{"id":"https://openalex.org/W2991157552","doi":"https://doi.org/10.1038/s41467-019-13247-6","title":"Structural determinants of microtubule minus end preference in CAMSAP CKK domains","display_name":"Structural determinants of microtubule minus end preference in CAMSAP CKK domains","publication_year":2019,"publication_date":"2019-11-20","ids":{"openalex":"https://openalex.org/W2991157552","doi":"https://doi.org/10.1038/s41467-019-13247-6","mag":"2991157552","pmid":"https://pubmed.ncbi.nlm.nih.gov/31748546","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6868217"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-019-13247-6","doi":"https://doi.org/10.1038/s41467-019-13247-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-019-13247-6","pdf_url":"https://www.nature.com/articles/s41467-019-13247-6.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-019-13247-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063033161","display_name":"Joseph Atherton","orcid":"https://orcid.org/0000-0002-6362-2347","observed_orcids":["https://orcid.org/0000-0002-6362-2347"]},"institutions":[{"id":"https://openalex.org/I4210157240","display_name":"Institute of Structural and Molecular Biology","ror":"https://ror.org/05wsetc54","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]},{"id":"https://openalex.org/I98259816","display_name":"Birkbeck, University of London","ror":"https://ror.org/02mb95055","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I98259816"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Joseph Atherton","raw_affiliation_strings":["Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London, UK. j.atherton@mail.cryst.bbk.ac.uk","Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London, UK. j.atherton@mail.cryst.bbk.ac.uk","institution_ids":["https://openalex.org/I4210157240","https://openalex.org/I98259816"]},{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London, UK","institution_ids":["https://openalex.org/I4210157240","https://openalex.org/I98259816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041678996","display_name":"Yanzhang Luo","orcid":"https://orcid.org/0000-0001-9149-2423","observed_orcids":["https://orcid.org/0000-0001-9149-2423"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Yanzhang Luo","raw_affiliation_strings":["NMR Spectroscopy, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-9149-2423","affiliations":[{"raw_affiliation_string":"NMR Spectroscopy, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013693935","display_name":"ShengQi Xiang","orcid":"https://orcid.org/0000-0002-6874-4925","observed_orcids":["https://orcid.org/0000-0002-6874-4925"]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["CN","NL"],"is_corresponding":false,"raw_author_name":"Shengqi Xiang","raw_affiliation_strings":["MOE Key Lab for biomolecular Condensates & Cellular Dynamics, School of Life Sciences, University of Science and Technology of China, 96 Jinzhai Road, Hefei, 230026, Anhui, China","NMR Spectroscopy, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MOE Key Lab for biomolecular Condensates & Cellular Dynamics, School of Life Sciences, University of Science and Technology of China, 96 Jinzhai Road, Hefei, 230026, Anhui, China","institution_ids":["https://openalex.org/I126520041"]},{"raw_affiliation_string":"NMR Spectroscopy, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062765084","display_name":"Chao Yang","orcid":"https://orcid.org/0000-0002-4035-6453","observed_orcids":["https://orcid.org/0000-0002-4035-6453"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Chao Yang","raw_affiliation_strings":["Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011792616","display_name":"Ankit Rai","orcid":"https://orcid.org/0000-0002-3732-3597","observed_orcids":["https://orcid.org/0000-0002-3732-3597","https://orcid.org/0000-0002-1569-0919"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ankit Rai","raw_affiliation_strings":["Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-3732-3597","affiliations":[{"raw_affiliation_string":"Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051446500","display_name":"Kai Jiang","orcid":"https://orcid.org/0000-0002-6871-737X","observed_orcids":["https://orcid.org/0000-0002-6871-737X"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Jiang","raw_affiliation_strings":["Medical Research Institute, School of Medicine, Wuhan University, 430071, Wuhan, China"],"raw_orcid":"https://orcid.org/0000-0002-6871-737X","affiliations":[{"raw_affiliation_string":"Medical Research Institute, School of Medicine, Wuhan University, 430071, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067802479","display_name":"Marcel Stangier","orcid":"https://orcid.org/0000-0001-6837-0823","observed_orcids":["https://orcid.org/0000-0001-6837-0823"]},"institutions":[{"id":"https://openalex.org/I2802229908","display_name":"Paul Scherrer