{"id":"https://openalex.org/W2991237708","doi":"https://doi.org/10.1111/ejh.13354","title":"Inhibition of PLK1 by capped\u2010dose volasertib exerts substantial efficacy in MDS and sAML while sparing healthy haematopoiesis","display_name":"Inhibition of PLK1 by capped\u2010dose volasertib exerts substantial efficacy in MDS and sAML while sparing healthy haematopoiesis","publication_year":2019,"publication_date":"2019-11-23","ids":{"openalex":"https://openalex.org/W2991237708","doi":"https://doi.org/10.1111/ejh.13354","mag":"2991237708","pmid":"https://pubmed.ncbi.nlm.nih.gov/31758597"},"language":"en","primary_location":{"id":"doi:10.1111/ejh.13354","doi":"https://doi.org/10.1111/ejh.13354","is_oa":true,"landing_page_url":"https://doi.org/10.1111/ejh.13354","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ejh.13354","source":{"id":"https://openalex.org/S159715054","display_name":"European Journal Of Haematology","issn_l":"0902-4441","issn":["0902-4441","1600-0609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ejh.13354","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Veronika Dill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Veronika Dill","raw_affiliation_strings":["Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048193173","display_name":"Johanna Kauschinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johanna Kauschinger","raw_affiliation_strings":["Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061339000","display_name":"Richard T. Hauch","orcid":"https://orcid.org/0000-0002-1282-4803","observed_orcids":["https://orcid.org/0000-0002-1282-4803"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Richard T. Hauch","raw_affiliation_strings":["Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020623160","display_name":"Lars Buschhorn","orcid":"https://orcid.org/0000-0001-7162-816X","observed_orcids":["https://orcid.org/0000-0001-7162-816X"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lars Buschhorn","raw_affiliation_strings":["Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034947094","display_name":"Timo O. Odinius","orcid":"https://orcid.org/0000-0002-9722-4582","observed_orcids":["https://orcid.org/0000-0002-9722-4582"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Timo O. Odinius","raw_affiliation_strings":["Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany"],"raw_orcid":"https://orcid.org/0000-0002-9722-4582","affiliations":[{"raw_affiliation_string":"Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011037332","display_name":"Catharina M\u00fcller\u2010Thomas","orcid":"https://orcid.org/0000-0003-2743-5154","observed_orcids":["https://orcid.org/0000-0003-2743-5154"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Catharina M\u00fcller\u2010Thomas","raw_affiliation_strings":["Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051236860","display_name":"Ritu Mishra","orcid":"https://orcid.org/0000-0002-3581-5918","observed_orcids":["https://orcid.org/0000-0002-3581-5918"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ritu Mishra","raw_affiliation_strings":["Center for Translational Cancer Research (TranslaTUM) Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany","Institute of Clinical Chemistry and Pathobiochemistry Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Cancer Research (TranslaTUM) Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"raw_affiliation_string":"Institute of Clinical Chemistry and Pathobiochemistry Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046344854","display_name":"Michele C. Kyncl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michele C. Kyncl","raw_affiliation_strings":["Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Burkhard Schmidt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Burkhard Schmidt","raw_affiliation_strings":["Gemeinschaftspraxis H\u00e4mato\u2010Onkologie Pasing Munich Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gemeinschaftspraxis H\u00e4mato\u2010Onkologie Pasing Munich Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055699890","display_name":"Peter Michael Prodinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter M. Prodinger","raw_affiliation_strings":["Department of Orthopedic Surgery Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044220735","display_name":"Dirk Hempel","orcid":"https://orcid.org/0000-0001-7449-3053","observed_orcids":["https://orcid.org/0000-0001-7449-3053"]},"institutions":[{"id":"https://openalex.org/I4210154157","display_name":"Onkozentrum