{"id":"https://openalex.org/W2991010417","doi":null,"title":"Palmitate-induced insulin resistance is attenuated by Pioglitazone and EGCG through reducing the gluconeogenic key enzymes expression in HepG2 cells.","display_name":"Palmitate-induced insulin resistance is attenuated by Pioglitazone and EGCG through reducing the gluconeogenic key enzymes expression in HepG2 cells.","publication_year":2017,"publication_date":"2017-10-01","ids":{"openalex":"https://openalex.org/W2991010417","mag":"2991010417","pmid":"https://pubmed.ncbi.nlm.nih.gov/29362600","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5771254"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:4686498","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5771254","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5771254","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005817026","display_name":"S Yadollah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166459259","display_name":"Shiraz University","ror":"https://ror.org/028qtbk54","country_code":"IR","type":"education","lineage":["https://openalex.org/I166459259"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"S Yadollah","raw_affiliation_strings":["Department of Basic Science, School of Veterinary Medicine, Shiraz University, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Science, School of Veterinary Medicine, Shiraz University, Shiraz, Iran","institution_ids":["https://openalex.org/I166459259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065231974","display_name":"Nasrin Kazemipour","orcid":"https://orcid.org/0000-0002-2939-1776","observed_orcids":["https://orcid.org/0000-0002-2939-1776"]},"institutions":[{"id":"https://openalex.org/I166459259","display_name":"Shiraz University","ror":"https://ror.org/028qtbk54","country_code":"IR","type":"education","lineage":["https://openalex.org/I166459259"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"N Kazemipour","raw_affiliation_strings":["Department of Basic Science, School of Veterinary Medicine, Shiraz University, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Science, School of Veterinary Medicine, Shiraz University, Shiraz, Iran","institution_ids":["https://openalex.org/I166459259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038815016","display_name":"Salar Bakhtiyari","orcid":"https://orcid.org/0000-0002-2500-269X","observed_orcids":["https://orcid.org/0000-0002-2500-269X"]},"institutions":[{"id":"https://openalex.org/I3017965041","display_name":"Medical University of Ilam","ror":"https://ror.org/042hptv04","country_code":"IR","type":"education","lineage":["https://openalex.org/I3017965041"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"S Bakhtiyari","raw_affiliation_strings":["Department of Clinical Biochemistry, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran","institution_ids":["https://openalex.org/I3017965041"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008790653","display_name":"Saeed Naz\u0131f\u0131","orcid":"https://orcid.org/0000-0002-5501-1028","observed_orcids":["https://orcid.org/0000-0002-5501-1028"]},"institutions":[{"id":"https://openalex.org/I166459259","display_name":"Shiraz University","ror":"https://ror.org/028qtbk54","country_code":"IR","type":"education","lineage":["https://openalex.org/I166459259"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"S Nazifi","raw_affiliation_strings":["Department of Clinical Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran","institution_ids":["https://openalex.org/I166459259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4868,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.57128132,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"10","issue":"4","first_page":"244","last_page":"249"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.4650999903678894,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.4650999903678894,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.4077000021934509,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11411","display_name":"Tea Polyphenols and Effects","score":0.04390000179409981,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/palmitate","display_name":"palmitate","score":0.9070000052452087},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pioglitazone","display_name":"pioglitazone","score":0.9940000176429749},{"id":"https://openalex.org/keywords/epigallocatechin-gallate","display_name":"epigallocatechin gallate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gluconeogenesis","display_name":"gluconeogenesis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/phosphoenolpyruvate-carboxykinase","display_name":"phosphoenolpyruvate carboxykinase","score":0.8019999861717224},{"id":"https://openalex.org/keywords/glucose-6-phosphatase","display_name":"glucose-6-phosphatase","score":0.9470000267028809},{"id":"https://openalex.org/keywords/glucose-production","display_name":"glucose production","score":0.7509999871253967},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8889999985694885},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.765999972820282},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C2778384471","wikidata":"https://www.wikidata.org/wiki/Q417765","display_name":"Pioglitazone","level":4,"score":0.9752047061920166},{"id":"https://openalex.org/C20904676","wikidata":"https://www.wikidata.org/wiki/Q191835","display_name":"Gluconeogenesis","level":3,"score":0.8012267351150513},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7510844469070435},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6910717487335205},{"id":"https://openalex.org/C143937172","wikidata":"https://www.wikidata.org/wiki/Q303568","display_name":"Phosphoenolpyruvate carboxykinase","level":3,"score":0.6893764734268188},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6817954778671265},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5708808898925781},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5037195086479187},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2887294888496399},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26987096667289734},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.2524817883968353},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20900452136993408},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.20531782507896423},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18109077215194702},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.17483308911323547}],"mesh":[{"descriptor_ui":"D000077205","descriptor_name":"Pioglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005943","descriptor_name":"Gluconeogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005954","descriptor_name":"Glucosephosphate Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005954","descriptor_name":"Glucosephosphate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010168","descriptor_name":"Palmitates","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019764","descriptor_name":"Phosphoenolpyruvate