{"id":"https://openalex.org/W2991158142","doi":"https://doi.org/10.3389/fonc.2019.01266","title":"Urine Biopsy\u2014Liquid Gold for Molecular Detection and Surveillance of Bladder Cancer","display_name":"Urine Biopsy\u2014Liquid Gold for Molecular Detection and Surveillance of Bladder Cancer","publication_year":2019,"publication_date":"2019-11-19","ids":{"openalex":"https://openalex.org/W2991158142","doi":"https://doi.org/10.3389/fonc.2019.01266","mag":"2991158142","pmid":"https://pubmed.ncbi.nlm.nih.gov/31803629","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6877686"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2019.01266","doi":"https://doi.org/10.3389/fonc.2019.01266","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2019.01266","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2019.01266/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fonc.2019.01266/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034589916","display_name":"Uttam Satyal","orcid":"https://orcid.org/0000-0003-3149-2100","observed_orcids":["https://orcid.org/0000-0003-3149-2100"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uttam Satyal","raw_affiliation_strings":["Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026214233","display_name":"Abhishek Srivastava","orcid":"https://orcid.org/0000-0002-9480-0847","observed_orcids":["https://orcid.org/0000-0002-9480-0847"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhishek Srivastava","raw_affiliation_strings":["Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011122559","display_name":"Philip H. Abbosh","orcid":"https://orcid.org/0000-0003-3611-9532","observed_orcids":["https://orcid.org/0000-0003-3611-9532"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Philip H. Abbosh","raw_affiliation_strings":["Department of Urology, Albert Einstein Medical Center, Elkins Park, PA, United States","Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Albert Einstein Medical Center, Elkins Park, PA, United States","institution_ids":[]},{"raw_affiliation_string":"Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I1289437631"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011122559"],"corresponding_institution_ids":["https://openalex.org/I1289437631"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":0.743,"has_fulltext":true,"cited_by_count":69,"citation_normalized_percentile":{"value":0.63375315,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":null,"first_page":"1266","last_page":"1266"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.04349999874830246,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12695","display_name":"Urinary and Genital Oncology Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.9010000228881836},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.9769999980926514},{"id":"https://openalex.org/keywords/upper-tract-urothelial-carcinoma","display_name":"upper tract urothelial carcinoma","score":0.8600000143051147},{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.7889999747276306},{"id":"https://openalex.org/keywords/cell-free-dna","display_name":"cell-free DNA","score":0.8109999895095825},{"id":"https://openalex.org/keywords/molecular-detection","display_name":"molecular detection","score":0.4009999930858612},{"id":"https://openalex.org/keywords/surveillance-medicine","display_name":"surveillance (medicine)","score":0.4560000002384186},{"id":"https://openalex.org/keywords/mutant-allele-fraction","display_name":"mutant allele fraction","score":0.7300000190734863},{"id":"https://openalex.org/keywords/sequencing-artifacts","display_name":"sequencing artifacts","score":0.4659999907016754},{"id":"https://openalex.org/keywords/capp-seq","display_name":"CAPP-Seq","score":0.9900000095367432},{"id":"https://openalex.org/keywords/non-invasive-diagnosis","display_name":"non-invasive diagnosis","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.8498318791389465},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.6006903648376465},{"id":"https://openalex.org/C8185291","wikidata":"https://www.wikidata.org/wiki/Q2844457","display_name":"Amplicon","level":4,"score":0.5648283362388611},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.48670080304145813},{"id":"https://openalex.org/C152110520","wikidata":"https://www.wikidata.org/wiki/Q14225730","display_name":"Cell-free fetal DNA","level":5,"score":0.4766881465911865},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.43770474195480347},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4268777370452881},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.401019424200058},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3997386693954468},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.309748113155365},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28722435235977173},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24334698915481567},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.24214789271354675},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21750840544700623},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.184552401304245},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12423011660575867},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.0},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C2778258057","wikidata":"https://www.wikidata.org/wiki/Q1136569","display_name":"Prenatal diagnosis","level":4,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fonc.2019.01266","doi":"https://doi.org/10.3389/fonc.2019.01266","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2019.01266","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2019.01266/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6877686","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6877686","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmid:31803629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31803629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8734a210a5d4424da77f557711a70101","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8734a210a5d4424da77f557711a70101","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 9 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2019.01266","doi":"https://doi.org/10.3389/fonc.2019.01266","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2019.01266","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2019.01266/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G501207485","display_name":null,"funder_award_id":"CA 006927","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5562880686","display_name":null,"funder_award_id":"CA218976","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000285491","display_name":"Comprehensive Cancer Center Program at Fox Chase","funder_award_id":"P30CA006927","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320311529","display_name":"Bladder Cancer Advocacy Network","ror":"https://ror.org/04p3pep55"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2991158142.pdf","grobid_xml":"https://content.openalex.org/works/W2991158142.