Institute","ror":"https://ror.org/03eh3y714","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I2802229908"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Marcel Stangier","raw_affiliation_strings":["Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, Villigen, PSI, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, Villigen, PSI, Switzerland","institution_ids":["https://openalex.org/I2802229908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083052890","display_name":"Annapurna Vemu","orcid":"https://orcid.org/0000-0003-1841-8678","observed_orcids":["https://orcid.org/0000-0003-1841-8678"]},"institutions":[{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annapurna Vemu","raw_affiliation_strings":["Cell Biology and Biophysics Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology and Biophysics Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014342835","display_name":"Alexander D. Cook","orcid":"https://orcid.org/0000-0003-1283-1541","observed_orcids":["https://orcid.org/0000-0003-1283-1541"]},"institutions":[{"id":"https://openalex.org/I4210157240","display_name":"Institute of Structural and Molecular Biology","ror":"https://ror.org/05wsetc54","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]},{"id":"https://openalex.org/I98259816","display_name":"Birkbeck, University of London","ror":"https://ror.org/02mb95055","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I98259816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexander D. Cook","raw_affiliation_strings":["Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London, UK","institution_ids":["https://openalex.org/I4210157240","https://openalex.org/I98259816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100463054","display_name":"Su Wang","orcid":"https://orcid.org/0000-0002-9463-6530","observed_orcids":["https://orcid.org/0000-0002-9463-6530"]},"institutions":[{"id":"https://openalex.org/I4210157240","display_name":"Institute of Structural and Molecular Biology","ror":"https://ror.org/05wsetc54","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]},{"id":"https://openalex.org/I98259816","display_name":"Birkbeck, University of London","ror":"https://ror.org/02mb95055","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I98259816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Su Wang","raw_affiliation_strings":["Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London, UK","institution_ids":["https://openalex.org/I4210157240","https://openalex.org/I98259816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014001664","display_name":"Antonina Roll\u2010Mecak","orcid":"https://orcid.org/0000-0003-2621-7307","observed_orcids":["https://orcid.org/0000-0003-2621-7307"]},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonina Roll-Mecak","raw_affiliation_strings":["Biophysics Center, National Heart, Lung and Blood Institute, Bethesda, MD, 20892, USA","Cell Biology and Biophysics Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, 20892, USA"],"raw_orcid":"https://orcid.org/0000-0003-2621-7307","affiliations":[{"raw_affiliation_string":"Biophysics Center, National Heart, Lung and Blood Institute, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I4210106489"]},{"raw_affiliation_string":"Cell Biology and Biophysics Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000351848","display_name":"Michel Olivier Steinmetz","orcid":"https://orcid.org/0000-0001-6157-3687","observed_orcids":["https://orcid.org/0000-0001-6157-3687","https://orcid.org/0000-0002-6633-5271"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802229908","display_name":"Paul Scherrer Institute","ror":"https://ror.org/03eh3y714","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I2802229908"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Michel O. Steinmetz","raw_affiliation_strings":["Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, Villigen, PSI, Switzerland","University of Basel, Biozentrum, CH-4056, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-6157-3687","affiliations":[{"raw_affiliation_string":"Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, Villigen, PSI, Switzerland","institution_ids":["https://openalex.org/I2802229908"]},{"raw_affiliation_string":"University of Basel, Biozentrum, CH-4056, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024109873","display_name":"Anna S. Akhmanova","orcid":"https://orcid.org/0000-0002-9048-8614","observed_orcids":["https://orcid.org/0000-0002-9048-8614"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Anna Akhmanova","raw_affiliation_strings":["Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-9048-8614","affiliations":[{"raw_affiliation_string":"Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080937302","display_name":"Marc Baldus","orcid":"https://orcid.org/0000-0001-7068-5613","observed_orcids":["https://orcid.org/0000-0001-7068-5613"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Marc