Carboxykinase (ATP)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019764","descriptor_name":"Phosphoenolpyruvate Carboxykinase (ATP)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:4686498","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5771254","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:29362600","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29362600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicine and life","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5771254","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5771254/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Med Life","raw_type":"Text"},{"id":"pmh:oai:eprints.medilam.ac.ir:998","doi":null,"is_oa":false,"landing_page_url":"http://eprints.medilam.ac.ir/998/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400609","display_name":"Research Repository Portal (Ilam University of Medical Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I3017965041","host_organization_name":"Medical University of Ilam","host_organization_lineage":["https://openalex.org/I3017965041"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"mag:2991010417","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29362600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4686498","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5771254","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W131917179","https://openalex.org/W1575011694","https://openalex.org/W1603928832","https://openalex.org/W1830151520","https://openalex.org/W1876389666","https://openalex.org/W1971316445","https://openalex.org/W1975407164","https://openalex.org/W1975955075","https://openalex.org/W1979804924","https://openalex.org/W1988725429","https://openalex.org/W1996299188","https://openalex.org/W2001863716","https://openalex.org/W2004885518","https://openalex.org/W2010124690","https://openalex.org/W2010585073","https://openalex.org/W2010594655","https://openalex.org/W2023447984","https://openalex.org/W2025814716","https://openalex.org/W2028038659","https://openalex.org/W2031773477","https://openalex.org/W2037447341","https://openalex.org/W2041088774","https://openalex.org/W2041432459","https://openalex.org/W2044186731","https://openalex.org/W2045362322","https://openalex.org/W2048276861","https://openalex.org/W2056370279","https://openalex.org/W2064030869","https://openalex.org/W2073412471","https://openalex.org/W2073751076","https://openalex.org/W2097784879","https://openalex.org/W2115158658","https://openalex.org/W2121970519","https://openalex.org/W2127301790","https://openalex.org/W2133208346","https://openalex.org/W2138004615","https://openalex.org/W2140603676","https://openalex.org/W2145530897","https://openalex.org/W2151664883","https://openalex.org/W2160271279","https://openalex.org/W2164849270","https://openalex.org/W2170869159","https://openalex.org/W2303883610","https://openalex.org/W2473632044"],"related_works":["https://openalex.org/W2001863716","https://openalex.org/W7071260747","https://openalex.org/W2237151023","https://openalex.org/W7014399626","https://openalex.org/W2809965093","https://openalex.org/W1995040627","https://openalex.org/W2564147974","https://openalex.org/W2394194435","https://openalex.org/W7157265535","https://openalex.org/W2192466411"],"abstract_inverted_index":{"HYPOTHESIS:":[0],"Palmitate":[1,102],"causes":[2],"insulin":[3,7,185,246],"resistance":[4,247],"(IR)":[5],"in":[6,55,91,180,213,216,244],"target":[8],"tissue.":[9],"Pioglitazone":[10,135],"(an":[11],"anti-hyperglycemic":[12,50],"agent)":[13],"and":[14,70,109,115,128,132,142,146,156,165,169,194,202,210,238],"epigallocatechin":[15,73],"gallate":[16,74],"(EGCG,":[17],"a":[18],"dietary":[19],"supplement)":[20],"can":[21],"be":[22],"used":[23,80],"for":[24],"the":[25,45,83,96,120,124,137,160,184,196,221,230,241],"treatment":[26,150,207],"of":[27,48,98,126,140,151,163,234],"type":[28],"2":[29],"diabetes.":[30],"However,":[31],"their":[32],"molecular":[33],"effects":[34],"on":[35,52,240],"gluconeogenesis":[36,53,99,242],"remain":[37],"unclear.":[38],"OBJECTIVE:":[39],"Hence,":[40],"we":[41],"aimed":[42],"to":[43,81,94,119,220],"investigate":[44,82],"simultaneous":[46],"effect":[47,233],"these":[49],"agents":[51],"through":[54],"vitro":[56],"experiments.":[57],"METHODS:":[58],"HepG2":[59,181,187,224,248],"cells":[60,153,188],"were":[61,189],"treated":[62,190,223],"with":[63,154,173,192,208,236],"0.5":[64],"mM":[65],"palmitate,":[66],"10":[67],"\u03bcM":[68,72],"pioglitazone,":[69,195],"40":[71],"(EGCG).":[75],"Gene":[76],"expression":[77,125],"assay":[78,88],"was":[79,89],"underlying":[84],"mechanism.":[85],"Glucose":[86],"production":[87,177,198,218],"applied":[90],"culture":[92],"medium":[93],"evaluate":[95],"activity":[97],"pathway.":[100],"RESULTS:":[101],"induced":[103],"IR":[104],"could":[105],"significantly":[106,158],"increase":[107],"G6Pase":[108,129,143,166],"PEPCK":[110,127,141,164],"gene":[111],"expressions":[112],"by":[113,130,144,167,178,200],"58":[114,145],"30%,":[116],"respectively,":[117],"compared":[118,219],"control.":[121],"EGCG":[122,155,193,209,239],"reduced":[123,136,199],"53":[131],"67%,":[133],"respectively.":[134,148,171,204],"mRNA":[138,161],"level":[139,162],"62%":[147],"Combined":[149],"insulin-resistant":[152],"pioglitazone":[157,211,237],"decreased":[159],"73":[168],"80%,":[170],"Treatment":[172],"palmitate":[174,222],"increased":[175],"glucose":[176,197,217],"50%":[179],"cells.":[182,225,249],"When":[183],"resistant":[186],"alone":[191],"50":[201],"55%,":[203],"The":[205],"combined":[206],"resulted":[212],"69%":[214],"reduction":[215],"CONCLUSIONS:":[226],"These":[227],"data":[228],"suggest":[229],"additive":[231],"inhibitory":[232],"co-treatment":[235],"pathway":[243],"palmitate-induced":[245]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-12-05T00:00:00"}