{"id":"https://openalex.org/W2991263208","doi":null,"title":"The killing effect of novel bi-specific Trop2/PD-L1 CAR-T cell targeted gastric cancer.","display_name":"The killing effect of novel bi-specific Trop2/PD-L1 CAR-T cell targeted gastric cancer.","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2991263208","mag":"2991263208","pmid":"https://pubmed.ncbi.nlm.nih.gov/31497363","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6726977"},"language":"en","primary_location":{"id":"pmid:31497363","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31497363","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6726977/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101425691","display_name":"Wei Zhao","orcid":"https://orcid.org/0000-0001-8557-297X","observed_orcids":["https://orcid.org/0000-0001-8557-297X"]},"institutions":[{"id":"https://openalex.org/I4405277390","display_name":"Nanjing First Hospital","ror":"https://ror.org/02hw73q19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405277390"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Zhao","raw_affiliation_strings":["Department of Pathology, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, China","Key Laboratory of Antibody Technique of National Health Commission, Nanjing Medical University Nanjing 211166, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, China","institution_ids":["https://openalex.org/I4405277390","https://openalex.org/I83519826"]},{"raw_affiliation_string":"Key Laboratory of Antibody Technique of National Health Commission, Nanjing Medical University Nanjing 211166, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026004747","display_name":"Lizhou Jia","orcid":"https://orcid.org/0000-0003-0645-1868","observed_orcids":["https://orcid.org/0000-0003-0645-1868"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lizhou Jia","raw_affiliation_strings":["Department of Pathology, Nanjing Medical University Nanjing 211166, China","Key Laboratory of Antibody Technique of National Health Commission, Nanjing Medical University Nanjing 211166, China","Central Laboratory, Bayannur Hospital Inner Mongolia 015000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Nanjing Medical University Nanjing 211166, China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Key Laboratory of Antibody Technique of National Health Commission, Nanjing Medical University Nanjing 211166, China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Central Laboratory, Bayannur Hospital Inner Mongolia 015000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059603836","display_name":"Mingjiong Zhang","orcid":"https://orcid.org/0009-0007-3894-4997","observed_orcids":["https://orcid.org/0009-0007-3894-4997","https://orcid.org/0000-0003-1416-2839"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingjiong Zhang","raw_affiliation_strings":["Key Laboratory of Antibody Technique of National Health Commission, Nanjing Medical University Nanjing 211166, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Antibody Technique of National Health Commission, Nanjing Medical University Nanjing 211166, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaochen Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaochen Huang","raw_affiliation_strings":["Department of Pathology, Nanjing Medical University Nanjing 211166, China","Key Laboratory of Antibody Technique of National Health Commission, Nanjing Medical University Nanjing 211166, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Nanjing Medical University Nanjing 211166, China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Key Laboratory of Antibody Technique of National Health Commission, Nanjing Medical University Nanjing 211166, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peng Qian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peng Qian","raw_affiliation_strings":["Sinobioway Cell Therapy Co., Ltd. Hefei 238000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sinobioway Cell Therapy Co., Ltd. Hefei 238000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101648289","display_name":"Qi Tang","orcid":"https://orcid.org/0000-0002-5196-5932","observed_orcids":["https://orcid.org/0000-0002-5196-5932"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Tang","raw_affiliation_strings":["Key Laboratory of Antibody Technique of National Health Commission, Nanjing Medical University Nanjing 211166, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Antibody Technique of National Health Commission, Nanjing Medical University Nanjing 211166, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111491081","display_name":"Jin Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152453","display_name":"Huadong Medical Institute of Biotechniques","ror":"https://ror.org/00vzyt138","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4387152453"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin Zhu","raw_affiliation_strings":["Key Laboratory of Antibody Technique of National Health Commission, Nanjing Medical University Nanjing 211166, China","Huadong Medical Institute of Biotechniques Nanjing 210000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Antibody Technique of National Health Commission, Nanjing Medical University Nanjing 211166, China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Huadong Medical Institute of Biotechniques Nanjing 210000, China","institution_ids":["https://openalex.org/I4387152453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101540867","display_name":"Zhenqing Feng","orcid":"https://orcid.org/0000-0001-5049-4959","observed_orcids":["https://orcid.org/0000-0001-5049-4959"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenqing Feng","raw_affiliation_strings":["Department of Pathology, Nanjing Medical University Nanjing 211166, China","Key Laboratory of Antibody Technique of National Health Commission, Nanjing Medical