Dresden","ror":"https://ror.org/05090cn78","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210154157"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dirk Hempel","raw_affiliation_strings":["Onkologiezentrum Donauw\u00f6rth Donauworth Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Onkologiezentrum Donauw\u00f6rth Donauworth Germany","institution_ids":["https://openalex.org/I4210154157"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085906961","display_name":"Frauke Bellos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093919","display_name":"Munich Leukemia Laboratory (Germany)","ror":"https://ror.org/00smdp487","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210093919"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frauke Bellos","raw_affiliation_strings":["Munich Leukemia Laboratory (MLL), Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Munich Leukemia Laboratory (MLL), Munich, Germany","institution_ids":["https://openalex.org/I4210093919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010906311","display_name":"Alexander H\u00f6llein","orcid":"https://orcid.org/0000-0002-9799-7809","observed_orcids":["https://orcid.org/0000-0002-9799-7809"]},"institutions":[{"id":"https://openalex.org/I4210093919","display_name":"Munich Leukemia Laboratory (Germany)","ror":"https://ror.org/00smdp487","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210093919"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander H\u00f6llein","raw_affiliation_strings":["Munich Leukemia Laboratory (MLL), Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Munich Leukemia Laboratory (MLL), Munich, Germany","institution_ids":["https://openalex.org/I4210093919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048388170","display_name":"Wolfgang Kern","orcid":"https://orcid.org/0000-0002-6452-2874","observed_orcids":["https://orcid.org/0000-0002-6452-2874","https://orcid.org/0000-0003-3945-9153"]},"institutions":[{"id":"https://openalex.org/I4210093919","display_name":"Munich Leukemia Laboratory (Germany)","ror":"https://ror.org/00smdp487","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210093919"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang Kern","raw_affiliation_strings":["Munich Leukemia Laboratory (MLL), Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Munich Leukemia Laboratory (MLL), Munich, Germany","institution_ids":["https://openalex.org/I4210093919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043414993","display_name":"Torsten Haferlach","orcid":"https://orcid.org/0000-0003-0196-2837","observed_orcids":["https://orcid.org/0000-0003-0196-2837"]},"institutions":[{"id":"https://openalex.org/I4210093919","display_name":"Munich Leukemia Laboratory (Germany)","ror":"https://ror.org/00smdp487","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210093919"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Torsten Haferlach","raw_affiliation_strings":["Munich Leukemia Laboratory (MLL), Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Munich Leukemia Laboratory (MLL), Munich, Germany","institution_ids":["https://openalex.org/I4210093919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076736029","display_name":"Julia Slotta\u2010Huspenina","orcid":"https://orcid.org/0000-0003-0057-2263","observed_orcids":["https://orcid.org/0000-0003-0057-2263"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Slotta\u2010Huspenina","raw_affiliation_strings":["Institute of Pathology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059538708","display_name":"Florian C. Bassermann","orcid":"https://orcid.org/0000-0003-4435-2609","observed_orcids":["https://orcid.org/0000-0003-4435-2609"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Florian Bassermann","raw_affiliation_strings":["Center for Translational Cancer Research (TranslaTUM) Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany","German Cancer Consortium (DKTK) DKFZ Heidelberg Germany","Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Cancer Research (TranslaTUM) Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK) DKFZ Heidelberg Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4391767962"]},{"raw_affiliation_string":"Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066200247","display_name":"Christian Peschel","orcid":"https://orcid.org/0000-0003-0547-2886","observed_orcids":["https://orcid.org/0000-0003-0547-2886"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Peschel","raw_affiliation_strings":["Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066615327","display_name":"Katharina