Baldus","raw_affiliation_strings":["NMR Spectroscopy, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands. M.Baldus@uu.nl","NMR Spectroscopy, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-7068-5613","affiliations":[{"raw_affiliation_string":"NMR Spectroscopy, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands. M.Baldus@uu.nl","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"NMR Spectroscopy, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052607183","display_name":"Carolyn Ann Moores","orcid":"https://orcid.org/0000-0001-5686-6290","observed_orcids":["https://orcid.org/0000-0001-5686-6290"]},"institutions":[{"id":"https://openalex.org/I4210157240","display_name":"Institute of Structural and Molecular Biology","ror":"https://ror.org/05wsetc54","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]},{"id":"https://openalex.org/I98259816","display_name":"Birkbeck, University of London","ror":"https://ror.org/02mb95055","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I98259816"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Carolyn A. Moores","raw_affiliation_strings":["Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London, UK. c.moores@mail.cryst.bbk.ac.uk","Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London, UK"],"raw_orcid":"https://orcid.org/0000-0001-5686-6290","affiliations":[{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London, UK. c.moores@mail.cryst.bbk.ac.uk","institution_ids":["https://openalex.org/I4210157240","https://openalex.org/I98259816"]},{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London, UK","institution_ids":["https://openalex.org/I4210157240","https://openalex.org/I98259816"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5052607183","https://openalex.org/A5063033161","https://openalex.org/A5080937302"],"corresponding_institution_ids":["https://openalex.org/I193662353","https://openalex.org/I4210157240","https://openalex.org/I98259816"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5200,"currency":"USD","value_usd":5200},"fwci":1.818,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.83546206,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"5236","last_page":"5236"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microtubule-minus-ends","display_name":"microtubule minus ends","score":0.828000009059906},{"id":"https://openalex.org/keywords/microtubule-dynamics","display_name":"microtubule dynamics","score":0.7590000033378601},{"id":"https://openalex.org/keywords/tubulin-conformation","display_name":"tubulin conformation","score":0.7870000004768372},{"id":"https://openalex.org/keywords/naegleria-gruberi","display_name":"Naegleria gruberi","score":0.8309999704360962},{"id":"https://openalex.org/keywords/microtubule-binding-protein","display_name":"microtubule-binding protein","score":0.6800000071525574},{"id":"https://openalex.org/keywords/microtubule-lattice","display_name":"microtubule lattice","score":0.6000000238418579},{"id":"https://openalex.org/keywords/protein-rigidity","display_name":"protein rigidity","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.8897830247879028},{"id":"https://openalex.org/C84425145","wikidata":"https://www.wikidata.org/wiki/Q422492","display_name":"Tubulin","level":3,"score":0.8312495946884155},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4714304506778717},{"id":"https://openalex.org/C25166345","wikidata":"https://www.wikidata.org/wiki/Q4914012","display_name":"Binding domain","level":3,"score":0.46706730127334595},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.43230000138282776},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4082765281200409},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.3706904649734497},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.35748955607414246},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3391326367855072},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3360522389411926},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3274664282798767},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17405104637145996}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009253","descriptor_name":"Naegleria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009253","descriptor_name":"Naegleria","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":12,"locations":[{"id":"doi:10.1038/s41467-019-13247-6","doi":"https://doi.org/10.1038/s41467-019-13247-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-019-13247-6","pdf_url":"https://www.nature.com/articles/s41467-019-13247-6.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.1101/586230","doi":"https://doi.org/10.1101/586230","is_oa":true,"landing_page_url":"https://doi.org/10.1101/586230","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/03/27/586230.