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W1488522305","https://openalex.org/W1530812988","https://openalex.org/W1536340771","https://openalex.org/W1568947382","https://openalex.org/W1869447700","https://openalex.org/W1893588230","https://openalex.org/W1902718972","https://openalex.org/W1962460712","https://openalex.org/W1967279935","https://openalex.org/W1969652104","https://openalex.org/W1975918912","https://openalex.org/W1983466841","https://openalex.org/W1983550086","https://openalex.org/W1985359974","https://openalex.org/W2011595291","https://openalex.org/W2020053158","https://openalex.org/W2031475510","https://openalex.org/W2031541885","https://openalex.org/W2033378968","https://openalex.org/W2035389419","https://openalex.org/W2048781023","https://openalex.org/W2051781679","https://openalex.org/W2064543601","https://openalex.org/W2073434270","https://openalex.org/W2073502643","https://openalex.org/W2074370020","https://openalex.org/W2075898170","https://openalex.org/W2081162953","https://openalex.org/W2084726969","https://openalex.org/W2089568995","https://openalex.org/W2097150676","https://openalex.org/W2101007787","https://openalex.org/W2104500293","https://openalex.org/W2106037418","https://openalex.org/W2119362132","https://openalex.org/W2120869188","https://openalex.org/W2125418992","https://openalex.org/W2132388337","https://openalex.org/W2143197030","https://openalex.org/W2152241467","https://openalex.org/W2154018281","https://openalex.org/W2160107406","https://openalex.org/W2162130153","https://openalex.org/W2164791945","https://openalex.org/W2208134400","https://openalex.org/W2239206886","https://openalex.org/W2281315182","https://openalex.org/W2329906190","https://openalex.org/W2341548114","https://openalex.org/W2399240278","https://openalex.org/W2498471190","https://openalex.org/W2531822697","https://openalex.org/W2581231749","https://openalex.org/W2598980403","https://openalex.org/W2599796007","https://openalex.org/W2603736483","https://openalex.org/W2729957262","https://openalex.org/W2734508763","https://openalex.org/W2734632385","https://openalex.org/W2763670669","https://openalex.org/W2765964920","https://openalex.org/W2783674487","https://openalex.org/W2790726106","https://openalex.org/W2795044597","https://openalex.org/W2800101422","https://openalex.org/W2804387369","https://openalex.org/W2885289995","https://openalex.org/W2890428656","https://openalex.org/W2902688662","https://openalex.org/W2906216049","https://openalex.org/W2912123626","https://openalex.org/W2916183155","https://openalex.org/W2945041523","https://openalex.org/W2945086019","https://openalex.org/W2952284474","https://openalex.org/W2952746993","https://openalex.org/W2964014383"],"related_works":["https://openalex.org/W3164358516","https://openalex.org/W4212870151","https://openalex.org/W2964616405","https://openalex.org/W2605944234","https://openalex.org/W4387826343","https://openalex.org/W2938290407","https://openalex.org/W4210621511","https://openalex.org/W3082221503","https://openalex.org/W4414518994","https://openalex.org/W7162641096"],"abstract_inverted_index":{"With":[0],"recent":[1],"advancements":[2],"in":[3,26,46,103,173],"a":[4,75,106,115],"non-invasive":[5],"approach":[6],"to":[7,67,126,171],"cancer":[8],"diagnosis":[9],"and":[10,28,53,108,144,184],"surveillance,":[11],"the":[12,83,178],"term":[13],"\"liquid":[14,69],"biopsy\"":[15],"has":[16],"gained":[17],"traction":[18],"but":[19],"is":[20,50],"currently":[21],"limited":[22],"by":[23],"technological":[24],"challenges":[25],"identifying":[27],"isolating":[29],"circulating":[30],"tumor":[31],"cells":[32],"(CTCs),":[33],"proteins,":[34],"cell-free":[35],"DNA":[36,88],"(cfDNA),":[37],"or":[38,187],"other":[39],"nucleic":[40],"acids.":[41],"Tumor":[42],"tissue":[43],"biopsy,":[44],"especially":[45,58],"genitourinary":[47],"(GU)":[48],"system":[49],"sometimes":[51],"inadequate":[52],"requires":[54,105],"invasive":[55,192],"surgical":[56],"options,":[57],"for":[59],"upper":[60],"tract":[61],"urothelial":[62],"cancer.":[63],"Urine":[64,150],"can":[65,156,168],"prove":[66,157],"be":[68,74,91,169],"gold\"":[70],"since":[71],"it":[72],"may":[73,90],"more":[76],"abundant":[77],"source":[78],"of":[79,101,111,118,162,180,191],"tumor-derived":[80],"material":[81],"without":[82],"background":[84],"noise;":[85],"however,":[86],"urine":[87,167],"(uDNA)":[89],"associated":[92],"with":[93],"low":[94],"mutant":[95],"allele":[96],"fraction":[97],"(MAF).":[98],"Molecular":[99],"detection":[100],"mutations":[102],"uDNA":[104],"sensitive":[107],"accurate":[109],"method":[110],"analysis":[112],"that":[113],"allows":[114],"high":[116],"depth":[117],"sequencing":[119,124,140,154],"while":[120],"minimizing":[121],"artifacts.":[122],"Several":[123],"approaches":[125,146],"address":[127],"this":[128],"hurdle":[129],"using":[130],"enhanced":[131],"library":[132],"preparation":[133],"techniques":[134],"such":[135],"as":[136],"Tagged":[137],"amplicon":[138],"deep":[139],"(TAm-Seq),":[141],"Safe-SeqS,":[142],"FAST-SeqS,":[143],"CAPP-Seq":[145],"have":[147],"been":[148],"developed.":[149],"biopsy":[151],"utilizing":[152],"next-generation":[153],"(NGS)":[155],"useful":[158],"at":[159],"all":[160,189],"stages":[161],"urologic":[163],"malignancy":[164],"care,":[165],"where":[166],"collected":[170],"aid":[172],"clinical":[174],"decision":[175],"making":[176],"through":[177],"identification":[179],"commonly":[181],"known":[182],"mutations,":[183],"potentially":[185],"reduce":[186],"avoid":[188],"forms":[190],"procedures.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-12-05T00:00:00"}