S. S. G\u00f6tze","orcid":"https://orcid.org/0000-0002-6276-8002","observed_orcids":["https://orcid.org/0000-0002-6276-8002"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katharina S. G\u00f6tze","raw_affiliation_strings":["Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023344154","display_name":"Irene C. Waizenegger","orcid":"https://orcid.org/0000-0002-3911-6970","observed_orcids":["https://orcid.org/0000-0002-3911-6970"]},"institutions":[{"id":"https://openalex.org/I4210119669","display_name":"Boehringer Ingelheim (Austria)","ror":"https://ror.org/026vtvm28","country_code":"AT","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210119669"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Irene C. Waizenegger","raw_affiliation_strings":["Boehringer Ingelheim RCV GmbH Co KG, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim RCV GmbH Co KG, Vienna, Austria","institution_ids":["https://openalex.org/I4210119669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040698250","display_name":"Ulrike H\u00f6ckendorf","orcid":"https://orcid.org/0000-0002-8218-3343","observed_orcids":["https://orcid.org/0000-0002-8218-3343"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrike H\u00f6ckendorf","raw_affiliation_strings":["Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090397464","display_name":"Philipp Jakob Jost","orcid":"https://orcid.org/0000-0003-2454-0362","observed_orcids":["https://orcid.org/0000-0003-2454-0362"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philipp J. Jost","raw_affiliation_strings":["Center for Translational Cancer Research (TranslaTUM) Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany","German Cancer Consortium (DKTK) DKFZ Heidelberg Germany","Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Cancer Research (TranslaTUM) Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK) DKFZ Heidelberg Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4391767962"]},{"raw_affiliation_string":"Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046674422","display_name":"Stefanie Jilg","orcid":"https://orcid.org/0000-0003-1774-7605","observed_orcids":["https://orcid.org/0000-0003-1774-7605"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Stefanie Jilg","raw_affiliation_strings":["Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany"],"raw_orcid":"https://orcid.org/0000-0003-1774-7605","affiliations":[{"raw_affiliation_string":"Medical Department III for Haematology and Oncology Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5046674422"],"corresponding_institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":{"value":3300,"currency":"USD","value_usd":3300},"fwci":0.913,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.76523899,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"104","issue":"2","first_page":"125","last_page":"137"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/volasertib","display_name":"volasertib","score":0.9879999756813049},{"id":"https://openalex.org/keywords/plk1-inhibition","display_name":"PLK1 inhibition","score":0.8949999809265137},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.9919999837875366},{"id":"https://openalex.org/keywords/secondary-acute-myeloid-leukemia","display_name":"secondary acute myeloid leukemia","score":1.0},{"id":"https://openalex.org/keywords/low-dose-chemotherapy","display_name":"low-dose chemotherapy","score":0.800000011920929},{"id":"https://openalex.org/keywords/hematopoietic-stem-and-progenitor-cells","display_name":"hematopoietic stem and progenitor cells","score":0.8849999904632568},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.6330000162124634},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.4090000092983246},{"id":"https://openalex.org/keywords/colony-forming-capacity","display_name":"colony-forming capacity","score":0.9789999723434448},{"id":"https://openalex.org/keywords/ripk3","display_name":"RIPK3","score":0.984000027179718},{"id":"https://openalex.org/keywords/mcl-1","display_name":"Mcl-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/treatment-biomarkers","display_name":"treatment