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:6868217","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6868217","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:31748546","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31748546","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.bbk.ac.uk.oai2:30016","doi":null,"is_oa":false,"landing_page_url":"https://eprints.bbk.ac.uk/id/eprint/30016/1/30016.pdf","pdf_url":"https://eprints.bbk.ac.uk/id/eprint/30016/1/30016.pdf","source":{"id":"https://openalex.org/S4306400465","display_name":"BIROn (Birkbeck, University of London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98259816","host_organization_name":"Birkbeck, University of London","host_organization_lineage":["https://openalex.org/I98259816"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:dora:psi_28059","doi":null,"is_oa":true,"landing_page_url":"https://www.dora.lib4ri.ch/psi/item/psi:28059","pdf_url":"https://www.dora.lib4ri.ch/psi/dload/psi:28059/PDF/view","source":{"id":"https://openalex.org/S4306402574","display_name":"DORA PSI (Paul Scherrer Institute)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802229908","host_organization_name":"Paul Scherrer Institute","host_organization_lineage":["https://openalex.org/I2802229908"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13247-6","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-019-13247-6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:3d87bd15c883481392c7b1e0dbdc5c01","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3d87bd15c883481392c7b1e0dbdc5c01","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:9af6bd9a7600426fa678b26b27c38c01","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9af6bd9a7600426fa678b26b27c38c01","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)","raw_type":"article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/389479","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/389479","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:openaire/175f5172-ad96-43ab-b7a9-0182067556b5","doi":null,"is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/files/134066179/s41467_019_13247_6.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Atherton, J, Luo, Y, Xiang, S, Yang, C, Rai, A, Jiang, K, Stangier, M, Vemu, A, Cook, A D, Wang, S, Roll-Mecak, A, Steinmetz, M O, Akhmanova, A, Baldus, M & Moores, C A 2019, 'Structural determinants of microtubule minus end preference in CAMSAP CKK domains', Nature Communications, vol. 10, 5236, pp. 1-16. https://doi.org/10.1038/s41467-019-13247-6","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/389479","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/389479","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, 10(1). Nature Publishing Group","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/s41467-019-13247-6","doi":"https://doi.org/10.1038/s41467-019-13247-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-019-13247-6","pdf_url":"https://www.nature.com/articles/s41467-019-13247-6.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2359355505","display_name":"Energy filter with direct electron detector for electron cryo tomography","funder_award_id":"BB/L014211/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G4078356467","display_name":"Cryo-electron microscopy equipment for structure determination of macromolecular and cellular assemblies.","funder_award_id":"079605","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G4562669","display_name":"Caught in the act: a combined magnetic resonance -modelling approach to capture cellular machines at work","funder_award_id":"718.015.001","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G494123624","display_name":null,"funder_award_id":"175.010.200","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G5786650183","display_name":"Building blocks of molecular complexity: the neuronal cytoskeleton in health and disease","funder_award_id":"MR/R000352/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G6927657787","display_name":null,"funder_award_id":"722.016.002","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G732857578","display_name":"Control of Tubulin Structure and Function by Accessory Proteins and Drugs","funder_award_id":"166608","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G739131091","display_name":"Cryo-electron microscopy equipment for structure determination of macromolecular and cellular assemblies.","funder_award_id":"079605/Z/06/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G7742023658","display_name":"An ultra-high field NMR facility for the Netherlands (uNMR-NL)","funder_award_id":"184.032.207","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G9000129426","display_name":null,"funder_award_id":"175.010.2009.002","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2991157552.pdf","grobid_xml":"https://content.openalex.org/works/W2991157552.