University Nanjing 211166, China","Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University Nanjing 211166, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Nanjing Medical University Nanjing 211166, China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Key Laboratory of Antibody Technique of National Health Commission, Nanjing Medical University Nanjing 211166, China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University Nanjing 211166, China","institution_ids":["https://openalex.org/I83519826"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.7288,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.97346179,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"9","issue":"8","first_page":"1846","last_page":"1856"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trop2","display_name":"TROP2","score":0.9449999928474426},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":1.0},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9750000238418579},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.6859999895095825},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.7540000081062317},{"id":"https://openalex.org/keywords/intratumoral-injection","display_name":"intratumoral injection","score":0.8700000047683716},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.6909999847412109},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6280844211578369},{"id":"https://openalex.org/C2778957590","wikidata":"https://www.wikidata.org/wiki/Q798033","display_name":"CD19","level":3,"score":0.5979598760604858},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.5453372597694397},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5283989310264587},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.49913716316223145},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4961636960506439},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4664292633533478},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4487522840499878},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4384653568267822},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4108179211616516},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.39691707491874695},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36108553409576416},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3212420344352722},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27617204189300537},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26349109411239624},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.2314903736114502},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10262569785118103},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:31497363","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31497363","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6726977","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6726977/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"mag:2991263208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31497363","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6726977","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6726977/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"score":0.979200005531311,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1545631997","https://openalex.org/W1548150084","https://openalex.org/W1635741485","https://openalex.org/W1971371234","https://openalex.org/W1971518635","https://openalex.org/W1990602451","https://openalex.org/W1999979584","https://openalex.org/W2001347099","https://openalex.org/W2048752843","https://openalex.org/W2087134443","https://openalex.org/W2094945699","https://openalex.org/W2117614828","https://openalex.org/W2130011407","https://openalex.org/W2161187689","https://openalex.org/W2173835427","https://openalex.org/W2188271125","https://openalex.org/W2238400138","https://openalex.org/W2253938658","https://openalex.org/W2272044596","https://openalex.org/W2510606169","https://openalex.org/W2515380678","https://openalex.org/W2517335663","https://openalex.org/W2518933333","https://openalex.org/W2567424265","https://openalex.org/W2573545464","https://openalex.org/W2591795399","https://openalex.org/W2617490000","https://openalex.org/W2793850646","https://openalex.org/W2805887896","https://openalex.org/W2886131798","https://openalex.org/W4205903024","https://openalex.org/W4248923712"],"related_works":["https://openalex.org/W4409626056","https://openalex.org/W2591441623","https://openalex.org/W4362544228","https://openalex.org/W4281760105","https://openalex.org/W2888468393","https://openalex.org/W3030447179","https://openalex.org/W3005601594","https://openalex.org/W2804623636","https://openalex.org/W2954641140","https://openalex.org/W4389868664"],"abstract_inverted_index":{",":[0],"this":[1],"study":[2],"testified":[3],"to":[4,69],"the":[5,33,50,77,85],"anti-tumor":[6],"effect":[7,43,79,87],"of":[8,11,88],"several":[9],"types":[10],"CAR-T":[12,28,47,65,89],"cells":[13,29,48,66,90],"through":[14,36],"a":[15,40],"xenograft":[16],"model":[17],"bearing":[18],"human":[19],"gastric":[20,81],"tumors.":[21,93],"The":[22],"results":[23,59],"indicated":[24],"that":[25,61],"bi-specific":[26,63],"Trop2/PD-L1":[27,64,71],"can":[30],"significantly":[31],"reduce":[32],"tumor":[34],"growth":[35],"intratumoral":[37],"injection,":[38],"with":[39],"higher":[41],"inhibition":[42],"than":[44],"Trop2":[45],"specific":[46],"and":[49,55,72,75],"independent":[51],"control":[52],"group":[53],"(CD19-CAR-T":[54],"untreated":[56],"group).":[57],"These":[58],"suggest":[60],"novel":[62],"are":[67],"able":[68],"target":[70],"checkpoint":[73],"blockade,":[74],"reveal":[76],"killing":[78,86],"on":[80],"cancer,":[82],"therefore":[83],"improving":[84],"in":[91],"solid":[92]},"counts_by_year":[{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":16}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-12-05T00:00:00"}