biomarkers","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C146276462","wikidata":"https://www.wikidata.org/wiki/Q21131841","display_name":"PLK1","level":4,"score":0.6336268186569214},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6313510537147522},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4870469868183136},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40570810437202454},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37676218152046204},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35598456859588623},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32480257749557495},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1703799068927765},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.15432468056678772},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10886150598526001},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.09443199634552002},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.08949771523475647}],"mesh":[{"descriptor_ui":"D000097869","descriptor_name":"Polo-Like Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011621","descriptor_name":"Pteridines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011621","descriptor_name":"Pteridines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015973","descriptor_name":"Gene Expression Regulation, Leukemic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053422","descriptor_name":"Receptor-Interacting Protein Serine-Threonine Kinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D064549","descriptor_name":"Myeloid Cell Leukemia Sequence 1 Protein","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/ejh.13354","doi":"https://doi.org/10.1111/ejh.13354","is_oa":true,"landing_page_url":"https://doi.org/10.1111/ejh.13354","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ejh.13354","source":{"id":"https://openalex.org/S159715054","display_name":"European Journal Of Haematology","issn_l":"0902-4441","issn":["0902-4441","1600-0609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:31758597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31758597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of haematology","raw_type":"Clinical Trial"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1554652","doi":null,"is_oa":true,"landing_page_url":"http://mediatum.ub.tum.de/node?id=1554652","pdf_url":null,"source":{"id":"https://openalex.org/S4377196330","display_name":"mediaTUM  (Technical University of Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1588861","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/1588861","pdf_url":null,"source":{"id":"https://openalex.org/S4377196330","display_name":"mediaTUM  (Technical University of Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1111/ejh.13354","doi":"https://doi.org/10.1111/ejh.13354","is_oa":true,"landing_page_url":"https://doi.org/10.1111/ejh.13354","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ejh.13354","source":{"id":"https://openalex.org/S159715054","display_name":"European Journal Of Haematology","issn_l":"0902-4441","issn":["0902-4441","1600-0609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Haematology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1087379496","display_name":null,"funder_award_id":"FOR2033","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G1241216728","display_name":null,"funder_award_id":"SFB 1243","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G1401877597","display_name":null,"funder_award_id":"project A09)","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G1503510435","display_name":null,"funder_award_id":"FOR\u20102036","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G1824425686","display_name":null,"funder_award_id":"R 14/16","funder_id":"https://openalex.org/F4320323359","funder_display_name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung"},{"id":"https://openalex.org/G3547788828","display_name":null,"funder_award_id":"#111738","funder_id":"https://openalex.org/F4320323556","funder_display_name":"Deutsche Krebshilfe"},{"id":"https://openalex.org/G4107161897","display_name":null,"funder_award_id":"Go 713/2\u20101","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6283766039","display_name":null,"funder_award_id":"DJCLS R 14/16","funder_id":"https://openalex.org/F4320323359","funder_display_name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung"},{"id":"https://openalex.org/G6934360771","display_name":null,"funder_award_id":"R 12/22","funder_id":"https://openalex.org/F4320323359","funder_display_name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung"},{"id":"https://openalex.org/G7616101663","display_name":null,"funder_award_id":"21R/2016","funder_id":"https://openalex.org/F4320323359","funder_display_name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung"},{"id":"https://openalex.org/G8673822855","display_name":null,"funder_award_id":"SFB 1243 Project A09","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320310693","display_name":"Deutsches Krebsforschungszentrum","ror":"https://ror.org/04cdgtt98"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321672","display_name":"Else Kr\u00f6ner-Fresenius-Stiftung","ror":"https://ror.org/03zcxha54"},{"id":"https://openalex.org/F4320323359","display_name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung","ror":"https://ror.org/00826gz80"},{"id":"https://openalex.org/F4320323556","display_name":"Deutsche Krebshilfe","ror":"https://ror.org/01wxdd722"},{"id":"https://openalex.org/F4320327569","display_name":"Deutschen Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2991237708.pdf","grobid_xml":"https://content.openalex.org/works/W2991237708.