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W30334872","https://openalex.org/W1596852471","https://openalex.org/W1603135767","https://openalex.org/W1785817244","https://openalex.org/W1789623687","https://openalex.org/W1964375816","https://openalex.org/W1971846833","https://openalex.org/W1973736387","https://openalex.org/W1975993538","https://openalex.org/W2009590415","https://openalex.org/W2024095838","https://openalex.org/W2026682681","https://openalex.org/W2037415133","https://openalex.org/W2041454099","https://openalex.org/W2042442392","https://openalex.org/W2044820159","https://openalex.org/W2048826637","https://openalex.org/W2048982317","https://openalex.org/W2058428747","https://openalex.org/W2058997498","https://openalex.org/W2059974078","https://openalex.org/W2060504185","https://openalex.org/W2065283382","https://openalex.org/W2065662125","https://openalex.org/W2071914973","https://openalex.org/W2075525059","https://openalex.org/W2079665723","https://openalex.org/W2087130779","https://openalex.org/W2100343024","https://openalex.org/W2102905759","https://openalex.org/W2104234755","https://openalex.org/W2110213040","https://openalex.org/W2112742202","https://openalex.org/W2121603566","https://openalex.org/W2122755030","https://openalex.org/W2127334851","https://openalex.org/W2132629607","https://openalex.org/W2144081223","https://openalex.org/W2152551552","https://openalex.org/W2154714625","https://openalex.org/W2157420503","https://openalex.org/W2165041848","https://openalex.org/W2166882183","https://openalex.org/W2168997921","https://openalex.org/W2191047704","https://openalex.org/W2198451860","https://openalex.org/W2237971187","https://openalex.org/W2329582709","https://openalex.org/W2406343444","https://openalex.org/W2409372323","https://openalex.org/W2519303614","https://openalex.org/W2536685478","https://openalex.org/W2593511418","https://openalex.org/W2600145630","https://openalex.org/W2762278743","https://openalex.org/W2762923953","https://openalex.org/W2767946881","https://openalex.org/W2786390877","https://openalex.org/W2789554578","https://openalex.org/W2790617822","https://openalex.org/W2799809717","https://openalex.org/W2800724568","https://openalex.org/W2804594934","https://openalex.org/W2809170986","https://openalex.org/W2809813558","https://openalex.org/W2892150329","https://openalex.org/W2895310363","https://openalex.org/W2899681969","https://openalex.org/W2899714098","https://openalex.org/W2917111827","https://openalex.org/W2950967305","https://openalex.org/W2951384153","https://openalex.org/W2951531210","https://openalex.org/W2953716540","https://openalex.org/W2980132977","https://openalex.org/W4233195329","https://openalex.org/W4234447934","https://openalex.org/W4252356526"],"related_works":["https://openalex.org/W4236806796","https://openalex.org/W2911277817","https://openalex.org/W2762923953","https://openalex.org/W2168997921","https://openalex.org/W4403952027","https://openalex.org/W2784080846","https://openalex.org/W2948092770","https://openalex.org/W2060504185","https://openalex.org/W4210980583","https://openalex.org/W2530060337"],"abstract_inverted_index":{"CAMSAP/Patronins":[0],"regulate":[1],"microtubule":[2,105,110,147],"minus-end":[3,48,148],"dynamics.":[4],"Their":[5],"end":[6],"specificity":[7],"is":[8,124],"mediated":[9],"by":[10],"their":[11],"CKK":[12,35,40,66],"domains,":[13],"which":[14,46,62],"we":[15,30,51],"proposed":[16],"recognise":[17],"specific":[18,142],"tubulin":[19,78,121,143],"conformations":[20,144],"found":[21],"at":[22,74],"minus":[23],"ends.":[24],"To":[25],"critically":[26],"test":[27],"this":[28],"idea,":[29],"compared":[31],"the":[32,69,75,104,115,120,136],"human":[33],"CAMSAP1":[34],"domain":[36,41,138],"(HsCKK)":[37],"with":[38],"a":[39],"from":[42],"Naegleria":[43],"gruberi":[44],"(NgCKK),":[45],"lacks":[47],"specificity.":[49],"Here":[50],"report":[52],"near-atomic":[53],"cryo-electron":[54],"microscopy":[55],"structures":[56],"of":[57],"HsCKK-":[58],"and":[59,92,113],"NgCKK-microtubule":[60],"complexes,":[61],"show":[63,88],"that":[64,89],"these":[65],"domains":[67],"share":[68],"same":[70],"protein":[71],"fold,":[72],"bind":[73],"intradimer":[76],"interprotofilament":[77],"junction,":[79],"but":[80],"exhibit":[81],"different":[82],"footprints":[83],"on":[84],"microtubules.":[85],"NMR":[86],"experiments":[87],"both":[90],"HsCKK":[91,107,137],"NgCKK":[93,99],"are":[94],"remarkably":[95],"rigid.":[96],"However,":[97],"whereas":[98],"binding":[100],"does":[101],"not":[102,125],"alter":[103],"architecture,":[106],"remodels":[108],"its":[109,128],"interaction":[111],"site":[112],"changes":[114],"underlying":[116],"polymer":[117],"structure":[118],"because":[119],"lattice":[122],"conformation":[123],"optimal":[126],"for":[127],"binding.":[129],"Thus,":[130],"in":[131],"contrast":[132],"to":[133,145],"many":[134],"MAPs,":[135],"can":[139],"differentiate":[140],"subtly":[141],"enable":[146],"recognition.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-12-05T00:00:00"}