Results:":[122],"The":[123],"geometric":[124],"mean":[125],"(GSD)":[126],"boys'":[129],"levels":[131,232],"was":[132,157,197],"2.5":[133],"mIU/mL":[134,139],"(1.7)":[135],"FSH,":[137],"1.7":[138],"(3.3)":[140],"LH,":[142],"66.6":[144],"ng/dL":[145],"(4.2)":[146],"testosterone.":[148,186],"A":[149,187],"two-fold":[150,188],"increase":[151,170,184,189],"MCBzP":[153],"MCPP":[155],"associated":[158,198],"with":[159,199],"a":[160,174],"respective":[161],"15.8%":[162],"(95%CI:":[163,176,181],"0.6,":[164],"33.3)":[165],"19.8%":[167],"(95%CI:0.1,":[168],"43.4)":[169],"LH":[172],"27.3%":[175],"5.0,":[177],"54.3)":[178],"42.7%":[180],"17.0,":[182],"74.1)":[183],"MCNP,":[191],"MCOP,":[192],"MEHP,":[193],"MECPP,":[194],"MEOHP":[196],"28.8%":[200],"(95%CI:0.2,":[201],"65.5),":[202],"28.7%":[203],"(95%CI:4.8,":[204],"58.1),":[205],"21.3%":[206],"(95%CI:1.7,":[207],"44.7),":[208],"25.3%":[209],"(95%CI:1.8,":[210],"54.2),":[211],"22.1%":[213],"(95%CI:0.8,":[214],"47.9)":[215],"increases":[216],"testosterone.Conclusion:":[218],"Prenatal":[219],"phthalates,":[222,227],"particularly":[223],"high":[224],"molecular":[225],"weight":[226],"is":[228],"related":[229],"higher":[231],"old":[238],"boys,":[239],"suggestive":[240],"earlier":[242],"onset":[243],"puberty.":[245]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2019-12-05T00:00:00"}