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1516211547","https://openalex.org/W1598054001","https://openalex.org/W1827063072","https://openalex.org/W1972644607","https://openalex.org/W2009021195","https://openalex.org/W2040146704","https://openalex.org/W2041238848","https://openalex.org/W2043085463","https://openalex.org/W2054834274","https://openalex.org/W2058153393","https://openalex.org/W2093189315","https://openalex.org/W2093484703","https://openalex.org/W2101725260","https://openalex.org/W2114135705","https://openalex.org/W2117692326","https://openalex.org/W2118771330","https://openalex.org/W2131593570","https://openalex.org/W2167831982","https://openalex.org/W2168541390","https://openalex.org/W2170989872","https://openalex.org/W2467902526","https://openalex.org/W2549761003","https://openalex.org/W2607156755","https://openalex.org/W2774533007","https://openalex.org/W2783529837","https://openalex.org/W2795741690","https://openalex.org/W2806061299","https://openalex.org/W2907885025","https://openalex.org/W2909289870","https://openalex.org/W2944727217","https://openalex.org/W3135020720","https://openalex.org/W4211114385","https://openalex.org/W4232645703","https://openalex.org/W6814270934","https://openalex.org/W7100962643"],"related_works":["https://openalex.org/W7029133027","https://openalex.org/W785285574","https://openalex.org/W2304398921","https://openalex.org/W2023834708","https://openalex.org/W2122059243","https://openalex.org/W3087629880","https://openalex.org/W2979393870","https://openalex.org/W2739928434","https://openalex.org/W1449405988","https://openalex.org/W2131572808"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Targeting":[1],"the":[2,28,64],"cell":[3,144,169],"cycle":[4],"machinery":[5],"represents":[6],"a":[7,52,181],"rational":[8],"therapeutic":[9,70,183],"approach":[10,184],"in":[11,147,161,185],"myelodysplastic":[12],"syndromes":[13],"(MDS)":[14],"and":[15,42,85,129,151,168,192],"secondary":[16],"acute":[17],"myeloid":[18],"leukemia":[19],"(sAML).":[20],"Despite":[21],"substantial":[22],"response":[23],"rates,":[24],"clinical":[25,173],"use":[26],"of":[27,55,78,127,140,154,172],"PLK":[29],"inhibitor":[30],"volasertib":[31,56,94,141,164,201],"has":[32],"been":[33],"hampered":[34],"by":[35,108],"elevated":[36],"side":[37],"effects":[38,62],"such":[39],"as":[40],"neutropenia":[41],"infections.":[43],"OBJECTIVES:":[44],"The":[45],"primary":[46,148],"objective":[47],"was":[48,57,106,120,131],"to":[49,59,97,200],"analyse":[50],"whether":[51],"reduced":[53,165],"dose":[54,138],"able":[58],"limit":[60],"toxic":[61],"on":[63],"healthy":[65,86,159],"haematopoiesis":[66,160],"while":[67],"retaining":[68],"its":[69],"effect.":[71],"METHODS:":[72],"Bone":[73],"marrow":[74],"mononuclear":[75],"cells":[76,153],"(BMMNCs)":[77],"patients":[79,156,186],"with":[80,93,187],"MDS/sAML":[81,155],"(n":[82,88],"=":[83,89],"73)":[84],"controls":[87],"28)":[90],"were":[91],"treated":[92],"(1":[95],"\u03bcM":[96],"1":[98],"nM)":[99],"or":[100,175],"vehicle":[101],"control.":[102],"Short-term":[103],"viability":[104,116],"analysis":[105],"performed":[107],"flow":[109,134],"cytometry":[110],"after":[111,122],"72":[112],"hours.":[113],"For":[114],"long-term":[115],"analysis,":[117],"colony-forming":[118,166],"capacity":[119,167],"assessed":[121],"14":[123],"days.":[124],"Protein":[125],"expression":[126],"RIPK3":[128,191],"MCL-1":[130,193],"quantified":[132],"via":[133],"cytometry.":[135],"RESULTS:":[136],"Reduced":[137],"levels":[139],"retained":[142],"high":[143],"death-inducing":[145],"efficacy":[146],"human":[149],"stem":[150],"progenitor":[152],"without":[157],"affecting":[158],"vitro.":[162],"Interestingly,":[163],"survival":[170],"independent":[171],"stage":[174],"mutational":[176],"status.":[177],"CONCLUSIONS:":[178],"Volasertib":[179],"offers":[180],"promising":[182],"adverse":[188],"prognostic":[189],"profile.":[190],"might":[194],"be":[195],"potential":[196],"biomarkers":[197],"for":[198],"sensitivity":[199],"treatment.":[202]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-12-05T00:00:00"}
